KEGG   PATHWAY: sgm01055
Entry
sgm01055                    Pathway                                
Name
Biosynthesis of vancomycin group antibiotics - Streptomyces aurantiacus
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
sgm01055  Biosynthesis of vancomycin group antibiotics
sgm01055

Organism
Streptomyces aurantiacus [GN:sgm]
Gene
GCM10017557_81720  alpha-hydroxy-acid oxidizing enzyme [KO:K16422] [EC:1.1.3.46]
GCM10017557_73820  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
GCM10017557_01780  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
GCM10017557_15260  epimerase [KO:K01710] [EC:4.2.1.46]
GCM10017557_73700  NDP-hexose 2,3-dehydratase [KO:K16435] [EC:4.2.1.159]
GCM10017557_01740  NDP-hexose 2,3-dehydratase [KO:K16435] [EC:4.2.1.159]
GCM10017557_01770  erythromycin biosynthesis sensory transduction protein EryC1 [KO:K16436] [EC:2.6.1.- 2.6.1.106]
GCM10017557_73970  rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [KO:K16438] [EC:5.1.3.-]
GCM10017557_01760  rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [KO:K16438] [EC:5.1.3.-]
GCM10017557_01070  glycosyl transferase [KO:K16444] [EC:2.4.1.310]
GCM10017557_03400  glycosyl transferase [KO:K16444] [EC:2.4.1.310]
Compound
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00842  dTDP-glucose
C01179  3-(4-Hydroxyphenyl)pyruvate
C03198  (S)-4-Hydroxymandelate
C03590  4-Hydroxyphenylglyoxylate
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C06689  Vancomycin
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12014  Chloroeremomycin
C12026  3,5-Dihydroxy-phenylglycine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12319  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
C12320  dTDP-L-4-oxovancosamine
C12321  dTDP-L-epivancosamine
C12322  dTDP-L-vancosamine
C12323  L-4-Hydroxyphenylglycine
C12324  3,5-Dihydroxyphenylacetyl-CoA
C12325  3,5-Dihydroxyphenylglyoxylate
Reference
PMID:24884615
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
Reference
PMID:12596194
  Authors
Hubbard BK, Walsh CT.
  Title
Vancomycin assembly: nature's way.
  Journal
Angew Chem Int Ed Engl 42:730-65 (2003)
DOI:10.1002/anie.200390202
Reference
PMID:11035791
  Authors
Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD.
  Title
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 97:11942-7 (2000)
DOI:10.1073/pnas.210395097
Reference
PMID:9545426
  Authors
van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.
  Title
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
  Journal
Chem Biol 5:155-62 (1998)
DOI:10.1016/S1074-5521(98)90060-6
Related
pathway
sgm00400  Phenylalanine, tyrosine and tryptophan biosynthesis
sgm00520  Amino sugar and nucleotide sugar metabolism
sgm00620  Pyruvate metabolism
KO pathway
ko01055   
LinkDB

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