Sorex fumeus (smoky shrew): 130027422 Help Entry 130027422         CDS       T10594                                  Symbol IL6 Name (RefSeq) interleukin-6   KO K05405   interleukin 6 Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum01521   EGFR tyrosine kinase inhibitor resistance sfum01523   Antifolate resistance sfum04060   Cytokine-cytokine receptor interaction sfum04061   Viral protein interaction with cytokine and cytokine receptor sfum04066   HIF-1 signaling pathway sfum04068   FoxO signaling pathway sfum04151   PI3K-Akt signaling pathway sfum04218   Cellular senescence sfum04620   Toll-like receptor signaling pathway sfum04621   NOD-like receptor signaling pathway sfum04623   Cytosolic DNA-sensing pathway sfum04625   C-type lectin receptor signaling pathway sfum04630   JAK-STAT signaling pathway sfum04640   Hematopoietic cell lineage sfum04657   IL-17 signaling pathway sfum04659   Th17 cell differentiation sfum04668   TNF signaling pathway sfum04672   Intestinal immune network for IgA production sfum04931   Insulin resistance sfum04932   Non-alcoholic fatty liver disease sfum04933   AGE-RAGE signaling pathway in diabetic complications sfum04936   Alcoholic liver disease sfum05010   Alzheimer disease sfum05020   Prion disease sfum05022   Pathways of neurodegeneration - multiple diseases sfum05132   Salmonella infection sfum05133   Pertussis sfum05134   Legionellosis sfum05135   Yersinia infection sfum05142   Chagas disease sfum05143   African trypanosomiasis sfum05144   Malaria sfum05146   Amoebiasis sfum05152   Tuberculosis sfum05161   Hepatitis B sfum05162   Measles sfum05163   Human cytomegalovirus infection sfum05164   Influenza A sfum05166   Human T-cell leukemia virus 1 infection sfum05167   Kaposi sarcoma-associated herpesvirus infection sfum05168   Herpes simplex virus 1 infection sfum05169   Epstein-Barr virus infection sfum05171   Coronavirus disease - COVID-19 sfum05200   Pathways in cancer sfum05202   Transcriptional misregulation in cancer sfum05321   Inflammatory bowel disease sfum05323   Rheumatoid arthritis sfum05332   Graft-versus-host disease sfum05410   Hypertrophic cardiomyopathy sfum05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:sfum00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     130027422 (IL6)    04668 TNF signaling pathway     130027422 (IL6)    04066 HIF-1 signaling pathway     130027422 (IL6)    04068 FoxO signaling pathway     130027422 (IL6)    04151 PI3K-Akt signaling pathway     130027422 (IL6)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     130027422 (IL6)    04061 Viral protein interaction with cytokine and cytokine receptor     130027422 (IL6)  09140 Cellular Processes   09143 Cell growth and death    04218 Cellular senescence     130027422 (IL6)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     130027422 (IL6)    04620 Toll-like receptor signaling pathway     130027422 (IL6)    04621 NOD-like receptor signaling pathway     130027422 (IL6)    04623 Cytosolic DNA-sensing pathway     130027422 (IL6)    04625 C-type lectin receptor signaling pathway     130027422 (IL6)    04659 Th17 cell differentiation     130027422 (IL6)    04657 IL-17 signaling pathway     130027422 (IL6)    04672 Intestinal immune network for IgA production     130027422 (IL6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     130027422 (IL6)    05202 Transcriptional misregulation in cancer     130027422 (IL6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     130027422 (IL6)    05161 Hepatitis B     130027422 (IL6)    05171 Coronavirus disease - COVID-19     130027422 (IL6)    05164 Influenza A     130027422 (IL6)    05162 Measles     130027422 (IL6)    05168 Herpes simplex virus 1 infection     130027422 (IL6)    05163 Human cytomegalovirus infection     130027422 (IL6)    05167 Kaposi sarcoma-associated herpesvirus infection     130027422 (IL6)    05169 Epstein-Barr virus infection     130027422 (IL6)   09171 Infectious disease: bacterial    05132 Salmonella infection     130027422 (IL6)    05135 Yersinia infection     130027422 (IL6)    05133 Pertussis     130027422 (IL6)    05134 Legionellosis     130027422 (IL6)    05152 Tuberculosis     130027422 (IL6)   09174 Infectious disease: parasitic    05146 Amoebiasis     130027422 (IL6)    05144 Malaria     130027422 (IL6)    05142 Chagas disease     130027422 (IL6)    05143 African trypanosomiasis     130027422 (IL6)   09163 Immune disease    05323 Rheumatoid arthritis     130027422 (IL6)    05321 Inflammatory bowel disease     130027422 (IL6)    05332 Graft-versus-host disease     130027422 (IL6)   09164 Neurodegenerative disease    05010 Alzheimer disease     130027422 (IL6)    05020 Prion disease     130027422 (IL6)    05022 Pathways of neurodegeneration - multiple diseases     130027422 (IL6)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     130027422 (IL6)    05410 Hypertrophic cardiomyopathy     130027422 (IL6)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     130027422 (IL6)    04932 Non-alcoholic fatty liver disease     130027422 (IL6)    04931 Insulin resistance     130027422 (IL6)    04933 AGE-RAGE signaling pathway in diabetic complications     130027422 (IL6)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     130027422 (IL6)    01523 Antifolate resistance     130027422 (IL6)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:sfum04052]     130027422 (IL6) Cytokines and neuropeptides [BR:sfum04052]  Cytokines   Interleukins    130027422 (IL6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IL6 IL11 GCSF Motif Other DBs NCBI-GeneID:  130027422 NCBI-ProteinID:  XP_055974163 LinkDB All DBs Position Unknown AA seq 214 aa AA seqDB search MNSLSPRAFSPVAFSLGLLLVLATGFPTPDPLREEAMDAVVPTLLPGTFRERTEDLIKYI LGKISLLKKELCGKHYKCENTKAALAENNLNLPKMANGKECLLSNFSQEHCLIRISSGLL EFQIYLEYLQKVYDGDKKNAMDMNHNTKNLIQLLMQNVKNPHEVTTPDPSRSVNVLSWLQ SQSQKNWLQSTTFHMVLQSLEDFLRFSLRAVRIM NT seq 645 nt NT seq  +upstreamnt  +downstreamnt atgaactcgctgtccccacgcgccttcagtccagtcgccttctccctggggctgctcctg gtgctggctactggcttccccacccctgaccccctgcgagaagaggccatggatgctgtt gtcccgaccctactgcccggcacctttcgcgaaagaaccgaagacctcattaagtacatc ctgggcaaaatctcgctactgaaaaaagagctgtgtggcaagcactacaagtgtgagaac accaaggcagcactggcagagaacaacctgaaccttccaaagatggcaaacggaaaggaa tgcctcctctcaaatttcagtcaggaacattgcctgataagaatcagctctggtctcttg gagtttcagatatatcttgagtaccttcagaaagtgtatgatggtgataagaaaaatgcc atggatatgaatcacaataccaaaaacctgattcagctcctgatgcaaaacgtgaagaac ccacatgaagtcacgaccccagaccccagccgcagtgtcaacgtgctcagctggcttcaa tcccagtcccagaaaaactggctacagagcaccacgttccacatggtgctgcagagcctg gaggatttcctgcggttcagcctgagggccgtccggatcatgtag

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