KEGG   Sorex fumeus (smoky shrew): 130021713
Entry
130021713         CDS       T10594                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum01521  EGFR tyrosine kinase inhibitor resistance
sfum01522  Endocrine resistance
sfum01524  Platinum drug resistance
sfum04012  ErbB signaling pathway
sfum04014  Ras signaling pathway
sfum04015  Rap1 signaling pathway
sfum04024  cAMP signaling pathway
sfum04062  Chemokine signaling pathway
sfum04066  HIF-1 signaling pathway
sfum04068  FoxO signaling pathway
sfum04070  Phosphatidylinositol signaling system
sfum04071  Sphingolipid signaling pathway
sfum04072  Phospholipase D signaling pathway
sfum04081  Hormone signaling
sfum04140  Autophagy - animal
sfum04150  mTOR signaling pathway
sfum04151  PI3K-Akt signaling pathway
sfum04152  AMPK signaling pathway
sfum04210  Apoptosis
sfum04211  Longevity regulating pathway
sfum04213  Longevity regulating pathway - multiple species
sfum04218  Cellular senescence
sfum04360  Axon guidance
sfum04370  VEGF signaling pathway
sfum04380  Osteoclast differentiation
sfum04510  Focal adhesion
sfum04550  Signaling pathways regulating pluripotency of stem cells
sfum04611  Platelet activation
sfum04613  Neutrophil extracellular trap formation
sfum04620  Toll-like receptor signaling pathway
sfum04625  C-type lectin receptor signaling pathway
sfum04630  JAK-STAT signaling pathway
sfum04650  Natural killer cell mediated cytotoxicity
sfum04660  T cell receptor signaling pathway
sfum04662  B cell receptor signaling pathway
sfum04664  Fc epsilon RI signaling pathway
sfum04666  Fc gamma R-mediated phagocytosis
sfum04668  TNF signaling pathway
sfum04670  Leukocyte transendothelial migration
sfum04722  Neurotrophin signaling pathway
sfum04725  Cholinergic synapse
sfum04750  Inflammatory mediator regulation of TRP channels
sfum04810  Regulation of actin cytoskeleton
sfum04910  Insulin signaling pathway
sfum04914  Progesterone-mediated oocyte maturation
sfum04915  Estrogen signaling pathway
sfum04917  Prolactin signaling pathway
sfum04919  Thyroid hormone signaling pathway
sfum04923  Regulation of lipolysis in adipocytes
sfum04926  Relaxin signaling pathway
sfum04929  GnRH secretion
sfum04930  Type II diabetes mellitus
sfum04931  Insulin resistance
sfum04932  Non-alcoholic fatty liver disease
sfum04933  AGE-RAGE signaling pathway in diabetic complications
sfum04935  Growth hormone synthesis, secretion and action
sfum04960  Aldosterone-regulated sodium reabsorption
sfum04973  Carbohydrate digestion and absorption
sfum05010  Alzheimer disease
sfum05017  Spinocerebellar ataxia
sfum05020  Prion disease
sfum05100  Bacterial invasion of epithelial cells
sfum05135  Yersinia infection
sfum05142  Chagas disease
sfum05146  Amoebiasis
sfum05160  Hepatitis C
sfum05161  Hepatitis B
sfum05162  Measles
sfum05163  Human cytomegalovirus infection
sfum05164  Influenza A
sfum05165  Human papillomavirus infection
sfum05166  Human T-cell leukemia virus 1 infection
sfum05167  Kaposi sarcoma-associated herpesvirus infection
sfum05168  Herpes simplex virus 1 infection
sfum05169  Epstein-Barr virus infection
sfum05170  Human immunodeficiency virus 1 infection
sfum05171  Coronavirus disease - COVID-19
sfum05200  Pathways in cancer
sfum05203  Viral carcinogenesis
sfum05205  Proteoglycans in cancer
sfum05206  MicroRNAs in cancer
sfum05207  Chemical carcinogenesis - receptor activation
sfum05208  Chemical carcinogenesis - reactive oxygen species
sfum05210  Colorectal cancer
sfum05211  Renal cell carcinoma
sfum05212  Pancreatic cancer
sfum05213  Endometrial cancer
sfum05214  Glioma
sfum05215  Prostate cancer
sfum05218  Melanoma
sfum05220  Chronic myeloid leukemia
sfum05221  Acute myeloid leukemia
sfum05222  Small cell lung cancer
sfum05223  Non-small cell lung cancer
sfum05224  Breast cancer
sfum05225  Hepatocellular carcinoma
sfum05226  Gastric cancer
sfum05230  Central carbon metabolism in cancer
sfum05231  Choline metabolism in cancer
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sfum05415  Diabetic cardiomyopathy
sfum05417  Lipid and atherosclerosis
sfum05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    130021713 (PIK3R1)
   04014 Ras signaling pathway
    130021713 (PIK3R1)
   04015 Rap1 signaling pathway
    130021713 (PIK3R1)
   04370 VEGF signaling pathway
    130021713 (PIK3R1)
   04630 JAK-STAT signaling pathway
    130021713 (PIK3R1)
   04668 TNF signaling pathway
    130021713 (PIK3R1)
   04066 HIF-1 signaling pathway
    130021713 (PIK3R1)
   04068 FoxO signaling pathway
    130021713 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    130021713 (PIK3R1)
   04072 Phospholipase D signaling pathway
    130021713 (PIK3R1)
   04071 Sphingolipid signaling pathway
    130021713 (PIK3R1)
   04024 cAMP signaling pathway
    130021713 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    130021713 (PIK3R1)
   04152 AMPK signaling pathway
    130021713 (PIK3R1)
   04150 mTOR signaling pathway
    130021713 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    130021713 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    130021713 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    130021713 (PIK3R1)
   04218 Cellular senescence
    130021713 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    130021713 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    130021713 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    130021713 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    130021713 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    130021713 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    130021713 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    130021713 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    130021713 (PIK3R1)
   04660 T cell receptor signaling pathway
    130021713 (PIK3R1)
   04662 B cell receptor signaling pathway
    130021713 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    130021713 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    130021713 (PIK3R1)
   04670 Leukocyte transendothelial migration
    130021713 (PIK3R1)
   04062 Chemokine signaling pathway
    130021713 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    130021713 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    130021713 (PIK3R1)
   04929 GnRH secretion
    130021713 (PIK3R1)
   04915 Estrogen signaling pathway
    130021713 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    130021713 (PIK3R1)
   04917 Prolactin signaling pathway
    130021713 (PIK3R1)
   04926 Relaxin signaling pathway
    130021713 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    130021713 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    130021713 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    130021713 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    130021713 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    130021713 (PIK3R1)
   04722 Neurotrophin signaling pathway
    130021713 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    130021713 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    130021713 (PIK3R1)
   04380 Osteoclast differentiation
    130021713 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    130021713 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    130021713 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130021713 (PIK3R1)
   05206 MicroRNAs in cancer
    130021713 (PIK3R1)
   05205 Proteoglycans in cancer
    130021713 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    130021713 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    130021713 (PIK3R1)
   05203 Viral carcinogenesis
    130021713 (PIK3R1)
   05230 Central carbon metabolism in cancer
    130021713 (PIK3R1)
   05231 Choline metabolism in cancer
    130021713 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130021713 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    130021713 (PIK3R1)
   05212 Pancreatic cancer
    130021713 (PIK3R1)
   05225 Hepatocellular carcinoma
    130021713 (PIK3R1)
   05226 Gastric cancer
    130021713 (PIK3R1)
   05214 Glioma
    130021713 (PIK3R1)
   05221 Acute myeloid leukemia
    130021713 (PIK3R1)
   05220 Chronic myeloid leukemia
    130021713 (PIK3R1)
   05218 Melanoma
    130021713 (PIK3R1)
   05211 Renal cell carcinoma
    130021713 (PIK3R1)
   05215 Prostate cancer
    130021713 (PIK3R1)
   05213 Endometrial cancer
    130021713 (PIK3R1)
   05224 Breast cancer
    130021713 (PIK3R1)
   05222 Small cell lung cancer
    130021713 (PIK3R1)
   05223 Non-small cell lung cancer
    130021713 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    130021713 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    130021713 (PIK3R1)
   05161 Hepatitis B
    130021713 (PIK3R1)
   05160 Hepatitis C
    130021713 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    130021713 (PIK3R1)
   05164 Influenza A
    130021713 (PIK3R1)
   05162 Measles
    130021713 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    130021713 (PIK3R1)
   05163 Human cytomegalovirus infection
    130021713 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    130021713 (PIK3R1)
   05169 Epstein-Barr virus infection
    130021713 (PIK3R1)
   05165 Human papillomavirus infection
    130021713 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    130021713 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    130021713 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    130021713 (PIK3R1)
   05142 Chagas disease
    130021713 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    130021713 (PIK3R1)
   05017 Spinocerebellar ataxia
    130021713 (PIK3R1)
   05020 Prion disease
    130021713 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    130021713 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    130021713 (PIK3R1)
   05415 Diabetic cardiomyopathy
    130021713 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    130021713 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    130021713 (PIK3R1)
   04931 Insulin resistance
    130021713 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    130021713 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    130021713 (PIK3R1)
   01524 Platinum drug resistance
    130021713 (PIK3R1)
   01522 Endocrine resistance
    130021713 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:sfum04131]
    130021713 (PIK3R1)
Membrane trafficking [BR:sfum04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    130021713 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 AAA_13 SH3_1 Laminin_I SH3_2 CCDC113_CCDC96_CC SH3_9 PI_PP_I
Other DBs
NCBI-GeneID: 130021713
NCBI-ProteinID: XP_055968467
LinkDB
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYEYKKEREEDIDLHLGDILTVNKGSLVALGFSEGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQALSIPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLESSTLYRTQSTSNPAELRQLLDCDAGSVDLDMIDVQ
VLADAFKRYLLDLPNPVIPGAVYNELVSLAQEVQSSEEYIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQAYSKNLLNARVLAELFSPLLFRFPAASPENTESLIKVIEILISTEWNE
RQPAPALPPKPPKPTPVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKESIEKFKREGNEKEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagcgccgagggctaccagtaccgggcgctctatgagtacaaaaaggagcgggaggaa
gacattgacttgcacttgggcgacatcctgactgtgaacaagggctccttagtggccctt
ggattcagcgaaggacaggaagctcggcccgaagaaattggctggttgaatggctataat
gaaaccactggggagcgaggggacttcccaggaacttatgtagaatatatcgggaggaaa
aaaatctcaccaccaacaccaaagccccggccacctcgaccccttcctgtagccccaggt
tcttcgaaagctgaagcagacagcgagcagcaagctttgtcgattccagatctggctgag
cagttcgcccctccagacatcgcgcccccccttctcatcaagctagtggaagccattgaa
aagaaaggtctggaatcttcgactctctacagaacccagagcaccagcaacccagcagag
ctacgacagcttcttgactgtgatgccggctccgtggacctggacatgatcgatgtgcaa
gtcttagcagatgctttcaagcgctatctcctggacttgcccaaccctgtcattccggga
gccgtttacaatgaactggtttctttagcccaagaagtacaaagctccgaagagtacatc
cagctgttgaagaagctcatacggtcaccgaacatacctcatcagtattggcttacactt
cagtatttgctaaaacatttcttcaagctctcccaggcctatagcaaaaatcttctgaat
gcacgagtacttgccgaacttttcagccctctgctgttcagattcccagcagccagccct
gagaatactgaatccctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcccaaaccgcccaaacccactcctgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagacatctccagg
gaagaagtgaatgagaaacttcgagacacagctgacgggacctttttggtacgagacgca
tctactaaaatgcatggtgattatactctcacactaagaaaaggaggaaataataaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccgttaaccttcaactct
gtggttgagctaataaaccactaccggaatgaatctctagcgcagtataatcccaagctg
gatgtgaaattgctctacccagtatccaagtaccaacaggatcaagttgtcaaagaggat
aatattgaagccgtagggaagaagttacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaggattatacccgcacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaactataaaaatatttgaagaacagtgccaaacc
caggagcggtacagcaaagaatccatagaaaaatttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgaaaagttgaagtctcgaatcagtgagattgttgac
agtagaagaaggttggaggaagatttgaagaagcaggcagccgagtaccgggagattgac
aaacgcatgaacagcatcaagccagacctcattcagctgcgaaagacccgagaccaatac
ctgatgtggttgactcagaaaggtgtccggcagaagaagctgaatgagtggctgggcaat
gaaaacactgaagaccaatattcgctggtggaggatgatgaggacctgccccaccatgac
gagaagacatggaatgttggaagcagcaaccgaaacaaagctgaaaaccttttacgaggg
aagcgagacggcactttcctggtccgggaaagcagcaagcagggctgttatgcctgctct
gtggtggtggacggcgaagtcaagcactgtgtcatcaacaagacggcgacaggctacggc
tttgcggagccctataacctgtacggctccctgaaagaactggtgctccattaccaacac
acctccctcgtgcagcacaacgactccctaaacgtcacactagcctacccagtatatgca
cagcagaggcgatga

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