KEGG   MODULE: smib_M00978
Entry
smib_M00978       Pathway   Module                                 
Name
Ornithine-ammonia cycle
Definition
K01915 K01955+K01956 K00611 K01940 K01755 (K27542,K27545)
Diagram
smib_M00978  Ornithine-ammonia cycle
smib_M00978

Class
Pathway modules; Amino acid metabolism; Arginine and proline metabolism
Pathway
smib00220  Arginine biosynthesis
smib01100  Metabolic pathways
smib01110  Biosynthesis of secondary metabolites
Organism
Streptomyces mirabilis [GN:smib]
Gene
SMIR_07680  argF; (GenBank) ornithine carbamoyltransferase [KO:K00611]
SMIR_27565  amidinotransferase [KO:K27545]
SMIR_27720  glnA; (GenBank) type I glutamate--ammonia ligase [KO:K01915]
SMIR_27905  glutamine synthetase beta-grasp domain-containing protein [KO:K01915]
SMIR_27965  glnA; (GenBank) type I glutamate--ammonia ligase [KO:K01915]
SMIR_31670  glutamine synthetase [KO:K01915]
SMIR_32025  argininosuccinate synthase [KO:K01940]
SMIR_32030  argH; (GenBank) argininosuccinate lyase [KO:K01755]
SMIR_32540  carA; (GenBank) glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit [KO:K01956]
SMIR_32545  carB; (GenBank) carbamoyl-phosphate synthase large subunit [KO:K01955]
SMIR_34120  amidinotransferase [KO:K27545]
Reaction
R00253  
R00575  
R01398  
R01954  
R01086  
R13308  
Compound
C00014  Ammonia
C00064  L-Glutamine
C00169  Carbamoyl phosphate
C00327  L-Citrulline
C03406  N-(L-Arginino)succinate
C00062  L-Arginine
C00011  CO2
Reference
PMID:29632414
  Authors
Zhang H, Liu Y, Nie X, Liu L, Hua Q, Zhao GP, Yang C.
  Title
The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
  Journal
Nat Chem Biol 14:575-581 (2018)
DOI:10.1038/s41589-018-0038-z
KO module
M00978
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