Streptomyces sp. RPA4-5: HEP86_27375
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Entry
HEP86_27375 CDS
T10325
Name
(GenBank) multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
srpa Streptomyces sp. RPA4-5
Pathway
srpa00020
Citrate cycle (TCA cycle)
srpa00630
Glyoxylate and dicarboxylate metabolism
srpa00785
Lipoic acid metabolism
srpa01100
Metabolic pathways
srpa01110
Biosynthesis of secondary metabolites
srpa01120
Microbial metabolism in diverse environments
srpa01200
Carbon metabolism
srpa01210
2-Oxocarboxylic acid metabolism
Module
srpa_M00009
Citrate cycle (TCA cycle, Krebs cycle)
srpa_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
srpa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
HEP86_27375
00630 Glyoxylate and dicarboxylate metabolism
HEP86_27375
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
HEP86_27375
Enzymes [BR:
srpa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
HEP86_27375
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
HEP86_27375
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
HEP86_27375
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
HEP86_27375
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Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
OxoGdeHyase_C
Transket_pyr
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
QIY57558
LinkDB
All DBs
Position
complement(6094895..6098683)
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AA seq
1262 aa
AA seq
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MSLQSPNSSSISTDQEGQGKNPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADYKP
GGATAPSQPAEGSPGASTGSTGAAGAAQPSGPAAPAKPAASAPAPAKAAPAKAAPAKAEP
AKAAPAKPAAKPAAEEGTAPAGPEFITLRGPSAAVAKNMNASLELPTATSVRAVPVKLLF
DNRIVINNHLKRARGGKVSFTHLIGYAMVQALKAMPTMNYSFAEKDGKPTLVKPEHVNLG
LAIDLVKPNGDRQLVVAAIKKAETLTFFEFWQAYEDIVRRARDNKLTMDDFTGVTASLTN
PGGIGTVHSVPRLMPGQSMIMGVGAMDYPAEFQGTSQDALNKLGVAKVMTLTSTYDHRVI
QGAASGEFLRIMSQLLLGDNEFFDDIFKSLRIPYEPVRWLRDIDASHDDDVTKAARVFEL
IHSYRVRGHVMADTDPLEYHQRKHPDLDITEHGLTLWDLEREFAVGGFSGKSMMKLRDIL
GVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERSHKSPEREEQLRILRRLNSAEAFETFL
QTKYVGQKRFSLEGGESVIPLLDAVIDSAAESRLDEVVIGMAHRGRLNVLANIVGKSYAQ
IFREFEGNLDPKSMHGSGDVKYHLGQEGVFTGLDGEQIKVSLAANPSHLEAVDPIVEGIA
RAKQDLINKGGTDFTVLPIQLHGDAAFAGQGVVAETLNMSQLRGYRTGGTVHVVINNQVG
FTAAPESSRSSMYATDVARMIEAPIFHVNGDDPEAVVRVARLAFEFRQAFNKDVVIDLIC
YRRRGHNESDNPAFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDFQGQLE
KVFTEVRDATTAPTAPEVPQPKAEFPVYVDTAISQEVVKRIAESQVNIPERVTVHPRLLP
QLQRRAAQVEDNTIDWGMGETLAVGSLLMEGTPVRLAGQDSRRGTFGQRHAVLIDRETGD
DYTPLLYLSEDQARFNVYDSLLSEYAAMGFEYGYSLARPEALVMWEAQFGDFVNGAQTVV
DEFISSAEQKWGQTSGVTLLLPHGYEGQGPDHSSARIERFLQLCAQNNMTVAMPTLPSNY
FHLLRWQVHNPHHKPLVVFTPKSMLRLKAAASRTDEFTTGGFRPVIGDSTVKPEDVRKVI
FCSGKVYYDLEAEREKRGAHDTAIIRIERLYPLPGKELQAEISKFPNAEKYLWTQEEPAN
QGAWPFLGLNLIDHLDLAVGADVPHGERLRRISRPHSSSPAVGSAKRHQAEQAQLVAEAF
DA
NT seq
3789 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgctacagtcccccaacagctcgagcatctcgaccgaccaggaggggcagggtaag
aaccctgctgctgcgttcggtcccaatgagtggctcgtcgacgagatctaccagcagtac
ctccaggacccgaactcggtagaccgagcctggtgggacttcttcgctgactacaagccg
ggcggcgccaccgcgccgagccagccggcggagggctcccccggtgcgagcaccggctcc
acgggagcggctggcgccgcgcagccttctgggccggccgccccggcgaagcccgccgcg
agcgctccggcaccggcgaaggccgctccggcgaaggccgctccggcgaaggccgagccc
gcgaaggcggctccggccaagcccgccgcgaagccggccgccgaggagggcacggctccg
gccggtcccgagttcatcaccctgcgtggcccctcggccgccgttgcgaagaacatgaac
gcctccctggagctgccgacggccacgtccgtccgcgcggtcccggtgaagctgctcttc
gacaaccgcatcgtgatcaacaaccacctcaagcgcgcccgcggtgggaaggtctccttc
acccacctcatcgggtacgcgatggtgcaggccctcaaggccatgccgacgatgaactac
tccttcgcggagaaggacggcaagccgacgctggtcaagcccgagcatgtgaacctcggt
ctcgccatcgacctggtgaagccgaacggtgaccgccagctcgtcgtcgccgccatcaag
aaggccgagacgctgaccttcttcgagttctggcaggcctacgaggacatcgtccgccgg
gcccgcgacaacaagctgacgatggacgacttcaccggagtcaccgcgtcgctgacgaac
ccgggcggcatcggcaccgtgcactccgtgccccgcctgatgcccggccagtccatgatc
atgggcgtcggcgcgatggactaccccgcggagttccagggcacctcccaggacgccctg
aacaagctgggtgtcgccaaggtcatgacgctgaccagcacctatgaccaccgggtgatc
cagggcgccgcctccggcgagttcctgcggatcatgagccagctgctgctcggcgacaac
gaattcttcgacgacatcttcaagtcgctgcggattccgtacgagcccgtccgctggctg
cgggacatcgacgcctcccacgacgacgacgtcaccaaggccgcccgggtcttcgagctg
atccactcctaccgggtccgcggccacgtcatggccgacaccgacccgctggagtaccac
cagcgcaagcaccccgacctcgacatcaccgagcacgggctcaccctgtgggacctggag
cgcgagttcgcggtcggcggcttctccggcaagtccatgatgaagctgcgcgacatcctg
ggcgtgctgcgtgactcgtactgccgcaccaccggcatcgagttcatgcacatccaggac
cccaagcagcgcaagtggatccaggaccgggtcgagcgctcgcacaagtcgcccgagcgc
gaggagcagctgcgcatcctgcgccggctgaactccgccgaggccttcgagacgttcctg
cagacgaagtacgtcggccagaagcgcttctcgctggagggcggcgagtccgtcatcccg
ctgctggacgcggtcatcgactccgcggccgagtcgcgcctcgacgaggtcgtcatcggc
atggcccaccgcggccgcctcaacgtcctggcgaacatcgtcggcaagtcgtacgcgcag
atcttccgcgagttcgagggcaacctcgacccgaagtcgatgcacggctccggcgacgtg
aagtaccacctgggccaggagggcgtcttcaccggcctggacggcgagcagatcaaggtc
tcgctggccgcgaacccctcccacctggaggccgtcgacccgatcgtcgagggcatcgcg
cgcgccaagcaggacctcatcaacaagggcggcacggacttcacggtcctgccgatccag
ctgcacggtgacgcggcgttcgccggtcagggcgtggtcgcggagacgctgaacatgtcc
cagctgcgcggctaccgcaccggcggcacggtgcacgtggtcatcaacaaccaggtcggc
ttcaccgccgccccggagtcgtcgcgttcgtccatgtacgccaccgacgtggcccgcatg
atcgaggcgccgatcttccatgtgaacggcgacgaccccgaggccgtcgtccgcgttgcc
cgtctggccttcgagttccgccaggcgttcaacaaggacgtcgtcatcgacctgatctgc
taccgccgccgcggccacaacgagtcggacaacccggccttcacccagccgctgatgtac
gacctgatcgacaagaagcgctcggtgcgcaagctctacaccgagtccctcatcggtcgc
ggcgacatcacgctggaagaggccgagcaggcgctccaggacttccagggccagctggag
aaggtcttcaccgaggtccgcgacgccacgaccgccccgaccgcccccgaggtgccgcag
cccaaggccgagttcccggtctacgtggacactgcgatctcccaggaggtcgtcaagcgg
atcgccgagtcgcaggtcaacatccccgagcgggtcaccgtccacccgcgtctgctgccc
cagctccagcgccgcgcggcccaggtcgaggacaacaccatcgactggggcatgggcgag
accctggccgtcggctcgctgctgatggagggcaccccggtccggctcgccggccaggac
tcccgccgtggcaccttcggccagcggcacgcggtgctcatcgaccgggagaccggcgac
gactacacgccgctgctctacctctccgaggaccaggcccgcttcaacgtctacgactcg
ctgctcagcgagtacgcggcgatgggcttcgagtacggctactccctggcccgcccggag
gcgctggtcatgtgggaggcgcagttcggtgacttcgtcaacggcgcccagacggtcgtc
gacgagttcatctcctcggcggagcagaagtggggccagacgtccggcgtcaccctgctg
ctgccgcacggctacgagggccagggcccggaccactcctcggcccgtatcgagcggttc
ctccagctgtgcgcgcagaacaacatgacggtcgccatgccgaccctgccgtcgaactac
ttccacctgctgcgctggcaggtccacaacccgcaccacaagccgctggtcgtcttcacc
ccgaagtcgatgctgcgtctgaaggctgcggcgtcgcggacggatgagttcacgacgggc
ggcttccgccccgtcatcggcgactccacggtcaagcccgaggatgtccgcaaggtcatc
ttctgctccggcaaggtctactacgacctggaggccgagcgggagaagcgcggcgcgcac
gacaccgcgatcatccgtatcgagcggctctacccgcttcccggcaaggagctccaggcg
gagatctccaagttcccgaacgccgagaagtacctgtggacccaggaagagccggcgaac
cagggtgcgtggccgttcctcggcctcaacctgatcgaccacctcgacctggccgtcggc
gccgatgtcccgcacggcgagcgcctgcgccgcatctcgcggccgcactcctcgtcgccg
gccgtcggctccgccaagcgccaccaggcagagcaggcacagctggtcgcggaggccttc
gacgcatag
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