KEGG   Salmonella enterica subsp. enterica serovar Typhi Ty21a: TY21A_20925
Entry
TY21A_20925       CDS       T02648                                 
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
sent  Salmonella enterica subsp. enterica serovar Typhi Ty21a
Pathway
sent00270  Cysteine and methionine metabolism
sent00450  Selenocompound metabolism
sent00670  One carbon pool by folate
sent01100  Metabolic pathways
sent01110  Biosynthesis of secondary metabolites
sent01230  Biosynthesis of amino acids
sent04981  Folate transport and metabolism
Module
sent_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:sent00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    TY21A_20925 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    TY21A_20925 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    TY21A_20925 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    TY21A_20925 (metH)
   04980 Cobalamin transport and metabolism
    TY21A_20925 (metH)
Enzymes [BR:sent01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     TY21A_20925 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: AGK69626
LinkDB
Position
4255376..4259059
AA seq 1227 aa
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLHEEDFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYRMESLSAEINYAAAKLARACADEWTA
RTPEKPRFVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKEEFEALGVDLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLSPRQLPDIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLSLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRERKIEICRRAYKILLEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDNLPAELRDAVEDVILNRRDDGTERLLDLAEKYRGSKTDEAASAQQAEWRSWDVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEKGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHARKKPR
TPPVTLEAARDNDLAFDWERYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKLLNPRGVVGLFPANRVGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLKEDALADAFEAQH
DDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAPNESLSNDELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEKHTGMKLTESFAMWPGASVSGWYFSHPESKYFAVAQIQRDQV
TDYAFRKGMSVEDVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagttgaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgtctacatgaagaagatttccgcggggag
cgctttgccgactggccctgcgacctgaaaggcaacaatgacctgctggtcctcagcaag
ccggaggtgatcgccgctatccacaacgcctactttgaggctggcgcggatatcatcgaa
accaacacctttaactcgacaaccattgcgatggcggattaccggatggaatccctgtcg
gcggaaattaactatgcggcggccaaactggcgcgcgcctgcgccgatgaatggacggcg
cgaacaccagaaaaaccacgctttgttgcgggcgtgcttggtccaactaaccgcacggcc
tccatttcgccggacgtcaacgacccggcgtttcgtaatatcaccttcgatcagctggtg
gcggcctaccgtgaatccaccaaagcgctggtggaaggcggggcggacctgatcctgatt
gaaactgtcttcgacaccctcaacgccaaagcggcggtgtttgcggtgaaagaagagttt
gaagcgctgggcgttgatctgccgatcatgatttccggcaccatcaccgacgcctctggc
cgtacgctttccggccagacgaccgaagccttttataactcgctgcgccacgccgaggcg
ctcacttttggccttaactgcgcgctggggccagatgaactgcgccagtacgtccaggaa
ctgtcgcggattgccgaatgctacgtcaccgcgcacccgaacgccggcctgccgaacgct
ttcggcgagtacgacctcgacgccgacaccatggcgaaacagattcgcgaatgggcggaa
gcgggcttcctgaatatcgttggcggctgctgcggcaccacgccggagcatattgcggcg
atgagccgcgccgttgccggtttgtcgccgcgccagctgccggatatcccggtggcctgc
cgcctttccggcctggagccgctgaacattggtgacgatagcctgtttgtcaacgtcggc
gaacgtactaacgtcaccggctcggccaaatttaaacgcttgatcaaagaagagaaatac
agcgaagcgctggatgtcgcccgtcagcaggtcgaaagcggcgcgcagattattgatatc
aatatggatgaggggatgctcgacgccgaagcggcgatggtgcgtttcctcagcctgatt
gccggtgagccggacattgcccgtgtaccaatcatgattgactcctccaaatgggaggtt
atcgaaaaagggctgaagtgcattcagggtaaaggcatcgtcaactctatttcgatgaaa
gagggcgtggaagcctttattcatcatgcgaagttgctacgtcgctacggcgccgcagtg
gtggtgatggcttttgatgagcaggggcaggccgacacccgcgaacgtaaaatcgagatt
tgccgccgcgcttacaaaattttgctcgaagaggtaggctttccgccggaagacatcatc
ttcgacccgaatatcttcgccgtcgccaccggtattgaagagcacaacaactacgcgcag
gactttatcggcgcttgtgaagacatcaaacgcgagctgccgcacgcgctgatctccggc
ggcgtgtctaacgtgtccttctcgtttcgcggcaacgacccggtacgtgaggctatccac
gcggtattcctctactacgccatccgcaacggcatggacatgggcatcgtcaacgccggg
caactggcgatttatgacaacctgcctgccgaactgcgcgatgcagttgaagatgtcatt
cttaaccgtcgcgatgacggcaccgagcgtttgctggatttggcggagaaatatcgcggc
agcaaaaccgacgaggctgccagtgcccagcaggcggaatggcgtagctgggacgtgaaa
aagcgtctcgaatactcgctggtgaaaggcattaccgagtttatcgaacaggataccgaa
gaagcccgtcagcaggccgcccgcccgattgaggtgattgaagggccgctgatggacggc
atgaacgtggtcggcgacctgttcggcgaagggaaaatgttcctgccgcaggtggtgaaa
tccgctcgcgtgatgaaacaagcggtggcctacctggagccgtttattgaagccagcaaa
gaaaaaggctccagcaacggcaagatggtgattgccaccgtgaagggcgatgtgcacgac
attggcaagaacattgtcggcgtggtgctgcaatgcaacaactacgaaatcgtcgatctt
ggcgtgatggtgccagcggagaaaatcctcagaacggcgcgtgaagtgaatgccgatctg
attggtctttccgggcttatcaccccgtcgctggacgaaatggtcaacgtggcgaaagag
atggagcgtcagggctttactatcccgctactgatcggcggcgcaaccacttcgaaagcg
catacggcggtgaaaatcgagcagaactacagcggtccgacggtctacgtgcagaatgct
tcgcgtaccgtgggcgtggtggcggcgctactctccgacacccagcgtgatgactttgtc
gcccgtacccgcaaagagtacgaaaccgtgcgtattcagcacgcccgcaaaaaaccgcgc
acgccgccggtcacgctggaagcggcgcgcgataatgatctggcatttgattgggaacgc
tacaccccgccggtagcccaccgtctgggcgtgcaggaggtggaagccagcatcgaaacg
ctgcgcaactacatcgactggacgccgttctttatgacctggtcgctggccggcaaatac
ccgcgcattctggaagatgaggtggtgggcgttgaggcgcagcgtctgtttaaagacgcc
aatgatatgctggataaactgagcgccgagaaactgttgaatccgcgtggcgtggtgggc
ctgttcccggcgaaccgtgtgggtgacgacatcgaaatctatcgcgacgaaacccgtact
catgttctgacggtcagccaccacctgcgccagcagaccgagaaagttggttttgctaac
tactgtctggcggattttgtcgcgccgaaactgagcggcaaagcggactacatcggtgct
ttcgcggtgaccggcggtctgaaggaggatgcgctggcggacgccttcgaagcgcaacac
gacgactataacaagatcatggtgaaagcgattgccgaccgtctggcggaagcgtttgcc
gagtatctgcatgagcgtgtacgtaaggtttactggggatatgcgccgaacgagagcctg
agtaacgacgaattaatccgcgaaaactaccaggggattcgcccggcgccgggttatcct
gcctgcccggaacataccgaaaaaggcactatctggcagctactggatgtcgaaaaacac
accgggatgaagctcaccgaatctttcgccatgtggcctggcgcgtcggtctccggctgg
tacttcagccatcctgagagcaaatacttcgcggtagcgcagatccaacgcgatcaggtg
acagattatgctttccgtaaaggaatgagcgttgaggacgttgagcggtggctcgcgccg
aacctgggttacgatgcggactga

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