KEGG PATHWAY: sft03070

PATHWAY: sft03070

Entry

sft03070                    Pathway

Name

Bacterial secretion system - Shigella flexneri NCTC1 (serotype 2a)

Description

Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.

Class

Environmental Information Processing; Membrane transport

Pathway map

sft03070

Bacterial secretion system

Other DBs

GO:	0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953

Organism

Shigella flexneri NCTC1 (serotype 2a) [GN:sft]

Gene

NCTC1_00095

yacA; SecA regulator SecM,Secretion monitor precursor,SecA regulator SecM,Secretion monitor precursor protein (SecM) [KO:K13301]

NCTC1_00277

[KO:K11904]

NCTC1_00354

yajC; preprotein translocase subunit YajC,hypothetical protein,preprotein translocase subunit YajC,preprotein translocase, YajC subunit,Preprotein translocase subunit [KO:K03210]

NCTC1_00355

secD; preprotein translocase subunit SecD,hypothetical protein,preprotein translocase subunit SecD,Predicted exporter,protein-export membrane protein SecD,Protein export membrane protein [KO:K03072]

NCTC1_00356

secF; preprotein translocase subunit SecF,hypothetical protein,preprotein translocase subunit SecF,protein-export membrane protein SecF,Protein export membrane protein [KO:K03074]

NCTC1_00703

tatE; twin arginine translocase protein E,Sec-independent protein translocase protein TatE,twin arginine translocase protein E,twin arginine-targeting protein translocase, TatA/E family,mttA/Hcf106 family [KO:K03425]

NCTC1_02936

ffh; signal recognition particle protein,p48,signal recognition particle protein,Signal recognition particle GTPase,signal recognition particle protein,SRP54-type protein, GTPase domain [KO:K03106] [EC:3.6.5.4]

NCTC1_03331

tolC; outer membrane channel protein,Outer membrane protein tolC precursor,outer membrane channel protein,type I secretion outer membrane protein, TolC family,Outer membrane efflux protein [KO:K12340]

NCTC1_03490

secG; Preprotein translocase IISP family, auxillary membrane component,Preprotein translocase band 1 subunit,preprotein translocase subunit SecG,preprotein translocase, SecG subunit,Preprotein translocase SecG subunit [KO:K03075]

NCTC1_03612

secY; preprotein translocase subunit SecY,hypothetical protein,preprotein translocase subunit SecY,Preprotein translocase subunit SecY,preprotein translocase, SecY subunit,SecY translocase [KO:K03076]

NCTC1_03763

ftsY; cell division protein FtsY,Cell division protein FtsY,signal recognition particle-docking protein FtsY,Signal recognition particle GTPase,signal recognition particle-docking protein FtsY,SRP54-type protein, GTPase domain [KO:K03110]

NCTC1_03944

secB; preprotein translocase subunit SecB,Protein-export protein SecB,preprotein translocase subunit SecB,protein-export chaperone SecB,Preprotein translocase subunit SecB [KO:K03071]

NCTC1_04053

yidC; putative inner membrane protein translocase component YidC,Oxa1Ec,membrane protein insertase,membrane protein insertase, YidC/Oxa1 family, N-terminal domain,60Kd inner membrane protein [KO:K03217]

NCTC1_04231

tatA; twin arginine translocase protein A,Sec-independent protein translocase protein TatA,twin arginine translocase protein A,twin arginine-targeting protein translocase, TatA/E family,mttA/Hcf106 family [KO:K03116]

NCTC1_04232

tatB; sec-independent translocase,Sec-independent protein translocase protein TatB,sec-independent translocase,twin arginine-targeting protein translocase TatB [KO:K03117]

NCTC1_04233

tatC; twin-arginine protein translocation system subunit TatC,Sec-independent protein translocase protein TatC,twin-arginine protein translocation system subunit TatC,twin arginine-targeting protein translocase TatC,Sec-independent protein translocase protein (TatC) [KO:K03118]

NCTC1_04398

secE; preprotein translocase subunit SecE,Preprotein translocase subunit SecE,preprotein translocase subunit SecE,preprotein translocase, SecE subunit,SecE/Sec61-gamma subunits of protein translocation complex [KO:K03073]

Compound

C00002

ATP

Reference

PMID:11173102

Authors

Kim JF.

Title

Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.

Journal

Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2

Reference

PMID:11309112

Authors

Plano GV, Day JB, Ferracci F.

Title

Type III export: new uses for an old pathway.

Journal

Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x

Reference

PMID:11413015

Authors

Gauthier A, Finlay BB.

Title

Bacterial pathogenesis: the answer to virulence is in the pore.

Journal

Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8

Reference

PMID:10047550

Authors

Burns DL.

Title

Biochemistry of type IV secretion.

Journal

Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6

Reference

PMID:10920394

Authors

Christie PJ, Vogel JP.

Title

Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.

Journal

Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3

Reference

PMID:11309113

Authors

Christie PJ.

Title

Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.

Journal

Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x

Reference

PMID:10481178

Authors

Nunn D.

Title

Bacterial type II protein export and pilus biogenesis: more than just homologies?

Journal

Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7

Reference

PMID:11309111

Authors

Sandkvist M.

Title

Biology of type II secretion.

Journal

Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x

Reference

PMID:11349009

Authors

Sandkvist M.

Title

Type II secretion and pathogenesis.

Journal

Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001

Reference

PMID:15546664

Authors

Delepelaire P

Title

Type I secretion in gram-negative bacteria.

Journal

Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001

Reference

PMID:18406342

Authors

Hazes B, Frost L

Title

Towards a systems biology approach to study type II/IV secretion systems.

Journal

Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011

Reference

PMID:16448494

Authors

Johnson TL, Abendroth J, Hol WG, Sandkvist M

Title

Type II secretion: from structure to function.

Journal

FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x

Reference

PMID:15546665

Authors

Filloux A

Title

The underlying mechanisms of type II protein secretion.

Journal

Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003

Reference

PMID:19396170

Authors

Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC

Title

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.

Journal

Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603

Reference

PMID:15590783

Authors

Ghosh P

Title

Process of protein transport by the type III secretion system.

Journal

Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004

Reference

PMID:12360191

Authors

Cornelis GR

Title

The Yersinia Ysc-Yop 'type III' weaponry.

Journal

Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932

Reference

PMID:17215876

Authors

Baron C

Title

VirB8: a conserved type IV secretion system assembly factor and drug target.

Journal

Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148

Reference

PMID:17943123

Authors

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S

Title

Helicobacter exploits integrin for type IV secretion and kinase activation.

Journal

Nature 449:862-6 (2007)
DOI:10.1038/nature06187

Reference

PMID:16092524

Authors

Christie PJ, Cascales E

Title

Structural and dynamic properties of bacterial type IV secretion systems (review).

Journal

Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316

Reference

PMID:15546668

Authors

Christie PJ

Title

Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.

Journal

Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013

Reference

PMID:15590781

Authors

Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D

Title

Type V protein secretion pathway: the autotransporter story.

Journal

Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004

Reference

PMID:9778731

Authors

Henderson IR, Navarro-Garcia F, Nataro JP

Title

The great escape: structure and function of the autotransporter proteins.

Journal

Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3

Reference

PMID:18524912

Authors

Filloux A, Hachani A, Bleves S

Title

The bacterial type VI secretion machine: yet another player for protein transport across membranes.

Journal

Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0

Reference

PMID:19251641

Authors

Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ

Title

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

Journal

Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106

Reference

PMID:17603507

Authors

Kulasekara HD, Miller SI

Title

Threonine phosphorylation times bacterial secretion.

Journal

Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734

Reference

PMID:18078384

Authors

Driessen AJ, Nouwen N

Title

Protein translocation across the bacterial cytoplasmic membrane.

Journal

Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747

Reference

PMID:14641032

Authors

Pool MR

Title

Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?

Journal

Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232

Reference

PMID:19299134

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004

Reference

PMID:15063851

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001

KO pathway

ko03070

DBGET integrated database retrieval system