KEGG   Spirochaeta africana: Spiaf_0490
Entry
Spiaf_0490        CDS       T01811                                 
Name
(GenBank) 5-methyltetrahydrofolate--homocysteine methyltransferase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
sfc  Spirochaeta africana
Pathway
sfc00270  Cysteine and methionine metabolism
sfc00450  Selenocompound metabolism
sfc00670  One carbon pool by folate
sfc01100  Metabolic pathways
sfc01110  Biosynthesis of secondary metabolites
sfc01230  Biosynthesis of amino acids
sfc04980  Cobalamin transport and metabolism
sfc04981  Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:sfc00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    Spiaf_0490
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    Spiaf_0490
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    Spiaf_0490
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    Spiaf_0490
   04980 Cobalamin transport and metabolism
    Spiaf_0490
Enzymes [BR:sfc01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     Spiaf_0490
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: AFG36593
UniProt: H9UGF0
LinkDB
Position
588919..592857
AA seq 1312 aa
MKGTKKTLIRGNVPADTAVRLRALEALIQERIVYLDGAMGTMIQNCKLQEADFRADYGGL
LTDHPKPLQGNNDLLLLTRPDIIREIHTEFLDAGADILETNTFNSTSVSQADYGTEHLVY
ELNRAGAALARECAAAADAREAGTIAGADASAAAADQSPAPPPTHFVAGVLGPTSKTLSL
SPDVNDPGFRAITFPELAESYREAVGGLIDGGADLILIETIFDTLNAKAAIYACKQEFHA
RGYELPIMISGTITDASGRTLSGQTVEAFYNSICHAEPFSVGLNCALGADLLKRYVSDLS
RVADQPVSTHPNAGLPNEFGEYDHSPEFMARIMGEFAAEGIVNIIGGCCGTTPEHLRQIV
AATGGHAPRAIPEHKQQLSLSGLEPLVNTPDLGFINVGERTNVTGSRKFLRLIRDKQYEE
ALEVARDQVEGGAQIIDINMDEAMLESADEMRTFLNLVGAEPDISRIPIMVDSSKWSVIE
AGLQCIQGKGVVNSISMKEGEAEFLEHARLVRLYGAAAIVMAFDEKGQADTLERRVEICR
RAYKLLTEKLDFPPEDIIFDLNIFAIGTGIEEHRNYAVDFIEAARIIRREMPLVSISGGV
SNVSFSFRGNNAVREAIHTVFLYHAVKAGMNMGIVNPGQLEVYDDIQPELLEHVEDLVMN
RREDATERLLELAESIQSGGKSRVKDLSWREQPVGKRLEHALVKGITAWVEEDTEEARQQ
LPQALEVIEGPLMDGMNVVGDLFGSGKMFLPQVVKSARVMKMAVAYLLPYIEAEKKAGGG
EQQAKGKILMATVKGDVHDIGKNIVGVVLGCNNYEIVDLGVMVECEDILAAAREHKVDVI
GLSGLITPSLDEMVHVASEMERQGFELPLMIGGATTSKIHTAVKIDPAYHAPIAHVKDAS
LAVNIVSRMIGDRENIGRELKAEYQRMREKRAATTSTKEYITIQEARDQRFLPGMTIPQP
EGTEVAMAQVASAPASAAAAPASANAADAATPAVAPGKPGWEGYVPPTPNLIGRKHFIDY
PLEHIRKYIDWAFFFYSWQLRGKFPDILDDPEMGEEARKLYADANAMLDRMISEKRIRAD
GSIFILPANSTEDDDIRIYDETGKQQIGVWNTLRQQKQKTETPYYLSLSDFTAPESSGIR
DYIGGFAVTAGHGADDFAKTFEDAGDDYSAILVKILADRMAEAFAECLHEDVRREHWGYA
PDEDLSIEDLLAIRYQGIRPAPGYPPCPNHEDKAGLFELLDTTPHTGIELTQSWMMTPPA
SVSGYIFAHPESHYFGVGTLMRDQVQDWARRKNLPLATAEKWLAPKLAYDPE
NT seq 3939 nt   +upstreamnt  +downstreamnt
gtgaagggtacaaaaaaaacactgatccggggcaatgttcccgctgataccgccgtgcgt
ctgcgcgcactcgaggcattgatacaggagcgcatcgtttacctcgatggcgccatgggc
accatgatccagaactgcaaactgcaggaggccgattttcgcgccgattacggcggtttg
ttgacagatcatcccaaacccctgcaaggcaacaacgacctgctgctgctgacccggccg
gatatcatccgcgagatccacaccgagtttctggatgccggtgctgatattctggagacc
aatacctttaacagcaccagcgtgtcccaggccgattacggcaccgagcatctggtgtac
gagctcaaccgggcaggggctgccctggcacgcgaatgcgccgctgccgccgatgcgcgc
gaggccgggaccattgcgggcgccgacgccagtgccgctgccgccgaccagtctccggca
ccacccccgacccacttcgtcgccggggtccttggcccgaccagcaaaaccctgtcgctc
tcgccggatgtgaacgacccgggcttccgcgccatcacctttcccgagctggccgagagc
tatcgcgaggcggtcggcgggctgattgacggcggggccgacctaatcctgatcgagacc
atctttgacaccctgaacgccaaggcggccatctacgcctgcaagcaggagtttcatgcc
cgcggttacgagctgccgatcatgatttccggtactataaccgatgccagcgggcgtacc
ctctccggccagaccgtcgaggccttctacaactccatctgccacgctgaaccattcagc
gtcgggctgaactgcgccctcggggccgacctgctcaagcgctatgtgtcggatctctcc
cgggttgccgaccagccggtcagcacccatcccaacgccggactgccgaacgagttcggc
gagtatgaccacagccccgagttcatggcccgcatcatgggcgagttcgctgccgagggc
atcgtcaacattatcgggggctgctgcggtaccacccccgaacacctgcgccagattgtg
gccgccaccggggggcacgccccccgggcaatccccgagcacaagcagcagctgtccctg
agcgggctggagccgctggtgaacacccccgatctcgggtttatcaacgtcggcgagcgc
accaacgttaccggctcgcgcaaattcctgcgcctgatccgcgacaagcagtacgaagag
gccctcgaggttgcccgcgaccaggtcgagggcggcgcccagatcatcgacatcaacatg
gacgaggccatgctggaatcggccgatgagatgcgtacctttctgaacctggtcggcgcc
gagccggacatcagccgcatcccgatcatggtcgactcttccaaatggtcggtaatcgag
gccggtctgcagtgcatacagggcaagggggtggtcaactccatcagtatgaaggaaggc
gaggccgagtttctcgagcatgcccgcttggtgcgcctgtacggcgcggccgccatcgta
atggcctttgacgagaaagggcaggctgataccctggagcgccgggtggaaatctgccgc
cgagcctataaactgctcaccgaaaagcttgattttccgcccgaggacatcatcttcgac
ctgaacatctttgccatcggcaccgggatcgaggagcatcgcaactatgcggtggatttt
atcgaggccgcccgcatcatacgtcgtgaaatgccgctggtcagcatctccggcggggtc
agcaatgtgtctttcagcttccgcggcaacaacgcggtgcgcgaggctatccacaccgtg
ttcctgtaccatgccgtaaaggccggtatgaacatgggcatcgtcaatcccgggcagctc
gaggtctacgacgacatccagcctgagctgctggagcatgtcgaggatctggtcatgaac
cgccgcgaggatgccaccgagcgcctgctggaactggccgagagcatccagtccggcggc
aagtcgcgggtgaaggacctctcctggcgcgagcagccggttggaaagcgactggagcac
gccctggtcaaggggattaccgcctgggtcgaggaggataccgaggaggcccggcagcag
ctgccgcaggccctggaggttatcgaaggccccctgatggacggcatgaatgtagtcggc
gatctgtttggcagcggcaagatgttcctcccgcaggtggtaaaaagtgcccgcgtcatg
aagatggcggtggcctatctgctgccctacatcgaggccgagaaaaaagccggcggcggt
gagcagcaggccaagggcaagatccttatggccaccgtgaagggcgacgtccacgacatc
ggcaagaacatcgtcggggtagtgctgggctgcaacaactatgagattgtcgacctcggg
gtgatggtggagtgcgaggacatcctggccgccgctcgcgagcacaaggtcgatgtgatc
ggtctgagcgggctgattacccccagcctggacgagatggtgcatgtcgcctcggagatg
gagcgccagggattcgagctgccgctgatgattggcggagccacaaccagcaagatccac
actgccgtcaagatcgatccggcttatcacgcccctattgcccacgtcaaggacgcttcg
ctggcggtgaacatcgtcagccgcatgatcggcgaccgcgagaacatcgggcgcgagctc
aaggcggagtatcagcggatgcgcgagaagcgtgccgctaccaccagcaccaaggagtac
ataaccatccaggaggcgcgggatcagcgctttctgccgggcatgaccataccgcagccc
gaaggaaccgaggttgccatggcccaggttgccagcgccccggcctcggcggccgctgcc
ccggcctcggcaaacgccgcggacgccgccacacccgccgttgcccccggcaaacccggc
tgggagggctacgttccgccgacccccaacctcatcggccgcaagcattttatcgactac
cccctggagcacatccggaagtacatcgactgggcctttttcttctacagctggcagctg
cgcggcaagttccccgacatcctggacgaccccgaaatgggcgaggaggcccgcaaactc
tatgccgacgccaacgccatgctcgaccgcatgatcagcgagaaacgcatccgcgctgac
ggctcgatctttattctgcccgccaattctaccgaggacgacgacatcaggatttatgac
gaaaccggcaagcagcagatcggggtctggaacaccctgcgccagcagaagcaaaaaaca
gaaaccccgtactatctcagcctctcggactttaccgcccccgaatccagtggaatccgc
gactacatcggcggcttcgccgtcaccgccggtcacggtgccgatgactttgccaaaacc
ttcgaggacgccggcgacgactactccgccatcctggtaaaaatcctcgccgaccgcatg
gccgaagccttcgctgaatgcctgcacgaggacgtccgccgcgaacactggggctacgcc
cccgacgaagacctcagcatcgaagatctcctggccatccgctaccagggcatccgtccg
gcccccggctaccccccgtgccccaatcacgaggacaaagccggcctgttcgagctcctg
gacaccaccccgcacaccggcatcgagctcacccaaagctggatgatgacgccccccgcc
tcggtctccggttacatctttgcccaccccgagtcgcactacttcggtgttggcaccctg
atgcgcgaccaggtccaggactgggcccgccggaaaaatctcccgctggcaaccgccgag
aaatggctggcccccaagctggcctacgaccccgaatag

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