Streptomyces laculatispora: P8A22_12285
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Entry
P8A22_12285 CDS
T09657
Name
(GenBank) multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
slai
Streptomyces laculatispora
Pathway
slai00020
Citrate cycle (TCA cycle)
slai00630
Glyoxylate and dicarboxylate metabolism
slai00785
Lipoic acid metabolism
slai01100
Metabolic pathways
slai01110
Biosynthesis of secondary metabolites
slai01120
Microbial metabolism in diverse environments
slai01200
Carbon metabolism
slai01210
2-Oxocarboxylic acid metabolism
Module
slai_M00009
Citrate cycle (TCA cycle, Krebs cycle)
slai_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
slai00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
P8A22_12285
00630 Glyoxylate and dicarboxylate metabolism
P8A22_12285
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
P8A22_12285
Enzymes [BR:
slai01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
P8A22_12285
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
P8A22_12285
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
P8A22_12285
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
P8A22_12285
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Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
Transket_pyr
OxoGdeHyase_C
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
WLQ40693
UniProt:
A0ABY9I3E4
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All DBs
Position
2934639..2938454
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AA seq
1271 aa
AA seq
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MSSQSPSNSSISTDQASPGSNPAAAFGPNEWLVDEIYQQYLQDPSSVDRAWWDFFADYKP
GTSGTADKPVPGVAAAGAAAPTAPAVTAPTATNHTAPAQPVAQAPAAPAAPAPTPAAPAP
AAPAAPAAPAKATPAPAAKAAAAPATEAPAGPEYVTLRGPSAAVAKNMNASLELPTATSV
RAVPVKLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQALKAMPAMNYSFAQKDGKPTL
VKPEHVNLGLAIDLVKPNGDRQLVVAAIKQAETLNFFEFWQAYEDIVRRARNGKLGMDDF
TGVTASLTNPGGIGTVHSVPRLMPGQGLIMGVGAMDYPAEFQGTSQDTLNKLGISKVMTL
TSTYDHRVIQGAASGEFLRILSQLLLGENDFYDEIFKALRIPYEPVRWLKDIDASHDDDV
TKAARVFELIHSYRVRGHVMADTDPLEYRQRKHPDLDITEHGLTLWDLERDFAVGGFAGQ
TLMKLRDILGVLRESYCRTTGIEFMHIQDPKERKWLQDRVERPRPAPEREEQLRILRRLN
AAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAEARLDEVVIGMAHRGRLNVLA
NIVGKSYAQIFREFEGNLDPRSMHGSGDVKYHLGAEGTFTGLDGEQIKVSLAANPSHLEA
VDPVLEGIARAKQDIINKAGTDFTVLPVALHGDAAFAGQGVVAETLNMSQLRGYRTGGTV
HVVINNQVGFTAAPEASRSSMYATDVARMIEAPIIHVNGDDPEAVVRVARLAFEYRQTFN
KDVVIDLICYRRRGHNEGDNPEFTNPQMYTLIDKKRSVRKLYTESLIGRGDITLEEAEQA
LQDFQGQLEKVFAEVREATSAPSQPHVPDVQAEFPVAVTTAVSSEVVKLIAESQVNIPDG
ITVHPRLMPQMQRRAASVDNGTIDWGMGETLAIGSLLMEGTPVRLAGQDTRRGTFGQRHA
VLVDQKTGEDYTPLLYLSEDQARYNVYDSLLSEYAAMGFEYGYSLARPESLVIWEAQFGD
FVNGAQTVVDEFISSAEQKWGQTSGVTLLLPHGYEGQGPDHSSARPERFLQMCAQDNMTV
AMPTLPSNYFHLLRWQVHNPHHKPLIVFTPKSMLRLKAAASKVEEFTTGGFRPVIGDESV
DPNAVRKVVFCAGKVYYDLEAEREKRGVTDTAIIRLERLYPLPGAELQAEIAKYPNAEKY
LWAQEEPANQGAWPFIALNLIDHLDLAVGADVPHGERLRRISRPRGSSPAVGSAKRHQAE
QAQLADEVFEA
NT seq
3816 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgtctcagtcccccagtaactcgagcatctcgaccgaccaagccagcccgggttcg
aacccggctgctgctttcggacccaatgagtggctcgtcgacgagatctaccagcagtac
ctccaggatcccagttcggtcgatcgcgcctggtgggacttcttcgccgactacaagccg
ggcacttccggcacggcggacaagcccgttcccggcgttgcagccgcgggggccgcggcg
ccgacggccccggccgtgaccgcaccgaccgccaccaaccacaccgcaccggcgcagccc
gtggcccaggccccggccgcacccgccgccccggcgcccaccccggccgcacccgccccg
gcagctccggcagctccggcagctccggcgaaggccaccccggctccggccgcgaaggcc
gccgccgctccggccaccgaggccccggccgggccggagtacgtgacgctgcgcggcccc
tcggccgcggtcgcgaagaacatgaacgcctcgctggagctgccgacggccacgtccgtc
cgcgccgtcccggtgaagctgctcttcgacaaccgcatcgtcatcaacaaccacctcaag
cgcgcccggggcgggaagatctccttcacgcacctcatcgggtacgcgatggtgcaggcc
ctcaaggccatgccggcgatgaactactccttcgcccagaaggacggcaagccgaccctg
gtcaagccggagcacgtcaacctcggcctggccatcgacctggtgaagccgaacggtgac
cgccagctggtcgtcgcggccatcaagcaggccgagacgctcaacttcttcgagttctgg
caggcctacgaggacatcgtccgccgggcccgcaacggcaagctcgggatggacgacttc
accggtgtcaccgcctcgctgaccaaccccggcggcatcggcaccgttcactcggtgccc
cgcctgatgcccggacagggcctcatcatgggtgtcggcgcgatggactacccggcggag
ttccagggcacgtcacaggacaccctgaacaagctcggtatctcgaaggtcatgaccctg
acctcgacgtacgaccaccgggtcatccagggcgccgcctccggcgagttccttcggatc
ctcagccagctgctgctcggcgagaacgacttctacgacgagatcttcaaggcgctccgc
atcccctacgagccggtccgctggctcaaggacatcgacgcctcgcacgacgacgacgtc
accaaggccgcgcgggtcttcgagctgatccactcctaccgggtccgcggccacgtcatg
gccgacaccgacccgctggagtaccgccagcgcaagcaccccgacctggacatcaccgag
cacggcctcaccctgtgggacctggagcgggacttcgcggtcggcggcttcgccgggcag
accctgatgaagctccgcgacatcctcggtgtgctgcgtgagtcgtactgccgcaccacc
ggcatcgagttcatgcacatccaggacccgaaggagcgcaagtggctccaggaccgggtg
gagcgtccgcgccccgcaccggagcgcgaggagcagctgcggatcctgcgccggctcaac
gccgccgaggcgttcgagacgttcctgcagaccaagtacgtcggccagaagcggttctcg
ctggagggcggcgagtccgtcatcccgctgctcgacgcggtcatcgactccgcggccgag
gcgcgcctcgacgaggtcgtcatcggcatggcccaccgcggccggctgaacgtgctggcg
aacatcgtcggcaagtcgtacgcgcagatcttccgggagttcgagggcaacctcgacccc
cgctcgatgcacggctccggcgacgtcaagtaccacctgggcgccgagggcaccttcacc
ggtctggacggcgagcagatcaaggtctcgctggccgccaacccctcgcacctggaggcg
gtcgacccggtcctggagggcatcgcccgcgccaagcaggacatcatcaacaaggcgggc
acggacttcacggtcctgccggtcgcactccacggcgacgcggccttcgcgggccagggc
gtcgtcgccgagacgctcaacatgtcgcagctgcgcggttaccgcaccggcggcacggtg
cacgtggtgatcaacaaccaggtcggcttcaccgccgccccggaggcttcacgctcctcg
atgtacgcgacggacgtcgcgcgcatgatcgaggcgccgatcatccatgtcaacggtgac
gacccggaggccgtggtccgcgtcgcgcggctcgccttcgagtaccggcagacgttcaac
aaggacgtcgtcatcgacctcatctgctaccgccgccgcggtcacaacgagggcgacaac
ccggagttcaccaacccgcagatgtacacgctgatcgacaagaagcgctcggtgcgcaag
ctctacaccgagtccctcatcggtcgcggcgacatcacgctggaggaggccgagcaggcg
ctccaggacttccagggccagctggagaaggtcttcgcggaggtccgcgaagccacctcc
gcgccgtcccagccgcatgtcccggacgtccaggccgagttcccggtggccgtgaccacc
gcggtgtcctcggaggtcgtgaagctgatcgccgagtcgcaggtcaacatccccgacggg
atcaccgtccatccgcgcctgatgccgcagatgcagcgccgcgccgcctcggtggacaac
ggcaccatcgactggggcatgggcgagacgctggccatcggatcgctgctgatggagggc
accccggtccggctcgccggccaggacacccgccgcggcacgttcggccagcggcacgcg
gtgctcgtcgaccagaagaccggcgaggactacaccccgctgctctacctctccgaggac
caggcccggtacaacgtctacgactcgctgctcagcgagtacgcggcgatgggcttcgag
tacggctactcgctggcccgcccggagtcgctggtcatctgggaggcccagttcggtgac
ttcgtcaacggcgcgcagaccgtcgtggacgagttcatctcctcggccgagcagaagtgg
ggccagacctccggcgtcacgctgctgctgccgcacggctacgagggccagggcccggac
cactcgtccgcccgcccggagcgcttcctccagatgtgcgcgcaggacaacatgacggtc
gccatgccgacgctgccgtcgaactacttccacctcctgcggtggcaggtgcacaacccg
caccacaagccgctcatcgtcttcaccccgaagtcgatgctccggctgaaggcggccgcg
tcgaaggtggaggagttcaccaccggcggcttccgtccggtgatcggcgacgagtcggtc
gacccgaacgcggtccgcaaggtcgtcttctgcgccggcaaggtctactacgacctggag
gccgagcgcgagaagcgcggcgtcacggacaccgcgatcatccgtcttgagcgcctgtac
ccgctgccgggtgccgagctccaggcggagatcgccaagtacccgaacgccgagaagtac
ctgtgggcccaggaggagccggccaaccagggtgcctggccgttcatcgccctgaacctg
atcgaccacctggatctggccgtcggcgccgacgtcccgcacggtgagcgcctgcgccgc
atctcgcggccgcgcggctcgtcccccgcggtcggctcggccaagcgtcaccaggccgaa
caggcccagctggccgacgaggtcttcgaggcctga
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