Sylvia atricapilla (blackcap): 136359237 Help Entry 136359237         CDS       T10263                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism sati  Sylvia atricapilla (blackcap) Pathway sati04020   Calcium signaling pathway sati04260   Cardiac muscle contraction sati04261   Adrenergic signaling in cardiomyocytes sati04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sati00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     136359237 (RYR2)    04020 Calcium signaling pathway     136359237 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     136359237 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     136359237 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sati04040]     136359237 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:sati04990]     136359237 (RYR2) Ion channels [BR:sati04040]  Voltage-gated cation channels   Ryanodine receptor    136359237 (RYR2) Domain-containing proteins not elsewhere classified [BR:sati04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    136359237 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  136359237 NCBI-ProteinID:  XP_066171775 LinkDB All DBs Position 3:complement(68675059..69053716) Genome browser AA seq 4958 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWSAQGGGHRTLLYGHAILLRHSY SGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECL TVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKY LSLLDDKSLLLTDKENADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQH VDTGLWLTYQSADAKSVRMGSLQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFL FNRFIRGLDSLSKKVKSSTIDLPIESVNLSLQDLIGYFHPPDEHLEHENKQNRLRALKNR QNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISE GSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSY GFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNID GLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRS YTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYG PVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEKVKKMK LPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVK NRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDMCSGIMEKF RIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRW HQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVADGFLPVC SLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNH EHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGS GLFAPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLK QRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGW ITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGL EIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMP LSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPL QFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDESQL LYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKK HGLPGIGLSTSLRPRMQFSSPSFVSISAECFQFSPEFPLEILKAKTIEMLTEAVQEGSLH VRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPRVFKEAMSQEDEIDFSE KEFSSDELKSEGEEETRGDQMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVA FSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCP CPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDSTIRGRLLYLMEKVTYLKKKQAEKA VDEDDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYT INSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLICKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMH LIHAGKGEAIRIRSILRSLIPLEDLVGVISIAFHMPTIAKDGTVVEPDMSAGFCPDHKAA MVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDAIEECLLSICGQLRPSMMQH LLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPSGWGNFGAASEEELHLSRKLFWG IFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVD TSNITIPEKLEYFINKYAEHAHDKWSMEKFANGWTYGETFSESAKVQPLMKQYKLLSEKE KEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTHRISQTSQISVDTAHGYTPRAID MSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKVGGGNHPLLVPYDTLTAKEKAKDR EKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGG SRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEKEMVTS LFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVRMALRAFLDNAAE DLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILDDV QVSCYRILDSLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNT KNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYM SHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPI ISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDL YAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEIN NMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQ ELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEK TVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVN LFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTE KCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQAR LHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFF QSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGH NSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAI QVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKE LMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSD AFKEYDPDGKGIISKRDFHRAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEP AKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYF EISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESD LNERSANKEENEKDNPEEEDPRMGFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKK VKKMTMKDMVMALFSSYWSILVGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAEL LANMPDPTQDEVRGEEEEGERKPTEAALPAEDLTDLQTLTEESDLLSDIFGLDLKREGGQ YKLIPHNPNAGLSDLLSTPSLAPMPEVQEKIQEKVKEDEKEEKEETKSEPEKAEGEDGEK EEKTKEDKGKQKLRQMHTHRYGEPEVQESVFWKNIIAYQQKLLNYFARNFYNMRMLALFV AFAINFILLFYKVSTSAVTEEKELPVVSDGENTKLNILESDDERVIAVHYVLEESSGYME PTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQ WDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPK KDSSFSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMG FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDM LTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDA FGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKD ETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14877 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaaccgttcacaaggaacaacagaaactgtgtcttgctgcagag ggatttggcaacaggctttgctttttggaatccacatcaaattctaagaatgttcctcct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggaa atgctggctaacacagaagaaaaggcggaagggctagttgatgtggaaaaatggtctgca caaggtggaggacatcgaaccctgctctacgggcacgcaatcttgctgcgccattcctac agtggcatgtacctgtgctgtctctctacatctcgatcgtcaatggataagctggcattt gatgtagggttgcaagaggacacaacaggtgaggcttgctggtggaccattcatccggct tccaaacagagatcggaaggagaaaaagtgcgtgttggagatgatctgattttagtcagt gtctcttcagaaagatacttgcatctctcttatggcaatggtagcttacatgttgacgca gccttccagcagacgctctggagtgtagcaccaatcagttcagggagtgaagttgcccaa ggatacctgataggaggggatgttctgaggttattgcatggtcacatggatgaatgtttg acagtcccttcgggtgaacatggagaagaacaaagaagaactgtccattacgaaggcggg gctgtgtccattcatgctcgctccctttggcgactagagactctaagagttgcgtggagt ggcagccacattagatggggacagccattcagactaagacatataacaacaggaaaatat ttaagtctcctggatgacaagagtctccttcttacagacaaagagaacgcagatgtaaaa tctacagcattctgttttcggtcttctaaggaaaaattggacatagggacaagaaaagag gtggatggaatgggagcacctgaaataaagtatggggactcaatatgcttcatacaacat gtagatacaggcttatggctcacataccagtctgctgatgcaaagtctgtaaggatgggt tctctgcagcgaaaggcaataatgcaccatgaagggcacatggatgatggtttaacactg tccagatctcagaatgaagaatcccgtacagcacgtgtcatccgtagtacagtcttcctt ttcaacaggttcataaggggccttgattctctcagcaagaaagtgaagtcttccaccatt gatttgcctatcgagtcagtcaatctgagccttcaggacttgattggctactttcacccc cctgatgaacacttggagcatgaaaacaaacaaaacaggctccgagcactgaagaatcgc cagaacctcttccaagaagagggtatgatcaaccttgtacttgaatgtattgatcgcttg aatgtgtacagcagtgcagctcactttgcagatgtagctgggaaggaagctggagaagca tggaaatctattctgaattctttgtatgaattactagcggctctgattcgaggaaatcgt aaaaactgtgctcagttttctgggtctcttgattggttgatcagcagattagaaagactg gaagcctcttctggaattctagaggttttacactgtgtgttggtagaaagcccagaagct ctaaacattattaaggaaggacatattaaatcaatcatctgtcttttggacaagcatgga agaaaccataaggttttggatgttttgtgttctctctgtgtttgtcatggagtagctgtg cggtctaatcaacatctaatctgtgataatctcctgccaggaagagatctgctcttacag acacgccttgtcaaccatgtgagcagcatgagacccaacatcttcttggggattagtgaa ggctcagcccaatacagaaaatggtactatgaacttatggtggaccatctggagcccttt gtgactgcagaatcaactcatctacgagtgggctgggcttcaacagaaggctactcgccc tacccagggggaggagcagaatggggaggaaatggtgttggtgatgacttatattcctat ggctttgatggtctgcatctgtggtcaggttgtgtagcacgaacagtaaattctcccaac caacatctgttaagaactgatgatgttattagctgctgtttggacctgagtgcccccagc atctctttccgaataaatggtcagccagttcaaggaatgtttgaaaacttcaacatagat ggcctcttcttcccagttgtcagcttctctgcaggaataaaggttcgtttcttgcttgga ggtcgccatggagagttcaagttccttcctccacctgggtatgctccatgctttgaagct gtcctaccaaaagagaagctgaaagtggagcacagccgagagtacaaacaagatcgtagc tacacaagggacctactgggacccactgtctctctgtcacaagcagctttcactccagtt cctgtagatactagccagattgttttgcccccccacctggaaaggattagagaaaaatta gcagagaacatccatgaactttgggtcatgaataagattgaacttggctggcagtatgga ccagttagagacgacaacaaaagacaacacccatgcttagtggagttctcgaaactgccg gaacaggaaagaaattataacttgcaaatgtcacttgaaacactgaaaaccctgctggca ttaggctgccatgttggaattgctgatgaacgtgctgaagaaaaagtgaaaaaaatgaaa cttccaaaaaactatcagttgttgagtggatataagccagcacccatggatctgagtttt atcaaactgaccccctctcaagaagctatggtggataaactagcagagaatgctcacaat gtgtgggcgagggaccgtataaggcaaggctggacatatggcatccagcaggatgtgaaa aatcgacgaaatcctcgccttgtaccatatgctcttttggatgatcggaccaagaagtcc aacaaagacagtcttcgggaagcagtccgcacccttctaggctatggttacaacctggaa gctcctgatcaagatcatgcaacaagactggacatgtgcagtgggataatggaaaagttc aggatcttccgcacagaaaagacttatgcagtgaaggctgggaagtggtactttgagttt gaggcagttactgcaggagacatgagggttggctggaccaggccaggttgtctgccagat caggaacttggctcagatgaagaagcttttgtttttgatggctttaaggcacagcgatgg catcaaggtaatgagcattttggccgctcttggttggcaggagatgttgttggatgtatg gttgacatgaatgagcacactatgatgttcaccttaaatggtgaaatcctgcttgatgac tcaggctcagaacttgcattcaaggactttgaggttgctgatggatttctacctgtgtgc agcctgggcccatctcaagtgggaagaatgaactttggaaaagatgtcagcactctaaaa tatttcactatatgtggcttacaggaagggtatgaaccctttgctgttaatacaaacaga gacatcaccatttggctgagtaaaaggcttcctcagtttctaccagtgccacaaaaccat gaacacattgaggtgatgagaattgatggcaccatagacagctgcccctgtctcaaggtc acacagaagtcctttggctcacagaacagtaaaacagacgtcatgttttttcgattaagc atgcccattgaatgtgctgaggtgttctccagatcagctgcaggagggttaccaggctct ggtctttttgccccaaaaaatgacttggaagattatgatgctgattctgattttgaggtt ctaatgaaaactgctcatggtcatctagttcctgaccggacagaaagagaaaaagatgcc acaaaaccagagttgaataaccataaagattatgttcaagaaaagccctcacgtcttaaa caaagatttatgctcaggaggacaaagccagattatagtacgagtcattctgcacggctt actgaggatgtgctagcagatgatagggatgactatgattatttgatgcaaacttccacg tactattattcagtgagaatatttcctggccaagagcctgctaatgtctgggtgggctgg attacatcagactttcaccagtatgacacaagctttgacttggacagagtgcgtaccgtc acagttacactgggagacgaaaaagggaaggttcatgagagtataaaacgcagcaactgc tatatggtgtgcgcaggagagagcctgagccctggacaaggacgtaacaataatggtctg gagatcggttgcttggttgatgctgccagtggcctcctgaccttcacagctaatggcaag gaactaggcacctactatcaagttgaaccaagtacaaagttgtttcctgctgtatttgct caagctacaagccccaatgttttccagtttgaattgggaagaataaagaatgtaatgcca ttatctgctggattattcaaaagtgaacacaaaaacccagtctctcaatgtcctccacgc ctccatgtccagtttctgactcatgtgctttggagcagagtgccaaaccacttcttgaag gtggatgtgtctcggatcagtgaacgtcaaggctggatgatacagtgcctgaatcctttg cagttcatggcccttcatattcctgaggaaaacagaacaattgatattttagagctgaca gagcaagaagaattgctgaaatttcactaccacaccctccgattgtattcagctgtttgt gctttaggcaataaccgagtggcccatgctctgtgtagccatgtggatgaatcccagctc ctctatgctattgagaataaatacatgccaggattattgcgtgcagggtattatgacttg ctcattgacatccatctcaacacctatgcaactgccaggctgatgatgaataatgaattt atagttccaatgacagatgaaaccaagagtattactttgtttcctgatgaaaacaaaaaa cacggccttcccggtataggacttagcacttcattaaggccaagaatgcagttttcctct ccgagttttgtaagcattagtgctgagtgctttcagttcagtcctgaattccctctggaa attttgaaggccaaaaccatagagatgctgactgaagctgtccaagagggaagcctccat gtcagagatccagttggaggttctacagaatttttgtttgtccctctcatcaagctcttt tataccctcctaattatgggaatcttccacaatgaagatctgaaacacatcttgcagttg attgagccacgggttttcaaggaagcaatgagccaggaagatgaaattgatttctcagag aaggagttcagttcagatgagctcaaatcagaaggagaggaagaaaccagaggggaccaa atgccaaaggaaggacttcttcagatgaaacttccagaacctgttaaattacagatgtgt cacctactccagtacctgtgtgactgccaagtacggcacagaatagaagctattgtagca ttttccgatgactttgtggctaagcttcaggagaatcaacgcttccggtacaatgaagtg atgcaggccttgaacatgtctgctgccctgacagctagaaaaacaaaagaattcagatcc cctcctcaagagcagattaacatgctgctgaactttaaagatgataaaaatgattgtcct tgccctgaagaaattcgggatcaactcttggatttccatgaagacctaatgacacactgt ggaattgaactagatgaagatggaaccttggatggcaacagtgattcaaccattaggggt cgcctcctataccttatggaaaaagttacatatctgaagaagaaacaagctgagaaggca gttgatgaggatgataagacatcctctactctccagcagttaatttcggacaccatggtg cgttgggcccaggagtcagtgatagaggacccagagttagtgagggccatgtttgtgttg ctgcatcgccaatatgatggtattggtggccttgttcgggccctgccaaagacctacacc ataaatagcgtgtctgtggaagacaccatcaatctgctggcgtcccttggccaaatccgt tccttgcttagtgtcagaatggggaaggaagaggagaagcttatgattcgtggattggga gacatcatgaataataaagtattttaccaacatccaaatctcatgagagctttaggcatg catgaaactgtcatggaggtgatggtgaatgtgcttggtggaggagaatccaaggaaatc actttcccaaagatggtggcaaactgttgtcgttttctatgttatttttgccgcatcagc aggcagaatcaaaaagctatgtttgatcatcttagctatttattggaaaacagcagtgtt ggccttgcctctccttctatgcgagggtcaactcctttagatgttgccgcagcatctgta atggataacaatgaacttgctctggccttaagggagcctgatctggagaaggtggttcgc tacttggctggatgtgggttgcagagttgtcctttgttgatttgtaaaggctacccagac attggatggaatccagttgaaggagaacgatacttggattttcttcgttttgctgttttt tgcaatggagagagtgtggaggagaatgctaatgttgtagtcagactgcttattcgccga cctgaatgttttggtcctgctctaagaggagaaggaggtaatgggttgcttgctgccatg gaggaggcaatacaaatatcagaagatcgaacaagagatggaccttccccaagtaatgga tctagtaaaacccttgaaatagaagaacaagaagatgacactattcacatgggaaatgca atcatgaccttttatgctgccttgattgatctcttaggacgttgtgcccccgaaatgcat ctaatccatgctggtaaaggggaagccattagaatcagatcaattctacggtctttgatt ccacttgaggatttggtgggagtaatcagtattgctttccacatgccaaccatagcaaaa gatggtactgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggcagcc atggttttgttccttgacagggtctatggaattgaggaccaggattttcttctacacctt cttgaagttggctttctgccagaccttcgtgctgctgcctcattagatacggctgcttta agtgctacagatatggctttggctctgaatcgatacctttgcacagcagtcttgcctctc ttgaccagatgtgctcctctatttgctggcacggagcaccatgcatccctcatcgattcc ttattacacactgtgtacagactctcaaagggatgctctcttaccaaagctcagcgagat gctattgaagagtgtttgctgtctatctgtgggcagttgcggccttccatgatgcagcat ttgctgaggagattagtattcgatgtgcctctgttaaatgaacatgcaaagatgcctctc aagctactgacaaatcattatgaaagatgctggaagtattactgtttgccaagtggatgg ggtaacttcggtgctgcctcagaagaagaacttcatttatctagaaaattgttctggggt atttttgatgctttatctcaaaagaagtatgaacaagaactgttcaaactggctttgcct tgtctgagtgcagttgcaggggccttacctccagattatatggaatcaaattatgtcaat atgatggaaaaacagtcttcaatggattcagatgggaactttaatcctcaacctgttgat acctcaaacattacaatccctgaaaaattagaatatttcattaacaaatatgcagaacat gctcatgacaaatggtcaatggaaaagtttgccaatggatggacctatggtgagacattt tctgaatctgcaaaagtgcaaccattaatgaaacagtataagttactgtctgaaaaggag aaagaaatttacagatggccaatcaaagaatcactaaaaaccatgctggcatggggatgg cgaattgaaagaacacgtgagggagattcaatggcactgtataatcggacgcatcgcata tctcaaaccagtcaaatctctgtagatacagcccatggttacactcctcgagcaattgac atgagcaatgtcaccctctccagagacttacatgctatggctgagatgatggctgaaaac taccataacatatgggcaaagaaaaagaagctggagcttgaagcaaaagtaggaggaggc aaccatccccttcttgttccttatgatacactcacagccaaagaaaaagccaaggacaga gaaaaagcacaggatattctgaaatttctacagattaatggatatgttgtctccagagga cttaaggacctggaattagacacgccttctattgagaaacgctttgcctacagtttcctt cagcagcttataagatatgtggatgaagcccatcagtacattttggagtttgatggtggc agcagaggcaaaggagagcaattcccatatgaacaagaaatcaagttttttgcaaaagtt gtgctccctttgattgatcagtattttaaaaatcatcgcctgtatttcttatcttcagca agtaggcctctcagcagtggaggccatgcttctaataaagaaaaagaaatggtgacaagc ctgttctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaatgatgca acatcaatagtcaactgtcttcacatccttggacagaccttggatgcaaggactgtgatg aaaactggtctggaatctgttaggatggcattgagagcatttttggacaatgctgctgag gatctggagaaaacaatggaaaatcttaagcaaggccagtttacacacagcagaaaccag ccaaaaggagttacacaaatcattaattatactacagttgctctcctgccagtgctatct tcattatttgagcatattggacagcaccagtttggggaagatttgatattggatgatgtt caggtctcttgttacagaatactggacagtttatatgctctgggaaccagcaagagtatc tatgtagagaggcaacgatcagcactaggagagtgcttggctgctttctcaggggccttt ccagtggcttttttggaaactcatttgaacaaacataatatctactcaatctacaatacc aagaatgcgagagatagagcagttctcaatttgccaactagtgtagaagaggtttgccca aatattccttccttggtgaagctaatggaagaaatagtggaactggcagaatccggtatt cgttacacgcagatgccacatatcatggaagtcattctgcctatgctgtgcagttacatg tcacactggtgggagcacgggccagagaacaatcctgacaaggctgaaatgtgttgcaca gccttgacctcagagcacatgaacactctgttgggtaacatattgaaaatcatctataac aaccttggtattgatgaaggagcctggatgaagagattggcagtgttttcccagcccatc ataagtaaagcgaagccacagctcttaaagacacacttccttccactgatggataaacta aagaaaaaggcagcagtggttgtatcggatgaagaacatctaagagcagaaggcagaggt gacatgtcggaggctgaactgctcatcctagatgagttcaccactttggcacgggacctc tatgccttctaccctttgttgattagatttgtggactataacagggcaaaatggcttaaa gagcccaatcctgaagcagaagagctgttccgcatggtggctgaggtctttatttactgg tcaaaatctcataatttcaaaagggaggaacagaactttgtggtacaaaatgaaatcaac aacatgtctttccttatcagtgacaccaaatctaagatgtctaaggcagcagtttctgac caggaaaggaagaagatgaagcgaaagggtgaccgctattctatgcagacctctctcatt gtggcagcactgaagagattgcttccaataggcctaaacatttgtgctcctggagaccaa gagctgattgcactggccaaaaatcgatttagcatgaaagacactgaagatgaagtacga gatgtcatccgcagtaatcttcaccttcagggcaagcttgaggatcccgccattagatgg cagatggcactttacaaagatttgccaaacaggactgaagattcctcagatccagagaag actgtggaaagagtccttgatatagctaatgtgctgtttcacctggaacaggttgagcat cctcagcgttccaaaaaagcagtgtggcataagctgctgtctaaacagaggaaaagagca gtggtggcctgctttagaatggcaccattgtataatctgccaagacaccgagccgtcaat ctctttcttcaaggctatgataaatcttggattgaaactgaagaacactactttgaagat aaactgatagaagacttagcaaaacctggagaggaaccaccagaagaagatgaaagcctt aaaagagttgatcctttacatcaacttattcttctattcagtcgaacagccttgactgaa aaatgcaaactggaagaagatttcctgtatatggcttatgctgacattatggcaaagagc tgccatgacgaagaagatgatgatggtgaagaagaagtgaagagttttgaagtgacagga tcacaacgcagcaaggaaaaagaaatggaaaagcaaaaacttctgtatcaacaagccaga ctgcatgatcgaggtgctgctgagatggtgctgcagacaatcagtgcaagtaaaggtgag atggggccaatggttgcagctacgctaaagctaggaattgccatcctaaatggaggaaat tctactgttcaacagaaaatgcttgactacctcaaggataaaaaagatgtggggttcttt cagagccttgctggtcttatgcagtcctgtagtgttcttgacctaaatgcctttgaacgt cagaacaaagcagaaggccttggcatggtgactgaagagggatcaggagaaaaggtgatg caggatgatgagttcacctgtgacctcttccgcttccttcagttgctttgtgaaggacac aattcagattttcagaattacctgagaactcaaactggtaacaacacaactgttaatatt atcatttctactgtggattacttattgagagttcaggaatccatcagtgatttctattgg tattattctgggaaggatgttattgatgaacaaggacaacgaaatttttccaaagccatc caggtggcaaaacaagttttcaatactctcacagagtatatccaggggccatgtactggg aatcagcaaagtctggcacacagcaggctgtgggatgctgtggttggtttccttcatgtg tttgcccacatgcagatgaagctgtctcaggattccagtcaaattgaactattgaaggaa ttaatggatcttcagaaagatatggttgtcatgttgctgtctatgctggaaggtaatgtt gtaaatggaactattggaaagcagatggtcgatatgcttgtggaatcttcaaataatgtg gagatgattctgaagttttttgatatgttcttaaaattgaaagatttgacttcctccgat gcattcaaagaatatgaccctgatggcaaagggataatttcgaagagggattttcacagg gcaatggaaagccataagcactacactcagtctgaaactgagtttctgctgtcatgtgct gaaacagatgagaatgagactttggactacgaggagtttgtgaaacgatttcatgagcct gcaaaagacattggtttcaatgttgctgttctcctgactaacctgtcagaacacatgccc catgacacgcgcttgcagactttccttgagctctcagagagtgtgctgaattactttcag cctttcctcggacgtatagaaatcatgggcagtgcaaagcgcattgaacgagtttatttt gaaataagtgagtcaagtcggactcagtgggaaaagcctcaggtaaaagagtcaaagaga cagtttatatttgatgtcgtcaatgaaggtggggagaaagaaaagatggagctttttgtt aacttctgtgaggataccatctttgaaatgcaactggctgcccagatctctgagtcagat ctgaatgaaaggtcagctaataaagaggagaatgagaaggataatcctgaggaagaagat cctagaatgggtttcttctctctcgtgaccatgaagtcagctttagtggctctcaagtat aatttaatgactcttatgaaaatgctcagcatgaagagtctgaagaaacaaatgaaaaaa gtgaagaaaatgactatgaaggatatggtcatggccttgttttcttcctactggagcatt ttggtgggcttactacattttgcttgtagtgttgtccggggcttttttcgcatcatttgc agtttgctgcttggaggaagcctagtagaaggagccaagaaaatcaaggtggctgaactg ttggctaatatgccagatcccactcaggatgaggttcgtggggaagaagaagaaggggag agaaaaccaacagaagctgctttgcctgcagaagatttaacagatctgcagactttaaca gaagagagtgatctgctctcagatatatttggtttggatttgaaacgagaaggtggacag tataaattgatccctcacaatccaaatgctggtttgagcgatttactgagcactccctcc ttagccccaatgcctgaggtacaggaaaaaatccaggagaaggtgaaagaagatgaaaag gaagagaaagaagaaacaaaatcagaacctgaaaaagctgaaggtgaagatggagaaaaa gaagagaaaaccaaagaagacaaagggaaacagaaattaaggcaaatgcatacacacaga tacggagaaccagaagttcaggaatcagttttctggaagaatatcattgcataccagcag aagcttctgaattactttgcacggaacttttacaacatgaggatgttggcgttatttgtt gcttttgccatcaactttatccttcttttctataaggtctctacatctgctgtgacagaa gaaaaggaacttcctgtggtatctgatggtgaaaataccaagttgaacatcctggaaagc gatgatgaaagagtcattgcagtgcattatgtcctggaagaaagcagtggctacatggag cctacactgaggattttggccatcctacacacagtcatctcattcttctgcatcataggg tattattgtttgaaagttccactggttatttttaagagagaaaaggaagtggcaaggaaa ttggaatttgatgggctgtatataactgagcagccatcagaagatgatattaagggacag tgggatagacttgttatcaacacacagtcttttccaaataactattgggacaagtttgtg aaaagaaaggtaatggataaatatggtgagttctatggccgtgacaggatcagtgaatta ctaggaatggacaaagctgctcttgattttagtgatgctcgagaaaagaagaaaccaaag aaggatagctccttttctgctgtgctaaattccattgatgttaagtatcagatgtggaaa ttaggagttgttttcactgataattctttcctttatctggcatggtacatgaccatgtca gtccttggccattacaacaattttttctttgctgctcatctcctggacatcgccatggga ttcaagaccttacgaactatcctgtcatcagttacccacaatggcaaacagcttgtcctc acagtgggattactggcagtagtggtatacttgtacacagtagtggcatttaattttttc cgcaagttctacaacaagagtgaagatggtgatatgccagacatgaaatgtgatgatatg ctaacatgctacatgtttcatatgtatgttggagtacgtgcaggaggaggcattggtgat gaaatagaagatccagcaggagatgaatatgaaatctatcggattatctttgacatcact ttcttcttctttgtgattgtcatcctgcttgcaattatccaaggtttaattattgatgct tttggtgagttaagagatcagcaagagcaagttaaggaagacatggagacgaagtgcttt atctgtggaataggaaatgactactttgatacagtgcctcatggctttgaaacacacaca ctacaggagcacaacttggccaattatttgttttttctgatgtatcttattaacaaagat gaaactgagcatacaggacaggaatcatatgtatggaaaatgtatcaagaacggtgctgg gagtttttccctgctggtgattgcttccgaaaacaatacgaagaccagctcaactaa

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