Streptomyces profundus: K4G22_08275
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Entry
K4G22_08275 CDS
T10233
Name
(GenBank) multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
sprf Streptomyces profundus
Pathway
sprf00020
Citrate cycle (TCA cycle)
sprf00630
Glyoxylate and dicarboxylate metabolism
sprf00785
Lipoic acid metabolism
sprf01100
Metabolic pathways
sprf01110
Biosynthesis of secondary metabolites
sprf01120
Microbial metabolism in diverse environments
sprf01200
Carbon metabolism
sprf01210
2-Oxocarboxylic acid metabolism
Module
sprf_M00009
Citrate cycle (TCA cycle, Krebs cycle)
sprf_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
sprf00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
K4G22_08275
00630 Glyoxylate and dicarboxylate metabolism
K4G22_08275
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
K4G22_08275
Enzymes [BR:
sprf01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
K4G22_08275
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
K4G22_08275
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
K4G22_08275
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
K4G22_08275
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
OxoGdeHyase_C
Transket_pyr
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
UED84206
LinkDB
All DBs
Position
1948575..1952354
Genome browser
AA seq
1259 aa
AA seq
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MSPQSPNTSSVDADREAQKNSAAGFGANEWLVDEIYQQYLQDPNSVDRAWWDFFADYQPG
GDSAQTKPAADGQAAAEPRSSAPAAAPAQPAAPSGPATPAPSQAARPAAPAKAPEPKPQA
QAQAPKAEAKPAPQAAPKAEAKEAPAGPELVTLRGPAAAVVKNMNASRDVPTATSVRAVP
VKLLFDNRVVINNHLKRARGGKVSFTHLIGYAMVQALKAMPAMNHSFVEKDGKPTLVKPE
HVKLGLAIDLVNKNGDRQLVVAGIERAETLSFFEFWQAYEDIVRRARTGKLTMADFSGVT
ASLTNPGGIGTVHSVPRLMPAQSVILGVGAMEYPAEFQGTSQVTLNRLGISKVMTLTSTY
DHRVIQGAASGEFLRQLSQLLLGEHDFYDDIFAALRIPYEPIRWHRDIDVNHDDEVTKAA
RVFDLIHSYRVRGHLMADTDPLEYKQRRHPDLDITEHGLTLWDLEREFAVGGFAGKSMLT
LRDILGVLRDSYCRTTGIEYMHIQDPKERTWIQDRVERSHSAPEREEQLRILRRLNASEA
FETFLQTKYVGQKRFSLEGGETVIPLLDTVLDEAAADKLDEAVIGMAHRGRLNVLANVVG
KSYAQIFREFEGNLDPKSMHGSGDVKYHLGTEGTFTGLSGEQIKVSLTANPSHLEAVDPV
VEGVARAKQDIIGRGGKDFTVLPILLHGDAAFAGQGVVAETLNMSQLRGYRTGGTIHIVI
NNQVGYTATAAAARSSTYCTDVARMIEAPIFHVNGDDPEAVCRVARLAFEYRQAFNKDVV
IDLVCYRRRGHNETDNPSFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDF
QGQLEKVFKEVRDATVTPAPAEVQLPRPDFPVTVETGVSGEVVKRIAESQVNIPERITVH
PRLLPQLQRRAAMVEEGTIDWAMGELLAVGSLLIEGTPVRLAGQDSRRGTFGQRHSVLID
RKTGEDYTPLLYLSNDQARFNVYDSLLSEYAAMGFEYGYSLARPEALVMWEAQFGDFANG
AATVIDEFISSAEQKWGQTSGVTLLLPHGYEGQGPDHSSARIERFLALCAQNNMTVAAPT
LPSNYFHLLRWQVHNPHHKPLVVFTPKSMLRLKAASSRAEEFTSGGFRPLIGDAEADPQQ
VRKVVLSSGKVYYDLAAEREKRGAHDVALVRLERLYPLPSEELRAELARFPHAERVVWAQ
EEPANQGAWPFVALNLPQAVEIPGQLIPVTRPASSSPAVGSAKRHQAEQQALLDEVFGL
NT seq
3780 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgccacagtccccgaacacctcaagcgttgacgccgatcgagaagcgcagaagaac
tctgccgccggcttcggagccaacgaatggcttgttgacgagatctatcagcagtacctc
caggacccgaactcggtagaccgggcctggtgggacttcttcgccgactaccagccggga
ggcgactcggcccagaccaagccggccgccgacgggcaggccgccgccgagccgcggtcg
agcgcgcccgcggctgcgccggcccaaccggccgcgccgagcgggccggccacgccggcg
ccgagccaggcagcgcggcccgccgcgccggccaaggcccccgagcccaagccacaggca
caggcacaggcccccaaggccgaggcgaagccggctccccaggccgcccccaaggcggag
gccaaggaggcgccggccggtcccgagctggtgacgctgcgcggcccggccgccgccgtc
gtcaagaacatgaacgcctcccgggacgtgcccaccgccacctcggtgcgcgcggtcccg
gtgaagctgctcttcgacaaccgcgtcgtgatcaacaaccacctcaagcgggccaggggc
gggaaggtctccttcacgcacctgatcggctacgcgatggtgcaggcgttgaaggcgatg
ccggcgatgaaccactcgttcgtcgagaaggacggcaagcccaccctggtcaagccggag
catgtcaagctcggcctggcgatcgacctggtgaacaagaacggcgaccgccagctggtg
gtggccgggatcgagcgcgccgagacgctctccttcttcgagttctggcaggcgtacgag
gacatcgtccgccgcgcccgcaccggcaagctgacgatggcggacttctccggcgtcacc
gcctcgctgaccaacccgggcggcatcggcacggtgcactcggtgccccgcctgatgccg
gcgcagagcgtcatcctgggcgtcggcgccatggagtacccggcggagttccagggcacc
tcgcaggtgaccctcaaccgcctgggcatctccaaggtcatgacgctgaccagcacctac
gaccaccgggtgatccagggcgcggcgtcgggcgagttcctgcggcagctcagccagctg
ctgctgggcgagcacgacttctacgacgacatcttcgccgcgctgcgcatcccgtacgag
ccgatccgctggcaccgggacatcgacgtcaaccacgacgacgaggtcaccaaggcggcc
cgggtcttcgacctgatccactcctaccgggtgcgcggccatctgatggccgacacggac
ccgctggagtacaagcagcggcgccaccccgacctggacatcacggagcacgggctcacc
ctgtgggacctggagcgggagttcgcggtcggcggcttcgccggcaagtcgatgctcacg
ctgcgggacatcctgggcgtgctgcgggactcgtactgccgcaccaccggcatcgagtac
atgcacatccaggaccccaaggagcgcacctggatccaggaccgggtggagcgttcgcac
agcgcgcccgagcgcgaggagcagctgcgcatcctgcgccggctgaacgcctcggaggcg
ttcgagacgttcctccagaccaagtacgtgggccagaagcgcttctcgctcgaaggcggg
gaaacggttatcccgctgctggacacggtcctggacgaggccgccgccgacaagctggac
gaggccgtcatcgggatggcgcaccgcggccggctcaacgtgctggccaacgtggtgggc
aagtcctacgcgcagatcttccgcgagttcgagggcaacctcgaccccaagtcgatgcac
ggctcgggcgacgtgaagtaccacctgggcaccgagggcacgttcaccggcctgtcgggg
gagcagatcaaggtctcgctgaccgccaacccctcgcatctggaggccgtcgacccggtg
gtcgagggcgtcgccagggccaagcaggacatcatcggccggggcggcaaggacttcacg
gtgctgccgatcctgctgcacggtgacgcggccttcgccggtcagggggtggtcgccgag
acgctcaacatgtcgcagctgcgcggctaccgcacgggcggcaccatccacatcgtgatc
aacaaccaggtgggctacaccgcgacggccgccgccgccaggtcctccacctactgcacc
gatgtggcccggatgatcgaggccccgatcttccacgtcaacggggacgacccggaggcg
gtgtgtcgggtcgcgaggctggccttcgagtaccggcaggcgttcaacaaggacgtcgtg
atcgacctcgtctgctaccggcgccgtggccacaacgagacggacaacccgtccttcacg
cagccgctgatgtacgacctgatcgacaagaagcgctcggtgcgcaagctgtacaccgag
tcgctgatcggccggggcgacatcacgctggaggaggccgagcaggcccttcaggacttc
cagggccagttggagaaggtcttcaaggaggtcagggacgccacggtcaccccggccccc
gccgaggtccagctgccgcgccccgacttccccgtcacggtggagaccggcgtctccggc
gaggtggtcaagcggatcgcggagtcgcaggtcaacatccccgagcggatcaccgtgcac
ccgcggctgctgccgcagttgcagcggcgcgcggcgatggtcgaggaaggcaccatcgac
tgggcgatgggcgagctgctggccgtcggttccctgctgatcgagggcaccccggtccgg
ctggccggccaggactccaggcgcggcaccttcgggcagcggcactcggtgctgatcgac
cgcaagaccggcgaggactacaccccgctgctctacctgtcgaacgaccaggccaggttc
aacgtctacgactcgctgctgagcgagtacgcggcgatgggcttcgagtacggctactcg
ctggccaggcccgaggcgctggtcatgtgggaggcgcagttcggtgacttcgccaacggc
gcggccaccgtgatcgacgagttcatctcgtcggccgagcagaagtggggccagacctcc
ggcgtcacgctgctgctgccgcacggctacgagggccaggggcccgaccactcctcggcg
aggatcgagcgcttcctcgcgctgtgcgcgcagaacaacatgacggtggcggcgccgacc
ctgccgtcgaactacttccatctgctgcgctggcaggtgcacaacccgcaccacaagccg
ctggtggtcttcacccccaagtcgatgctgcggctgaaggccgcctcgtcgcgggccgag
gagttcacctccggcgggttccggccgctgatcggggacgccgaggccgacccgcagcag
gtgcgcaaggtggtgctgagcagcggcaaggtctactacgacctcgcggccgagcgggag
aagcgcggcgcccacgatgtggcgctggtgcgtcttgagcggctctacccgctgcccagc
gaggagctgcgcgccgagctggccaggttcccgcacgccgagcgcgtggtctgggcccag
gaggagccggccaaccagggcgcctggccgtttgttgcgctcaacctgccgcaggcggtg
gagatccccggccagctgatcccggtgacccgccccgcttcctcctcgccggccgtcggc
tcggcgaagcggcaccaggcggagcagcaggccctgttggacgaggtgttcgggctgtga
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