Salmonella enterica subsp. enterica serovar Typhimurium ST4/74: STM474_4378
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Entry
STM474_4378 CDS
T01760
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
seb
Salmonella enterica subsp. enterica serovar Typhimurium ST4/74
Pathway
seb00270
Cysteine and methionine metabolism
seb00450
Selenocompound metabolism
seb00670
One carbon pool by folate
seb01100
Metabolic pathways
seb01110
Biosynthesis of secondary metabolites
seb01230
Biosynthesis of amino acids
seb04981
Folate transport and metabolism
Module
seb_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
seb00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
STM474_4378 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
STM474_4378 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
STM474_4378 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
STM474_4378 (metH)
04980 Cobalamin transport and metabolism
STM474_4378 (metH)
Enzymes [BR:
seb01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
STM474_4378 (metH)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ADX19953
UniProt:
E8X8U6
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Position
4429524..4433312
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AA seq
1262 aa
AA seq
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MGGKLNMSHVARCSLFRQHALCQYGSLRGALSGASVSSKVEQLRAQLNERILVLDGGMGT
MIQSYRLHEEDFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIETNTFN
STTIAMADYRMESLSAEINYAAAKLARACADEWTARTPEKPRFVAGVLGPTNRTASISPD
VNDPAFRNITFDQLVAAYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKEEFEALGV
DLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGLNCALGPDELRQYVQELSRIA
ECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAV
AGLLPRQLPDIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALD
VARQQVESGAQIIDINMDEGMLDAEAAMVRFLSLIAGEPDIARVPIMIDSSKWEVIEKGL
KCIQGKGIVNSISMKEGVEAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAY
KILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNV
SFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRD
DGTERLLDLAEKYRGSKTDEAANAQQAEWRSWDVKKRLEYSLVKGITEFIEQDTEEARQQ
AARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEKGSS
NGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAREVNADLIGLSG
LITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVG
VVAALLSDTQRDDFVARTRKEYETVRIQHARKKPRTPPVTLEAARDNDLAFDWERYTPPV
AHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFKDANDMLD
KLSAEKLLNPRGVVGLFPANRVGDDIEIYRDETRTHVLTVSHHLRQQTEKVGFANYCLAD
FVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKAIADRLAEAFAEYLHE
RVRKVYWGYAPNESLSNDELIRENYQGIRPAPGYPACPEHTEKGTIWQLLDVEKHTGMKL
TESFAMWPGASVSGWYFSHPESKYFAVAQIQRDQVTDYAFRKGMSVEDVERWLAPNLGYD
AD
NT seq
3789 nt
NT seq
+upstream
nt +downstream
nt
gtgggtggcaagctgaacatgtctcatgttgcccgttgttctcttttccgccagcacgct
ttgtgccagtatggctcgttacgtggagcgttgtcgggagcgagtgtgagcagcaaagtt
gaacaactgcgtgcgcagttaaatgaacgtattctggtgctggacggcggtatgggcact
atgatccagagctatcgtctacatgaagaagatttccgcggggagcgctttgccgactgg
ccctgcgacctgaaaggcaacaatgacctgctggtcctcagcaagccggaggtgatcgcc
gctatccacaacgcctactttgaggctggcgcggatatcatcgaaaccaacacctttaac
tcgacaaccattgcgatggcggattaccggatggaatccctgtcggcggaaattaactat
gcggcggccaaactggcgcgcgcctgcgccgatgaatggacggcgcgaacaccagaaaaa
ccacgctttgttgcgggcgtgcttggtccaactaaccgcacggcctccatttcgccggac
gtcaacgacccggcgtttcgtaatatcaccttcgatcagctggtggcggcctaccgtgaa
tccaccaaagcgctggtggaaggtggcgcagatctgattctgattgagaccgtttttgac
accctgaatgcgaaagcggcggtgtttgcggtgaaagaagagtttgaagcgctgggcgtt
gacctgccgatcatgatttccggcaccatcaccgacgcctctggccgtacgctttccggc
cagactaccgaagccttttataactcgctgcgccacgccgaggcgctcacttttggcctt
aactgcgcactggggccagatgaactgcgccagtacgtccaggaactgtcgcggattgcc
gaatgctacgtcaccgcgcacccgaacgccggcctgccgaacgctttcggcgagtatgac
ctcgacgccgacaccatggcgaaacagattcgcgaatgggcggaagcgggcttcctgaat
atcgttggcggctgctgcggcaccacgccggagcatattgcggcgatgagccgcgccgtt
gccggtttgctgccgcgccagctgccggatatcccggtcgcctgccgcctttccggcctg
gagccgctgaacattggcgacgatagcctgtttgtgaacgtcggcgaacgtactaacgtc
accggctcggccaaatttaaacggctgatcaaagaagagaaatacagcgaagcgctggat
gtcgcccgtcagcaggtagaaagcggcgcgcagattattgatatcaatatggatgagggg
atgctcgacgccgaagcggcgatggtgcgtttcctcagcctgattgccggtgagccggac
attgcccgtgtaccaatcatgatcgactcctccaaatgggaggttatcgaaaaagggctg
aagtgcattcagggtaaaggcatcgtcaactctatttcgatgaaagagggcgtggaagcc
tttattcatcatgcgaagcttctgcgtcgctacggcgcggcagtggtggtgatggccttt
gatgagcaggggcaggccgatacccgcgcgcgtaaaatcgaaatttgccgccgagcctac
aaaattctcaccgaagaggtgggtttcccgccggaagacatcatcttcgacccgaatatc
ttcgccgtggcgaccggtattgaagagcacaacaactacgcgcaggactttatcggcgct
tgcgaagacatcaaacgcgagctgccgcacgcgctgatctccggcggcgtgtctaacgtg
tccttctcgttccgcggcaacgacccggtacgtgaggctatccacgcggtattcctctac
tacgccatccgcaacggtatggacatgggcatcgtcaacgccggacagctggctatctac
gacgacctgcccgccgagctgcgcgatgcggttgaagatgtcattcttaaccgtcgcgat
gacggcactgagcgtttgctggatttggcggagaaataccgcggcagcaaaaccgacgaa
gctgccaacgcccagcaggcggaatggcgtagctgggacgtgaaaaagcgtctcgaatac
tcgctggtgaaaggcattaccgaatttatcgaacaggataccgaagaagcccgtcagcag
gccgcccgcccgattgaggtgattgaagggccgttgatggacggcatgaacgtggtcggc
gacctgttcggcgaagggaaaatgttcctgccgcaggtggtgaaatccgctcgcgtgatg
aaacaagcggtggcctacctggagccgtttattgaagccagcaaagaaaaaggctccagc
aacggcaagatggtgatcgccaccgtgaagggcgatgtgcacgatattggtaaaaatatc
gttggcgtggtgctgcaatgtaacaactacgaaatcgtcgatcttggcgtgatggtgcca
gcggagaaaatcctcagaacggcgcgtgaagtgaatgccgatctgatcggtctttccggg
ctgattaccccgtcgctggacgaaatggtcaacgtggcgaaagagatggagcgtcagggc
tttactatcccgctactgatcggcggcgcaaccacttcgaaagcgcatacggcggtgaaa
atcgagcagaactacagcggtccgacggtctacgtgcagaatgcttcgcgtaccgtgggc
gtggtggcggcgctactctccgacacccagcgtgatgactttgtcgcccgtacccgcaaa
gagtacgaaaccgtgcgtattcagcacgcccgcaaaaaaccgcgcacgccgccggtcacg
ctggaggcggcgcgcgataacgatctggcattcgattgggaacgctacaccccgccggta
gcccaccgtctgggcgtgcaggaggtggaagccagcatcgaaactctgcgcaactatatc
gactggacgccgttctttatgacctggtcgctggccggcaaatacccgcgcattctggaa
gatgaggtggtgggcgttgaggcgcagcgtctgtttaaagacgccaatgatatgctggat
aaactgagcgccgagaaactgttgaatccgcgtggcgtggtgggcctgttcccggcgaac
cgtgtgggtgacgacatcgaaatctatcgcgacgaaacccgtactcatgttctgacggtc
agccaccacctgcgccagcagaccgagaaagtcggttttgccaactactgtctggcggat
tttgtcgcgccgaaactgagcggcaaagcggattacatcggtgctttcgcggtgaccggc
ggtctggaggaggatgcgctggcggacgccttcgaagcgcaacacgacgactataacaag
atcatggtgaaagcgattgccgaccgtctggcggaagcgttcgcggaatatctgcatgag
cgtgtacgtaaggtttactggggatatgcgccgaacgagagcctgagtaacgacgaatta
atccgcgaaaactaccaggggattcgcccggcgccgggttatcctgcctgcccggaacat
accgaaaaaggcactatctggcagctactggatgtcgaaaaacacaccgggatgaagctc
accgaatctttcgccatgtggccaggcgcgtcggtctccggctggtacttcagccatcct
gagagcaaatacttcgcggtagcgcagatccaacgcgatcaggtgacagattatgctttc
cgtaaaggaatgagcgttgaggatgttgagcggtggctcgcgccgaacctgggttacgat
gcggactga
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