Saccharomyces cerevisiae (budding yeast): YCL030C
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Entry
YCL030C CDS
T00005
Symbol
HIS4
Name
(RefSeq) trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
KO
K14152
phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase [EC:
3.6.1.31
3.5.4.19
1.1.1.23
]
Organism
sce
Saccharomyces cerevisiae (budding yeast)
Pathway
sce00340
Histidine metabolism
sce01100
Metabolic pathways
sce01110
Biosynthesis of secondary metabolites
sce01230
Biosynthesis of amino acids
Module
sce_M00026
Histidine biosynthesis, PRPP => histidine
Brite
KEGG Orthology (KO) [BR:
sce00001
]
09100 Metabolism
09105 Amino acid metabolism
00340 Histidine metabolism
YCL030C (HIS4)
Enzymes [BR:
sce01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.23 histidinol dehydrogenase
YCL030C (HIS4)
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.19 phosphoribosyl-AMP cyclohydrolase
YCL030C (HIS4)
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.31 phosphoribosyl-ATP diphosphatase
YCL030C (HIS4)
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Ortholog
Paralog
GFIT
Motif
Pfam:
Histidinol_dh
PRA-CH
PRA-PH
Motif
Other DBs
NCBI-GeneID:
850327
NCBI-ProteinID:
NP_009900
SGD:
S000000535
UniProt:
P00815
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Position
III:complement(65934..68333)
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AA seq
799 aa
AA seq
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MVLPILPLIDDLASWNSKKEYVSLVGQVLLDGSSLSNEEILQFSKEEEVPLVALSLPSGK
FSDDEIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKERVVVEENGVFSNQFMVKQKFS
QDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYERCLGLVYSSKKSIAKAIDL
GRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGE
FKHGLVGLESLLKQRLQDAPEESYTRRLFNDSALLDAKIKEEAEELTEAKGKKELSWEAA
DLFYFALAKLVANDVSLKDVENNLNMKHLKVTRRKGDAKPKFVGQPKAEEEKLTGPIHLD
VVKASDKVGVQKALSRPIQKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVL
NAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKV
GLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIV
LAGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLV
IADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVR
KCIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCG
DYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGH
RNAVKIRMSKLGLIPKDFQ
NT seq
2400 nt
NT seq
+upstream
nt +downstream
nt
atggttttgccgattctaccgttaattgatgatctggcctcatggaatagtaagaaggaa
tacgtttcacttgttggtcaggtacttttggatggctcgagcctgagtaatgaagagatt
ctccagttctccaaagaggaagaagttccattggtggctttgtccttgccaagtggtaaa
ttcagcgatgatgaaatcattgccttcttgaacaacggagtttcttctctgttcattgct
agccaagatgctaaaacagccgaacacttggttgaacaattgaatgtaccaaaggagcgt
gttgttgtggaagagaacggtgttttctccaatcaattcatggtaaaacaaaaattctcg
caagataaaattgtgtccataaagaaattaagcaaggatatgttgaccaaagaagtgctt
ggtgaagtacgtacagaccgtcctgacggtttatataccaccctagttgtcgaccaatat
gagcgttgtctagggttggtgtattcttcgaagaaatctatagcaaaggccatcgatttg
ggtcgtggcgtttattattctcgttctaggaatgaaatctggatcaagggtgaaacttct
ggcaatggccaaaagcttttacaaatctctactgactgtgattcggatgccttaaagttt
atcgttgaacaagaaaacgttggattttgccacttggagaccatgtcttgctttggtgaa
ttcaagcatggtttggtggggctagaatctttactaaaacaaaggctacaggacgctcca
gaggaatcttatactagaagactattcaacgactctgcattgttagatgccaagatcaag
gaagaagctgaagaactgactgaggcaaagggtaagaaggagctttcttgggaggctgcc
gatttgttctactttgcactggccaaattagtggccaacgatgtttcattgaaggacgtc
gagaataatctgaatatgaagcatctgaaggttacaagacggaaaggtgatgctaagcca
aagtttgttggacaaccaaaggctgaagaagaaaaactgaccggtccaattcacttggac
gtggtgaaggcttccgacaaagttggtgtgcagaaggctttgagcagaccaatccaaaag
acttctgaaattatgcatttagtcaatccgatcatcgaaaatgttagagacaaaggtaac
tctgcccttttggagtacacagaaaagtttgatggtgtaaaattatccaatcctgttctt
aatgctccattcccagaagaatactttgaaggtttaaccgaggaaatgaaggaagctttg
gacctttcaattgaaaacgtccgcaaattccatgctgctcaattgccaacagagactctt
gaagttgaaacccaacctggtgtcttgtgttccagattccctcgtcctattgaaaaagtt
ggtttgtatatccctggtggcactgccattttaccaagtactgcattaatgcttggtgtt
ccagcacaagttgcccaatgtaaggagattgtgtttgcatctccaccaagaaaatctgat
ggtaaagtttcacccgaagttgtttatgtcgcagaaaaagttggcgcttccaagattgtt
ctagctggtggtgcccaagccgttgctgctatggcttacgggacagaaactattcctaaa
gtggataagatcttgggtccaggtaatcaatttgtgactgccgccaaaatgtatgttcaa
aatgacactcaagctctatgttccattgatatgccagctggcccaagtgaagttttggtt
attgccgatgaagatgccgatgtggattttgttgcaagtgatttgctatcgcaagctgaa
cacggtattgactcccaagttatccttgttggtgttaacttgagcgaaaagaaaattcaa
gagattcaagatgctgtccacaatcaagctttacaactgccacgtgtggatattgttcgt
aaatgtattgctcacagtacgatcgttctttgtgacggttacgaagaagcccttgaaatg
tccaaccaatatgcaccagaacatttgattctacaaatcgccaatgctaacgattatgtt
aaattggttgacaatgcagggtccgtatttgtgggtgcttacactccagaatcgtgcggt
gactattcaagtggtactaaccatacattaccaacctatggttacgctaggcagtacagt
ggtgccaacactgcaaccttccaaaagtttatcactgcccaaaacattacccctgaaggt
ttagaaaacatcggtagagctgttatgtgcgttgccaagaaggagggtctagacggtcac
agaaacgctgtgaaaatcagaatgagtaagcttgggttgatcccaaaggatttccagtag
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