Streptomyces pratensis: Sfla_4643
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Entry
Sfla_4643 CDS
T01647
Name
(GenBank) 2-oxo-acid dehydrogenase E1 subunit, homodimeric type
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
sfa
Streptomyces pratensis
Pathway
sfa00010
Glycolysis / Gluconeogenesis
sfa00020
Citrate cycle (TCA cycle)
sfa00620
Pyruvate metabolism
sfa00785
Lipoic acid metabolism
sfa01100
Metabolic pathways
sfa01110
Biosynthesis of secondary metabolites
sfa01120
Microbial metabolism in diverse environments
sfa01200
Carbon metabolism
sfa01210
2-Oxocarboxylic acid metabolism
Module
sfa_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
sfa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
Sfla_4643
00020 Citrate cycle (TCA cycle)
Sfla_4643
00620 Pyruvate metabolism
Sfla_4643
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
Sfla_4643
Enzymes [BR:
sfa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
Sfla_4643
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Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
DUF3135
Transket_pyr
Motif
Other DBs
NCBI-ProteinID:
ADW06044
UniProt:
A0A8D4BCH5
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Position
complement(5352962..5355631)
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AA seq
889 aa
AA seq
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MTDPVAKLPSELDQLPDRDPEETAEWAASLDAVTKAAGPHRAAYLMRRSLQHAEGAGIAL
PKLLETDYVNTIPTSAEPAFDGDLEMESKITAWNRWNAAAMVTRGARYGVGGHIATFASA
AWLYETGFNHFFRGKEGDGSGDQLYIQGHASPGIYARAFLDGRLSEQQLDNFRQESGGDG
LPSYPHPRRLPWLWEFPTVSMGLGPLSAIYQARFNRYLTNRKIKDTSNSHVWAFLGDGEM
DEPESTAALALAAREQLDNLTFVINCNLQRLDGPVRANFRVVQELEGAFRGAGWNVVKTL
WGNAWDELFQLDTTGALIRRLREVPDAQFQTYATRDVAYIREHFFGTDPALVELAKLLSD
AKIGECFYSSRGGHEARKVYAAYRAALEHKGAPTVILAQTVKGYTLGKGFESKNANHQMK
KLSIDEFKGMRELLGLPIPDSAFEDGLVPYGHPGADSPEVRYLQERRAALGGPAPARRVH
AVALPEPEERAFKALYKGSGKQEMATTMAFVRLVKDLMRDKETGRRWVPIVPDEARTFGM
ESLFPSAGIYSPLGQTYEPVDRDQLMYYKEAKDGQILNEGITEAGAMADFIAAASSYATH
GETMIPFYIFYSMFGWQRTGDQMWQLADQLGKGFIVGATAGRTTLTGEGLQHADGHSHLI
ASTNPASLNYDPAFAYEIAVIVKDGLRRMYGPEAEDVFYYLTVYNEPKQQPAMPEGVEEG
IVKGLYRFKEGTPSTADAPRIQLLGSGTAIHWVLEAQELLAADWGVTADVWSATSWGELR
RDALESDEALLRGEERVPYVTQALSGAAGPVLAVSDWMRAVPDQISQWVEQDWSSLGTDG
FGLSDTREGARRHFGVDPQSVVVAALAQLARRGEIPVSKVKEAREKYGM
NT seq
2670 nt
NT seq
+upstream
nt +downstream
nt
atgaccgaccccgtagcaaagcttccgagcgagctcgaccagctcccggaccgcgacccc
gaggagaccgccgagtgggcggcctccctggacgccgtcaccaaggccgcgggcccgcac
cgcgccgcctacctgatgcgacgttcgctgcagcacgccgagggcgccggcatcgcgctg
cccaagctgctggagaccgactacgtcaacaccatccccacctccgccgagcccgcgttc
gacggcgacctggagatggaatcgaagatcaccgcgtggaaccgctggaacgcggccgcg
atggtcacccgcggcgcccggtacggcgtcggcggccacatcgccacgttcgcctcggcg
gcctggctgtacgagaccggcttcaaccacttcttccgcggcaaggaaggtgacggctcc
ggcgaccagctctacatccagggccacgcctcgcccggcatctacgcccgcgccttcctc
gacggccgcctctccgagcagcagctcgacaacttccgccaggagtcgggtggcgacggc
ctgccctcctacccgcacccgcggcggctgccctggctgtgggagttccccacggtgtcg
atgggcctcggccccctctcggcgatctaccaggcgcgcttcaaccgctacctgaccaac
cgcaagatcaaggacacgtcgaactcgcacgtctgggccttcctgggcgacggcgagatg
gacgagcccgagtcgaccgctgccctcgccctcgcggcccgtgagcagctcgacaacctg
accttcgtcatcaactgcaacctgcagcgcctcgacggcccggtccgcgccaacttccgc
gtggtccaggagctggagggcgcgttccgcggagccggctggaacgtcgtgaagacgctc
tggggcaacgcctgggacgagctgttccagctggacaccacgggcgcgctgatccgccgt
ctccgcgaggtcccggacgcgcagttccagacgtacgcgacgcgtgacgtggcctacatc
cgcgagcacttcttcggcaccgacccggcgctcgtcgagctggcgaaactcctgagcgac
gcgaagatcggcgagtgtttctacagctcccgcggtggtcacgaggcccgcaaggtgtat
gcggcctaccgtgccgcgctggagcacaagggcgcgccgaccgtgatcctggcccagacg
gtcaagggctacacgctgggcaagggcttcgagtccaagaacgccaaccaccagatgaag
aagctgtcgatcgacgagttcaagggcatgcgcgagctgctcggcctcccgatcccggac
agcgccttcgaggacgggctggtcccctacggccacccgggcgccgactcccccgaggtg
cgctacctccaggagcgccgtgcggctctcggcggcccggcccccgcccgccgggtgcac
gccgtggcgctgcccgagccggaggagcgtgccttcaaggccctgtacaaggggtccggc
aagcaggagatggccaccaccatggcgttcgtccgcctggtgaaggacctgatgcgggac
aaggagaccggcaggcgctgggttccgatcgtcccggacgaggcccgtaccttcggtatg
gagtcgctgttcccctcggcgggcatctactccccgctcggccagacgtacgagccggtc
gaccgcgaccagctgatgtactacaaggaggccaaggacggccagatcctcaacgagggg
atcaccgaggccggtgccatggccgacttcatcgccgccgcctcgtcgtacgcgacgcac
ggcgagacgatgatcccgttctacatcttctactcgatgttcggctggcagcggaccggc
gaccagatgtggcagctcgccgaccagctcggcaagggcttcatcgtcggcgccacggcc
ggccgtacgaccctgacgggtgagggcctccagcacgccgacggccactcgcacctgatc
gcgtccacgaaccccgcgtcgctcaactacgacccggcgttcgcgtacgagatcgcggtg
atcgtcaaggacggtctgcgcaggatgtacggccccgaggccgaggacgtcttctactac
ctgacggtctacaacgagcccaagcagcagcccgcgatgccggaaggcgtcgaggagggc
atcgtcaagggcctctaccgcttcaaggagggcacgccctccaccgcggacgcgccccgg
atccagctgctgggctccggtacggcgatccactgggtcctggaggcccaggaactgctc
gccgccgactggggcgtcacggcggacgtgtggtccgccacctcgtggggtgagctgcgc
cgcgacgcgctggagtccgacgaggcgctgctccgcggcgaggagcgggtgccgtacgtg
acccaggcgctgtcgggtgcggcaggcccggtcctggccgtcagcgactggatgcgcgcg
gtcccggaccagatcagccagtgggtggagcaggactggtcctcgctcggcacggacggc
ttcggtctctccgacacccgcgagggcgcccgccgccacttcggtgtcgacccgcagtcc
gtcgtggtcgccgcgctggcccagctggcccgccgtggcgagatcccggtctcgaaggtc
aaggaggcccgggagaagtacgggatgtga
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