Sarcophilus harrisii (Tasmanian devil): 100917396
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Entry
100917396 CDS
T02286
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
shr
Sarcophilus harrisii (Tasmanian devil)
Pathway
shr01521
EGFR tyrosine kinase inhibitor resistance
shr01522
Endocrine resistance
shr04010
MAPK signaling pathway
shr04012
ErbB signaling pathway
shr04014
Ras signaling pathway
shr04015
Rap1 signaling pathway
shr04022
cGMP-PKG signaling pathway
shr04024
cAMP signaling pathway
shr04066
HIF-1 signaling pathway
shr04068
FoxO signaling pathway
shr04071
Sphingolipid signaling pathway
shr04072
Phospholipase D signaling pathway
shr04140
Autophagy - animal
shr04148
Efferocytosis
shr04150
mTOR signaling pathway
shr04151
PI3K-Akt signaling pathway
shr04210
Apoptosis
shr04218
Cellular senescence
shr04270
Vascular smooth muscle contraction
shr04370
VEGF signaling pathway
shr04371
Apelin signaling pathway
shr04540
Gap junction
shr04550
Signaling pathways regulating pluripotency of stem cells
shr04613
Neutrophil extracellular trap formation
shr04620
Toll-like receptor signaling pathway
shr04650
Natural killer cell mediated cytotoxicity
shr04660
T cell receptor signaling pathway
shr04662
B cell receptor signaling pathway
shr04664
Fc epsilon RI signaling pathway
shr04720
Long-term potentiation
shr04722
Neurotrophin signaling pathway
shr04730
Long-term depression
shr04810
Regulation of actin cytoskeleton
shr04910
Insulin signaling pathway
shr04912
GnRH signaling pathway
shr04915
Estrogen signaling pathway
shr04916
Melanogenesis
shr04917
Prolactin signaling pathway
shr04919
Thyroid hormone signaling pathway
shr04921
Oxytocin signaling pathway
shr04926
Relaxin signaling pathway
shr04929
GnRH secretion
shr04934
Cushing syndrome
shr04935
Growth hormone synthesis, secretion and action
shr05010
Alzheimer disease
shr05022
Pathways of neurodegeneration - multiple diseases
shr05132
Salmonella infection
shr05135
Yersinia infection
shr05160
Hepatitis C
shr05161
Hepatitis B
shr05163
Human cytomegalovirus infection
shr05164
Influenza A
shr05165
Human papillomavirus infection
shr05166
Human T-cell leukemia virus 1 infection
shr05167
Kaposi sarcoma-associated herpesvirus infection
shr05170
Human immunodeficiency virus 1 infection
shr05200
Pathways in cancer
shr05205
Proteoglycans in cancer
shr05206
MicroRNAs in cancer
shr05207
Chemical carcinogenesis - receptor activation
shr05208
Chemical carcinogenesis - reactive oxygen species
shr05210
Colorectal cancer
shr05211
Renal cell carcinoma
shr05213
Endometrial cancer
shr05214
Glioma
shr05215
Prostate cancer
shr05216
Thyroid cancer
shr05218
Melanoma
shr05219
Bladder cancer
shr05220
Chronic myeloid leukemia
shr05221
Acute myeloid leukemia
shr05223
Non-small cell lung cancer
shr05224
Breast cancer
shr05225
Hepatocellular carcinoma
shr05226
Gastric cancer
shr05230
Central carbon metabolism in cancer
shr05231
Choline metabolism in cancer
shr05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
shr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100917396 (MAP2K2)
04012 ErbB signaling pathway
100917396 (MAP2K2)
04014 Ras signaling pathway
100917396 (MAP2K2)
04015 Rap1 signaling pathway
100917396 (MAP2K2)
04370 VEGF signaling pathway
100917396 (MAP2K2)
04371 Apelin signaling pathway
100917396 (MAP2K2)
04066 HIF-1 signaling pathway
100917396 (MAP2K2)
04068 FoxO signaling pathway
100917396 (MAP2K2)
04072 Phospholipase D signaling pathway
100917396 (MAP2K2)
04071 Sphingolipid signaling pathway
100917396 (MAP2K2)
04024 cAMP signaling pathway
100917396 (MAP2K2)
04022 cGMP-PKG signaling pathway
100917396 (MAP2K2)
04151 PI3K-Akt signaling pathway
100917396 (MAP2K2)
04150 mTOR signaling pathway
100917396 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100917396 (MAP2K2)
04148 Efferocytosis
100917396 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
100917396 (MAP2K2)
04218 Cellular senescence
100917396 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
100917396 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
100917396 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100917396 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100917396 (MAP2K2)
04620 Toll-like receptor signaling pathway
100917396 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
100917396 (MAP2K2)
04660 T cell receptor signaling pathway
100917396 (MAP2K2)
04662 B cell receptor signaling pathway
100917396 (MAP2K2)
04664 Fc epsilon RI signaling pathway
100917396 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
100917396 (MAP2K2)
04929 GnRH secretion
100917396 (MAP2K2)
04912 GnRH signaling pathway
100917396 (MAP2K2)
04915 Estrogen signaling pathway
100917396 (MAP2K2)
04917 Prolactin signaling pathway
100917396 (MAP2K2)
04921 Oxytocin signaling pathway
100917396 (MAP2K2)
04926 Relaxin signaling pathway
100917396 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
100917396 (MAP2K2)
04919 Thyroid hormone signaling pathway
100917396 (MAP2K2)
04916 Melanogenesis
100917396 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100917396 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
100917396 (MAP2K2)
04730 Long-term depression
100917396 (MAP2K2)
04722 Neurotrophin signaling pathway
100917396 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100917396 (MAP2K2)
05206 MicroRNAs in cancer
100917396 (MAP2K2)
05205 Proteoglycans in cancer
100917396 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
100917396 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
100917396 (MAP2K2)
05230 Central carbon metabolism in cancer
100917396 (MAP2K2)
05231 Choline metabolism in cancer
100917396 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100917396 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
100917396 (MAP2K2)
05225 Hepatocellular carcinoma
100917396 (MAP2K2)
05226 Gastric cancer
100917396 (MAP2K2)
05214 Glioma
100917396 (MAP2K2)
05216 Thyroid cancer
100917396 (MAP2K2)
05221 Acute myeloid leukemia
100917396 (MAP2K2)
05220 Chronic myeloid leukemia
100917396 (MAP2K2)
05218 Melanoma
100917396 (MAP2K2)
05211 Renal cell carcinoma
100917396 (MAP2K2)
05219 Bladder cancer
100917396 (MAP2K2)
05215 Prostate cancer
100917396 (MAP2K2)
05213 Endometrial cancer
100917396 (MAP2K2)
05224 Breast cancer
100917396 (MAP2K2)
05223 Non-small cell lung cancer
100917396 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100917396 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
100917396 (MAP2K2)
05161 Hepatitis B
100917396 (MAP2K2)
05160 Hepatitis C
100917396 (MAP2K2)
05164 Influenza A
100917396 (MAP2K2)
05163 Human cytomegalovirus infection
100917396 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
100917396 (MAP2K2)
05165 Human papillomavirus infection
100917396 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
100917396 (MAP2K2)
05135 Yersinia infection
100917396 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
100917396 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
100917396 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100917396 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100917396 (MAP2K2)
01522 Endocrine resistance
100917396 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
shr01001
]
100917396 (MAP2K2)
Enzymes [BR:
shr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100917396 (MAP2K2)
Protein kinases [BR:
shr01001
]
Serine/threonine kinases: STE group
STE7 family
100917396 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Kdo
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
100917396
NCBI-ProteinID:
XP_031803704
Ensembl:
ENSSHAG00000009251
UniProt:
A0A7N4NKN1
LinkDB
All DBs
Position
1:655001559..655037491
Genome browser
AA seq
400 aa
AA seq
DB search
MLAKRKPVLPALNITPTIAEGPSPTSEGASEANLADLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNTRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPMVDGAEGEPHSISPRPKP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAM
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggccaagaggaagccggtgctgccggcgctcaacatcacccctaccatcgccgag
ggcccgtccccgaccagcgagggcgcgtccgaggcaaacttagcagatctgcagaaaaaa
ttagaagagctagaacttgatgagcagcagaaaaagcgactggaagctttcctcacccag
aaggcaaaggtgggagaactgaaggatgatgactttgagagaatctctgagctgggagct
ggcaatggtggagtggtcaccaaagtacaacatagaccctcaggcctcatcatggcccga
aagttaattcacctagagatcaaaccagcaattcggaaccagattatccgtgaactccag
gtcctacatgaatgcaattctccatacatcgtgggtttctatggtgccttttatagtgat
ggagagattagcatctgcatggaacacatggatggaggctctctggatcaggtattgaaa
gaggccaagagaattcctgaagaaatcttggggaaggttagcattgcggttcttcggggt
ttggcttatctaagagagaaacaccagattatgcacagagatgtgaaaccttctaacatt
ttggtcaatactcggggagagatcaagctctgtgactttggagtgagtgggcaactcata
gactctatggcaaattcctttgtaggaacccgatcctacatgtctccagagcggttacaa
ggcacccactactcagtccagtcagatatctggagtatgggcctgtccttagtagagctg
tccattggaaggtacccgattcccccgccagactccaaggaactagaagcgatatttggg
cggcccatggtcgatggggcagagggagaacctcacagcatctcaccacggccaaaaccc
ccaggacgtcccatcagtggtcatggaatggacagtcgacctgctatggccatctttgag
ctgttggactatattgttaatgagcctccacctaaactgccgaatggtgttttcacacaa
gatttccaggagtttgtaaataaatgcttaattaaaaacccagccgagagagcagatctg
aagatgctgatgaatcacacttttatcaaacggtcagaagtggaagaagtggattttgca
ggctggttatgtaaaactctgaggttaaaccagcccagcacccccacacgcactgccatg
tga
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