Scomber japonicus (chub mackerel): 128362230 Help Entry 128362230         CDS       T09718                                  Symbol obscna Name (RefSeq) LOW QUALITY PROTEIN: obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism sjo  Scomber japonicus (chub mackerel) Pathway sjo04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:sjo00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     128362230 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:sjo01001]     128362230 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:sjo04131]     128362230 (obscna) Enzymes [BR:sjo01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      128362230 (obscna) Protein kinases [BR:sjo01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    128362230 (obscna) Membrane trafficking [BR:sjo04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     128362230 (obscna) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 PK_Tyr_Ser-Thr Ig_4 Izumo-Ig SOS1_NGEF_PH C1-set Ig_CD22 V-set_CD47 RhoGEF ABC1 C2-set_2 Kdo fn3 PH IQ_SEC7_PH IQ APH Zwei_Ig_N RHG20_PH Motif Other DBs NCBI-GeneID:  128362230 NCBI-ProteinID:  XP_053178947 LinkDB All DBs Position 7:complement(18000679..18042339) Genome browser AA seq 6640 aa AA seqDB search MGDNKPGGIVAAAKNRLQVVKGLEDVEVSECESCSFEVTLNLAYIEGVWTKDGMRLKSKP TCRISTNAKRHSLILSRVALGDAGLISFQANDIQTSSRLSVRARDIHMVKELEDVDTMER QPVSFLCEVNQVDVDGRWYRDDCRIRPGDNIKIRHQGKTHTLSFKSVRPEHAGEIRFTAE RVSTYATLTVEELPIQIVRPLRVKIAMYHHRGLLECQVSRPNAQVRWYKNRKELLPSRKY QLISEDVYRQLTIDNVCSSDEDTYTCDAGDDKTSCQLLVEEQAIKIVRGMSSVEVMEPEP AQFQVETSLKSGRPPKWTLNGEVLEHGTAVNIDREGTVHSLCLTSTESSMSGPVLFVAGK SRSSAQLTVKERPLQIARHLDDAEAKENSSVTLSCAFAPSPRVVRWFKGRTALKTSNKYS MKREGKRAELTIHGLTGMDAGQYRCMAGGSQSTAHVTVEVRTLKLVKHLKAVEIEEDGVA TFSCELNYVVANVEWLLNNVRLYSNAINRIQHMGTMHSLTIKKLRPQKSMVTFKVGLLSE TTTLEVKERPAVFLRSLEDAVGEEQGEVCLQCEISKETLTPVWRKDGVVLMADDKHELLQ CGKSMALIVHSLSKDDAGLYTCDLGTSQTKAKVCVHDLHITIIHRLKTTSIMEGENCTFE CQLSHDLNDEPSWTINGQVVVTNSRIQVFNNHCRYRMTIRDAVLSDAGDVVFTIKDLSCR TMLFVKEKPVHIYRELLNVKAVPGEDAELSCEITKPEATIRWMKNGHVIRQSPKYEMSVE KNLARLLIKNTTIKDSGEYCCEADGVASRAKVEIRELQHTFARELKDTQAEEKGKVTLEC ETRRPAKRVTWRKGMMELRSGRKYVLRQKGAVLSLTITCLEKSDTDIYTCDVGTMQSWAQ LTVQGQKVLILDELQDIECLEGDTVTFRCQICPSDYTGVKWYLDETLLYTNNLNEIQMVP GGYHTLTFRQLARKDTGTISFAAGDKRSYASLLVRERRPTICKALEDCEAIEGGGLVLSC VTSKPCHIMWYKDSCLMWNSSRYFASRSGCEARLTIREVCSGDAGVYECSAGSVTTRAIV TVKAIPAEFTQPLQTVEAKEGETVTLTCEYSLPGVQFHWRKGLESIRHGDKYVMKQRKTI NSLTIKVLKSEDSGEYTCQCRDHCTTARLKVHAIPITFVQQLKNMQAEEGSNVILRCELS KPGIPVEWRKDHELLKNGVKYQIRKRETTLELLIWKPVPEDSGVYSCLCADQRTTATIKI TALPVTFKQRLRNVLMEEGNTATLRCELSKPGHLVEWKKSGDEPIRNGEKYHMRQRDMLI ELRIFNVTPEDSDIYTCICGNIESTATLTVNALPITFKQKLKNLQVEEGNNITLHCEISK PGILGEWRLKGDLLENGEKYQIKQRDSVLELTIRDAILEDSGVYTCVCREQKTKATVKVI AVPATFKVSLKSQEAEEGNSVTLHCELSKKGVQVQWQKEGQVLSEEVSRGKYQIKIEEKT AQMTILNVQPEDAGKYSCITGDEKTTAAVKVKPLPIKFKWEIQHLVVTEGDGGVFCCELS KPGAPVEWRKGRVILKPGDKYEMTQEGRLTKLIINNVEESDAGKYTCKSKDSQSTAELTV QESPQRRRERALPPRFKLPLVNQEVTEGNSVVLRCELDKPAPSVEWRRREVLLRNGDKYQ MRKKELQVEMKIVDISLDDIGDYTCICGEERTTASILVNERPIRFLQELKNIQVQEGNGV TLRCELSKPGVPVQWRKGDNVLTNGDKYQMKQSSSTLELLIRKSQPENSGIYSCVCEDIK TTATVIITAIPVTFKQKLKNQEAVEEGCVTLRCELSKPGVPVEWRRDALLLKEGEKYQMK QEGRVSELLIRNVALTDAAEYSCFVGTVVTSADIKIRALPVTFKQEVKNLEVKEGDSGVF CCELSKPGAPVDWRKGRVILKPGYKYEMKQEGHLAKLIVNNIEENDAGKYTCKTKDSQST AELIVKAPPITFKTKLRNQQVEEENSVTLSCELSKPGLAVEWKKGNELLKSNFKYQIKNR TSTLELTIKNAQLEDSGLYSCIYGDVKTTANITITSIPLTFKTGLKNQEAPEGGNVTLRC ELSRAGVPVQWWKGEDQLCHGGRYQMSLKGMIAEMHIRNIQPEDVGEYSCTFGEQRTTAE VNVRAAASVFFVKELENQAVMEGKSVLLFCEISSGNVPVTWKKDSTVLEDGGRYILKKQG PKHTLEIKKLNLYDAGEYCCITRGKKTTAKLIVRERVQIVTELRDMTVTAGQDAVFVCEL SHADVTEGVWWLGSSQLQQNEMNQMSCQGRQHRLVLTMTTPEETGTVAFVVGEERTSASL LVVPKPKVLFEEEPKDIVIMEGETATLSCTTSDFTTPVTWRRNHIPLRNGDKYEICKEGK VNLLLIHDVEPLDTGIYSCDTGDVQSTAKLTVTVLPPFFQEELQSVEAEEGDSASLYCEV SKLGVPVQWKKNGLPLRASRKYEMKQDGCFLQLHIKDLKLEDSGSYSCQAGSAETTAAVL VTELPPFFKKELRSVEAEEGGTVSLYCELSKPGVPVQWKKNRMPLRAIGKYEMKQDGCLL QLHIKDLKPEDSGIYSCKAESAETAATVKVKELPPFFKEELQNIKAEEGGTALLCCEVSK PEVAIQWKKNKLPLRTSRKYEMKQDGCLLQLHIKDIKPEDSGSYTCQAGSAETTAAVSVK ELPPFFKIDLQSVEAEEGGEASLYCELSKPGVSVQWKKNRLTLRANRRYEIKQDGCLLQL HIKDLIPEDSGSYSCQAESAETAATVKVKELPPFFKEELQNIKAEEGGTALLCCEVSKPE VAIQWKKNKLPLRTSRKYEMKQDGCLLQLHIKDIKPEDSGSYTCQAGSAETTAAVSVKEL PPFFKKDLQSVEAEEGGEAFLFCELSKPGVPVQWKKNRLPLRASKKYEMKQDGCLIQLNI KELKPEDSGSYTCKAGSEETTASLSVXKVCLFWQKAIQCNLQCELAKKKKNCNLAFIKIT LXSSLFSHDAKDAXXYFSNPXPFLPEHPPLFTQDLQSIEAEEGGTACLRCELSKPGVPVQ WRKNKLPLRANRKYDIKQDGFLLELHIKELKTEDTGSYSCHAGNAETTATVSVKELPPFF KKDLQSVEAEEGGEAFLFCELSKPGVPVQWKKNRLPLRASKKYEMKQDGCLIQLNIKELK PEDSGSYTCKAGSEETTASLSVEGVFNWQKAIQCNLQCELHPPLFTQDLQSIEAEEGGTA CLRCELSKPGVPVQWRKNKLPLRANRKYDMKQDGFLLELHIKELKTEDTGSYSCYAGNVE TTATVSVKELSSFFKEDLKNVEAEEGGTALLCCEVSKPGLSVQWKKNTLPLRASRKYEMK QDGCVFQLHIKDLKPEDSGSYMCQAGNAETTSSVSVKEFPLFFKEKLESVEAEEGGEASL YCELSKSGVPVQWKKNRLPLRASRKYEMKQDGCLLQLHIKDLKLEDSGSYTCQAGSAETT VTVTVKELRPLFNKDLQNVEAEEGSSASLCCEVSKAGLSIQWKKNRLTLRASRKYEMKQD GCLLQLSIKDLKPEDSGSYCCQAGSAETTSTVTVKELPHFFKKELQNMEAEEGGTTFLYC ELSKPGVPVQWNKNGLPLRANRKYEMKQDGCLLQLHIKDLKPEDSASYTCQAGTAETTAT VSVKELQSDPHKAEPPTILPRAKGTVSEPTPTPENERPDLPDAQLVPPVPKRRTMRKASI TVSEKDMELMIDVRQPIQSMQSENNKDQNGIQPTRSVEGDFDIVNVKQLERNKDKDSQVY KKDDKPEMLLEKDGGKVKKPCRALEMESEIFMERMQPERNLEKLVSVGHEVSQSDRFLGE TVCEQKKPEAEQSSNQPAKPSEKTREVEKKVNPPGTVVWKNSEDEKEPLKPHERLIGEET MKKEEVRSTVKEVEINKKEEEPLKPPIRSKVKVPREREPFHYVGKETEEIIPQSLNTTIT DSEEDLKQRDNMTTKEKMPVTQVPSMNQLDKQAVKLPEKPVNKEAELAPPKPPVRTKSKA KGGMEKQLSRDTETDQDEQQPTRGMVRTTEDEPIKHAIRPLKQEVVEKPTFERNQSVTTD TEIPEKMKQQVKAAEKDAITKQPIKQPVKPIRKEPDVDREMTLAVEPMRREEEPQTTGNI PLLYISEDETFLEALTELPADNSNDQPIGSFTERSTQPSTLSPVNVLQRTLPSEEATPEV DISIEDEPQMQEAAVKIQAAFKGFKTRKDMRPAFKEVFKNQSADLNSTVTLVCVVEGKLS TVNWLKDGQQITNDKRYRIETSENGVCTLVITKLTTNDSGIYTCEVVNKFGVTSYNGNIT VVQKPVHPPLAAITPLQLALLKPEAQVITQTHNLSQTQTQVPTSTIDAANYVESVNVSLW EAYNLTEKDTQINLQERRRSSLIAASSMSSPSDYDTAPDIMEPVEISPAIRRQEPKAADQ VPPKDSKEQIAAPQPPKNLLKVKGTHEGKMRTPSPKHHRAHTPLTGTVSGSESEGEEDRQ ETFEMYVARADCSPISGNKDSFILKEGQYVEVVDSVHPDRWLVRTKPTKTNPARQGWVCP AYLEKKRKETFPQLRAPQEDLDGIGSTGEEYRRTLSQLIQGLIDGEEEFVKEMRVFTSHQ LKYLESSRQAPVNVLNQKEIIFRNIKDIVSLHERSILPRLRDCVTDDDVAMHLIKHTEDF EKYLYYMVGQAQAEACLTDKAIQQYFKELTESGKPEAPVMDVITFLQRPVERIQTYQALL KEFIKNKAKSGQSCFLLEDAFSLVSCLPWRSDNIHQVSLIENYPAPLVALGEPVRQGVFT VWEESPEMKTTSRGHQRQVFLFKECIVLCKLKRDTGMNSDTYTFKNKMKLNDVEIKETLG GDEKSWRLWHEHRGSVRRYTLQGRSTMVKLSWLKDLKELQQRSCLPTNSPLVFESQLSDC TTKIGQTIKLSCKVTGSPKPAVSWLKDGLPLEDDPRHIITEDRTGTCCLILDSLTAEDSG QYTCYAASSMGSAATLAKVVVQAPPRFVSRLESACLIEREDIQFTCSTLTTPLPRIRWLK DGRELTDQQKYSVLNDARSGILSLTVICATEADIGQYECELWNEFGCVKCKAGLCPAYVP PIDIKSDQPQDLPSKDEDSEGWSTAFVKKWLQTDFNPSSTAKMILPPGYNEHTEETVPAS TSIEQQPLYFLEEEEEEIYITEPMQEITDAPPSIQVPTEDLCVEPGQPATFTAIITGRPI PKIQWYKDGEEVTANENVEIVQHGARCSVTILCPEGEDSGIYTCLSYNDSGHASCQAELT VEEGPLESQEREVELGKRRKLFSVYDVHEEIGRGTFGVVKRVVHRRTAEIFAAKFLPLRS SNRTRSFQERDLLSRLAHPRVACLLDFFCTRRTLVLITEICCSHGIVDHLLLRGSVSEKE VQSYIQQILEGVGHIHSMNILHLDIKPENILMVYPPRDEIKICDFGFCQEIDTSRHQYSM FGTPEFVAPEIVHQEPVTAATDIWSVGVTTYLCLVCRCPFVGETDRATLLRVGEGTLNWD APDVMYRSPEAQDFLRMLLQPDPEKRPSAFECLSHQWFQDAHAGEDTDEINTKSLKVFLS KRKWQRSLTCVGSVLTLRPVPELLDAPLRETAVTVPREPQEHSSTSVSSGSSSEYDEADS WDFFQHYSQTEEEEETEEDNDPLIERALIPEPFVKLHLDEEEEEEVTLGEEEDGEIVGRR SVLERSISRQSITSSEVSYQHTPQRERRFSKDSSPSLYLSDGDEGSGSDGGRIPRGSVIR STFYSTSHQLSPMSARHMTLRDKFQAKKQERGRKPLRRSFSGRLNEPLIEYVEDETETNR GQRRASVQPTMQKSCSFDSGVGLVHTNISPHRRSRSLDEYSRRSPSSPKRTKPGDEEGSQ SLKEDFTDDEVGGKNLLAIPGPRRPARLRGSVAPLQGTRTLSGPSSLLAGDRGGLRLNQE QTEGDTFAGSQGSLAESSILEQGGSESSSRLGSHEDLSHGRLRGRYRSGGSEEYDDQGEP LISPSPCSSFQEVKPRNSYPQAPPRNRTRSNPNLSANSRSQMGSSLIPSPSPSPSLSSLQ APERPPRAKDKKEGHNLQRHASAPALEARPPTGKSPKLGLLKIFRRQSWTGHSYAQLEDT ELGPTLGEIMKPDTPTMSLRKKMRASASSLTKLFSRSSSKEDVSKGGPIVKGSAPIPPER KRGTGLETSKKRTSKLLPSLKIPAFKRTKVRPNKADVFQLDGGGVLLVWRPVQSSDPVTY CVQYCTDGGEWTVLSEEVTDSCYVVKDLPRGASYVFRVGCITKTGAGPFSDTSSPVVMAT HPEETHIPLIQTESLGSKVVRSQQPTTQQTYNFLSEINRGRFSIVTLCRDAKTSQVFAAK ITPYQAEQRQLVLREYQLLKKLHHTHLVQLHTAYITSSHLVLVEELCPGKELLYSLAGRD LYSEAQVAELLVQILSAVDYLHSRRVIHLDLKSDNMLVDDGNHLKIIDFGSAQFFIPGQP LNIEHIQGLSESKDCSSKVYIVLPKAPEILEGQGVGPETDVWAIGVLSFIMLSAESPFHA EHSWEQDRNIRKGKIQFGRCYPGLSEGALNFMKSSLNNKSWGRPTVAECLQNPWLRAHRA PHKARHSKVCFSTDKLKAYLSQKEEKRDQVCTKLRSPFFQ NT seq 19923 nt NT seq  +upstreamnt  +downstreamnt atgggagacaataaacctggaggaatagtagcagctgcaaagaaccgtctgcaggtggtg aaaggtttggaggatgtggaggtgtctgagtgtgagagctgctcctttgaggtgaccctc aacttggcctacatcgagggtgtgtggacgaaggatgggatgaggctcaagtctaagccc acctgccgcatcagcacaaatgcgaagagacactccctcatactgagcagggtggctttg ggagacgctggcttgatctcttttcaggccaatgatattcagacctcgagcagactcagt gtcagagctagggacatccacatggtaaaggagctggaggatgttgatacgatggagcgt caacctgtcagtttcctgtgtgaggttaaccaggtggatgtggatggtcggtggtataga gatgactgcagaatccgacctggggacaacatcaagatcagacatcagggtaaaactcac accctgtcctttaagtcagtcaggccagagcatgctggagagatcagattcactgcagag cgtgtctcaacctatgccactctcacagtagaagagctccctattcaaatagtgcgtcct ctgagggtcaagatagccatgtatcaccaccgaggtcttctggagtgccaggtgtcacgg cctaatgctcaggtcagatggtacaagaataggaaggagctcttgcccagtaggaagtat cagctgatcagtgaagatgtctacaggcagctgaccattgacaacgtctgctcctctgat gaggatacctacacctgtgatgctggagatgacaaaacctcttgtcagcttctggtggag gagcaggctattaaaattgtgcggggcatgagctcagtggaggtgatggagccagaacct gcgcagttccaggtagagaccagcctgaagtcagggaggccacctaaatggaccctgaac ggtgaggtgctggagcacggcacagcagtgaacatcgacagagagggcaccgtccacagc ctctgtctcacctccacagaaagctccatgtctgggcctgtgctttttgttgctggcaag agtcgttcctctgctcagctgactgtgaaagagcgacctctccagattgcccgccatttg gacgatgcagaggcaaaagagaacagctctgtgaccctgagctgtgcgtttgccccctct ccaagggtggtaaggtggttcaaaggtcgtacagctctgaagacctcaaacaagtacagc atgaagagagagggtaaacgagcagagttgaccattcatggcttgacagggatggatgca ggacagtaccgctgcatggctgggggttcacagagcacagcacatgtgacggtagaagtg agaacattgaagttagtgaaacaccttaaagctgtggaaattgaggaggacggtgttgcc acattctcatgtgagctcaactatgtggttgccaatgtggagtggctcctcaacaatgtt cgcctctattccaacgccatcaacaggatacagcacatgggcactatgcacagcctcaca attaagaagctgcggccacagaagagcatggtcaccttcaaagtaggccttctttctgag acaacaaccttagaggtcaaagagcgcccagcagtgttcctcaggtctcttgaggatgca gtaggagaagagcaaggggaggtctgcttgcagtgtgaaatttccaaagagacactgacc cctgtttggaggaaggacggtgtggtgctgatggctgatgacaaacatgagctgcttcag tgcgggaagtccatggcactaattgttcattccctgagcaaggacgacgctggcctgtac acctgtgacctgggcaccagccagaccaaagctaaagtttgtgtacatgacttgcatatc accattattcatcgcttgaagacaacctctattatggagggtgaaaactgcacttttgag tgtcagctctctcatgatctcaatgatgagccttcctggaccatcaatggccaggtggta gtcaccaacagccgaatccaggttttcaacaatcactgcaggtacagaatgaccattaga gatgctgtactgtctgacgctggagatgtggtcttcacaattaaagacctaagctgtagg accatgctctttgtgaaagagaagccagtgcacatttatagggagctgctgaatgtcaag gctgtgccgggtgaggatgcagagctgagctgtgagatcaccaaacctgaagccacaatc cgctggatgaaaaatggacatgtaatcaggcagagcccaaagtatgagatgagtgtggag aaaaaccttgcaaggctgctaatcaaaaataccaccatcaaagactctggagagtactgc tgtgaagcagacggtgttgcctcccgtgccaaggtggagatcagagagctccagcacaca tttgcaagggagttaaaagacacccaagcagaggaaaagggtaaagtgactctggagtgt gagaccaggcggccagccaagcgtgtgacctggcggaagggcatgatggagctgcggtct ggtaggaagtatgtcttgaggcagaagggtgcggtgctttccctgaccatcacctgtctg gagaaatcggacacggatatttacacatgtgacgttggtaccatgcagagctgggcacag ttgactgtacagggccagaaggtattgatcctggatgaactacaggatattgagtgccta gagggggatacggttacattcaggtgtcaaatctgccccagcgactataccggggtcaag tggtatctggatgagacactactgtacaccaataatcttaatgagatccagatggtgcca ggaggctaccacaccctcacgtttagacagcttgcccgcaaagacactggcactatctcg tttgcagcaggggacaaacggtcatatgcctcactgttggttagagagaggcgtccaacc atctgtaaagcgctggaagactgtgaggctattgaaggaggtggtttggttttgtcctgt gtgacctccaagccatgtcacatcatgtggtacaaagatagctgcctgatgtggaactca tcaaggtattttgctagtcgttctggctgcgaggctcggctgaccattcgggaggtctgc agtggtgatgccggggtgtacgagtgcagtgctggatctgttacaactagggccattgta acagttaaagccatcccagctgagttcactcagcctctacagaccgtggaggccaaagaa ggtgagactgttaccctgacctgtgaatactctttgcctggagtccagttccactggagg aaaggtctggagagcatcagacatggagacaaatatgtgatgaaacagaggaagacgatc aattctctcaccatcaaagtcctgaagtctgaggactcaggagagtacacgtgtcaatgc agagaccactgcactacagcaagacttaaagtacatgctatccctattacattcgtacag cagctgaagaacatgcaagcagaggagggcagcaatgtcatcttgcgctgtgaactttcc aaacctggaataccagtggaatggaggaaggaccatgaactgttgaagaatggggttaag taccagataaggaaaagggaaaccacgctggaacttctcatatggaagcctgtgcctgaa gacagtggtgtctacagctgcctttgtgccgatcagaggacaactgccactatcaaaatt acagctctcccagtcaccttcaagcagaggttaaggaatgtactgatggaggagggcaac actgcaactttacgctgtgagttgtctaaaccgggtcacttggtggagtggaagaagagt ggggatgagcccattaggaatggtgagaaatatcatatgcggcagagagacatgctgatt gaactgaggatctttaatgtgacacctgaagacagcgatatctacacgtgcatctgtgga aacatagagagcactgcaactctgactgtaaatgctcttcccatcaccttcaagcaaaag ctgaagaaccttcaagtcgaggaaggaaacaacatcacactgcattgtgagatctctaaa cctggcatcctaggggagtggagactcaaaggagatctgttggaaaatggagagaagtac cagattaagcagagggactcagtcctggagttgaccatcagagatgctatactagaggac agcggagtctatacatgtgtctgtagagagcagaagacgaaggcaactgttaaagttata gcggttcctgccacatttaaagtgagcctgaaaagtcaggaggctgaagaggggaacagc gtgacattacactgtgagctgtcaaaaaaaggagtccaagtgcagtggcagaaggagggt caggtgttgtctgaggaggtatctcgaggaaaatatcagattaagatagaagaaaaaaca gctcagatgaccattctcaatgttcaaccagaggatgcagggaagtacagctgcatcaca ggagatgagaagaccactgctgcggtcaaagtgaagccactgcccattaaattcaaatgg gagattcagcatctggtggtgacggaaggagatggtggagtcttctgctgtgagctctca aaacctggcgctccagtggagtggaggaaaggcagagtcatcctgaagcctggagacaaa tatgagatgacgcaagagggacgtctcactaaactaatcatcaataacgttgaggagagt gatgctgggaaatacacctgcaagagcaaagacagccaatcaactgctgagctcactgtc caagaatcaccacagcgcagacgtgaaagagctttgccaccaaggttcaagttgccacta gttaaccaggaggttactgagggcaacagtgtggttctgcgatgtgagcttgacaaacct gctccatcggtggagtggagaagaagagaggtccttctgaggaatggagacaaataccag atgaggaagaaggaattgcaggtggagatgaagattgtggacatcagtctggacgacatc ggagattacacttgcatatgtggagaagaaaggacaacagcttctatcctagtcaacgaa cggcccatcagattcctccaagaactgaaaaatattcaggtgcaggagggcaatggagta actctccgctgtgagctgtccaaacccggagtcccagtgcagtggaggaagggagacaat gtgttgaccaacggagataagtaccagatgaagcagagcagctccactctggagcttctc atcaggaaaagccagcctgagaacagtggcatttacagctgtgtttgtgaagacataaaa actactgctactgttataatcactgcgattccagtgacttttaagcagaagttgaagaac caggaagctgtggaggagggctgtgtgacactgcgctgtgagctctctaagccaggagtc ccagtcgagtggaggagagatgctttactcctgaaggaaggtgaaaagtatcagatgaag caagagggcagagtgtctgagttgctgatcagaaatgtagctctcacagatgctgcggag tacagctgttttgttggcactgttgtgacttcagctgacatcaaaataagagcacttcct gtaacatttaagcaagaggtgaagaatttggaggtaaaggaaggggacagtggagtcttc tgttgtgagctctccaagcctggagctccagtggactggaggaaaggcagagtcatcctt aagcctggttacaaatatgagatgaaacaggagggacatcttgcaaaactgattgttaat aacatagaggagaatgatgctggaaaatacacctgcaagactaaagacagccaatcaact gctgagctcattgttaaagctcctcccatcacattcaaaaccaagttaaggaaccagcaa gtggaggaagagaacagtgtcacgttaagttgcgagttgtctaagcctggccttgcggtg gagtggaagaaagggaatgagctgctgaagagcaatttcaaataccagattaaaaatcga actagcaccttggagctgaccattaaaaatgcacagctggaggacagtggactctacagc tgtatctacggcgatgtcaagaccactgccaacatcaccattacatctatccccctaacc tttaagacgggtctgaagaaccaggaggcccctgaaggaggcaatgtgacccttcggtgt gaactgtccagggcaggggtgcctgtacagtggtggaaaggggaagaccagctctgtcat ggaggacgatatcagatgtcactgaaggggatgatagctgaaatgcacattcgaaacatc cagccagaggatgttggagagtacagctgtacctttggagagcaaaggacaacagctgaa gtgaacgtgagagcggcggcatcagtgttctttgtgaaggagctggagaaccaagcagtg atggaggggaaatctgtgctgctgttttgtgagatttccagtggtaatgtccctgtaaca tggaagaaggacagcactgtgttggaagatggaggacgatacattttaaagaaacaaggt cctaaacacacactggagatcaagaaattgaatctgtatgatgcgggcgagtactgctgt atcaccaggggcaagaaaaccactgccaagctgattgtgagggagcgcgtgcagattgtt acagagctgcgagacatgacagtgacagcgggacaggacgcagtgtttgtgtgtgagctg agccatgctgatgtgactgagggtgtctggtggcttggctccagtcaattgcagcagaat gagatgaaccagatgtcatgccagggtcgccaacaccgactggtcctcaccatgaccaca cctgaggagacaggcactgtggcatttgtggttggggaggagaggacctctgcaagtttg ctagtggttcctaagcccaaagttttatttgaggaggagcctaaagatattgtgataatg gaaggggagactgctactctgtcctgcacaacctctgacttcaccactcctgtaacttgg agacgcaaccatatccccctccgaaatggtgataaatacgagatatgtaaggaaggaaaa gttaacctgttgcttatccatgatgtggagcccctggatactggaatatactcctgtgat actggagatgtgcagagcactgccaagcttactgtaacagtgctccctccattcttccag gaggaattgcagagtgtagaggcagaggagggagattcagcttctctgtactgtgaggta tctaaacttggagtgccagttcaatggaaaaagaacgggctgccactgagagccagcagg aaatatgagatgaaacaagatggctgcttcctccagctccacatcaaggatctcaaactt gaggacagtggcagctactcatgtcaagcaggaagtgcagagaccactgcagctgtgtta gtgacagagctccctccattcttcaagaaagaattgcgaagtgtggaggctgaggaggga ggtacagtctctctgtactgtgagctgtctaaacctggtgtgccagtacagtggaagaaa aacaggatgccactgagggccatcgggaagtatgagatgaaacaagatggctgcctcctt cagctacacatcaaggatctcaaacctgaagacagtggcatctactcatgtaaagcagaa 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ctgagagccagcaaaaagtatgagatgaagcaagatggctgcctcattcagctcaacatc aaagagctcaaacctgaggacagtggcagctacacatgtaaagcaggaagtgaagagacc actgcatcactgtcagtgnngaaggtgtgtttattttggcagaaagcaattcagtgcaat ctacaatgtgaattggcaaaaaaaaaaaaaaattgtaatctagcattcattaaaataacg ttgnnttcttctctcttttcccatgatgctaaagatgcataataatatttttccaatcct taaccatttctaccagagcacccacctttattcacccaagacttacaaagcatagaggct gaggagggaggtacagcctgcctgcgctgtgagttgtctaaacctggtgtgccagtgcag tggaggaaaaacaagctgcctctgagggccaacaggaagtatgacataaagcaggatggc ttcctccttgagcttcacattaaagagctcaaaactgaagacactggaagctactcatgc catgcaggaaatgcagagaccaccgcgactgtgtcagtgaaagagctcccaccattcttc aagaaagacctacagagtgtggaggctgaggagggaggtgaagccttcctgttctgtgaa ctgtctaaacctggagtgcccgtgcaatggaagaagaacaggctgccactgagagccagc aaaaagtatgagatgaagcaagatggctgcctcattcagctcaacatcaaagagctcaaa cctgaggacagtggcagctacacatgtaaagcaggaagtgaagagaccactgcatcactg tcagtggaaggtgtgtttaattggcagaaagcaattcagtgcaatctacaatgtgaattg cacccacctttattcacccaagacttacaaagcatagaggctgaggagggaggtacagcc tgcctgcgctgtgagttgtctaaacctggtgtgccagtgcagtggaggaaaaacaagctg cctctgagggccaacaggaagtatgacatgaagcaggatggcttcctccttgagcttcac attaaagagctcaaaactgaagacactggaagctactcatgctatgcaggaaatgtagag accaccgcgactgtgtcagtgaaagagctttcatcattcttcaaggaagacttaaaaaat gtggaagctgaggagggaggaacagccttactgtgctgtgaggtatctaagcctgggtta tcagtgcaatggaagaagaacacgctgccactgagagccagcaggaagtatgaaatgaag caggatggctgcgtcttccagctccacatcaaggatctcaaacctgaggacagtgggagc tacatgtgtcaagcaggaaatgcagagaccacttcaagtgtgtctgtcaaagagttcccg ttattcttcaaggaaaaattagaaagtgtggaggccgaggagggaggtgaagcctccctg tactgtgaactgtccaaatctggagtgccagtacagtggaagaagaacaggttgccactc agagccagcagaaagtatgagatgaaacaagatggctgcctcctccagctacatatcaag gacctcaaactcgaggacagtggcagttatacatgccaagcgggaagtgcagaaaccact gtgactgtgacagtgaaagagctccgtccactcttcaacaaagacttacaaaatgtagag gctgaggagggaagttcagcctctctatgctgtgaggtatctaaggctgggttgtccatt caatggaagaagaacagactgacactgagagccagcaggaagtatgaaatgaaacaagat ggctgtctcctccagctcagcatcaaggatctcaagcccgaagacagtggcagctactgc tgtcaagcaggaagtgcagagaccacttcaactgtaacagtaaaagaactccctcacttc ttcaagaaagaattgcaaaacatggaggctgaggaaggaggtacaaccttcctgtactgt gagctgtctaaacctggagtgccagtgcaatggaacaagaatgggctgccactgagagca aacaggaagtatgagatgaagcaagatggttgcctccttcagctccacatcaaggatctc aaacctgaggacagtgccagctatacatgtcaagcaggaactgcagagaccactgcaact gtgtcagtaaaagaactacaatctgatccacataaggcagagcctcccacaatactgcct cgggcaaaaggtactgtctcagaaccaactcctacaccagagaatgagcggcctgacctc ccagacgcccaacttgttcctccagttcccaagagaaggacaatgcgaaaagcatctatt acagtttcagaaaaagatatggaactcatgattgacgtaagacagcctatacaatctatg cagagtgagaataacaaagaccaaaatgggatccaacctacaagatctgtggagggagac tttgatattgtaaatgtaaaacagctggagaggaataaggacaaagacagtcaagtttac aagaaagatgataaaccagagatgttacttgagaaggatggtgggaaagtgaaaaagcca tgtagggctttggaaatggaaagtgaaattttcatggagaggatgcaaccagaaagaaat ctggagaaattggttagcgttggccatgaagtaagtcagtcagataggtttcttggagaa acagtgtgtgaacaaaagaaacctgaagctgaacagagctcaaaccaaccagcaaaacca tcagagaaaacaagggaagtggagaagaaggtgaaccctccaggaacagttgtatggaag aacagcgaggacgaaaaagagcccttgaaaccacatgagaggcttattggggaggaaaca atgaagaaagaagaagtgaggtctacagttaaggaggttgaaattaacaagaaagaagag gagcctttgaaaccaccaataagatctaaagtaaaggtaccaagggaaagggaaccattt cattatgttggaaaggaaactgaggagatcattcctcaatcattaaacactacaataact gattctgaagaagaccttaaacagagagacaacatgacaacaaaagagaaaatgccagtg acacaggtgccttctatgaatcagttggacaaacaagcagtaaaactaccagaaaaacct gtgaataaagaggctgaacttgcccctccgaaaccacctgtgaggacaaaaagcaaagcg aaggggggaatggaaaaacaattatcgagggacactgagacagatcaagatgaacaacag ccgacaagaggtatggtgagaacaactgaagatgagccaataaaacatgcaataaggcct ttgaaacaagaggttgtagagaaaccaacatttgaaagaaaccagtcagtaacaacagac accgaaatacctgagaaaatgaagcaacaggtgaaagctgcagagaaggatgcaatcact aaacagccaatcaaacaaccagtaaaacccatcagaaaagaacctgacgtggaccgggaa atgacactggcagttgaaccaatgagaagggaggaagaaccacaaacaacaggaaacatt cctcttctttatatttctgaagatgaaactttcttagaagctttgactgagttaccagca gacaacagcaatgaccaacccattggttcttttactgagaggtcaacccaaccttccacc ctttctccagttaacgtgctccagaggaccctcccatcagaggaggccacacctgaggtg gacattagcattgaggatgaaccacaaatgcaagaggctgcagtaaagattcaggctgcc tttaaaggcttcaaaactcgcaaagacatgcgaccagcctttaaagaggtctttaagaac cagagtgcagatcttaacagtacagtcactttagtgtgtgttgtagaaggaaaactcagc acagtgaattggctgaaagatggacagcaaatcactaatgataagagataccgtattgag acttcagagaatggggtatgcactctggtgatcaccaaactgaccaccaatgacagtggc atctatacatgtgaggtggtgaacaagtttggtgtgacctcctacaatggaaacataaca gtagtccagaagcctgtacacccgcctcttgcagccattactcctctgcaactcgcccta ctgaagcctgaggctcaggtcataacacagactcataatctgtctcagactcaaactcag gtacccacttcaactatagatgctgcaaattatgtagagagtgtgaacgtctctctgtgg gaggcctacaatctgacagagaaggatactcagatcaacctccaagagaggagaagatcc tcgctcattgctgccagctccatgtcaagtccctctgattatgacaccgctccagatata atggaacctgttgaaatcagtccagctatacgaaggcaagaacctaaagcagcagaccaa gtgcctccaaaagacagtaaagagcagatagctgctccacaacctcctaagaacctacta aaggtcaaaggaacccatgaaggcaaaatgaggacaccatctcctaaacatcatcgtgcc cacacacccttaactggtactgtttctggatcagagtctgaaggggaagaggatagacaa gagacatttgaaatgtatgtggctcgagctgactgcagtcctatcagtggaaataaggac agttttattctgaaagagggccagtatgtagaggtcgtggactctgttcatcctgacaga tggctggtgaggaccaaacccaccaaaaccaaccctgcacggcaggggtgggtgtgtcca gcctacttggagaagaagagaaaggagaccttcccacaactgagagcacctcaagaggat cttgatggcattggatctacaggagaagagtacaggagaacactgagccaactgattcaa ggcctgattgatggagaggaggagtttgtaaaggagatgagggtgttcacctctcatcag ctaaaatatttggagtctagtcgccaagcccccgtcaacgtcctcaaccaaaaagagatt atcttcaggaatatcaaggacattgtttctctccatgagcggtccattcttcccagactg agagactgcgtcacagatgatgatgttgctatgcacctcatcaagcacactgaagacttt gaaaagtatctttactatatggtggggcaggcacaagcagaggcatgcctcactgacaag gctatccagcaatatttcaaagagttaacagaatctggtaagcctgaagctcctgtcatg gatgtcattaccttccttcagagaccagtagagaggattcagacctaccaggctttactg aaggaattcatcaagaacaaagcaaagagtggccagagctgtttcctactggaagatgct ttctctctggtgtcctgtctaccctggaggtctgacaacatacaccaggtctccctcatc gagaattacccagcacctcttgttgctctgggcgagcctgtgcgacagggagtcttcaca gtatgggaggaatcgcctgaaatgaagacaacctctagagggcatcagagacaagtcttt ctcttcaaggaatgtattgtactttgtaagctgaaaagagacactggcatgaacagtgat 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acagatatttggtctgtgggtgttacaacctatttatgtctggtgtgccggtgccctttt gtgggtgagacggatcgtgccacactgctgagggtaggcgaagggaccctgaactgggat gcccctgatgtcatgtacaggagccctgaggcccaggactttctccgcatgctccttcag ccagatccagaaaagcgtccgtctgcctttgagtgtttgagccaccaatggttccaggat gcacatgctggtgaagatactgatgaaatcaacacaaagagtttgaaagtcttcctctca aaaagaaagtggcaacgttctttgacttgtgttggttcagtgctcacattgaggcccgtc cctgaactgctggacgctcctctcagggagactgcagtgacagtgccccgcgagccccag gaacacagcagcacctcagtgagcagtggctcatcatctgaatatgatgaggctgactct tgggactttttccagcactacagccaaactgaggaggaggaagaaacagaggaggacaat gaccctctgattgagagagcactgatccctgagccttttgtcaaactccacctagatgaa gaggaggaagaggaagtgacattaggggaggaagaggatggggagattgtaggaaggagg agtgtgctagagcggagtataagtcggcagtcaattacttcatcagaagtgtcgtaccaa catacaccacagagggagcgtaggttcagcaaggacagtagtccatctctctacctgtct gacggagatgagggttcagggagtgatggaggtcgaatccctcgaggtagcgtcatccga agcactttctatagcacctctcaccagctttcgcctatgtctgccagacacatgacatta cgggacaaattccaggccaaaaagcaagagagaggtcgcaagccactccgaagaagcttt tcaggacgcctgaatgaacctcttattgaatatgtggaggatgagacagagaccaatcgt ggtcagagacgggcatctgtccagcccacaatgcagaaatcctgttcctttgacagtgga gttggcctcgtccacaccaacatatcccctcacaggaggagcaggtctctggatgagtat tctcggcgatctcccagctcacccaagcgcactaagccaggtgacgaagagggcagtcaa agtctgaaggaagatttcacagatgatgaagtgggagggaaaaacttgttggccattcca ggtcctcgacgacctgcaagattaaggggctctgttgcaccgttacaagggactcgcaca cttagtggaccctcaagcctccttgctggagacagagggggcctcaggctgaatcaggag cagacagaaggagacacttttgctggctcccagggttccctggctgagtcgtctattcta gaacaaggtggctcagagtcttcaagtagacttggctctcatgaggacttgagtcacggt cgtctcagaggaagatacagatcaggagggagtgaggagtacgatgatcaaggggaacct ctgatttcaccatcaccttgctcctcattccaagaagttaaacccagaaactcatatccg caggcaccaccacggaaccgcacacgctccaaccccaacttatctgcaaacagcagaagt cagatggggagttcacttatacccagccccagccccagccccagcctctcctctctccag gctccagagaggcctcccagggccaaagacaagaaggaaggccacaacctccagaggcat gcatctgctcccgcccttgaagcccggccacctacaggaaaatcacccaagctgggactg ctgaagatcttccgcaggcagtcctggactggccattcctacgcgcagctagaggacaca gagttaggaccaacactaggagagataatgaagccagatactcccaccatgtctttgagg aagaaaatgagagcttcggcctccagcctgaccaaactgttttcaaggtcttccagtaag gaggacgtgagtaaaggaggcccaatagtaaaaggatcagctcccatcccacctgaaagg aagcgtggtactggtcttgagacctcaaaaaagaggacttccaaactcttgccttctttg aaaataccagcattcaaaaggacaaaagtccgtccaaacaaggctgatgtgttccagtta gatggaggtggagtcctgctggtgtggaggccagtccagtctagtgaccccgtcacgtac tgcgtgcagtactgtacagacggtggagagtggacagtcctgtcggaggaagtgacagat agctgctatgtggtgaaggatttacccagaggagcttcttatgtgttcagggtgggctgc atcactaagacaggagcaggaccttttagtgatacttcatcacctgttgttatggctact caccctgaagagactcacattcctctcatccagactgagtccctggggtcaaaggtcgtt aggtcacagcaaccgacaacacagcagacctacaactttctctctgagatcaacaggggt cgtttcagcatagtaaccctgtgtagggatgctaagaccagccaagtgtttgctgccaag atcaccccttaccaagcagagcagagacagttggtgctgagggaataccagctgttgaag aagctgcatcacacccacctggtccagctgcacactgcctacatcacctcctcccacctg gtattagtggaggagctctgccctggcaaagagctgctctacagtctggctggaagagat ctctattcagaggctcaggttgcagagttgctggttcagattctgagcgcagttgactac cttcacagccgtcgagtcatccacctggacctgaagtctgacaacatgctggtggacgat ggcaaccacctgaaaatcatagactttggctcggctcagttcttcatacctggtcagcct ctcaacatagagcacattcagggcctgtcggagagcaaagactgcagcagcaaagtttat attgtccttcctaaagctccggagatcctggagggtcagggtgttgggcctgagactgat gtttgggctattggagttctgtctttcatcatgttgagtgctgaaagcccatttcatgca gaacacagctgggagcaagacagaaacatcaggaaaggaaaaatccagtttggacgttgt taccctggtctctcagagggagccttaaacttcatgaagagcagcctgaataacaaatcc tgggggaggcccactgtagctgagtgtctccagaacccatggctacgcgcccatcgtgcc ccacacaaggcacgtcactccaaggtgtgtttctccacagacaagcttaaagcttacctc agccagaaggaggagaaacgagaccaggtctgcaccaagcttcggagtccattcttccag taa

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