KEGG   Sarcophilus harrisii (Tasmanian devil): 100935230
Entry
100935230         CDS       T02286                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr01521  EGFR tyrosine kinase inhibitor resistance
shr01522  Endocrine resistance
shr01524  Platinum drug resistance
shr04012  ErbB signaling pathway
shr04014  Ras signaling pathway
shr04015  Rap1 signaling pathway
shr04024  cAMP signaling pathway
shr04062  Chemokine signaling pathway
shr04066  HIF-1 signaling pathway
shr04068  FoxO signaling pathway
shr04070  Phosphatidylinositol signaling system
shr04071  Sphingolipid signaling pathway
shr04072  Phospholipase D signaling pathway
shr04081  Hormone signaling
shr04140  Autophagy - animal
shr04150  mTOR signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04152  AMPK signaling pathway
shr04210  Apoptosis
shr04211  Longevity regulating pathway
shr04213  Longevity regulating pathway - multiple species
shr04218  Cellular senescence
shr04360  Axon guidance
shr04370  VEGF signaling pathway
shr04380  Osteoclast differentiation
shr04510  Focal adhesion
shr04550  Signaling pathways regulating pluripotency of stem cells
shr04611  Platelet activation
shr04613  Neutrophil extracellular trap formation
shr04620  Toll-like receptor signaling pathway
shr04625  C-type lectin receptor signaling pathway
shr04630  JAK-STAT signaling pathway
shr04650  Natural killer cell mediated cytotoxicity
shr04660  T cell receptor signaling pathway
shr04662  B cell receptor signaling pathway
shr04664  Fc epsilon RI signaling pathway
shr04666  Fc gamma R-mediated phagocytosis
shr04668  TNF signaling pathway
shr04670  Leukocyte transendothelial migration
shr04722  Neurotrophin signaling pathway
shr04725  Cholinergic synapse
shr04750  Inflammatory mediator regulation of TRP channels
shr04810  Regulation of actin cytoskeleton
shr04910  Insulin signaling pathway
shr04914  Progesterone-mediated oocyte maturation
shr04915  Estrogen signaling pathway
shr04917  Prolactin signaling pathway
shr04919  Thyroid hormone signaling pathway
shr04923  Regulation of lipolysis in adipocytes
shr04926  Relaxin signaling pathway
shr04929  GnRH secretion
shr04930  Type II diabetes mellitus
shr04931  Insulin resistance
shr04932  Non-alcoholic fatty liver disease
shr04933  AGE-RAGE signaling pathway in diabetic complications
shr04935  Growth hormone synthesis, secretion and action
shr04960  Aldosterone-regulated sodium reabsorption
shr04973  Carbohydrate digestion and absorption
shr05010  Alzheimer disease
shr05017  Spinocerebellar ataxia
shr05020  Prion disease
shr05100  Bacterial invasion of epithelial cells
shr05135  Yersinia infection
shr05142  Chagas disease
shr05146  Amoebiasis
shr05160  Hepatitis C
shr05161  Hepatitis B
shr05162  Measles
shr05163  Human cytomegalovirus infection
shr05164  Influenza A
shr05165  Human papillomavirus infection
shr05166  Human T-cell leukemia virus 1 infection
shr05167  Kaposi sarcoma-associated herpesvirus infection
shr05168  Herpes simplex virus 1 infection
shr05169  Epstein-Barr virus infection
shr05170  Human immunodeficiency virus 1 infection
shr05171  Coronavirus disease - COVID-19
shr05200  Pathways in cancer
shr05203  Viral carcinogenesis
shr05205  Proteoglycans in cancer
shr05206  MicroRNAs in cancer
shr05207  Chemical carcinogenesis - receptor activation
shr05208  Chemical carcinogenesis - reactive oxygen species
shr05210  Colorectal cancer
shr05211  Renal cell carcinoma
shr05212  Pancreatic cancer
shr05213  Endometrial cancer
shr05214  Glioma
shr05215  Prostate cancer
shr05218  Melanoma
shr05220  Chronic myeloid leukemia
shr05221  Acute myeloid leukemia
shr05222  Small cell lung cancer
shr05223  Non-small cell lung cancer
shr05224  Breast cancer
shr05225  Hepatocellular carcinoma
shr05226  Gastric cancer
shr05230  Central carbon metabolism in cancer
shr05231  Choline metabolism in cancer
shr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
shr05415  Diabetic cardiomyopathy
shr05417  Lipid and atherosclerosis
shr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:shr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100935230 (PIK3R3)
   04014 Ras signaling pathway
    100935230 (PIK3R3)
   04015 Rap1 signaling pathway
    100935230 (PIK3R3)
   04370 VEGF signaling pathway
    100935230 (PIK3R3)
   04630 JAK-STAT signaling pathway
    100935230 (PIK3R3)
   04668 TNF signaling pathway
    100935230 (PIK3R3)
   04066 HIF-1 signaling pathway
    100935230 (PIK3R3)
   04068 FoxO signaling pathway
    100935230 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    100935230 (PIK3R3)
   04072 Phospholipase D signaling pathway
    100935230 (PIK3R3)
   04071 Sphingolipid signaling pathway
    100935230 (PIK3R3)
   04024 cAMP signaling pathway
    100935230 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    100935230 (PIK3R3)
   04152 AMPK signaling pathway
    100935230 (PIK3R3)
   04150 mTOR signaling pathway
    100935230 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100935230 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100935230 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    100935230 (PIK3R3)
   04218 Cellular senescence
    100935230 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100935230 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    100935230 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100935230 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100935230 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    100935230 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    100935230 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    100935230 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    100935230 (PIK3R3)
   04660 T cell receptor signaling pathway
    100935230 (PIK3R3)
   04662 B cell receptor signaling pathway
    100935230 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    100935230 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    100935230 (PIK3R3)
   04670 Leukocyte transendothelial migration
    100935230 (PIK3R3)
   04062 Chemokine signaling pathway
    100935230 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100935230 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    100935230 (PIK3R3)
   04929 GnRH secretion
    100935230 (PIK3R3)
   04915 Estrogen signaling pathway
    100935230 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    100935230 (PIK3R3)
   04917 Prolactin signaling pathway
    100935230 (PIK3R3)
   04926 Relaxin signaling pathway
    100935230 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    100935230 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    100935230 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100935230 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100935230 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    100935230 (PIK3R3)
   04722 Neurotrophin signaling pathway
    100935230 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100935230 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    100935230 (PIK3R3)
   04380 Osteoclast differentiation
    100935230 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    100935230 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    100935230 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100935230 (PIK3R3)
   05206 MicroRNAs in cancer
    100935230 (PIK3R3)
   05205 Proteoglycans in cancer
    100935230 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    100935230 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    100935230 (PIK3R3)
   05203 Viral carcinogenesis
    100935230 (PIK3R3)
   05230 Central carbon metabolism in cancer
    100935230 (PIK3R3)
   05231 Choline metabolism in cancer
    100935230 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100935230 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100935230 (PIK3R3)
   05212 Pancreatic cancer
    100935230 (PIK3R3)
   05225 Hepatocellular carcinoma
    100935230 (PIK3R3)
   05226 Gastric cancer
    100935230 (PIK3R3)
   05214 Glioma
    100935230 (PIK3R3)
   05221 Acute myeloid leukemia
    100935230 (PIK3R3)
   05220 Chronic myeloid leukemia
    100935230 (PIK3R3)
   05218 Melanoma
    100935230 (PIK3R3)
   05211 Renal cell carcinoma
    100935230 (PIK3R3)
   05215 Prostate cancer
    100935230 (PIK3R3)
   05213 Endometrial cancer
    100935230 (PIK3R3)
   05224 Breast cancer
    100935230 (PIK3R3)
   05222 Small cell lung cancer
    100935230 (PIK3R3)
   05223 Non-small cell lung cancer
    100935230 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100935230 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    100935230 (PIK3R3)
   05161 Hepatitis B
    100935230 (PIK3R3)
   05160 Hepatitis C
    100935230 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    100935230 (PIK3R3)
   05164 Influenza A
    100935230 (PIK3R3)
   05162 Measles
    100935230 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    100935230 (PIK3R3)
   05163 Human cytomegalovirus infection
    100935230 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100935230 (PIK3R3)
   05169 Epstein-Barr virus infection
    100935230 (PIK3R3)
   05165 Human papillomavirus infection
    100935230 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100935230 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    100935230 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100935230 (PIK3R3)
   05142 Chagas disease
    100935230 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100935230 (PIK3R3)
   05017 Spinocerebellar ataxia
    100935230 (PIK3R3)
   05020 Prion disease
    100935230 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100935230 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    100935230 (PIK3R3)
   05415 Diabetic cardiomyopathy
    100935230 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100935230 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    100935230 (PIK3R3)
   04931 Insulin resistance
    100935230 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100935230 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100935230 (PIK3R3)
   01524 Platinum drug resistance
    100935230 (PIK3R3)
   01522 Endocrine resistance
    100935230 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:shr04131]
    100935230 (PIK3R3)
Membrane trafficking [BR:shr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100935230 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1
Other DBs
NCBI-GeneID: 100935230
NCBI-ProteinID: XP_031825058
UniProt: A0A7N4PEE9
LinkDB
Position
4:28942226..28997042
AA seq 476 aa
MYTPPWGMEREDGGEGEGEGGEGGEGEDWRDVTMPYSTELIFYIEMDPPALPPKPPKSLT
QAGANGLKDSSGFSLPDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKVQGDYTLTLR
KGGNNKLIKIYHRDGKYGFSDPLTFSSVVELINHYRHESLAQYNPKLDVKLMYPISRYQQ
DQLVKEDNIDAVGTKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKI
FEEQCATQERQSKDYIERFRREGNEKEIERIMMNYEKLKSRLGEIHDSKMRLEQDLKKQA
LDNRETDKKMNSIKPDLIQLRKIRDQYLVWLSHKGVRQKRLNDWLGIKNDHIDETYFMNE
EDENLPHYDEKTWFVGDLNRLQAEDLLHGKPDGAFLIRESSKKGCYACSVVADGDVKHCV
IYSTARGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVRLAHPVYAQLPSHCR
NT seq 1431 nt   +upstreamnt  +downstreamnt
atgtacacgccgccgtggggcatggagcgcgaggacggcggggaaggagaaggcgagggc
ggcgagggcggcgaaggcgaggactggagggacgtgaccatgccctactccactgagctc
atcttctacatcgagatggaccccccagctcttccgccaaagccgcccaaatccttgact
caagccggtgccaacggcctgaaggacagttcagggttttccctccctgacgcagagtgg
tactggggagacatctcaagggaagaggtcaatgataaactccgggacatgcccgacgga
accttcctggtgcgagacgcatccaccaaggtgcagggagactacacgcttactctgcgg
aagggaggcaataataaattgattaagatttaccatcgggatggcaaatacggcttctca
gacccgctgaccttcagctctgtggtggagctgatcaatcactaccgccatgagtctctg
gcccagtacaatcccaagctcgacgtgaagctgatgtaccccatctccaggtaccagcag
gatcagctggtgaaagaagacaacatcgatgccgttggcacaaagctgcaggaataccac
tctcagtaccaagagaagagcaaagagtatgatcggctgtatgaggagtataccaggacc
tcacaggaaattcaaatgaagaggacggcgatcgaagcttttaacgagacaattaagatc
tttgaggagcagtgtgcaacccaggagcgccagagcaaagactacattgaacgctttcgg
cgagaggggaacgaaaaggagattgagcggataatgatgaattatgagaagctgaaatcg
cgtctgggtgaaattcacgatagcaaaatgcgtctggagcaggacctgaagaagcaggcg
ctggataaccgggagacggacaagaagatgaacagcatcaagccggacctgattcagctg
cgcaagatccgcgaccagtacctagtatggctcagccacaaaggagtccgacagaaacga
ctcaacgactggctgggaatcaaaaatgaccacatcgatgagacctattttatgaatgag
gaagatgaaaatctgccacactatgacgagaaaacgtggtttgttggggatctcaaccgg
ctccaggcggaagacctgctccacgggaagcccgacggagccttcttaattcgcgagagc
agcaagaagggctgctacgcctgctccgtggtggccgacggggacgtgaagcactgcgtg
atctacagcacggcgcggggctacggcttcgccgagccctacaacctgtatggcagcctg
aaggagctggtcctgcactaccagcacacgtccctcgtccagcacaacgactccctcaac
gtccggctggcccaccccgtctacgcacagctgccctcccactgcagatag

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