Salmonella enterica subsp. enterica serovar Typhimurium ST4/74: STM474_4285
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Entry
STM474_4285 CDS
T01760
Symbol
metL
Name
(GenBank) bifunctional aspartate kinase II/homoserine dehydrogenase II
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
seb
Salmonella enterica subsp. enterica serovar Typhimurium ST4/74
Pathway
seb00260
Glycine, serine and threonine metabolism
seb00261
Monobactam biosynthesis
seb00270
Cysteine and methionine metabolism
seb00300
Lysine biosynthesis
seb01100
Metabolic pathways
seb01110
Biosynthesis of secondary metabolites
seb01120
Microbial metabolism in diverse environments
seb01230
Biosynthesis of amino acids
Module
seb_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
seb_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
seb_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
seb00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
STM474_4285 (metL)
00270 Cysteine and methionine metabolism
STM474_4285 (metL)
00300 Lysine biosynthesis
STM474_4285 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
STM474_4285 (metL)
Enzymes [BR:
seb01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
STM474_4285 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
STM474_4285 (metL)
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Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
HTH_11
Motif
Other DBs
NCBI-ProteinID:
ADX19878
UniProt:
E8XKH0
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Position
4332315..4334747
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AA seq
810 aa
AA seq
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MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLISW
LKLSQTDRLSAHQVLQTLRRYQCDLISGLLPADAADDLTSAFISDLERLAALLDGGVTDA
VYAEIVGHGEIWSARLMSAVLNQQGLDAAWLDARAFLRAERAAQPQVDEGLSYPLLQQLL
AQHPGKRLVVTGFISRNHDGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSDIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDICLIEFQVPASQDFRLAHKELDHILKRAQVRPLAVGVHRDRQLL
QFCYTAEVADSVLKLLDDVGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSEEGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLMLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLNYEGLDASRALAFFDDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASAQLADQYLDFASHGFHVISANKLAGASASDKYRQIHDAFEKTGRYWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGTVPFTDLVDQAWQQGLT
EPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSIDHFFENGDALNE
QMVQRLEAARELGLVLRYVARFDANGKARVGVEAVRPEHPLAALLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcaactgcataaatttggcggcagt
agtctggcggatgtgaagtgttacctgcgtgtcgcaggcattatggcggagtattcgcag
cctgacgatatgatggtagtgtccgccgcaggcagtaccaccaaccagttgattagctgg
ctcaagttaagccagaccgatcgcctttctgcgcatcaggtattacagacgttacgccgc
taccagtgcgatctgattagcgggctgcttcccgccgacgcggcagatgatttaaccagc
gcttttattagcgatctggaacgtcttgccgccttgctcgacggcggcgtaacggatgcc
gtctatgctgagatcgtcggacacggcgaaatttggtcggcgagattgatgtccgccgtc
ctgaatcagcaggggctggatgccgcctggctggacgcgcgcgcatttttacgcgccgaa
cgcgccgcacagccgcaggttgatgaagggctatcttatcctttattgcagcagctactg
gcgcagcatccgggcaaacgtctggtcgtgaccggctttatcagccgcaatcatgacggc
gaaacagtcctgttaggccggaacggttccgactattccgccacgcaaatcggcgcgctg
gcgggcgtttcccgcgtgaccatctggagcgatgtcgcgggcgtttatagcgccgacccg
cgcaaagtgaaagatgcctgcctgctgccgttgctgcgtctggacgaagccagcgagctg
gcgcgtctggcggcgcctgttctgcacgcccgcacgctacagccagtgtccggcagcgat
atcgatttgcagttgcgctgtagctacacgccggatcaagggtcaacccgaattgaacga
gtgctggcttccgggacgggcgcgcgtatcgtgaccagtcacgatgatatctgtctgatt
gagtttcaggtgccagccagccaggatttcaggctggcgcataaagagctcgaccacatt
ttaaaacgggcgcaggtgcgtccgctggcggtgggcgtgcatcgcgatcgccagctattg
cagttctgctataccgccgaggtagcggatagcgtactgaaactcctcgacgatgtcggg
ctgccgggcgaattgcgcctgcgacaggggctggcgctggtggcgatggtcggtgcgggc
gtcactcgcaatccgctacactgccatcgcttctggcagcagttgaaaggtcagccagtg
gagtttacctggcagtcggaggagggcatcagtctggtggcggtgctgcgtaccggccca
actgagagcctgattcaggggctgcatcagtctgttttccgcgccgaaaaacgcattggc
ctgatgctgttcggtaaggggaacatcggctcccgttggctggaactgtttgcccgtgaa
caaagcacgctttccgcgcgtactggttttgaatttgtgctggcgggcgtggtggatagc
cgccgtagcctgttgaattatgaagggctggacgccagccgcgcgttggcattctttgat
gatgaagccgttgagcaggacgaagagtcgctattcctgtggatgcgtgcgcatccgtat
gatgatttagtggtgctggatgtaaccgccagtgcacagttagccgatcagtaccttgat
ttcgccagccacggttttcatgtgattagcgccaataaactggcgggcgcaagcgccagc
gataagtatcgccagattcatgacgcgtttgaaaaaaccgggcgttactggctgtataac
gccaccgtgggcgcgggattgccgatcaaccacacggtgcgggatctgattgacagcggc
gatacgattctctcgatcagcgggatcttctccgggacgctatcctggctgttcctgcaa
tttgacggtacggtgccgttcaccgatctggtggatcaggcctggcagcaggggctgacc
gaacccgatccgcgcgtcgatctttccggaaaagatgtcatgcgtaagctggtgattctg
gcgcgcgaggcgggatacgacatcgagccggatcaggtgcgtgtagaatcgttggtgccg
gcgcattgtgaagaaggatctatcgatcactttttcgaaaacggcgacgcgctgaatgaa
cagatggtgcagcgtctggaggcagcccgcgaactggggctggtgttgcgttacgtggcg
cgtttcgacgccaatggcaaagcgcgcgtcggcgttgaagcggtgcgtccggaacatccg
ctggcggcgctgctgccgtgcgataatgtctttgctattgaaagccgctggtatcgcgat
aacccgctggtgatccgtgggccgggcgcgggtcgcgatgtgaccgccggggcgattcag
tcggatatcaaccgtctggcgcagttgctgtaa
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