Streptomyces sp. RPA4-2: HEP85_26910
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Entry
HEP85_26910 CDS
T10422
Name
(GenBank) multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
srpz Streptomyces sp. RPA4-2
Pathway
srpz00020
Citrate cycle (TCA cycle)
srpz00630
Glyoxylate and dicarboxylate metabolism
srpz00785
Lipoic acid metabolism
srpz01100
Metabolic pathways
srpz01110
Biosynthesis of secondary metabolites
srpz01120
Microbial metabolism in diverse environments
srpz01200
Carbon metabolism
srpz01210
2-Oxocarboxylic acid metabolism
Module
srpz_M00009
Citrate cycle (TCA cycle, Krebs cycle)
srpz_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
srpz00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
HEP85_26910
00630 Glyoxylate and dicarboxylate metabolism
HEP85_26910
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
HEP85_26910
Enzymes [BR:
srpz01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
HEP85_26910
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
HEP85_26910
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
HEP85_26910
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
HEP85_26910
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Gene cluster
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Motif
Pfam:
E1_dh
2-oxoacid_dh
OxoGdeHyase_C
Transket_pyr
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
XDO61150
LinkDB
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Position
complement(6056324..6060154)
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AA seq
1276 aa
AA seq
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MSPQSPSNSSTSTEDQAGKNPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADYKPG
APAASAPAGTAAAGAAGTTTTAAASAPAAPAAPAAPAAPQAPAQAAPAAPAAPAPAPAAA
PAAPKPPAAAPAPVPAKAAPAAAKPKAAPATEAPAGPEFVTLRGPAAAVAKNMNASIEVP
TATSVRAVPVKLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQAIKAMPTMNHSFAEKD
GKPTLVKPEHVNFGLAIDLVKPNGDRQLVVAGIKKAETLNFFEFWQAYEDIVRRARDGKL
TMDDFTGVTVSLTNPGGLGTVHSVPRLMPGQSVIMGVGSMDYPAEFQGTSQDTLNKLGIS
KVMTLTSTYDHRVIQGAASGEFLRIVANLLLGENGFFDEIFEALRIPYEPVRWLKDIDAS
HDDDVTKAARVFELIHSYRVRGHVMADTDPLEYRQRKHPDLDITEHGLTLWDLEREFAVG
GFSGKSMMKLRDILGVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERPHSKPEREEQLRI
LRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAESRLDEVVIGMAHRGR
LNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGAQGTFTGLDGEQIKVSLAANP
SHLETVDPVIEGIARAKQDIINKGGTDFTVLPVALHGDAAFAGQGVVAETLNMSQLRGYR
TGGTVHIVINNQVGFTAAPESSRSSMYATDVARMIEAPIFHVNGDDPEAVVRVARLAFEF
RQAFNKDVVIDLICYRRRGHNESDNPAFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLE
EAEQALQDFQGQLEKVFTEVREAVSQGAEVQISDPQAQFPVAVQTAVSQEVVKRIAESQV
NIPDNVTVHPRLLPQLQRRAAMIEDGTIDWGMGETLAIGSLLLEGTPVRLSGQDSRRGTF
GQRHAVLIDRVTGEDFTPLQYLSDDQARYNVYDSLLSEYAVMGFEYGYSLARPDALVMWE
AQFGDFVNGAQTVVDEYISAAEQKWGQTSGVTLLLPHGYEGQGPDHSSARIERFLALCAQ
NNMTVAQPTLPSNYFHLLRWQVHNPHHKPLVVFTPKSMLRLKAAASKAEEFTTGAFRPVI
GDDSVEAAAVRRVVFCAGKLYYDLEAERQKRGVTDTAIIRIERLYPLAGAELQAEIAKYP
NAEKYLWAQEEPANQGAWPFIALNLIDHLDLAVGADIPGAERLRRISRPAGSSPAVGSAK
RHQAEQEQLVREVFEA
NT seq
3831 nt
NT seq
+upstream
nt +downstream
nt
gtgtcgccacagtcccccagtaactcgagcacttcgaccgaagaccaagccgggaagaac
cccgccgctgcgttcggtcccaatgagtggctcgtcgacgagatctatcagcagtacctc
caggacccgaattcggtagaccgagcctggtgggacttcttcgccgactacaagccaggg
gctccggccgcctcggctccggcgggtactgcggccgcgggggccgcagggaccaccacc
acggcagctgcgtccgcgcctgccgcgccggcagcccctgccgcgcccgcggcgccccag
gctccggcccaggccgctccggcggctcctgcggccccggcgcccgctccggccgccgca
cccgcggcgccgaagcctcctgccgctgccccggccccggttcccgcgaaggccgctccg
gccgccgcgaagccgaaggccgcgcccgcgaccgaggcccctgccggtcccgagttcgtg
acgctgcgcggccccgccgccgcggtcgcgaagaacatgaacgcctcgatcgaggtgccc
acggccacatccgtgcgcgcggtcccggtgaagctgctcttcgacaaccgcatcgtcatc
aacaaccacctgaagcgtgcccggggcgggaagatctccttcacccacctcatcggctac
gcgatggtgcaggccatcaaggccatgccgaccatgaaccactccttcgcggagaaggac
ggcaagccgaccctggtcaagccggagcacgtcaacttcggtctcgccatcgacctggtg
aagccgaacggtgaccgccagctcgtcgtcgccggcatcaagaaggccgagacgctgaac
ttcttcgagttctggcaggcctacgaggacatcgtccgccgcgcccgcgacggcaagctg
acgatggacgacttcaccggcgtcacggtctccctgaccaaccccggcggcctcggcacc
gtccactcggtcccccgcctgatgcccggccagtcggtcatcatgggcgtcggctccatg
gactacccggcggagttccagggcacctcccaggacaccctgaacaagctcggcatctcg
aaggtcatgacgctcacgtcgacctacgaccaccgggtgatccagggcgccgcctccggc
gagttcctccgcatcgtcgccaacctcctcctcggcgagaacggcttcttcgacgagatc
ttcgaggcgctgcgcatcccctacgagccggtccgctggctcaaggacatcgacgccagc
cacgacgacgacgtcaccaaggccgcccgcgtcttcgagctgatccactcctaccgggtc
cgcggccacgtcatggccgacaccgacccgctggagtaccgccagcgcaagcaccccgac
ctcgacatcaccgagcacggtctcaccctgtgggacctggagcgcgagttcgcggtcggc
ggcttctccggcaagtcgatgatgaagctgcgcgacatcctcggcgtgctgcgcgactcg
tactgccgcaccaccggcatcgagttcatgcacatccaggacccgaagcagcgcaagtgg
atccaggaccgcgtcgagcgcccgcactccaagccggagcgcgaggagcagctgcgcatc
ctgcgccggctgaacgcggcggaggccttcgagaccttcctgcagaccaagtacgtcggc
cagaagcggttctccctggagggcggcgagtccgtcatcccgctcctcgacgccgtcatc
gacagcgccgcggagtcccgcctggacgaggtcgtcatcggcatggcccaccgcggccgc
ctgaacgtcctcgccaacatcgtcggcaagtcgtacgcgcagatcttccgcgagttcgag
ggcaacctcgacccgaagtcgatgcacggctccggcgacgtgaagtaccacctgggcgcc
cagggcaccttcaccggcctggacggcgagcagatcaaggtctcgctggccgcgaacccc
tcccacctggagacggtcgacccggtcatcgagggcatcgcccgcgccaagcaggacatc
atcaacaagggcggcacggacttcacggtcctgcccgtcgccctgcacggtgacgcggcc
ttcgcgggccagggtgtcgtcgccgagaccctcaacatgtcgcagctgcgcggctaccgc
accggcggcacggtgcacatcgtcatcaacaaccaggtcggcttcaccgccgccccggag
tcgtcgcgctcgtccatgtacgccaccgacgtggcccgcatgatcgaggcgccgatcttc
cacgtgaacggcgacgaccccgaggccgtcgtccgcgtcgcccgcctggccttcgagttc
cgccaggcgttcaacaaggacgtcgtcatcgacctcatctgctaccgccgccgcggacac
aacgagtccgacaacccggcgttcacgcagccgctgatgtacgacctgatcgacaagaag
cgctcggtgcgcaagctctacaccgagtccctcatcggccgcggcgacatcaccctcgaa
gaggccgagcaggcgctgcaggacttccagggccagctggagaaggtcttcaccgaggtc
cgcgaggccgtctcgcagggggcggaggtgcagatctcggacccgcaggcgcagttcccc
gtcgccgtgcagaccgcagtctcccaggaggtcgtcaagcggatcgccgagtcccaggtc
aacatccccgacaacgtcaccgtccacccgcgtctgctgccgcagctgcagcgccgggcg
gcgatgatcgaggacggcacgatcgactggggcatgggcgagaccctcgccatcggctcc
ctcctcctggagggcaccccggtccggctgtcgggccaggactcccgccgcggcaccttc
ggccagcgccacgcggtcctgatcgaccgggtcacgggcgaggacttcaccccgctccag
tacctctcggacgaccaggcccgctacaacgtctacgactcgctgctctccgagtacgcg
gtcatgggcttcgagtacggctactcgctggcccgcccggacgccctcgtgatgtgggag
gcgcagttcggcgacttcgtcaacggcgcgcagacggtcgtcgacgagtacatctcggcc
gccgagcagaagtggggccagacgtccggcgtcaccctgctcctgccgcacggctacgag
ggccagggcccggaccactcctcggcccgcatcgagcgcttcctcgcgctgtgcgcccag
aacaacatgacggtcgcccagccgacgctcccgtcgaactacttccacctcctgcggtgg
caggtgcacaacccgcaccacaagccgctggtcgtcttcaccccgaagtcgatgctgcgc
ctcaaggccgccgcctcgaaggcggaggagttcaccaccggcgccttccgcccggtcatc
ggcgacgactcggtcgaggccgcggcggtccgcagggtcgtgttctgcgccggcaagctg
tactacgacctcgaggccgagcggcagaagcgcggcgtcacggacacggcgatcatccgc
atcgagcgcctgtaccccctcgcgggtgcggagctccaggcggagatcgccaagtacccg
aacgccgagaagtacctgtgggcccaggaggagccggcgaaccagggcgcgtggcccttc
atcgccctcaacctgatcgaccacctggacctggccgtcggcgccgacatcccgggcgcc
gagcggctgcgccgcatctcccgcccggccggctcgtccccggccgtgggttcggcgaag
cggcaccaggccgagcaggagcagctggtgcgcgaggtgttcgaggcctag
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