Streptomyces griseofuscus: HEP81_02754
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Entry
HEP81_02754 CDS
T07010
Symbol
kgd
Name
(GenBank) alpha-ketoglutarate decarboxylase
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
sgf
Streptomyces griseofuscus
Pathway
sgf00020
Citrate cycle (TCA cycle)
sgf00630
Glyoxylate and dicarboxylate metabolism
sgf00785
Lipoic acid metabolism
sgf01100
Metabolic pathways
sgf01110
Biosynthesis of secondary metabolites
sgf01120
Microbial metabolism in diverse environments
sgf01200
Carbon metabolism
sgf01210
2-Oxocarboxylic acid metabolism
Module
sgf_M00009
Citrate cycle (TCA cycle, Krebs cycle)
sgf_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
sgf00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
HEP81_02754 (kgd)
00630 Glyoxylate and dicarboxylate metabolism
HEP81_02754 (kgd)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
HEP81_02754 (kgd)
Enzymes [BR:
sgf01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
HEP81_02754 (kgd)
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
HEP81_02754 (kgd)
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
HEP81_02754 (kgd)
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
HEP81_02754 (kgd)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
OxoGdeHyase_C
Transket_pyr
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
QNT93070
UniProt:
A0A7H1PYE0
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All DBs
Position
3126981..3130781
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AA seq
1266 aa
AA seq
DB search
MSPQSPSNSSISTDDQATGKNPAAAFGANEWLVDEIYQQYLQDPNSVDRAWWDFFADYKP
GAPATPAPAGTAAAGVAATPTPAPQAAPAPAAPAAPKPAAAPAPAAAAPAAPAAKTAPSP
AKPAQPAQAPAQPQAKAAPATEAPAGPEQITLRGPAAAVAKNMDASLEMPTATSVRAVPV
KLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQAIKAMPAMNHSFTVKDGKPTLVKPAH
VNLGLAIDLVKPNGDRQLVVAAIKKAETLNFFEFWQAYEDIVRRAREGKLTMDDFTGVTV
SLTNPGGLGTVHSVPRLMPGQAVIMGVGSMDYPAEFQGTSQDTLNKLGVSKVMTLTSTYD
HRVIQGAASGEFLRQVANLLLGENKFYDEIFEALRIPYEPVRWLKDIDASHDDDVTKAAR
VFELIHSYRVRGHVMADTDPLEYRQRKHPDLDIVEHGLTLWDLEREFAVGGFAGKSMMKL
RDILGVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERGHAKPEREEQLRILRRLNAAEAF
ETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAESRLDEVVIGMAHRGRLNVLANIVGK
SYAQIFREFEGNLDPKSMHGSGDVKYHLGANGTFTGLDGEQIKVSLVANPSHLEAVDPIL
EGVARAKQDIINKGGTDFTVLPVAIHGDAAFAGQGVVAETLNMSQLRGYRTGGTVHIVIN
NQVGFTAAPESSRSSMYATDVARMIEAPIFHVNGDDPEAVVRVARLAFEFRQAFNKDVVI
DLICYRRRGHNESDNPAFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDYQ
GQLEKVFTEVREATAQPAAGAPQEAQDGFPVAVPTAVSAEVVKRIAESQVNIPEHITVHP
RLQPQLQRRAAMVEDGTIDWGMGETLAIGSLLLDGTPVRLAGQDSQRGTFGQRHAVLIDR
ETGEEYTPLQYLAEDQARLNVYNSLLSEYAAMGFEYGYSLARPDALVMWEAQFGDFVNGA
QTVVDEFISSAEQKWGQTSGVVLLLPHGYEGQGPDHSSARPERFLQLCAQNNMTVAMPTS
PSNYFHLLRWQVHNPAHKPLVVFTPKSMLRLKAAASKAEEFTTGGFQPVIGDATAEAAAV
RRVVFCSGKVYYDLEAERKKRGATDTAIIRIERLYPLPGAELQAEVNKYPNAEKYLWVQE
EPANQGAWPFIALNLIDHLDLAVGADIPAGERLRRISRPHSSSPAVGSAKRHQAEQEQLV
REVFEA
NT seq
3801 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgccacagtcccccagtaactcgagcatctccaccgacgaccaagccaccgggaag
aaccccgcggccgcgttcggcgcgaacgagtggctcgtcgacgagatctatcagcagtac
ctccaggacccgaattcggtagaccgtgcctggtgggacttcttcgccgattacaagccg
ggcgcgcctgccacgcccgcgccggcgggtactgcggccgcgggggtcgcagcgaccccc
actccggcgccccaggccgctccggcgcccgcggccccggcggcaccgaagcccgccgcc
gccccggcgcccgctgcggccgctccggcggctcccgcggcgaagacggccccctccccg
gccaagccggcgcagcccgcacaggcgcccgctcagccgcaggcgaaggccgctcccgcc
accgaggcccccgccggtcccgagcagatcactctgcgcggcccggccgccgcggtcgcc
aagaacatggacgcctcgctggagatgccgaccgccacctcggtccgcgccgtcccggtg
aagctgctgttcgacaaccgcatcgtcatcaacaaccacctcaagcgtgcccgcggcggg
aagatctccttcacgcacctcatcgggtacgcgatggtgcaggccatcaaggccatgccg
gcgatgaaccactcgttcaccgtcaaggacggcaagccgaccctggtcaagcctgcccac
gtcaacctcggtctcgccatcgacctggtcaagcccaacggcgaccgccagctcgtcgtc
gcggcgatcaagaaggccgagacgctgaacttcttcgagttctggcaggcctacgaggac
atcgtccgccgcgcccgcgagggcaagctgaccatggacgacttcaccggtgtcacggtc
tccctgaccaaccccggcggcctgggcaccgtgcactccgtgccgcgtctgatgcccggc
caggccgtgatcatgggcgtcggctccatggactacccggccgagttccagggcaccagc
caggacaccctgaacaagctcggtgtctccaaggtcatgaccctcacgtcgacctacgac
caccgggtcatccagggcgccgcctccggcgagttcctgcgccaggtcgccaacctgctg
ctcggcgagaacaagttctacgacgagatcttcgaggcgctgcgcatcccctacgagccg
gtccgctggctcaaggacatcgacgcgtcccacgacgacgacgtcaccaaggccgcgcgg
gtcttcgagctgatccactcctaccgggtccgcggccatgtcatggccgacaccgacccg
ctggagtaccgccagcgcaagcaccccgacctggacatcgtcgagcacggcctcaccctg
tgggacctggagcgcgagttcgccgtcggtggtttcgccggcaagtcgatgatgaagctg
cgcgacatcctcggggtgctccgcgactcgtactgccgcaccaccggcatcgagttcatg
cacatccaggaccccaagcagcgcaagtggatccaggaccgggtcgagcgcggtcacgcc
aagccggagcgcgaggagcagctgcgcatcctgcgccggctgaacgctgccgaggcgttc
gagaccttcctccagacgaagtacgtcggccagaagcgcttctccctggagggcggcgag
tccgtcatcccgctgctggacgcggtcatcgactccgccgccgagtcccgcctggacgag
gtcgtcatcggcatggcccaccgcggccgtctgaacgtgctcgccaacatcgtcggcaag
tcgtacgcgcagatcttccgcgagttcgagggcaacctcgacccgaagtcgatgcacggc
tccggcgacgtgaagtaccacctgggcgccaatggcaccttcaccggcctggacggcgag
cagatcaaggtctcgctggtcgccaacccctcccacctggaggcggtcgacccgatcctg
gagggcgtcgcccgcgccaagcaggacatcatcaacaagggcggcacggacttcaccgtc
ctgccggtggcgatccacggcgacgcggccttcgcgggccagggcgtggtggccgagacc
ctgaacatgtcgcagctgcgcggctaccgcaccggcggcaccgtgcacatcgtcatcaac
aaccaggtcggcttcacggcggcccccgagtcctcgcgttcctccatgtacgcgacggac
gtggcccgcatgatcgaggccccgatcttccacgtgaacggcgacgaccccgaggccgtc
gtccgggtcgcgcggctggcgttcgagttccgccaggcgttcaacaaggacgtggtgatc
gacctcatctgctaccgccgccgcggtcacaacgagtcggacaacccggccttcacccag
ccgctgatgtacgacctgatcgacaagaagcgctcggtgcgcaagctctacaccgagtcc
ctgatcggtcgtggcgacatcaccctggaagaggccgagcaggccctccaggactaccag
ggccagctggagaaggtcttcacggaggtccgcgaggccaccgcgcagccggctgccggt
gccccccaggaggcccaggacggcttcccggtcgcggtcccgaccgccgtctccgccgag
gtcgtcaagcggatcgccgagtcccaggtcaacatccccgagcacatcaccgtgcacccg
cggctccagccgcagctccagcgccgtgcggcgatggtcgaggacggcaccatcgactgg
ggcatgggcgagaccctggccatcggctccctgctgctggacggcaccccggtccgcctc
gcgggccaggactcccagcgcggcaccttcggccagcgccacgcggtgctgatcgaccgg
gagaccggcgaggagtacaccccgctccagtacctcgccgaggaccaggcgcggctgaac
gtctacaactcgctgctgtccgagtacgcggccatgggcttcgagtacggctactcgctc
gcgcgtcccgacgcgctggtgatgtgggaggcccagttcggcgacttcgtcaacggcgcc
cagacggtcgtcgacgagttcatctcctcggccgagcagaagtggggccagacctccggc
gtcgtcctgctgctgccgcacggctacgagggccagggcccggaccactcgtccgcgcgc
ccggagcggttcctccagctgtgcgcccagaacaacatgacggtggccatgcccacctcg
ccgtcgaactacttccacctgctgcgctggcaggtgcacaacccggcccacaagccgctg
gtcgtcttcaccccgaagtcgatgctgcgtctgaaggccgccgcctccaaggcggaggag
ttcacgaccggcggcttccagccggtcatcggcgacgcgaccgccgaggcggccgccgtc
cgcagggtcgtcttctgctccggcaaggtctactacgacctggaggccgagcgtaagaag
cgcggcgccacggacacggcgatcatccgcatcgagcgcctgtacccgctgccgggtgcc
gagctccaggcggaggtcaacaagtacccgaacgccgagaagtacctgtgggtccaggag
gagccggcgaaccagggtgcctggccgttcatcgcgctcaacctgatcgatcacctcgac
ctggcggtcggcgcggacatcccggccggcgagcggctgcggcgcatctcgcgcccgcac
tcctcgtccccggcggtgggttccgccaagcgccaccaggccgagcaggagcagctggtg
cgtgaggtgttcgaggcctaa
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