KEGG   Suncus etruscus (white-toothed pygmy shrew): 126017276
Entry
126017276         CDS       T09902                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
setr  Suncus etruscus (white-toothed pygmy shrew)
Pathway
setr00562  Inositol phosphate metabolism
setr01100  Metabolic pathways
setr01521  EGFR tyrosine kinase inhibitor resistance
setr04012  ErbB signaling pathway
setr04014  Ras signaling pathway
setr04015  Rap1 signaling pathway
setr04020  Calcium signaling pathway
setr04062  Chemokine signaling pathway
setr04064  NF-kappa B signaling pathway
setr04066  HIF-1 signaling pathway
setr04070  Phosphatidylinositol signaling system
setr04072  Phospholipase D signaling pathway
setr04360  Axon guidance
setr04370  VEGF signaling pathway
setr04613  Neutrophil extracellular trap formation
setr04650  Natural killer cell mediated cytotoxicity
setr04658  Th1 and Th2 cell differentiation
setr04659  Th17 cell differentiation
setr04660  T cell receptor signaling pathway
setr04664  Fc epsilon RI signaling pathway
setr04666  Fc gamma R-mediated phagocytosis
setr04670  Leukocyte transendothelial migration
setr04722  Neurotrophin signaling pathway
setr04750  Inflammatory mediator regulation of TRP channels
setr04919  Thyroid hormone signaling pathway
setr04933  AGE-RAGE signaling pathway in diabetic complications
setr04935  Growth hormone synthesis, secretion and action
setr05012  Parkinson disease
setr05022  Pathways of neurodegeneration - multiple diseases
setr05135  Yersinia infection
setr05167  Kaposi sarcoma-associated herpesvirus infection
setr05170  Human immunodeficiency virus 1 infection
setr05171  Coronavirus disease - COVID-19
setr05200  Pathways in cancer
setr05205  Proteoglycans in cancer
setr05206  MicroRNAs in cancer
setr05214  Glioma
setr05223  Non-small cell lung cancer
setr05225  Hepatocellular carcinoma
setr05231  Choline metabolism in cancer
setr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
setr05417  Lipid and atherosclerosis
Module
setr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:setr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    126017276 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    126017276 (PLCG1)
   04014 Ras signaling pathway
    126017276 (PLCG1)
   04015 Rap1 signaling pathway
    126017276 (PLCG1)
   04370 VEGF signaling pathway
    126017276 (PLCG1)
   04064 NF-kappa B signaling pathway
    126017276 (PLCG1)
   04066 HIF-1 signaling pathway
    126017276 (PLCG1)
   04020 Calcium signaling pathway
    126017276 (PLCG1)
   04070 Phosphatidylinositol signaling system
    126017276 (PLCG1)
   04072 Phospholipase D signaling pathway
    126017276 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    126017276 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    126017276 (PLCG1)
   04660 T cell receptor signaling pathway
    126017276 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    126017276 (PLCG1)
   04659 Th17 cell differentiation
    126017276 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    126017276 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    126017276 (PLCG1)
   04670 Leukocyte transendothelial migration
    126017276 (PLCG1)
   04062 Chemokine signaling pathway
    126017276 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    126017276 (PLCG1)
   04919 Thyroid hormone signaling pathway
    126017276 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    126017276 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126017276 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    126017276 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126017276 (PLCG1)
   05206 MicroRNAs in cancer
    126017276 (PLCG1)
   05205 Proteoglycans in cancer
    126017276 (PLCG1)
   05231 Choline metabolism in cancer
    126017276 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126017276 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    126017276 (PLCG1)
   05214 Glioma
    126017276 (PLCG1)
   05223 Non-small cell lung cancer
    126017276 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    126017276 (PLCG1)
   05171 Coronavirus disease - COVID-19
    126017276 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    126017276 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    126017276 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    126017276 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    126017276 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126017276 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    126017276 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126017276 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:setr04131]
    126017276 (PLCG1)
Enzymes [BR:setr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     126017276 (PLCG1)
Membrane trafficking [BR:setr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    126017276 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    126017276 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 126017276
NCBI-ProteinID: XP_049635089
LinkDB
Position
9:21948075..21986623
AA seq 1292 aa
MAGAASPCANGCAPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAVDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKMMDIPFLEARISRT
VEQSEPGQMSLSEFQQFLLEYQGELWAVDRLQVQEFMLNFLRDPLREIEEPYFSLDEFVT
FLFSKENSVWNSQLDAVYPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSI
SMASVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVY
CRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLD
SSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMREEAFDPFDK
SSLRGLEPCGICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPV
WPAKVFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSED
LELASLLVKINIFAAKQENGDLSPFSGTSLRERGSDTSGHLFHGRAREGSFEARYQQPFE
DFHISQEHLTDHFDSRERRAPRRTRINGDNRL
NT seq 3879 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaacggctgcgcccccggcgcgccctcggacgcg
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcgcaagacgttccaggtcaagctggagacgcggcagatc
acgtggagccgcggcgccgacaagatcgagggggccgttgacattcgagaaatcaaggaa
attcgcccagggaagacctcacgggactttgatcgctaccaagaggaccctgctttccgc
ccagaccaatcacactgttttgtcatcctatatggaatggaatttcgactaaagaccctg
agcttgcaagctacatctgaggatgaggtgaacatgtggatcaagggcttaacttggttg
atggaggacacgttgcaggcagccaccccgctgcagatcgagaggtggctcaggaagcag
ttttactcggtggatcggaatcgcgaagatcgtatatcggccaaggatctgaagaacatg
ctgtcccaagtcaactatcgtgtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcagtgacatcacctatgggcagttcgctcagctgtaccgaagcctc
atgtacagcgcccagaagatgatggacatccccttcttagaagccaggatttcaaggaca
gtagagcagtcagagcctggccagatgtccctttctgaattccagcagtttcttcttgag
taccagggggaactgtgggcagttgaccggctgcaggtgcaggagttcatgctaaacttc
ctccgagaccccctccgagagatcgaggagccgtacttctctctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgcagctggatgcagtgtacccagac
accatgaataaccctctctctcactactggatctcctcttcacataacacgtacctgaca
ggagaccaattctccagtgagtcttccctggaagcctatgcccgatgcctgaggatgggc
tgtcgttgcattgagttggactgttgggacggccctgatgggatgccagtcatttatcat
ggacacacgcttaccaccaagatcaaattctctgatgtgcttcataccattaaggagcat
gcctttgtggcctcagagtacccagttatcctgtctatcgaggatcactgcagcattgcc
caacagaggaatatggcccagtacttcaagaaggtgcttggggatacactccttaccaag
cctgtggacattgctgccgatggactcccctcacccaaccagctcaagaggaagattctt
atcaagcacaagaaactggctgagggcagtgcctatgaggaggtgcctacatccgtgatg
tactcagagaatgacatcagcaactccatcaagaatggcattctctacctagaggacccc
gtgaaccatgagtggtacccccactactttgtcttgaccagcagtaaaatctactactct
gaggagaccagtagtgaccagggcaatgaggatgaggaggagcccaaagaggccagcagc
agcacagagctgcactccaatgagaagtggttccacgggaagcttggggctgggcgggac
gggcggcacatcgcagagcgcctgctcaccgagtactgcatcgagactggggcccccgac
ggctccttccttgtgcgcgagagcgagacctttgtgggcgactacaccctctctttctgg
cgaaacgggaaagttcaacactgccgaatccactcccggcaggatgctgggacccccaag
ttcttcttgacagacaaccttgtctttgactcactctatgacctcatcacacactaccag
caggtgcccctgcgttgcaatgaatttgagatgcgcctctcagagcctgtcccacagacc
aatgcccatgagagcaaagagtggtaccatgcaagcctgaccagagcacaggctgagcac
atgctgatgcgggtccctcgggacggggccttcctggtgcggaagcgaaatgagcccaac
tcctatgccatctccttccgggctgaagggaagatcaagcattgccgagtccagcaggag
ggccagacggtgatgctaggcaactctgaatttgacagcctggtagaccttatcagctac
tatgagaagcacccgctgtatcgtaagatgaagctgcggtaccccatcaacgaggaggca
ctggagaagattggcacagctgagcctgactatggggccctctatgagggacgcaaccct
ggtttctatgtggaggcaaaccctatgccaactttcaagtgtgccgtaaaagccctcttt
gactacaaggcccagagagaagatgagttgactttcaccaagagtgccatcatccagaat
gtggagaagcaagaaggaggctggtggcggggggactatggtgggaagaagcagctgtgg
ttcccgtccaactatgtggaagagatggtcagtcctgcagcagccctggagcctgagagg
gagcacttggatgagaacagccctctgggggacttgctgcggggggtcttggatgtgccg
gcttgtcagattgccattcgtcctgagggcaagaacagtcggctcttcgtattctccatc
agcatggcctcggtggcccagtggtctctggatgttgctgctgactcacaggaggagtta
caggactgggtgaagaagatccgtgaagtggcccagactgcagatgccaggctcactgag
gggaagatgatggagcgcaggaagaaaatcgccctggagctttcggaacttgttgtctac
tgccggcctgttcccttcgatgaagagaagattggcacagagcgtgcctgttaccgggac
atgtcatcctttccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaaa
ttcctccagtacaaccggctgcagctctcccgcatctaccctaagggccagcggctggac
tcctccaattatgatcctctgcccatgtggatctgtggcagtcagcttgttgccctcaac
ttccagaccccagataagcccatgcagatgaaccaggccctcttcatggccggtggacac
tgtggctatgtcctgcagcccagcaccatgcgcgaggaagcttttgacccctttgacaag
agcagcctccgagggttggagccctgtggcatttgcattgaggtgctgggggcccggcat
cttccaaagaatggtcggggcattgtgtgtccctttgtagagattgaggtggcaggagct
gaatatgacagcaccaagcagaagacagaatttgtagtggacaatggactaaacccggta
tggccggccaaggttttccactttcagatcagtaaccctgaattcgccttcctccgtttt
gtggtgtatgaggaagacatgttcagtgaccagaacttcctggcacaggccactttccca
gtgaaaggcttgaagacaggatacagagcagttcctttgaagaacaactacagtgaggac
ctggagttggcctctctgctggtcaaaatcaacatttttgctgccaagcaggagaatggc
gacctcagtcctttcagtggcacctccctgcgggaacgcggctctgatacctcaggccac
ctgtttcatggccgggcaagggaaggctccttcgaagcccgttatcagcagccattcgag
gactttcacatctcccaggagcatctcacagaccattttgacagtcgagaacgaagggcc
ccacgaaggactcggatcaatggagacaaccgtctctag

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