Sorex fumeus (smoky shrew): 130018356 Help Entry 130018356         CDS       T10594                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum00230   Purine metabolism sfum01100   Metabolic pathways sfum01522   Endocrine resistance sfum04015   Rap1 signaling pathway sfum04020   Calcium signaling pathway sfum04022   cGMP-PKG signaling pathway sfum04024   cAMP signaling pathway sfum04062   Chemokine signaling pathway sfum04072   Phospholipase D signaling pathway sfum04081   Hormone signaling sfum04082   Neuroactive ligand signaling sfum04114   Oocyte meiosis sfum04211   Longevity regulating pathway sfum04213   Longevity regulating pathway - multiple species sfum04261   Adrenergic signaling in cardiomyocytes sfum04270   Vascular smooth muscle contraction sfum04371   Apelin signaling pathway sfum04540   Gap junction sfum04611   Platelet activation sfum04713   Circadian entrainment sfum04714   Thermogenesis sfum04723   Retrograde endocannabinoid signaling sfum04724   Glutamatergic synapse sfum04725   Cholinergic synapse sfum04727   GABAergic synapse sfum04750   Inflammatory mediator regulation of TRP channels sfum04911   Insulin secretion sfum04912   GnRH signaling pathway sfum04913   Ovarian steroidogenesis sfum04914   Progesterone-mediated oocyte maturation sfum04915   Estrogen signaling pathway sfum04916   Melanogenesis sfum04918   Thyroid hormone synthesis sfum04921   Oxytocin signaling pathway sfum04922   Glucagon signaling pathway sfum04923   Regulation of lipolysis in adipocytes sfum04925   Aldosterone synthesis and secretion sfum04926   Relaxin signaling pathway sfum04927   Cortisol synthesis and secretion sfum04928   Parathyroid hormone synthesis, secretion and action sfum04934   Cushing syndrome sfum04935   Growth hormone synthesis, secretion and action sfum04970   Salivary secretion sfum04971   Gastric acid secretion sfum04972   Pancreatic secretion sfum04976   Bile secretion sfum05032   Morphine addiction sfum05163   Human cytomegalovirus infection sfum05166   Human T-cell leukemia virus 1 infection sfum05200   Pathways in cancer sfum05207   Chemical carcinogenesis - receptor activation sfum05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:sfum00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     130018356 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     130018356 (ADCY2)    04371 Apelin signaling pathway     130018356 (ADCY2)    04020 Calcium signaling pathway     130018356 (ADCY2)    04072 Phospholipase D signaling pathway     130018356 (ADCY2)    04024 cAMP signaling pathway     130018356 (ADCY2)    04022 cGMP-PKG signaling pathway     130018356 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     130018356 (ADCY2)    04081 Hormone signaling     130018356 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     130018356 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     130018356 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     130018356 (ADCY2)    04062 Chemokine signaling pathway     130018356 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     130018356 (ADCY2)    04922 Glucagon signaling pathway     130018356 (ADCY2)    04923 Regulation of lipolysis in adipocytes     130018356 (ADCY2)    04912 GnRH signaling pathway     130018356 (ADCY2)    04913 Ovarian steroidogenesis     130018356 (ADCY2)    04915 Estrogen signaling pathway     130018356 (ADCY2)    04914 Progesterone-mediated oocyte maturation     130018356 (ADCY2)    04921 Oxytocin signaling pathway     130018356 (ADCY2)    04926 Relaxin signaling pathway     130018356 (ADCY2)    04935 Growth hormone synthesis, secretion and action     130018356 (ADCY2)    04918 Thyroid hormone synthesis     130018356 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     130018356 (ADCY2)    04916 Melanogenesis     130018356 (ADCY2)    04925 Aldosterone synthesis and secretion     130018356 (ADCY2)    04927 Cortisol synthesis and secretion     130018356 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     130018356 (ADCY2)    04270 Vascular smooth muscle contraction     130018356 (ADCY2)   09154 Digestive system    04970 Salivary secretion     130018356 (ADCY2)    04971 Gastric acid secretion     130018356 (ADCY2)    04972 Pancreatic secretion     130018356 (ADCY2)    04976 Bile secretion     130018356 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     130018356 (ADCY2)    04727 GABAergic synapse     130018356 (ADCY2)    04725 Cholinergic synapse     130018356 (ADCY2)    04723 Retrograde endocannabinoid signaling     130018356 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     130018356 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     130018356 (ADCY2)    04213 Longevity regulating pathway - multiple species     130018356 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     130018356 (ADCY2)    04714 Thermogenesis     130018356 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     130018356 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     130018356 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     130018356 (ADCY2)    05163 Human cytomegalovirus infection     130018356 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     130018356 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     130018356 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     130018356 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     130018356 (ADCY2) Enzymes [BR:sfum01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      130018356 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  130018356 NCBI-ProteinID:  XP_055965012 LinkDB All DBs Position Unknown AA seq 1093 aa AA seqDB search MWREAMRRRRYLRDRAEAAAAAAAGGGEGPRPSRDWLYESYYCMSQQHPLIVFLLLIVMG ACLALLAVFFALRLEAEDHVAFLITVPTALAIFFAIFILVCIESVFRKLLRLFSVLIWIC LVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTASSHTVVLSVC LSSAPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFE KRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADI VGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAK NCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHM EAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHL FRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQ NRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKMLEKEYRATA LPAFKYYVTCACLIFFCIFIVQVLVLPKTSILGISFGAAFLLLAFILFVCFAGQLLQCSK KAPASLLWLLRSSGIIASRPWPRIALTVITTVIVLTMAVFNMFFLSDPEDTVPSALNTSN TSAPTVPAALLRAQSLFFLPYFIYSCILGLLSCSVFLRVNYELKMLIMMVALVGYNTILL HTHAHVLDDYSQVLFRRPGIWKDLKTMGSVSLFIFFVTLLVLGRQNEYYCRLDFLWKNKF NKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASIPDFKE FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE HAQEPERQHLHIGTMVEFAFALVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY DIWGNTVNVASRMDSTGVLDRIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNT EMSRSLSQSNLAS NT seq 3282 nt NT seq  +upstreamnt  +downstreamnt atgtggcgggaggcgatgcggcggcgccgctacctgcgggaccgagccgaggcggcggcg gcggcggcggcgggtggcggagaggggccgcggccgtcgcgggactggctgtacgagtcc tactactgcatgagccagcagcacccgctcatcgtcttcctgctgctcatcgtgatgggc gcctgcctcgccctgctcgccgtcttcttcgccctgcgcctggaagctgaggaccacgtg gcgtttctcatcaccgtccccaccgccctggccatcttcttcgccatcttcatcctcgtg tgcatcgagtctgtgttcaggaagctactgcgactcttctccgtgctgatctggatctgc ctggtggccatgggctacttgttcatgtgcttcggcggcactgtctccccatgggaccag gtctccttcttcctcttcatcatcttcgtggtgtacaccatgctgcccttcaacatgcgg gacgccatcatcgccagcgtgctcaccgcctcatcacacaccgtcgtgctgagcgtctgc ctgtcctctgcccccggagccaaggagcacctagtctggcagatcctggccaacgtgatc atcttcatctgcggcaacctggcgggcgcctaccacaagcacctcatggaactggcgctg caacagacctaccaggacacctgcaactgcatcaagtcccgcatcaagctagagttcgag aagcgccagcaggagcggctgctgctgtctctgctgccggcccacatcgccatggagatg aaggctgagatcatccagcggttgcagggccccaaggccggccagatggagaataccaac aacttccacaacctctatgtcaagcgacacaccaatgtgagcattctgtacgctgacatc gtgggcttcacccggctggccagtgactgctccccgggagaactggtccacatgctgaac gagctctttggaaagtttgatcagatcgctaaggagaatgaatgcatgagaataaagatc ctcggggactgctactactgtgtgtcggggctccccatctccctccccaaccatgccaag aactgtgtcaagatgggcttggacatgtgtgaagccattaagaaagtgagggacgcgact ggtgtggacatcaacatgcgtgtgggcgtgcactccgggaacgtgctgtgcggcgtgatc ggcctgcagaagtggcagtacgacgtgtggtcccacgacgtcaccctggccaaccacatg gaagccgggggggtccccgggcgtgtccacatctcatctgtcaccctggagcacttgaat ggggcttataaagtggaggaaggagatggtgacatccgggacccatatttaaagcagcac ctagtgaagacctacttcgtcatcaaccccaagggagaacgtcggagcccccaacacctc ttcaggccccggcacaccctggatggggccaaaatgagggcttcggtgcgcatgacccgg tacctggagtcctggggggcggccaagccttttgcacacctgcaccacagagatagcatg accacggagaacggcaagatcagcaccacggatgttccaatgggtcagcataattttcag aatcgcaccttaagaaccaagtcacagaagaagagatttgaagaggaattgaatgaaagg atgattcaggcaattgatgggattaatgcacaaaagcagtggctcaagtctgaagatatc cagagaatctcgctgcttttctacaataaaatgctcgagaaagaatatcgagccacagca ctgccggccttcaagtactacgtgacgtgcgcatgcctcatcttcttctgcatcttcatc gtgcaggtcctggtgttacccaaaacctccatacttgggatttccttcggagctgcgttt ctcctgctcgcctttatccttttcgtctgctttgctggacagcttttgcagtgcagcaag aaggcccctgcctcgctgctctggctcctgaggtcctcgggcatcatcgccagccggccg tggccgcgcatcgccctgacagtcatcaccacggtcatcgtcctcaccatggccgtcttt aacatgttcttcctgagtgacccagaggacaccgtcccttcagctctcaacacgtcgaac acgagtgcgcccaccgtgccagctgccctgctgagggcccagagcctgttcttcctgccg tacttcatctacagctgcatcctggggctactgtcctgctccgttttcctacgtgtcaac tatgagctcaagatgttgatcatgatggtggccctggtgggctacaacaccatcctcctg cacacgcacgcgcacgtgctggacgactacagccaggtgctgttccgcagacccggcatc tggaaggacctgaagaccatgggctccgtgtcactcttcatcttcttcgtcacactgctc gtgctgggcagacagaatgaatattactgtaggttagacttcctgtggaagaacaagttc aacaaagagcgggaggagatcgagaccatggagaacttgaaccgcgtgctactggagaac gtcctgcccgcacacgtggccgagcacttcctggccaggagcctcaagaacgaggactta taccaccagtcctatgactgcgtctgcgtcatgtttgcctccatccccgacttcaaagaa ttctacacagagtcggatgtgaacaaggaaggcctggagtgcctgcggctgctcaacgag atcatcgccgactttgacgatctgctgtccaagcccaagttcagtggcgtcgagaagatc aagaccattggcagcacatacatggcggcgacagggctgagcgctgtgcccagccaggag catgcccaggagcccgagcggcagcacctgcacattggcaccatggtggagtttgccttc gccctggtggccaagctggatgccatcaacaagcactccttcaacgacttcaagctgcga gtgggcatcaaccacgggcctgtcatagcgggcgtgatcggagcccagaagccacagtac gacatctggggcaacacagttaacgtggccagccgcatggacagcaccggggtcctggac agaatccaggtcacggaagagaccagcctcgtcctgcagaccctgggctacacgtgcacg tgtcggggcatcatcaacgtgaagggcaagggggacctgaagacgtactttgtcaacacg gagatgtcgcggtccctttcccagagcaacctggcctcctga

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