KEGG   Sorex fumeus (smoky shrew): 130030466
Entry
130030466         CDS       T10594                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum00562  Inositol phosphate metabolism
sfum01100  Metabolic pathways
sfum01521  EGFR tyrosine kinase inhibitor resistance
sfum04012  ErbB signaling pathway
sfum04014  Ras signaling pathway
sfum04015  Rap1 signaling pathway
sfum04020  Calcium signaling pathway
sfum04062  Chemokine signaling pathway
sfum04064  NF-kappa B signaling pathway
sfum04066  HIF-1 signaling pathway
sfum04070  Phosphatidylinositol signaling system
sfum04072  Phospholipase D signaling pathway
sfum04360  Axon guidance
sfum04370  VEGF signaling pathway
sfum04517  IgSF CAM signaling
sfum04613  Neutrophil extracellular trap formation
sfum04650  Natural killer cell mediated cytotoxicity
sfum04658  Th1 and Th2 cell differentiation
sfum04659  Th17 cell differentiation
sfum04660  T cell receptor signaling pathway
sfum04664  Fc epsilon RI signaling pathway
sfum04666  Fc gamma R-mediated phagosome formation
sfum04670  Leukocyte transendothelial migration
sfum04722  Neurotrophin signaling pathway
sfum04750  Inflammatory mediator regulation of TRP channels
sfum04919  Thyroid hormone signaling pathway
sfum04933  AGE-RAGE signaling pathway in diabetic complications
sfum04935  Growth hormone synthesis, secretion and action
sfum05012  Parkinson disease
sfum05022  Pathways of neurodegeneration - multiple diseases
sfum05135  Yersinia infection
sfum05167  Kaposi sarcoma-associated herpesvirus infection
sfum05170  Human immunodeficiency virus 1 infection
sfum05171  Coronavirus disease
sfum05200  Pathways in cancer
sfum05205  Proteoglycans in cancer
sfum05206  MicroRNAs in cancer
sfum05214  Glioma
sfum05223  Non-small cell lung cancer
sfum05225  Hepatocellular carcinoma
sfum05231  Choline metabolism in cancer
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sfum05417  Lipid and atherosclerosis
Module
sfum_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    130030466 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    130030466 (PLCG1)
   04014 Ras signaling pathway
    130030466 (PLCG1)
   04015 Rap1 signaling pathway
    130030466 (PLCG1)
   04370 VEGF signaling pathway
    130030466 (PLCG1)
   04064 NF-kappa B signaling pathway
    130030466 (PLCG1)
   04066 HIF-1 signaling pathway
    130030466 (PLCG1)
   04020 Calcium signaling pathway
    130030466 (PLCG1)
   04070 Phosphatidylinositol signaling system
    130030466 (PLCG1)
   04072 Phospholipase D signaling pathway
    130030466 (PLCG1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    130030466 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    130030466 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    130030466 (PLCG1)
   04660 T cell receptor signaling pathway
    130030466 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    130030466 (PLCG1)
   04659 Th17 cell differentiation
    130030466 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    130030466 (PLCG1)
   04666 Fc gamma R-mediated phagosome formation
    130030466 (PLCG1)
   04670 Leukocyte transendothelial migration
    130030466 (PLCG1)
   04062 Chemokine signaling pathway
    130030466 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    130030466 (PLCG1)
   04919 Thyroid hormone signaling pathway
    130030466 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    130030466 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    130030466 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    130030466 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130030466 (PLCG1)
   05206 MicroRNAs in cancer
    130030466 (PLCG1)
   05205 Proteoglycans in cancer
    130030466 (PLCG1)
   05231 Choline metabolism in cancer
    130030466 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130030466 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    130030466 (PLCG1)
   05214 Glioma
    130030466 (PLCG1)
   05223 Non-small cell lung cancer
    130030466 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    130030466 (PLCG1)
   05171 Coronavirus disease
    130030466 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    130030466 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    130030466 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    130030466 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    130030466 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    130030466 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    130030466 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    130030466 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:sfum04131]
    130030466 (PLCG1)
Enzymes [BR:sfum01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     130030466 (PLCG1)
Membrane trafficking [BR:sfum04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    130030466 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    130030466 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG PH C2 SH3_1 EF_HAND_1_PLCG SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7 PH_9
Other DBs
NCBI-GeneID: 130030466
NCBI-ProteinID: XP_055977740
LinkDB
Position
Unknown
AA seq 1292 aa
MAGAASPCANGCAPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKMMDIPFLEARISRT
VEQSEPGQMSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFSLDEFVT
FLFSKENSIWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSI
SMASVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVY
CRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLD
SSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMREEAFDPFDK
SSLRGLEPCGICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPV
WPAKVFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSED
LELASLLVKINIFASKQENGDLSPFSGTSLRERGSDASGHLFHGRAREGSFEARYQQPFE
DFHISQDHLTDHFDSRERRAPRRTRINGDNRL
NT seq 3879 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgcgcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagactttccaggtcaagctggagacgcggcagatc
acgtggagccgcggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccaggaaagacctcacgggactttgatcgctaccaggaggaccctgctttccgc
ccagaccaatcacactgctttgtcatcctgtatggaatggaattccgactgaagaccctg
agcctgcaagctacatcggaggatgaggtgaatatgtggatcaagggcttaacttggctg
atggaggacacgttgcaggcagccactccactgcagattgagaggtggttgcggaagcag
ttttactcagtggataggaatcgcgaagatcgtatatcagccaaggacttgaagaacatg
ctgtcccaggtcaattaccgtgtccccaatatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagcgacatcacctatgggcagtttgctcagctgtaccgaagcctc
atgtacagcgcccagaagatgatggacatccccttcctggaagccagaatctcaaggaca
gtggagcagtcagagcctggccaaatgtccctttctgagttccagcagttccttcttgag
taccaaggagaactgtgggcggtcgaccggctccaggtacaggaattcatgctgagtttc
ctccgagaccctctccgagagatcgaggagccatacttctctctggatgagtttgtcacc
ttcctgttctccaaagagaacagtatatggaactcacaactggatgcagtgtgccctgac
accatgaataaccctctttcccactactggatctcctcctcacacaatacgtacctgacg
ggagaccagttctccagtgagtcctccctggaagcctacgcccgctgcctgaggatgggc
tgtcgctgcattgagttggactgctgggatggccccgatgggatgccagttatttaccac
ggacacacccttaccaccaagatcaaattctctgatgtccttcacaccattaaggagcat
gcctttgtggcctcagagtatccagtcattctgtcaatcgaggaccactgtagcattgcc
cagcagaggaacatggcccagtacttcaagaaggtactcggcgacacactcctaaccaag
cctgtggacattgcagccgatgggctcccctcacccaaccagctcaagaggaagatcctt
atcaagcacaagaaactggctgagggcagtgcctacgaggaggtgcctacgtctgtgatg
tactccgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggacccc
gtgaaccatgagtggtatccccactactttgttctgaccagcagtaagatctactattct
gaggagaccagcagtgaccagggcaatgaggatgaggaggagcccaaagaggccagcggc
agcacagagctgcactccaatgagaaatggttccacgggaagctcggggcagggcgggat
gggcggcacatcgccgagcgactgctcaccgagtactgcatcgagactggggccccagac
ggctccttccttgtgcgcgagagcgagacctttgtgggcgactacaccctctctttctgg
cgaaatgggaaagtccagcactgccggatccactcccggcaggacgctgggacccccaag
ttcttcctgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag
caggttcccctgcgctgcaacgaatttgagatgcgcctctcagagcctgtcccacagacc
aatgcccatgagagcaaagagtggtaccatgcaagcctgaccagagcacaggctgagcac
atgctgatgcgggtcccccgggatggggccttcctcgtgcggaagcgaaatgagcccaac
tcctatgccatctccttccgggctgaagggaagatcaagcattgccgtgtccagcaggag
ggccagacagtgatgctgggcaactcggagtttgacagcctggtagatctcatcagctac
tatgagaagcacccgctgtaccgcaagatgaagttgcggtaccccatcaatgaggaggca
ctggagaagattggcacagctgagccggactatggggccctgtatgagggacgcaaccct
ggcttctatgtggaggcaaaccccatgccaacttttaagtgtgcagtcaaagccctcttt
gactacaaagcccagagagaagatgagctgacattcaccaagagtgccatcatccagaat
gtggagaagcaagagggaggctggtggcggggggactatggtgggaagaagcagctgtgg
ttcccgtccaactacgtggaagagatggtcagtccggcagcagccctggagcctgagagg
gagcacttggatgagaacagcccgctgggggacttgctacggggggtcttggatgtgcca
gcttgtcagattgccattcgtcctgagggcaagaatagtcggctcttcgtcttctccatc
agcatggcctcggtggcacagtggtccctggatgtcgccgccgactctcaggaggagcta
caggattgggtgaagaagatccgtgaagtggctcagactgcagacgccaggctcactgag
gggaagatgatggagcgcaggaagaaaattgccctggagctctcagagctagttgtctac
tgccggcctgttcccttcgatgaagagaagattggcaccgagcgtgcctgctaccgggac
atgtcgtctttcccggaaaccaaggctgagaaatacgtgaataaggccaaaggcaagaaa
ttcctccagtacaatcggctgcagctctcacggatataccctaaggggcagcggctggac
tcttccaattatgatcccttgcccatgtggatctgtggcagtcagcttgtggccctcaac
ttccagaccccagacaagcccatgcagatgaaccaggccctcttcatggccggtgggcac
tgtggctatgtcctgcagcccagcaccatgcgcgaggaggctttcgacccctttgacaag
agcagcctccgagggttggagccctgtggcatctgcatcgaggtgctgggcgcccggcat
ctgccaaagaatggccggggcattgtgtgtcccttcgtggagatcgaggtggctggagcc
gagtatgatagcaccaaacagaagacagagtttgtggtggacaatggactaaatccagta
tggccggccaaggttttccacttccagattagtaaccctgaattcgccttcctgcgcttc
gtggtgtatgaggaagacatgttcagtgaccagaacttcctggcacaggccactttccca
gtgaaaggcctcaagacagggtacagagcagtgcctttgaagaacaactacagtgaggac
ctggagttggcctccctgctggtcaagatcaacattttcgcttccaagcaggagaatgga
gacctcagtcccttcagtggtacctccctgcgggagcgcggctctgatgcctcaggccat
ctgttccacggccgggcaagggaaggctccttcgaagcccgttaccagcagccattcgag
gactttcacatctcccaggaccatctcacagatcattttgacagccgggaacgaagggcc
ccacgaaggactcggatcaacggagacaaccggctctag

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