Salmonella enterica subsp. enterica serovar Paratyphi C: SPC_4248
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Entry
SPC_4248 CDS
T00862
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
sei
Salmonella enterica subsp. enterica serovar Paratyphi C
Pathway
sei00270
Cysteine and methionine metabolism
sei00450
Selenocompound metabolism
sei00670
One carbon pool by folate
sei01100
Metabolic pathways
sei01110
Biosynthesis of secondary metabolites
sei01230
Biosynthesis of amino acids
sei04981
Folate transport and metabolism
Module
sei_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
sei00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
SPC_4248 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
SPC_4248 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
SPC_4248 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
SPC_4248 (metH)
04980 Cobalamin transport and metabolism
SPC_4248 (metH)
Enzymes [BR:
sei01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
SPC_4248 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ACN48311
UniProt:
C0Q492
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All DBs
Position
4338450..4342133
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLHEEDFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYRMESLSAEINYAAAKLARACADEWTV
RTPNKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKEEFEALGVDLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPDIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLSLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDEAANAQQAEWRSWDVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEKGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPVLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHARKKPR
TPPVTLEAARDNDLAFDWERYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKLLNPRGVVGLFPANRIGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAPNESLSNDELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEKHTGMKLTESFAMWPGASVSGWYFSHPESKYFAVAQIQRDQV
TDYAFRKGMSVEDVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagttgaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgtctacatgaagaagatttccgcggggag
cgctttgccgactggccctgcgacctgaaaggcaacaatgacctgctggtcctcagcaag
ccggaggtgatcgccgctatccacaacgcctactttgaggcgggcgcggatatcatcgaa
accaacacctttaactcgacaaccattgcgatggcggattaccggatggaatccctgtcg
gcggaaattaactatgcggcggccaaactggcgcgcgcctgcgccgatgaatggacggtg
cgtacgccgaacaaaccgcgctacgtcgcgggtgtgctcggcccaaccaaccgcacggcc
tccatttcgccggacgtcaacgacccggcgtttcgtaatatcaccttcgatcagctggtg
gcggcctaccgtgaatccaccaaagcgctggtggaaggcggggcggacctgatcctgatt
gaaaccgtcttcgacaccctcaacgccaaagcggcggtgtttgcggtgaaagaagagttt
gaagcgctgggcgttgatctgccgatcatgatttccggcaccatcaccgacgcctctggc
cgtacgctttccggccagacgaccgaagccttttataactcgctgcgccacgccgaggcg
ctcacttttggccttaactgcgcgctggggcctgatgagctgcgccagtacgtccaggaa
ctgtcgcggattgccgaatgctacgtcaccgcgcacccgaacgccggcctgccgaacgct
ttcggcgagtacgacctcgacgccgacaccatggcgaaacagattcgcgaatgggcggaa
gcgggcttcctgaatattgttggcggctgctgcggcaccacgccggagcatattgcggcg
atgagccgcgccgttgccggtttgccgccgcgccagctgccggatatcccggtggcctgc
cgcctttccggcctggagccgctgaatatcggcgacgatagcctgtttgtcaacgtcggc
gaacgtactaacgtcaccggctcggccaaatttaagcgcttgatcaaagaagagaaatac
agcgaagcgctggatgtcgcccgtcagcaggtagaaagcggcgcgcagattattgatatc
aatatggatgaggggatgctcgacgccgaagcggcgatggtgcgtttcctcagcctgatt
gccggtgagccggacattgcccgtgtaccaatcatgattgactcctccaaatgggaggtt
atcgaaaaagggctgaagtgcattcagggtaaaggcatcgtcaactctatttcgatgaaa
gagggcgtggaagcctttatccatcatgcgaagttgctacgtcgctatggcgccgcagtg
gtggtgatggcttttgatgagcaggggcaggccgatacccgcgagcgtaaaatcgaaatt
tgccgccgagcctacaaaattctcaccgaagaggtgggcttcccgccggaagacatcatt
ttcgacccgaatatctttgccgtcgccaccggtattgaagagcacaacaactacgcgcag
gactttatcggcgcctgtgaggacatcaaacgcgagctgccgcatgcgctgatctccggc
ggcgtgtctaacgtgtccttctcgttccgcggcaacgacccggtacgtgaggctatccac
gcggtattcctctactacgccatccgcaatggcatggacatgggcatcgtcaacgccggg
caactggcgatttatgacgacctgcctgccgaactgcgcgatgcggttgaagatgtcatt
cttaaccgtcgcgatgacggcaccgagcgtttgctggaactggccgagaaataccgcggc
agcaaaaccgacgaagctgccaacgcccagcaggcggaatggcgtagctgggacgtgaaa
aagcgtctcgaatactcgctggtgaaaggcattaccgaatttatcgaacaggataccgaa
gaagcccgccagcaggccgcccgcccgattgaggtgatcgaaggcccgctgatggacggc
atgaacgtggtcggcgacctgttcggcgaagggaaaatgttcctgccgcaggtggtgaaa
tccgctcgcgtgatgaaacaagcggtggcctacctggagccgtttattgaagccagcaaa
gaaaaaggctccagcaacggcaagatggtgattgccaccgtgaagggcgatgtgcacgac
attggcaagaacattgttggcgtggtgctgcaatgcaacaactacgaaatcgtcgatctt
ggcgtgatggtgcctgcggagaaaatcctcagaacggcgcgtgaagtgaatgccgatctg
attggcctttccgggctgattaccccgtcgctggacgaaatggtcaacgtggcgaaagag
atggagcgtcagggctttactatcccggtactgatcggcggcgcaaccacttcgaaagcg
catacggcggtgaaaatcgagcagaactacagcggtccgacggtctacgtgcagaatgct
tcgcgtaccgtgggcgtggtggcggcgctactctccgacacccagcgtgatgactttgtc
gcccgtacccgcaaagagtacgaaaccgtgcgtattcagcacgcccgcaaaaaaccgcgc
acgccgccggtcacgctggaagcggcgcgcgataacgatctggcgttcgattgggaacgc
tacaccccgccggtagcccaccgtctgggcgtgcaggaggtggaagccagtatcgaaact
ctgcgcaactacatcgactggacgccgttctttatgacctggtcgctggccggcaaatac
ccgcgcattctggaagatgaggtggtgggcgttgaggcgcagcgtctgtttaaagacgcc
aatgatatgctggataaactgagcgccgagaaactgttgaatccgcgtggcgtggtgggc
ctgttcccggcgaaccgcatcggcgatgacatcgaaatctatcgcgacgaaacccgtact
catgttctgacggtcagccaccacctgcgccagcagaccgagaaagtcggttttgccaac
tactgtctggcggattttgttgcgccgaaactgagcggcaaagcggattacatcggtgct
ttcgcggtgaccggcggtctggaggaggatgcgctggcggacgccttcgaagcgcaacac
gacgactataacaagatcatggtgaaagcgattgccgaccgtctggcggaagcgttcgcg
gaatatctgcatgagcgtgtacgtaaggtttactggggatatgcgccgaacgagagcctg
agtaacgacgaattaatccgcgaaaactaccaggggattcgcccggcgccgggttatcct
gcctgcccggaacataccgaaaaaggcactatctggcagctactggatgtcgaaaaacac
accgggatgaagctcaccgaatctttcgccatgtggccaggcgcgtcggtctccggctgg
tacttcagccatcctgagagcaaatactttgcggtagcgcagatccaacgcgatcaggtg
acagattatgctttccgtaaaggaatgagcgttgaggatgttgagcggtggctcgcgccg
aacctgggttacgatgcggactga
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