KEGG   Sorex fumeus (smoky shrew): 130028914
Entry
130028914         CDS       T10594                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum01521  EGFR tyrosine kinase inhibitor resistance
sfum01522  Endocrine resistance
sfum04010  MAPK signaling pathway
sfum04012  ErbB signaling pathway
sfum04014  Ras signaling pathway
sfum04015  Rap1 signaling pathway
sfum04022  cGMP-PKG signaling pathway
sfum04024  cAMP signaling pathway
sfum04066  HIF-1 signaling pathway
sfum04068  FoxO signaling pathway
sfum04071  Sphingolipid signaling pathway
sfum04072  Phospholipase D signaling pathway
sfum04140  Autophagy - animal
sfum04148  Efferocytosis
sfum04150  mTOR signaling pathway
sfum04151  PI3K-Akt signaling pathway
sfum04210  Apoptosis
sfum04218  Cellular senescence
sfum04270  Vascular smooth muscle contraction
sfum04370  VEGF signaling pathway
sfum04371  Apelin signaling pathway
sfum04517  IgSF CAM signaling
sfum04540  Gap junction
sfum04550  Signaling pathways regulating pluripotency of stem cells
sfum04613  Neutrophil extracellular trap formation
sfum04620  Toll-like receptor signaling pathway
sfum04650  Natural killer cell mediated cytotoxicity
sfum04660  T cell receptor signaling pathway
sfum04662  B cell receptor signaling pathway
sfum04664  Fc epsilon RI signaling pathway
sfum04720  Long-term potentiation
sfum04722  Neurotrophin signaling pathway
sfum04730  Long-term depression
sfum04810  Regulation of actin cytoskeleton
sfum04910  Insulin signaling pathway
sfum04912  GnRH signaling pathway
sfum04915  Estrogen signaling pathway
sfum04916  Melanogenesis
sfum04917  Prolactin signaling pathway
sfum04919  Thyroid hormone signaling pathway
sfum04921  Oxytocin signaling pathway
sfum04926  Relaxin signaling pathway
sfum04929  GnRH secretion
sfum04934  Cushing syndrome
sfum04935  Growth hormone synthesis, secretion and action
sfum05010  Alzheimer disease
sfum05022  Pathways of neurodegeneration - multiple diseases
sfum05132  Salmonella infection
sfum05135  Yersinia infection
sfum05160  Hepatitis C
sfum05161  Hepatitis B
sfum05163  Human cytomegalovirus infection
sfum05164  Influenza A
sfum05165  Human papillomavirus infection
sfum05166  Human T-cell leukemia virus 1 infection
sfum05167  Kaposi sarcoma-associated herpesvirus infection
sfum05170  Human immunodeficiency virus 1 infection
sfum05200  Pathways in cancer
sfum05205  Proteoglycans in cancer
sfum05206  MicroRNAs in cancer
sfum05207  Chemical carcinogenesis - receptor activation
sfum05208  Chemical carcinogenesis - reactive oxygen species
sfum05210  Colorectal cancer
sfum05211  Renal cell carcinoma
sfum05213  Endometrial cancer
sfum05214  Glioma
sfum05215  Prostate cancer
sfum05216  Thyroid cancer
sfum05218  Melanoma
sfum05219  Bladder cancer
sfum05220  Chronic myeloid leukemia
sfum05221  Acute myeloid leukemia
sfum05223  Non-small cell lung cancer
sfum05224  Breast cancer
sfum05225  Hepatocellular carcinoma
sfum05226  Gastric cancer
sfum05230  Central carbon metabolism in cancer
sfum05231  Choline metabolism in cancer
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    130028914 (MAP2K2)
   04012 ErbB signaling pathway
    130028914 (MAP2K2)
   04014 Ras signaling pathway
    130028914 (MAP2K2)
   04015 Rap1 signaling pathway
    130028914 (MAP2K2)
   04370 VEGF signaling pathway
    130028914 (MAP2K2)
   04371 Apelin signaling pathway
    130028914 (MAP2K2)
   04066 HIF-1 signaling pathway
    130028914 (MAP2K2)
   04068 FoxO signaling pathway
    130028914 (MAP2K2)
   04072 Phospholipase D signaling pathway
    130028914 (MAP2K2)
   04071 Sphingolipid signaling pathway
    130028914 (MAP2K2)
   04024 cAMP signaling pathway
    130028914 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    130028914 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    130028914 (MAP2K2)
   04150 mTOR signaling pathway
    130028914 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    130028914 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    130028914 (MAP2K2)
   04148 Efferocytosis
    130028914 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    130028914 (MAP2K2)
   04218 Cellular senescence
    130028914 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    130028914 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    130028914 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    130028914 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    130028914 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    130028914 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    130028914 (MAP2K2)
   04660 T cell receptor signaling pathway
    130028914 (MAP2K2)
   04662 B cell receptor signaling pathway
    130028914 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    130028914 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    130028914 (MAP2K2)
   04929 GnRH secretion
    130028914 (MAP2K2)
   04912 GnRH signaling pathway
    130028914 (MAP2K2)
   04915 Estrogen signaling pathway
    130028914 (MAP2K2)
   04917 Prolactin signaling pathway
    130028914 (MAP2K2)
   04921 Oxytocin signaling pathway
    130028914 (MAP2K2)
   04926 Relaxin signaling pathway
    130028914 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    130028914 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    130028914 (MAP2K2)
   04916 Melanogenesis
    130028914 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    130028914 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    130028914 (MAP2K2)
   04730 Long-term depression
    130028914 (MAP2K2)
   04722 Neurotrophin signaling pathway
    130028914 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130028914 (MAP2K2)
   05206 MicroRNAs in cancer
    130028914 (MAP2K2)
   05205 Proteoglycans in cancer
    130028914 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    130028914 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    130028914 (MAP2K2)
   05230 Central carbon metabolism in cancer
    130028914 (MAP2K2)
   05231 Choline metabolism in cancer
    130028914 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130028914 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    130028914 (MAP2K2)
   05225 Hepatocellular carcinoma
    130028914 (MAP2K2)
   05226 Gastric cancer
    130028914 (MAP2K2)
   05214 Glioma
    130028914 (MAP2K2)
   05216 Thyroid cancer
    130028914 (MAP2K2)
   05221 Acute myeloid leukemia
    130028914 (MAP2K2)
   05220 Chronic myeloid leukemia
    130028914 (MAP2K2)
   05218 Melanoma
    130028914 (MAP2K2)
   05211 Renal cell carcinoma
    130028914 (MAP2K2)
   05219 Bladder cancer
    130028914 (MAP2K2)
   05215 Prostate cancer
    130028914 (MAP2K2)
   05213 Endometrial cancer
    130028914 (MAP2K2)
   05224 Breast cancer
    130028914 (MAP2K2)
   05223 Non-small cell lung cancer
    130028914 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    130028914 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    130028914 (MAP2K2)
   05161 Hepatitis B
    130028914 (MAP2K2)
   05160 Hepatitis C
    130028914 (MAP2K2)
   05164 Influenza A
    130028914 (MAP2K2)
   05163 Human cytomegalovirus infection
    130028914 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    130028914 (MAP2K2)
   05165 Human papillomavirus infection
    130028914 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    130028914 (MAP2K2)
   05135 Yersinia infection
    130028914 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    130028914 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    130028914 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    130028914 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    130028914 (MAP2K2)
   01522 Endocrine resistance
    130028914 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sfum01001]
    130028914 (MAP2K2)
Enzymes [BR:sfum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     130028914 (MAP2K2)
Protein kinases [BR:sfum01001]
 Serine/threonine kinases: STE group
  STE7 family
   130028914 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Seadorna_VP7 Kdo DUF3216 APH
Other DBs
NCBI-GeneID: 130028914
NCBI-ProteinID: XP_055975725
LinkDB
Position
Unknown
AA seq 400 aa
MLARRKPVLPALTINTAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFEKISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVGDGAEGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPTGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEVEEVDFAGWLCRTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaacaccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcgaacctggtggacctgcagaagaag
ctcgaggagctcgaactcgatgagcagcagaagaagcgcctggaagccttcctcacccag
aaggccaaggtcggggagctcaaagatgacgacttcgagaagatctctgagctcggggcc
ggcaatggcggcgtggtcaccaaggtccagcacagaccctcggggctcatcatggcccga
aagctgatccacctggagatcaagcctgccgtccggaaccagatcatccgggagctgcag
gtgctgcacgagtgcaactcgccgtacatcgtgggcttctacggcgccttctacagcgat
ggcgagatcagcatctgcatggagcacatggacgggggctccctggaccaggtgctgaag
gaggccaagcgcatccccgaggagatcttggggaaggtcagcatagcggtccttcggggc
ttggcctacctccgggagaagcaccagatcatgcaccgagatgtgaagccgtccaacatc
ctggtcaactccaggggggagatcaagctgtgcgactttggggtgagcgggcagctcatt
gactccatggccaactcgttcgtggggacgcggtcctacatgtcgcccgagcgtctgcag
ggcacccactattcagtccagtcggacatctggagcatgggcctgtccctcgtggagctg
tccatcggccgctaccccatccccccgcccgacgccaaggagctggaggccatcttcggc
cggcccgtgggggacggcgccgagggcgagccccacagcgtgtcgccccggccgcggccc
cccgggcgccccatcagcgggcacggcatggacagccggccggccatggccatcttcgag
ctgctggactatattgtgaatgagccaccacccaagctgcccactggtgttttcacacag
gatttccaggagtttgtaaataaatgtctaatcaagaacccagcggaacgagcagacctg
aagatgctcatgaaccatgctttcatcaaacgctccgaggtggaagaggtggactttgcc
ggttggctctgccggacactgcggctgaaccaacccagcacgcccacccgcaccgccgtg
tga

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