KEGG   PATHWAY: ko01055
Entry
ko01055                     Pathway                                
Name
Biosynthesis of vancomycin group antibiotics
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
ko01055  Biosynthesis of vancomycin group antibiotics
ko01055

Drug
D00212  Vancomycin (USP)
Orthology
K01710  rfbB, rmlB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
K16421  hmaS, nocF; 4-hydroxymandelate synthase [EC:1.13.11.46]
K16422  hmo, nocN; 4-hydroxymandelate oxidase [EC:1.1.3.46]
K16423  hpgT, nocG; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
K16424  dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246]
K16425  dpgB; isomerase DpgB
K16426  dpgD; dehydration protein DpgD
K16427  dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
K16428  cepA; nonribosomal peptide synthetase CepA
K16429  cepB; nonribosomal peptide synthetase CepB
K16430  cepC; nonribosomal peptide synthetase CepC
K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase [EC:1.14.19.-]
K16432  cepK; nonribosomal peptide synthetase CepK
K16433  cepL; hydroxylation protein CepL
K16434  cepJ; thioesterase CepJ
K16435  evaA, eryBVI, tylCVI, tylX3, staJ; dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase [EC:4.2.1.159]
K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106]
K16437  evaC; methylation protein EvaC
K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase [EC:5.1.3.-]
K16439  evaE; reductase EvaE
K16440  gtfA; chloroorienticin B synthase [EC:2.4.1.311]
K16442  gtfC; glycosyltransferase GtfC
K16443  gtfD; desvancosaminyl-vancomycin vancosaminetransferase [EC:2.4.1.322]
K16444  gtfB, gtfE; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
K16445  cepE, oxyA, CYP165A3; oxidation protein CepE
K16446  cepF, oxyB, CYP165B3; oxidation protein CepF
K16447  cepG, oxyC, CYP165C4; oxidation protein CepG
K16448  mtfA; methylation protein MtfA
K18836  vcaE; reductase VcaE
Compound
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00842  dTDP-glucose
C01179  3-(4-Hydroxyphenyl)pyruvate
C03198  (S)-4-Hydroxymandelate
C03590  4-Hydroxyphenylglyoxylate
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C06689  Vancomycin
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12014  Chloroeremomycin
C12026  3,5-Dihydroxy-phenylglycine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12319  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
C12320  dTDP-L-4-oxovancosamine
C12321  dTDP-L-epivancosamine
C12322  dTDP-L-vancosamine
C12323  L-4-Hydroxyphenylglycine
C12324  3,5-Dihydroxyphenylacetyl-CoA
C12325  3,5-Dihydroxyphenylglyoxylate
Reference
PMID:24884615
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
Reference
PMID:12596194
  Authors
Hubbard BK, Walsh CT.
  Title
Vancomycin assembly: nature's way.
  Journal
Angew Chem Int Ed Engl 42:730-65 (2003)
DOI:10.1002/anie.200390202
Reference
PMID:11035791
  Authors
Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD.
  Title
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 97:11942-7 (2000)
DOI:10.1073/pnas.210395097
Reference
PMID:9545426
  Authors
van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.
  Title
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
  Journal
Chem Biol 5:155-62 (1998)
DOI:10.1016/S1074-5521(98)90060-6
Related
pathway
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00520  Amino sugar and nucleotide sugar metabolism
ko00620  Pyruvate metabolism

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