Streptomyces malaysiensis subsp. malaysiensis DSM 4137: SMALA_5249
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Entry
SMALA_5249 CDS
T05189
Name
(GenBank) alpha-ketoglutarate decarboxylase
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
smal
Streptomyces malaysiensis subsp. malaysiensis DSM 4137
Pathway
smal00020
Citrate cycle (TCA cycle)
smal00630
Glyoxylate and dicarboxylate metabolism
smal00785
Lipoic acid metabolism
smal01100
Metabolic pathways
smal01110
Biosynthesis of secondary metabolites
smal01120
Microbial metabolism in diverse environments
smal01200
Carbon metabolism
smal01210
2-Oxocarboxylic acid metabolism
Module
smal_M00009
Citrate cycle (TCA cycle, Krebs cycle)
smal_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
smal00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
SMALA_5249
00630 Glyoxylate and dicarboxylate metabolism
SMALA_5249
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
SMALA_5249
Enzymes [BR:
smal01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
SMALA_5249
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
SMALA_5249
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
SMALA_5249
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
SMALA_5249
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Paralog
Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
Transket_pyr
OxoGdeHyase_C
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
ATL85479
LinkDB
All DBs
Position
complement(6455111..6458956)
Genome browser
AA seq
1281 aa
AA seq
DB search
MSPQSPNTSSVSTEEQDGQGSNPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADYK
PGQDTGSAVAAPPQAVAASAAPAAPAKPAAAQPAEAKPAVPAAKPAAAAPAAPKPAAAQP
AAPAAKAAPAAPAAPAKPAPVKPTPAEPTVSKKEPAAPAAGPEFVTLRGPSAAVAKNMNA
SLELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKVSFTHLIGYAMVQALKAMPSMNHS
FAEKDGKPTLVKPEHINLGLAIDLVKPNGDRQLVVAAIKKAETLNFFEFWQAYEDIVRRA
RAGKLTMDDFTGVTASLTNPGGIGTVHSVPRLMPGQGLIVGVGAMEYPAEFQGTSQDTLN
KLGISKVMTLTSTYDHRVIQGAASGEFLRIMSQLLLGENDFFDEIFKALRIPYEPVRWLK
DIDVSHDDDVTKAARVFDLIHSYRVRGHVMADTDPLEYRQRKHPDLDIIEHGLTLWDLER
EFAVGGFAGKTMMKLRDILGVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERSHDKPERE
EQLRILRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVLDAAAESRLDEVVVGM
AHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGADGTFTGLDGEQIKVS
LTANPSHLEAVDPVLEGVVRAKQDIIGKAGTDFTVLPVALHGDAAFAGQGVVAETLNMSQ
LRGYRTGGTVHIVINNQVGFTAAPAASRSSMYATDVARMIEAPIFHVNGDDPEAVVRVAR
LAFEFRQAFNKDVVIDLICYRRRGHNETDNPGFTQPLMYDLIDKKRSVRKLYTESLIGRG
DITLEEAEQALQDFQGQLEKVFTEVRDAVSAPAPAHVPEPQPEFPVTVQTAVSQEVVKRI
AESQVNIPDRITVHPRLYPQLQRRAAMIEDDSIDWGMGETLAIGSLLMEGTPVRLAGQDS
RRGTFGQRHAVLVDRETGDDYTPLLYLTEDQGRYNVYDSLLSEYAAMGFEYGYSLARPDA
LVMWEAQFGDFVNGAQTIVDEFISSAEQKWGQTSGVTLLLPHGYEGQGPDHSSARIERFL
QLCAQNNMTVAAPTLPSNYFHLLRWQVHNPHHKPLVVFTPKSMLRLKAAASSTEEFLSGS
FRPVIGDETADPAAVRKVVFCSGKVYYDLAAERDKRGAHDTAIIRLERLYPLPGAELQAE
IAKYSGVQKFVWAQEEPANQGAWPFVALNLIDHLELSVGADVPAAERLVRVSRPHSSSPA
VGSNKRHQSEQGALASEVFEI
NT seq
3846 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgccacagtcccccaacacctcgagcgtctcgaccgaagaacaggacgggcaggga
agtaaccctgccgctgccttcggccccaatgagtggctcgtcgacgagatctaccagcag
tacctccaggacccgaactcggtcgaccgagcctggtgggacttcttcgccgactacaag
ccgggtcaggacaccggctccgcggtggccgcgccaccacaggcagtagccgcgagcgcc
gccccggcggccccggccaagcccgccgcggcccagccggcggaggccaagcccgccgtc
ccggccgccaagcccgcggccgcggctccggctgccccgaagcccgcggcggcgcagccc
gcggcccccgccgcgaaggccgccccggccgcccccgcggctccggccaagcccgccccg
gtcaagccgaccccggccgagccgacggtctccaagaaggagcccgccgcgcccgccgcc
gggcccgagttcgtcacgctgcgcggtccctccgccgcagtggcgaagaacatgaacgcg
tcgctggagctgccgacggccacctcggtgcgcgccgtcccggtcaagctgctgttcgac
aaccgcatcgtcatcaacaaccacctcaagcgcgcccgcggcggcaaggtgtccttcacg
cacctgatcggctacgccatggtgcaggcgctgaaggcgatgccctcgatgaaccactcg
ttcgccgagaaggacggcaagccgaccctggtcaagccggagcacatcaacctcggcctc
gccatcgacctggtcaagcccaacggcgaccgccagctcgtggtggccgcgatcaagaag
gccgagaccctcaacttcttcgagttctggcaggcgtacgaggacatcgtccgccgtgcc
cgcgccggcaagctcacgatggatgacttcaccggcgtcacggcctccctgaccaacccc
ggcggcatcggcaccgtccactcggtgccgcggctgatgcccggccagggcctgatcgtc
ggcgtcggcgccatggagtacccggccgagttccagggcacctcccaggacaccctgaac
aagctgggcatctccaaggtcatgacgctgaccagcacctatgaccaccgggtgatccag
ggcgccgcctccggcgagttcctgcggatcatgagccagctgctgctcggcgagaacgac
ttcttcgacgagatcttcaaggcgctgcgcatcccgtacgagccggtccgctggctcaag
gacatcgacgtcagccacgacgacgatgtcaccaaggcggcgcgggtcttcgacctgatc
cactcctaccgggtccgcggccatgtcatggccgacaccgacccgctggagtaccgccag
cgcaagcaccccgacctggacatcatcgagcacgggctcaccctgtgggacctggagcgc
gagttcgcggtcggcggcttcgcgggcaagaccatgatgaagctgcgcgacatcctgggc
gtgctgcgcgactcgtactgccgcaccaccggcatcgagttcatgcacatccaggacccc
aagcagcgcaagtggatccaggaccgcgtcgagcgcagccacgacaagccggagcgcgag
gagcagctgcgcatcctgcgccggctgaacgcggccgaggcgttcgagaccttcctccag
accaagtacgtcggccagaagcggttctccctggagggcggcgagtccgtcattccgctg
ctggacgcggtgctggacgcggccgccgagtcgcgcctggacgaggtcgtcgtcggcatg
gcccaccgcggccggctcaacgtcctcgccaacatcgtcggcaagtcgtacgcgcagatc
ttccgcgagttcgagggcaacctcgacccgaagtccatgcacggctccggcgacgtcaag
taccacttgggcgccgacggcaccttcaccggcctggacggtgagcagatcaaggtctcg
ctgaccgcgaacccctcccatctggaggccgtggacccggtcctggagggcgtcgtccgc
gccaagcaggacatcatcggcaaggccggcaccgacttcacggtgctgcccgtcgccctc
cacggcgacgcggccttcgcgggccagggcgtggtcgccgagacgctgaacatgtcgcag
ctgcgcggctaccgcaccggcggcaccgtgcacatcgtgatcaacaaccaggtcggcttc
accgccgccccggccgcgtcccgctcctcgatgtacgccacggatgtcgcgcgcatgatc
gaggcgccgatcttccacgtcaacggcgacgacccggaggccgtcgtgcgcgtggcgcgg
ctcgccttcgagttccgccaggcgttcaacaaggacgtggtcatcgacctgatctgctac
cgccgccgcggccacaacgagaccgacaaccccggtttcacccagccgctgatgtacgac
ctgatcgacaagaagcgctcggtgcgcaagctctacaccgagtcgctgatcgggcgcggc
gacatcacgctggaagaggccgagcaggcgctccaggacttccagggccagctggagaag
gtcttcaccgaggtccgcgacgcggtctcggccccggccccggcccatgtccccgagccg
cagccggagttcccggtcaccgtccagacggccgtctcccaggaggtcgtcaagcggatc
gccgagtcccaggtcaacatccccgaccggatcaccgtccacccgcggctgtacccgcag
ctccagcggcgcgcggcgatgatcgaggacgactcgatcgactggggcatgggcgagacc
ctcgccatcggctcactgctgatggagggcaccccggtccggctcgccggccaggactcc
cgccgcggcaccttcggccagcgccacgcggtgctggtggaccgcgagaccggtgacgac
tacaccccgctgctgtacctcaccgaggaccaggggcggtacaacgtctacgactcgctg
ctgagcgagtacgcggcgatgggcttcgagtacggctactcgctggcccgcccggacgcg
ctggtcatgtgggaggcgcagttcggtgacttcgtcaacggcgcgcagaccatcgtcgac
gagttcatctcctcggccgagcagaagtggggccagacctccggagtcaccctgctgctg
ccgcacggctacgagggccagggcccggaccactcctcggcccgtatcgagcgcttcctc
cagctgtgcgcgcagaacaacatgacggtcgccgcgcccacgctgccgtcgaactacttc
cacctgctgcgctggcaggtccacaacccgcaccacaagccgctggtcgtcttcaccccg
aagtcgatgctgcgtctgaaggccgcggcgtcgagcaccgaggagttcctgagcggctcg
ttccgcccggtgatcggtgacgagacggccgacccggccgcggtgcgcaaggtggtcttc
tgctccggcaaggtctactacgacctggccgcggagcgggacaagcgcggtgcgcacgac
acggcgatcatccgcctggagcggctgtatccgctgccgggcgcggagctccaggccgag
atcgccaagtactcgggcgtccagaagttcgtctgggcgcaggaggaaccggccaaccag
ggtgcctggccgttcgtcgcgctcaacctgatcgaccacctggagctgtcggtcggcgcg
gatgtccccgccgccgagcggctggtccgggtctcccgcccgcactcgtcctcgcccgcg
gtggggtcgaacaagcggcaccagtcggagcagggggcgctggcgagcgaggtcttcgag
atctga
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