KEGG   Shigella flexneri NCTC1 (serotype 2a): NCTC1_04441
Entry
NCTC1_04441       CDS       T03751                                 
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase,Methionine synthase,B12-dependent methionine synthase,Predicted cobalamin binding protein,methionine synthase,Homocysteine S-methyltransferase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
sft  Shigella flexneri NCTC1 (serotype 2a)
Pathway
sft00270  Cysteine and methionine metabolism
sft00450  Selenocompound metabolism
sft00670  One carbon pool by folate
sft01100  Metabolic pathways
sft01110  Biosynthesis of secondary metabolites
sft01230  Biosynthesis of amino acids
sft04980  Cobalamin transport and metabolism
sft04981  Folate transport and metabolism
Module
sft_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:sft00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    NCTC1_04441 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    NCTC1_04441 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    NCTC1_04441 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    NCTC1_04441 (metH)
   04980 Cobalamin transport and metabolism
    NCTC1_04441 (metH)
Enzymes [BR:sft01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     NCTC1_04441 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: CDX09509
UniProt: A0A9P2MXP4
LinkDB
Position
1:4158937..4162620
AA seq 1227 aa
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLAAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKADDTANAQQAEWRSWDVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRIAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFAIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTCKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDHARRKGMSVSDVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgttggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgacctcaaaggcaacaacgacctgctggtactcagtaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgctgacgagtggaccgcg
cgcacgccggagaaaccgcgctacgttgccggtgttcttggcccaaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggcg
gcggcctatcgcgaatccaccaaagcgctggtggaaggtggtgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtctttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggcccgatgaactgcgccagtacgtgcaggaa
ctatcacggattgcggaatgctacgtcaccgcccacccgaacgccgggctgcctaacgcc
tttggtgaatacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggctttctcaatatcgtcggtggttgctgcgggaccacgccgcaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgccggaaattcccgtagcctgc
cgtttgtctggcctggagccgctgaacattggcgacgatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggctctgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcgcgtcagcaggtggaaaacggcgcgcagattatcgatatc
aacatggatgaagggatgctcgatgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggatgtc
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggcgtcgacgcctttatccatcacgcgaaattgttgcgtcgctacggtgcggcagtg
gtggtgatggcctttgacgaacagggacaggccgatactcgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
ttcgacccgaacatcttcgcggtcgccaccggtattgaagagcacaacaactacgcgcag
gactttatcggcgcgtgtgaagacatcaaacgcgaactgccgcacgcgctgatttccggc
ggcgtatctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcagtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctacccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgtgacgatggcactgagcgtttactggagcttgccgagaaatatcgcggc
agtaaagcggacgacactgctaacgcccagcaagcggagtggcgctcgtgggacgtgaat
aaacgtctggaatactcgctggtcaaaggcataaccgagtttatcgagcaggatactgaa
gaagcccgccagcaggctacgcgcccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgatctgtttggcgaaggcaaaatgttcctgccacaggtggtcaaa
tcggcgcgcgtcatgaaacaggcagtggcgtatctcgaaccgtttattgaagccagcaaa
gagcagggtaaaaccaacggcaagatggtgatcgccaccgtgaaaggcgatgtccacgac
atcggtaaaaatatcgttggtgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgttatggtgcctgcggaaaaaattctccgtatcgccaaagaagtgaatgctgatttg
attggcctttcggggcttatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcgccattccgttactgattggcggcgcgaccacctcaaaagcg
cacacggcggtgaaaatcgagcagaactacagcggccctacggtgtatgtgcagaatgcc
tcgcgcaccgttggtgtggtagcggcgctgctttccgatactcagcgtgatgattttgtc
gctcgtacctgcaaggagtacgaaaccgtgcgtattcagcacgggcgcaagaaaccacgc
acaccaccggtcacgctggaagcggcgcgcgataacgatttcgcatttgactggcaggct
tacacgccgccggtggcgcaccgtctcggcgtgcaggaagtggaagccagcatcgaaacg
ctgcgtaattacatcgactggacaccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggtgggcgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgagaaaacgctgaatccgcgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgcacc
catgtgatcaacgtcagccaccatctgcgtcaacagaccgaaaaaacgggattcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcgcagcac
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgtttagccgaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagaactgatccgcgaaaactaccagggcatccgtccggcaccgggctatccg
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggaagtggaaaaacat
actggcatgaaactcacagaatctttcgcgatgtggcctggtgcatcggtttcgggttgg
tatttcagtcatccggacagcaagtactacgcggtggcgcaaattcagcgcgatcaggtt
gaagaccatgcccgccgtaaaggtatgagcgtctccgatgttgagcgctggctggcaccg
aatctggggtatgacgcggactga

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