Sorex fumeus (smoky shrew): 130034243 Help Entry 130034243         CDS       T10594                                  Symbol IRS4 Name (RefSeq) insulin receptor substrate 4   KO K17446   insulin receptor substrate 4 Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum04022   cGMP-PKG signaling pathway sfum04068   FoxO signaling pathway sfum04081   Hormone signaling sfum04140   Autophagy - animal sfum04152   AMPK signaling pathway sfum04211   Longevity regulating pathway sfum04213   Longevity regulating pathway - multiple species sfum04910   Insulin signaling pathway sfum04920   Adipocytokine signaling pathway sfum04923   Regulation of lipolysis in adipocytes sfum04930   Type II diabetes mellitus sfum04935   Growth hormone synthesis, secretion and action sfum05010   Alzheimer disease Brite KEGG Orthology (KO) [BR:sfum00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     130034243 (IRS4)    04022 cGMP-PKG signaling pathway     130034243 (IRS4)    04152 AMPK signaling pathway     130034243 (IRS4)   09133 Signaling molecules and interaction    04081 Hormone signaling     130034243 (IRS4)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     130034243 (IRS4)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     130034243 (IRS4)    04923 Regulation of lipolysis in adipocytes     130034243 (IRS4)    04920 Adipocytokine signaling pathway     130034243 (IRS4)    04935 Growth hormone synthesis, secretion and action     130034243 (IRS4)   09149 Aging    04211 Longevity regulating pathway     130034243 (IRS4)    04213 Longevity regulating pathway - multiple species     130034243 (IRS4)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     130034243 (IRS4)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     130034243 (IRS4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH_11 PH Motif Other DBs NCBI-GeneID:  130034243 NCBI-ProteinID:  XP_055981785 LinkDB All DBs Position Unknown AA seq 1260 aa AA seqDB search MASRSSARDRATGRPRAAAAATATAAARAAVATTPLLPSAPPTALIGTGSSCPGAMWRSA AAGSRSDSESEEEDLPVGDEVCKRGYLRKKRGHRRYFVLRLETAGAPARLEYYENARKFR DSVRAAAAAAAATASGAAEVPDLIPPRRVITLHQCFSVSQRADARYRYLIALFTQDEYFA LVAENESEQGSWYLLLSRLILESKRRRRGTPSARPVAEGDDERAVATVAEPPFYRDVWQV VVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNAEVASVVVQLLSIRRCGHTEQYFFLEVG RSTVIGPGELWMQVDDRVVARNMHELFLLKMRALCAEEYRARCRGYTFTIGAHLLTLLST RRQLDKRPGEPGGWFRRSRFEQFYHLRAIRDREDDESLLTRRNQSPNVAVPQARRGRPQL PHLPRARRARRAASLPASCYRRFTLSPAGAVQPAEAPSDGARPASNRSGSSPGNSGEEGE PQGKEELESNEGDYMPMRKWGSGNGRGSGDGQGPCGQSPGGNQCSGGGKGSGGGQGSSGS QGASGSQGSSGQSSGGQGAGGNQCSGRGQGTAGGHGSGGGQGAGGGRDSGSGQGPRDGPG SCSGKISGGEKGSGSGKVSGGSGDQGKSLKKRSYFGKLTQSKQHRIPLPPPPPPPPTPAG GAKGRAGGRFRLYFCADRSATKERKEVKEVKEKGLPEGGARGLHRARAFDEEEDDPYVPM RPGVAFPLASSSDYMPMAPRHPAASKSRHSRSPFEDSRGYMMMFPRVSPPAAPSPPKAPG PDKKDESKDNDSDSDYMFMAPGAGAIPKNPPSPQGGSSSKSWSSYFSLPTPSQTSPLGQM DHSEYVPMLTRKFLGMGLDKEGSPEWGSPKDTVSKPSVEGSFSEPGDGGSFSQSLVDIPF QGKANKPDQLAFIKKGNTIEPSSQKPTHDQRENDSASVYVNIDFTERASHSSVPFGQGQA DTRGILADPREYSFSHYINIQLRVPFLSQENLSDLLRAIPGANLFSLDFARWPLRPSATG GIVSVGEGEYIEVRFSPAMASSAPFADSAFRYDAETGRIYVVDPFSECCMDISLSPSRCS EPPPVARLRQEEEQERRSAPSRSQSSASARAAASAFPADSLEGNPSASAAAPTLAMGPAL AAASALAAAPAVGSAAAGFGVDSAPARWFQLVANGAGAEAERGAQEIAGGPNRRAPNPFE ALAGGENGARGAAAAAAAPPVPPPRRRVPRPPERDDSDDDDSTYVRMDFSRADNEESDAP NT seq 3783 nt NT seq  +upstreamnt  +downstreamnt atggcgagccgctcctccgctcgagaccgagcgaccgggagaccgagggcggcagcggca gcgacagcgactgcggcggctcgcgctgcggtggcgaccaccccgcttctaccctcggcc cctccgaccgcactcattgggaccgggtcgtcttgtccgggagccatgtggcgctccgcg gccgctggctctcggtccgactccgagtccgaggaggaagacctccccgtcggggacgaa gtctgcaagcgtggctacctgaggaagaagcgcgggcatcggcgctacttcgtgctcaga ctcgagacggccggagccccggcgcggctcgaatactatgaaaacgccaggaagttccgc gacagtgtccgcgcggcggcggctgcagccgcggcgaccgcttcgggcgccgccgaggtt ccggatctcatcccgccgcggcgcgtgatcaccttgcaccagtgcttctcggtgagccag agagccgatgcccgctaccggtacctcatcgccctcttcacccaggatgagtacttcgcc ctggtcgccgagaacgagtcagaacaggggagctggtacttgctgctcagccgcctcatc ctcgagagtaagcgccgccgccgcggcacgcccagcgcccgaccggtggcagaaggggac gacgagagggcggtcgcaacggtggccgagccacccttctacagagatgtgtggcaggta gtggtcaaacccaggggcctggggcaccgcaaagagctgagcggcgtgttccggctgtgc ctgaccgacgaggaggtcgtgttcgtgaggctgaatgccgaggtggccagcgtggtcgtc cagctcctgagcatccgtcgctgtgggcacacggagcagtatttcttcttagaagtcggc aggtccaccgtcatcggtccgggggagctctggatgcaggtcgatgaccgcgtagtagct cgaaacatgcacgagctgtttcttttaaagatgagagccctgtgcgcagaggaatacaga gcccgctgccgcggctacaccttcaccatcggcgcccacctgttaactctgctgtccact aggaggcagctagacaagcggcccggggagccgggcggctggttccgtaggtcccgcttt gagcagttttaccacctcagggccatcagggaccgggaagacgacgaaagcctactcacc cgccgcaatcaatcacccaatgttgctgtgccccaggccaggcgaggacggccacaactg ccccacctgcccagagcccgcagggcgagaagagctgcttccttgcccgccagctgctac cgccgctttacgctgagtcctgcgggtgcagtgcaacctgctgaagctcccagtgatgga gctcgcccggcttctaacagatcaggttccagccctggtaactctggggaagaaggcgag cctcagggcaaagaggagctggaaagcaatgaaggcgactatatgcccatgagaaaatgg ggctcaggaaatggccgaggatccggagacggccagggcccctgtggacagagtccagga ggaaatcagtgctctggaggaggaaagggctccggaggtggccagggctcaagtggcagc cagggtgcaagtggcagccagggctctagtggccagagttcaggaggccagggtgcagga ggaaaccagtgttcaggacgtggtcagggcacagcaggtggccatggctcaggcggtgga cagggagctggaggtggccgtgactcagggagtggccaggggccccgcgatggtcctggg tcttgcagtggtaaaatctctggtggggaaaaaggttctggaagtgggaaggtatctggt ggcagtggtgatcaggggaaatctctgaagaaaagatcctactttggcaaattaacccaa agcaagcaacatcgaattccgctgccacccccacccccgcccccacccacaccagcaggt ggagcaaagggaagggctggaggaaggttccgactttatttttgtgctgaccgaagtgcc acaaaagaacgtaaagaagtcaaagaagttaaagagaaagggctcccagaaggtggagct cggggtcttcacagagccagagcttttgatgaagaggaggatgacccctatgtgccaatg agacctggggtggctttccctcttgccagctccagtgactatatgccaatggcccctcga caccctgctgcctcaaaatcacgccactctcgatccccttttgaagattcaagagggtac atgatgatgtttcccagagtgagcccaccagctgcaccaagtcctcccaaagcacccggg cctgataagaaagatgagtcaaaggacaatgacagtgacagtgactatatgtttatggct cctggagctggtgcaattcccaaaaaccctccaagtcctcagggcggttcttcctccaaa agttggagctcctacttctctctgccaactccttctcagacctccccattaggacagatg gaccacagtgagtatgtcccaatgttaaccagaaaattcctggggatgggtctggacaaa gaaggctcacctgaatggggcagccccaaagatacagtctcaaagccttcagttgagggg tccttctccgagcctggagatgggggatcattttcacagtctttggttgatattcccttc cagggcaaagctaacaaacctgaccagcttgcttttattaagaagggaaatacaattgag cccagttcgcaaaagcccacacatgatcagagagaaaatgacagtgcttctgtctacgtc aacattgacttcactgaaagagctagccattcgtcagttccctttggtcaaggacaggca gatactcggggcatccttgctgaccccagagaatactccttttctcattacataaatatt cagttgagagtgccatttctgagccaagaaaatctctcagaccttttaagggccattccg ggtgccaacctcttctctctggactttgcaaggtggccacttcgccccagtgctacaggt ggcatcgttagtgtaggagagggtgaatacattgaagtgaggtttagcccggcaatggca tcttcggcaccttttgctgacagtgcctttcgctacgatgctgaaacaggtcgaatctac gtggtcgatccattttccgagtgctgtatggacatctctctctccccgagccggtgctca gagccaccacctgtagctcggctgaggcaggaggaagagcaagagagaagaagcgcacca agtcgctcgcaaagttctgcctccgctagagccgccgcttcggctttcccagcggacagc ctggagggaaacccctcggcctctgctgctgcgccgactttagccatgggccctgcacta gctgccgcctctgcgctagccgccgccccagcagtcggctctgcagctgcgggctttggg gtagactccgcccccgcccgctggttccaacttgttgctaacggtgcaggtgcagaagct gagagaggggcccaagaaattgctggtggtccgaaccgaagggccccaaatccatttgaa gcccttgctggaggtgagaatggggcccgcggggcggctgccgcagctgctgctcccccc gtaccgcctccccgccgccgggtgccgagacccccggagcgagatgattctgacgacgac gacagtacctacgtgagaatggacttttccagggctgacaacgaggagtctgacgcacct taa

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