KEGG   PATHWAY: spu00533
Entry
spu00533                    Pathway                                
Name
Glycosaminoglycan biosynthesis - keratan sulfate - Strongylocentrotus purpuratus (purple sea urchin)
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
spu00533  Glycosaminoglycan biosynthesis - keratan sulfate
spu00533

Other DBs
GO: 0018146
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
592434  alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
115924182  alpha-(1,6)-fucosyltransferase-like [KO:K00717] [EC:2.4.1.68]
100893980  alpha-(1,6)-fucosyltransferase-like [KO:K00717] [EC:2.4.1.68]
580837  alpha-(1,6)-fucosyltransferase-like [KO:K00717] [EC:2.4.1.68]
575664  alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
586950  alpha-(1,6)-fucosyltransferase-like [KO:K00717] [EC:2.4.1.68]
100889005  alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
115927592  alpha-(1,6)-fucosyltransferase-like [KO:K00717] [EC:2.4.1.68]
100891771  beta-1,3-galactosyltransferase 1-like [KO:K09664] [EC:2.4.1.-]
579709  carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
115919258  carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
100891836  carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
581661  carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
105440812  carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
579726  carbohydrate sulfotransferase 1 isoform X2 [KO:K01022] [EC:2.8.2.21]
100889433  carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
100891876  carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
586919  carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
115929052  carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
754196  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase [KO:K00781] [EC:2.4.3.6]
100891100  carbohydrate sulfotransferase 3-like [KO:K04745] [EC:2.8.2.-]
115925919  carbohydrate sulfotransferase 3-like [KO:K04745] [EC:2.8.2.-]
579907  carbohydrate sulfotransferase 2-like [KO:K04745] [EC:2.8.2.-]
587922  carbohydrate sulfotransferase 3-like [KO:K04745] [EC:2.8.2.-]
590209  st; uncharacterized protein LOC590209 [KO:K03368] [EC:2.4.3.2 2.4.3.4]
Reference
PMID:11030741
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
DOI:10.1093/glycob/10.10.951
Reference
PMID:14706853
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
DOI:10.1016/S0014-5793(03)01440-6
Reference
PMID:12511560
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)
DOI:10.1074/jbc.M211480200
Related
pathway
spu00510  N-Glycan biosynthesis
spu00512  Mucin type O-glycan biosynthesis
KO pathway
ko00533   
LinkDB

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