Entry Name Protein export - Schizosaccharomyces pombe (fission yeast)
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Schizosaccharomyces pombe (fission yeast) [GN:
spo ]
Gene 2540769 sec6102; translocon subunit Sec61-like protein [KO:K10956 ]
2542396 sec62; translocation subcomplex subunit Sec62 [KO:K12275 ]
2540961 sec63; translocation subcomplex subunit Sec63 [KO:K09540 ]
2542565 srp14; signal recognition particle subunit Srp14 [KO:K03104 ]
2538791 srp72; signal recognition particle subunit Srp72 [KO:K03108 ]
2539391 srp68; putative signal recognition particle subunit protein [KO:K03107 ]
2539061 sec65; putative signal recognition particle subunit Sec65 [KO:K03105 ]
2540909 srp101; signal recognition particle receptor alpha subunit Srp101 [KO:K13431 ]
2541760 srp102; signal recognition particle receptor beta subunit Srp102 [KO:K12272 ]
2542401 sgt2; SGT2 family TPR repeat-containing protein [KO:K16365 ]
14217705 spc1; signal peptidase complex subunit Spc1 [KO:K12946 ] [EC:3.4.-.-]
2543318 spc3; signal peptidase subunit Spc3 [KO:K12948 ] [EC:3.4.-.-]
2540493 mmp1; endopeptidase catalytic subunit [KO:K09647 ] [EC:3.4.21.-]
2540235 mmp2; endopeptidase catalytic subunit [KO:K09648 ] [EC:3.4.21.-]
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal KO pathway LinkDB All DBs
