Sinocyclocheilus rhinocerous: 107728853 Help Entry 107728853         CDS       T04916                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism srx  Sinocyclocheilus rhinocerous Pathway srx04020   Calcium signaling pathway srx04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:srx00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107728853    04020 Calcium signaling pathway     107728853  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:srx01009]     107728853   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:srx04147]     107728853    04040 Ion channels [BR:srx04040]     107728853 Protein phosphatases and associated proteins [BR:srx01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      107728853 Exosome [BR:srx04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    107728853 Ion channels [BR:srx04040]  Voltage-gated cation channels   Ryanodine receptor    107728853 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 YebO Motif Other DBs NCBI-GeneID:  107728853 NCBI-ProteinID:  XP_016394626 LinkDB All DBs Position Unknown AA seq 5086 aa AA seqDB search MAEGAEGEEEIQFLRTDDQVVLQCTATILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTTELNEAVDLDKWSSQGGGHRTLLYGHAILLRHTHS GMYLSCLTTSRSLTDKLAFDVGLREESTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGDLMVDASFMQTLWNMNPVCSGCELAEGYLTGGHVLRLFHGHMDECLT IPTADQGDDQRRNAHYEGGAVCSHARSLWRLEPLRIGWSGSHMKWGQSFRVRHITTGRYL CLDEEKGLLLVDAEKANTKNSAFCFRASKEKTEVAQKRDVEGMGIPEIKYGESMCFVQHV STSLWLTYASVDAKSARLGPLKRKAILHQEGHMDDALTVARSQTAESQAARMIYSTTGLF TQFIKGLDSLRGKSKSPGPSSPSLPLDAVVLSLQDLIFYFRPPEEELEHEEKQTKLRSLR NRQNLFQEEGMISLVLDCVDRLNVYNTSAHFSEFAGEEAAEYWKEIVNLFYELLASLIRG NRANCALFCDNLDWLVSKLDRLEASSGILEVLYCILIESPEVLNIIQENHIKSIIALLDK HGRNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIINYVTSMRPNIFLGT CEGSTQYKKWYYELIVDHVESFLTAQACHLRVGWALTEGYSPYPGGGEGWGSNGVGDDLY SYGFDGLHLWTGRVLRQVSSSNPHILAAGDVVSCCLDLSVPSISFRINGHPVQGMFENFN LDGLFFPAVSFSAGIKVRFLLGGRHGDFKFLPPPGYAPCYEAVLPKDRLRIEPIKEYKHD FDGVRNLLGPTQSLSHTAFTPCPVDTVQIVLPPHLERIREKLAENSHELWAVTRIEQGWT YGPFRDDNKKLHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKK IKLPKTYMQSNGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIIQD IVNKRNPRLVPYNLLDEKTKKTNRDSVCAAVRTLIGYGYNIEPPDQESSGHGAGSGRSDK IRVFRAEKSYAVTQGKWYFEFEAVTVGEMRVGWARPSVHADRELGSDDLAYVFNGFKAQR WHIGNEPFGRQWQSGDVVGCMIDLTEQNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPV CSLGLSQVGRINLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTD HPHIEVSRVDGTVDSAPCLKLNHRTFGSQNANTGLLFFRLSMPIEFHETFKVPVGASPLT RTLTIPEDEALEVDPESEFELLKKSATRKEQDEKEKEPSVPKELPGNKEGENEKDTTTEK SKKRGFFSKAKKAAFIAPPPVVPTVPRLMEDVVPDDRDDTDIISSTTTYYYSVRVFAGQE PSGVWVGWVTPDYHQYDPHFDLGKVRNVTVTVGDDKGNIHDSVKRSNCYMVWGGEFSSSQ QTRISQEDFVIGCLVDLDTGLMSFTANGKEINAFYQVEPNTKLFPAVFCLPSSQNMLQVE LGKLKNIMPISAAMFRSDHKNPVPQCPPRLDAQMLTPVIWSRMPNHFLAPETGRVSERQG WKLQCMEPLIMMALHIPEENRCIDILELSECTDLMKFHYHTLKLYGSVCALGNNRVAHAL CSHVDESQLFYAIENTYLPGPIRSGYYDLLISMHLESAKRNRLMTNKEFIVPMTDDTRSI TLYSDAEKAHALPGVGLTTCLRPKLHFAPTGFVGTNADLYTLSPILPLQMLKDHALSMLT EAVQDGGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFDDSDVKHILKLIEPSVFTDGEN PAEELEAAKTGDAEQQLVCKEEGMKAKEEEEEVEGENEREQLDEAMGEEEEEELEEEEED ELEPEEEEYEKHAGKEGKEDEHAAEKMDREKTTDEDVEKETGAAEAKEEEDVGEGLLHMK LPESVKLQMCTLLQYFCDCELRHRVEAIIAFSYRFVNQVQTNQRQRYNELMQAFTMSAAE TARKTREFRSPPQEQVNMLMSFKNSPEEEVCPVPEEVRNDLLTFHHDLLAHCGVHIEEEE QEEELDTSLRGRLLRLVAKVKSLRKKPEAEPEPEEDKKPSTLQELISHTMIHWAQESFIQ NPELVRLMFSLLHRQYDALGELIRALPKAYTINAVSVQDTMELLECLGQIRSLLIVQMGP EEERLMIQSIGNIMSNRVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRMVTNC CRFLCYFCRISRQNQRSMFDHLGYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQE QDLEMVVKYLAGCGLQSCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANV VVRLLIRRPECFGPALRGEGGNGLLAAIEEAIKISEDPARDGPTVKKDRRFPMFGGEEQH EENRVHLGNAIMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVIS LPFQIPAFGKDNSIIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMR AAASLDTAAFSTTEMALALNRYLCSAVLPLITKCAPLFAGTDHRAIMIDSMLHTIYRLSR GRSLTKAQRDVIEECLMSLCRYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERC WKYYCLPNGWANFGVSSEEELHLTRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIP PDYVDASYSSKTEKKASVDAEGNFDPKPVDTTNTIIPEKLDGFINRYAEYTHDKWAFEKI QNNWTFGEVLDENAKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWEWTLDKARDGDD EKTEKKTARKISQTAQVTYDPSHGYSPQPIDISGMTLSRELQSMAEQLAENYHNTWGRKK KMELQAKGGGTHPLLVPYDTLTAKEKARDREKAYELLKFLQLNGYAVTRGLKDMESDISS IEKRFAYGFLQKLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYF KNHCLYFLSTPAKILGSGGHASNKEKEMIASIFCKMSALVRHRVFLFGTDAPAIVNCLHI LARSLDARTVMKSGPEIVKAGLRLFFESAADDIEKMVENLKLGKVSKGNQPVKGVSQNIN YTTTALLPVLTSLFDHIAQHQFGDDVILDDLQMSCYRITCSIYSSGTVKTPHAERHRPAL GECLAHLAAAMPVAYLEPHLNEYNAFSVYTTKTPRERAILGLPNHVHELCDIPELDILLK EIGDLAESGARYTEMPHVIEVTLPMLCNYLPRWWERGVEIFPELEGKLCTDVTSDHLNQL LGSIMKIVVNNLGIDEASWMKRLAVFSQPIVSRAKAEMLKSHFIPTMEKLKKRTAKVVAE EEHLRMEGKSEGDEEEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCRDPDAEELF RMVGEVFIFWSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKTGDSEAGGTDVERTK KKRRGDRYSVQTSLIVAALKKILPIGLNMCSPADQELINLAKTRYSLKDTNEEVREFLQN NLHLQGKVDNPSMRWQMALYKEMAGKAEDADAPEKVVMRVQEVSAVLYHIEVTEHPFKSK KMVWHKLLSKQRRRAVVACFRMTPLYNLPRHRACNMFLDGYKRNWIQTEGYSFEDRMIDD LSKAMEKEEEEEEEKETKPDPLHQLILHFSRTALTEKSKLDIDYLYMAYADIMAKSCHMG EEDEGGEEEEEGGEEEMPFEVRQTEMEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKG ETGCMVSSTLKLGISILNGGNSEVQQKMLDYLKDKKDVGFFLSVQALMQTCSVLDLNAFE RQNKAEGLGMVSEEGTNVKLERGEKVMADDEFTCDLFRFVQLLCEGHNNDFQNYLRTQTG STTTINVIICTVDYLLRLQESISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEY IQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQGRDSSQIGLLKELLDLQKDMVVM LLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRG LISKKDFQKAMDSQKQYTPVEIQFLLSCSEADENEMINYEEFASRFQEPAKDIGFNIAVL LTNLSEHVPHDTRLQNFLEQAESVLNYFRPFLGRIEIMGASRKIERIYFEISEVNRKQWE MPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMNIASQISEQDEEEKEEDDAEE PDGGGGGDEEAGGEEGQPESSSAFSDFIQSIMNFLGMFTFRNIRRQYRRLRKMTIKDIVV QLATFLWTILMGILYFIYSVCKGLFLLIWHTLFGGGLVEGAKNITVTELLASMPDPTQDE VHGDLPGEPRGGEEQDTGGITDSMEVGGGEEEDEDIQEKDGGKIPGIDTPGGLGDMGDTT PVEPPTPEGTPLLKRKMQPEEAGPEQPPAIEEPPPEPEKADTENGEKAEKEAEVKPEATP EEPKPEKATKAKKEKKSVKGAGFELWNELDVQRNKFMNCLSRNFYNLRFLALFIAFALNF ILLFYKVSGTPPISDEFDGSGMFEGSGLFEGPGEDFEGSAGEDGGDDDDDEEGPVYFFLE ESTGYMQPTLSCLAIVHTIIAFLSIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQPE DDDIKGQWDRLVLNTPSFPTNYWDKFVKRKGLDKYGDIYGRERIAELLGMDLASLDVSKQ QTDKKPEEPDNSMLAWLTSIDIKYQIWKFGVVFTDNTFLYLVWYTVMSLLGHYNNFFFAC HLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDE PDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAI IQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFF LMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15261 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggagctgagggagaggaggaaatccagttcttacgaacagatgaccaggtg gttctacagtgcactgctactatcctgaaggagcagatcaaactctgtctgtcctgtgag ggttttgggaatcgcctgtgttttctggaaactacgtccaatgcccagaatgttcctcct gatctggctatatgctgctttattctggagcagtccttatctgtgcgggcccttcaggag atgctggctaacacaactgagcttaatgaggcagtcgatttggataaatggtcttcacaa ggaggaggccaccgcacgttgttgtatggccacgccatcctgctcagacacactcactct ggcatgtacctcagctgtttgacgacatcaaggtcactcacagacaagctggcctttgac gtgggcttgcgtgaggagtcgacaggtgaggcatgttggtggaccattcaccctgcatcc aagcagaggtcagagggtgagaaggtcagggtgggcgacgatctcatcctggttagcgtg tcttctgaaagatatctgcacctttcctatgccagcggagacctcatggtggatgcttct tttatgcaaactctttggaacatgaacccagtctgttctggttgtgagctggcagagggg tatctgactggagggcatgttctgcgtcttttccacgggcacatggatgaatgtttaaca attcctactgctgaccagggcgatgaccagagacgaaatgcacactatgaaggtggagcc gtgtgcagccacgccagatctctgtggaggctggagcctcttcgcattgggtggagtggt agccacatgaagtggggtcaatccttcagagtgcgtcacatcaccacaggcaggtatttg tgtctggatgaagagaaaggactcctgcttgtggatgcggaaaaagcgaatacaaagaac tctgctttctgctttcgagcttcaaaggagaagacggaggtggctcagaaacgtgatgtg gagggaatggggatcccagagatcaagtatggagagtccatgtgctttgtgcagcatgtc tctaccagtctatggcttacatatgcctcggtggatgccaaatctgctcggctggggcca ctgaaaaggaaggctatacttcatcaggagggtcacatggatgatgctctgactgtggcg cgttctcaaacagcagaatcccaggctgctagaatgatctatagcacaacaggactcttc actcagttcattaagggtctggactctctgagagggaagagtaaatctccaggcccatcg tccccgtctctgcctctagatgccgtggttctgtccctgcaggatctcatcttctatttc cgccctccagaggaggagctggaacatgaggagaagcagaccaaactgcgctccttaagg aaccgacagaatctattccaagaggagggcatgatcagtcttgtattggactgtgttgat cggctgaatgtctacaacacttcagcccacttctcagaatttgccggggaagaagcagca gagtactggaaagagatagtcaacttattttatgagctgttggcatctctgatcagagga aacagggcaaactgtgctttgttctgtgataatcttgactggttggtcagcaaactggac cgtttagaggcatcctcaggcattctggaggtgctgtattgtatccttattgaaagccct gaggtgcttaacatcatccaggagaaccacatcaaatctatcattgcacttttggacaaa catggacgcaatcacaaggttctagatgtcctctgctctttatgcgtgtgtaatggtgtt gccgtgaggtccaatcagaatctgatcactgagaatctgcttccagggcgtgatctcctc ctgcagaccaacatcatcaattatgtcaccagtatgagacccaacatttttctgggcaca tgtgaaggctctacacaatataagaagtggtactacgagttaattgtagaccatgtggag tcattcttgactgctcaggcatgtcaccttcgtgttggctgggctttgaccgagggttac agcccttaccctggaggaggagagggatggggaagcaatggagttggagatgatctttac tcatacggctttgatgggctacatctgtggacaggtcgcgtactacgtcaggtgtcctca tcaaatccacacattctcgcggctggagatgtggtgagctgctgtttggatctgagcgtt cccagcatctccttccggatcaatggacatcccgttcaaggcatgtttgagaacttcaac ctggatggtctctttttccctgcggtcagcttctcagctgggatcaaagttcggtttctc cttggtggacggcatggagactttaaattccttcctcctcctggttatgccccatgctat gaggcagttctgcccaaagatagactgcgtattgagcccattaaagagtacaagcatgac tttgatggggtccggaaccttttgggaccgacccagtctctttctcacactgccttcact ccctgcccggtggacactgtgcagattgtgcttcctcctcatctagagcggattagagag aaactggctgagaacagccatgagctgtgggccgtcactcgaattgagcagggctggacc tatgggccgtttcgtgatgacaacaagaagctgcatccttgtctagtggatttccagagc ctcccagagcctgagaagaactacaacttggcaatgtccggagagacactgaagactctt ctggctttaggatgtcacgttggcatgggtgacgaaaaagcagaggagaacttgaagaaa atcaaacttcctaaaacgtatatgcaaagtaatggatacaaacctgctcctctggacctc aaccatgtgaaactgacaccgaatcagaacacacttgtggaaagactggctgaaaatgga cacaacgtctgggctcgagaccgtgttcgtcaaggctggacttacagcattattcaggac attgtgaacaagcgcaacccccgtcttgtgccatacaatctactggatgaaaagacgaaa aagaccaatcgtgacagtgtatgtgccgctgtacggactctaattggctatggctacaat attgagccacctgaccaggagagcagtggccatggggctggcagtggtcggagtgataag atccgtgtgttcagggcagagaaatcctacgccgtaacccagggaaaatggtactttgag tttgaggcggtaacagtgggagagatgagagttgggtgggcaagaccaagtgtccatgca gacagagagttgggatcagatgacctggcctatgtcttcaatgggttcaaggctcagcgt tggcacatagggaatgagccatttggccggcagtggcagtctggtgacgtggtgggctgc atgattgacctgacggagcagaacatcatgtttactctgaatggagaaatgcttattagt gactctggatctgagatggccttcaaagacattgagatcggagaaggcttcatccctgtg tgcagtctggggctgtctcaggttggccgtatcaaccttgggcagaatgtgagcagcctg cgttacttcacaatctgtggcctgcaggaaggttttgagccttttgccatcaacatgaag agagatatcaccatgtggttcagcaagagcttgccccagtttgtgcctgtgccaacagac caccctcatattgaggtgtcccgtgtggatggaacagtggatagcgccccttgtctgaaa ctgaaccataggacatttgggtctcagaatgccaacacaggccttctgttctttagactc agcatgccaatcgaattccatgaaaccttcaaagtgccagtgggagcttcacccctcacc cgaaccctcactatccctgaggatgaggcccttgaggtggaccctgaatctgaatttgag ctcctgaagaagtcagccactcgtaaggagcaagatgagaaagaaaaagagccatctgtc cctaaagagcttcctggcaacaaagagggcgagaatgagaaggacaccaccacagagaag agcaaaaagagagggtttttttccaaggcgaagaaggcagcgtttattgccccaccaccg gtggttccaacagtgcctcgtctgatggaggacgttgtcccagatgatcgagacgatact gatattatctctagcacaacgacttattattattcagtccgggtctttgccggacaggag cccagtggagtatgggtagggtgggtcactcctgactaccaccagtatgacccacatttt gatctgggtaaagtcagaaatgtaactgttacggttggggacgataaaggcaacattcat gacagtgtaaaacgcagcaattgctacatggtttggggaggagagtttagcagctcacag caaacacgcatcagccaggaggattttgtgattggctgcttggtggacctggacacagga ctgatgagctttacagccaatgggaaagagatcaatgccttctaccaggtggaacctaat actaagctcttccctgctgtcttttgtttgccgtcaagccagaacatgttacaggtggaa ctcggcaaactaaagaacattatgcccatctctgcggccatgttccgtagcgaccataag aatccggtccctcagtgtcctcccaggttggatgcccagatgttgacacctgtcatatgg agccggatgcccaatcactttttggctcctgaaactggccgtgtgagtgagaggcagggc tggaaattgcaatgcatggagcctcttattatgatggcgctgcacattccagaagaaaac aggtgcattgacatcctggaactgtcggagtgcaccgacctaatgaagttccattaccac acactgaaattgtacggctcggtgtgcgctctgggcaacaaccgtgtcgctcacgccctc tgcagccacgttgacgaatcgcagctcttttacgccatcgaaaacacctaccttcccggc cccatccgcagcggctactacgacttgctcatctccatgcacctagagtctgccaagcgc aaccgtctcatgactaataaagagttcattgtgcccatgacggatgacacacgtagcatc accctctattcagatgctgagaaggcccatgcgcttcctggtgttgggctcaccacctgt ctacgccccaaactacactttgccccaactggatttgtgggtactaatgcagacctttac accctcagtcccattttacctctgcagatgcttaaagaccatgccctcagcatgcttaca gaagccgtgcaggatggtgggcaggccatgcgagatcctgtaggtggcagcgttgagttc cactttgtgcccattctgaagctcattagcaccttgctaataatgggcgtgtttgatgac agcgacgtcaagcacatcctgaagctaatcgaaccatccgtcttcactgatggtgagaac ccagctgaagaactggaggctgccaaaactggagatgccgaacaacagctggtctgcaaa gaggaaggaatgaaggcaaaagaggaagaggaggaagtagagggtgaaaatgagagagag cagctggatgaagcaatgggagaggaagaggaagaagagcttgaagaagaggaggaggat gagctcgaacctgaggaggaggaatatgaaaagcatgcaggaaaagaagggaaggaggat gaacatgctgcagaaaaaatggatagagagaaaacaacagatgaagacgttgagaaagaa actggtgcagcagaagcaaaggaagaggaggatgtgggagagggactgctgcacatgaag cttcctgagtctgttaaacttcagatgtgtactctcctgcaatatttctgcgactgtgag ctacgtcacagagtggaagccataattgctttctcatacaggtttgtcaaccaggtgcag accaatcagagacagcgatataatgagctcatgcaggccttcacgatgagcgccgcagaa acagctcgcaagacccgcgaattccgctcccctccacaggaacaggtgaacatgttgatg agctttaagaactctccagaggaggaagtttgccccgttcctgaggaagtccggaatgac ctgctgacatttcaccatgaccttttggctcactgtggggttcatattgaagaggaagag caggaagaggagttggacacctctctgcgtgggcgcctcctgagactagtggcgaaagtt aagagcttgcgaaagaagccggaggctgagcctgaacctgaagaagataaaaaacccagt actctgcaggagctgatttcccacaccatgatccactgggctcaggagtctttcattcag aaccctgagctggtgcggctcatgttcagtctgctacaccgacagtacgacgccctgggt gagctgatccgagcattgcccaaagcctacactatcaatgcagtgtctgtgcaagacaca atggagctactggagtgtctgggacagatccgctccctgctcatcgtacagatggggcct gaagaggagaggctgatgatccaaagtattggaaatattatgagcaacagggtattctac cagcaccccaacctgatgagagctctggggatgcatgagacggtcatggaggttatggtg aacgtacttggaggtggagattccaaggagatcagattccctcgaatggtgaccaactgc tgtcgttttctgtgttatttctgccgtatcagcagacaaaatcagcgctcaatgtttgat cacctgggctacctcctgcagaacagtggcattgggctgggaatgcgtggctccactcct cttgatgttgctgctgcatcctgtatcgataataacgaacttgccctggccctccaagag caagacctggagatggtggtgaagtacttggcaggttgtggtctgcagagttgccccatg ctcttatcaaaaggttacccagatattgggtggaatccctgcggaggcgagaagtatctg gatttcctgcgctttgctgtattcgttaatggagagagcgtggaggagaacgctaacgtg gtggtccgactgctgatcaggaggcctgagtgttttggtcccgcgctgagaggagaaggg ggcaacggtctgcttgctgccattgaagaggccattaagatctcagaagatcctgcaaga gatggacccactgttaaaaaagacagacgcttccctatgtttggaggtgaagagcagcat gaggagaacagagtgcacctgggaaatgccatcatgtccttttactcagctctcattgat ttgctgggtcgctgtgcacctgagatgcatttgatccaagctggtaaaggcgaggctttg agaatcagggccattcttaggtctctggtgcctattgaggatctggttggtgtgatcagc ttgccattccagatccctgcttttggaaaagataacagcatcattgagccaaagatgtct gccagttttgtgcctgatcataaagcaccaatggtcctgttcctggacagagtttatggc atagacaaccaggacttcctgttgcatgtactggaagtgggcttcctgcctgacatgaga gcagcagcttccttagacacagccgcattcagcactaccgaaatggccctggcgctgaac cgttacctgtgctccgctgtgcttcctcttatcactaaatgtgctcctttatttgccggc acggaccaccgtgccatcatgatcgactccatgcttcacaccatctacaggctgtcccga ggacgctctctaaccaaagctcagagggatgttattgaggaatgcctcatgtctttgtgc aggtacctgcgtccatccatgctccagcacctcctcaggcggctggtgtttgacgtgccg attctgaacgagtatgctaaaatgccccttaagctgcttactaatcattacgagcgttgt tggaagtactattgtttgcctaatggctgggctaactttggcgtatcatcagaggaggag cttcatctgacccgtaaactcttctggggaatttttgaatctctagcccacaagaaattt gatgcagagctatttaaaattgccatgccatgtatatgtgcgattgctggagcgattcct cctgattatgtggatgccagttactcctccaaaacagagaaaaaggcctctgtcgatgct gagggcaactttgatcccaaacctgtggatacgaccaacactatcattccagagaagctg gacggtttcatcaacagatatgcagaatacacacacgataaatgggcttttgaaaagatt caaaacaactggacttttggtgaggtgctggatgaaaatgccaagactcatccaatgctc aggccttacaaaacgttctctgaaaaggataaagaaatctaccgctggcccattaaagag tccatcaaggccatgattgcgtgggagtggacgctggacaaagccagagatggagatgac gagaaaaccgaaaagaagacagctcgcaagatctcacagactgcacaggtgacttatgac cccagtcatggctacagccctcagcccattgatatctcaggcatgacactttccagagag ctacagtccatggcagagcagcttgcagaaaactaccacaacacctgggggcgcaaaaag aaaatggaattacaagcaaaagggggcggcacacaccctttgctagtgccttatgacaca ctgacggctaaagaaaaggctcgagatagagagaaggcatatgagctgctcaagtttctc cagctgaatggatatgctgtgacaagagggctcaaagatatggaaagtgacatttcctct attgagaagcgttttgcatatggcttcctacagaagctgctaaagtggatggatattgcc caggaattcatagcccatcttgaggctgttgtgagcagcggccgtgtggaaaagtcgcca cacgaacaagagataaagttcttcgccaagattcttttgcctttaataaatcaatatttt aaaaatcactgcctctacttcctttccacacctgccaaaatcctgggcagtggcggacat gcctccaacaaggaaaaagagatgattgcaagcatcttctgtaagatgtctgccctggtg cgacacagagtgtttctctttggtacggatgcacctgctattgtcaactgccttcatatc cttgcacggtcacttgatgccagaactgtgatgaaatctggacctgagatcgtaaaagca ggactgcgtttgttctttgagagtgcagctgatgacattgaaaagatggtggagaacctc aaactcggtaaagtgtccaaaggcaatcagccggttaaaggtgtatcccagaatattaac tacaccacaacagctctgctccctgtcctcacttcactgtttgaccacatcgctcaacac caatttggagatgatgttatcctggacgatttgcagatgtcctgttatcgaatcacgtgt agtatctactcttctggaactgtaaaaacacctcatgcagagaggcatagaccagccctt ggagaatgtcttgctcatctcgctgcagccatgcctgtggcctacctggagccccatctt aatgaatacaatgcgttttcagtgtacactaccaagacacctagagaaagagcaatcctg ggccttccgaaccacgtccatgagctgtgtgacattcctgagctagacatattattgaaa gagattggggacctggctgaatcgggggctcgctacactgaaatgcctcatgtgatcgag gtcaccctgcccatgctgtgtaactatctgccccgctggtgggagagaggagtggagatc tttcccgaattggagggtaagttgtgtacagacgtcacctctgatcatctcaaccagctt ctgggaagtatcatgaaaattgtggtcaacaacttgggaattgacgaagcttcctggatg aagaggcttgcagtgttctcccagcctattgtgagccgagccaaagcagagatgctcaaa tcccatttcattcccaccatggagaagctgaagaagcgtacagctaaagtagtggctgag gaggagcacctgcgtatggaggggaagtctgagggggacgaggaggaaggcactattaga gatgaatttgcagttctctgtagagacctatatgcgctgtaccctcttctcatccgctat gtggataacaacagagcaagatggctgacgtgccgggacccagatgctgaggagctgttc cgcatggtgggagaggtcttcatcttctggtccaaatctcataatttcaagcgagaggag caaaattttgtggtgatgaatgaaattaacaatatgtcctttctcactgctgacagtaag agcaagatgagcaagaccggggactctgaggctggtggcacggatgtggagcgtaccaag aaaaagagacggggagatcgatactctgttcaaacatccctcattgtggcggccctgaag aaaattcttcccattggactaaacatgtgctctcctgcagaccaggagctcattaacctg gccaagacacgctattctttgaaagacacaaatgaggaggtcagagagttcttgcaaaat aacctgcacctccagggcaaggttgataacccgtctatgcgctggcagatggcactgtat aaggaaatggcaggaaaggcagaagatgcagatgccccagagaaagttgtgatgcgggtt caagaggtctctgcagttctctaccacattgaagtgactgagcaccctttcaagtccaaa aagatggtttggcataaactgctgtcaaagcaacgacgtagagcagtggtggcttgtttt aggatgactccactttacaacctgcccaggcacagagcatgtaacatgttcctggatggg tacaagcgaaactggatccaaaccgaaggatattcctttgaggatagaatgattgatgac ctgtctaaagcaatggagaaagaagaagaggaggaagaagaaaaggagacaaagccagac cctcttcatcagctcatacttcactttagtcgcacagccctcaccgagaagagtaaactg gacatagattacttatacatggcatatgctgatatcatggctaagagttgccacatgggt gaagaggatgaggggggcgaggaggaggaagaggggggagaggaggagatgccctttgag gtgcgacagacagagatggagaaagagatggaaaagcaaagactcctctaccaacagtca cgtctccacaacagaggggctgctgagatggtcctacagatgattagcgcctgcaagggt gagactggttgcatggtctcttccaccctaaaacttggtatttccattctaaatggtggg aacagtgaggtccaacagaaaatgctggactatctgaaagacaagaaagatgtgggtttc ttcctcagtgtccaggctctaatgcagacctgcagtgttttggacctgaacgcctttgag aggcagaataaagcagagggtctaggtatggtgtcagaggagggaacaaacgtgaagcta gagcggggtgagaaggtcatggctgacgatgagttcacttgtgacctcttccgctttgtg cagctcctctgtgagggtcacaacaatgacttccagaactacctgagaacgcagacaggc agcaccaccaccatcaatgtgattatctgtacagtggattacctgcttagactacaggag tctatcagtgatttctactggtattattcaggaaaagacatcatagatgaaccaggcaag aggaacttctctaaagcgatgactgtggccaagcaggtgttcaacagccttactgagtat attcagggtccctgcacaggaaaccagcagtccctggcccacagtcgcctgtgggatgct gtggtgggctttctgcacgtgtttgcccatatgatgatgaaactggctcagggaagagat tccagtcagattggtcttctgaaagagttgttggaccttcagaaagatatggtggtcatg ttattgtctctgctggagggtaatgttgtaaatggcaccattgctcgccaaatggtggac atgctagtggagtcctccagcaatgtagaaatgatccttaaattctttgacatgttcctc aagctgaaggacattgttgcatctgatgcattccgcgactatgtgacagaccccagaggt ttgatatccaagaaggatttccagaaagccatggacagccagaaacagtacacacctgtg gagatccaattcctattgtcctgctctgaggcagatgagaatgagatgattaattacgag gagtttgccagtcggttccaagagccagcaaaagacattggttttaacatagcagtgctg ctaaccaacctctctgaacatgttcctcatgataccaggttgcagaatttccttgaacaa gctgagagcgttctgaactatttccgcccattcttgggtcgtattgagataatgggtgcc agcaggaagatcgagaggatctactttgagatcagtgaggtgaatcgtaagcaatgggaa atgcctcaggtcaaagagtccaagcggcagttcatatttgacgtggtcaatgaaggtggc gaatcagagaagatggagctttttgtcaacttctgtgaggacaccatctttgagatgaac atcgcttcacagatttcagagcaggatgaggaggagaaagaagaggacgatgccgaggaa cccgatggaggaggcggaggagatgaagaggcaggtggagaggagggccagccagaatca agctctgccttttccgatttcatccaaagcattatgaatttcctgggcatgtttaccttt aggaatattcgcagacagtaccgtaggctcaggaagatgaccatcaaggacattgtggtc cagcttgctaccttcctatggacaatcctcatgggcatcctctatttcatttacagtgtg tgtaaaggtttattcctgctcatctggcatacactttttggaggtggtttagttgaaggg gccaagaacatcaccgtgacggagttgctggccagcatgccggatcccacgcaggatgag gtgcatggagacctaccgggagaaccaaggggcggagaagagcaggatacaggagggata acagactcaatggaagtaggagggggagaggaggaggatgaggacatccaagaaaaagac ggtgggaagattcctggtatcgatacaccaggtggacttggagatatgggtgacacgacc cctgtggaaccgccaactccagagggcactccattactgaagaggaaaatgcaaccagaa gaagcaggacctgaacaacctcctgctattgaagaacctcctcctgagcctgagaaagca gacactgagaatggagagaaggctgagaaggaagcagaggtcaagcctgaggccacacca gaagaaccaaaacctgagaaagccactaaagccaaaaaggaaaagaaatcagtcaaggga gcaggatttgagctctggaatgagttggatgttcaaagaaataaattcatgaactgtttg tcccgtaacttctacaaccttcgtttcctggctttgttcatcgcctttgccctgaacttc attcttctcttctacaaggtatctggtactcctccgattagtgatgagtttgatggctca ggtatgtttgaaggctctgggctgtttgaaggccctggggaagactttgagggctctgct ggagaggatggaggtgatgatgatgatgatgaggaaggtcctgtgtattttttcctggaa gagagtaccggatacatgcagcccactttgtcctgcctggcaattgtgcacaccatcatt gctttcttatctatcattggatacaactgcctcaagattccactggtcatctttaagaga gagaaagagctggcaagaaagctggagttcgatgggctttacatcactgaacagccggag gatgatgacatcaaaggccaatgggacagattggtgctaaacacaccctcctttcccacc aactactgggacaaatttgttaagcgaaagggtctggataaatacggagatatttatggt cgtgagcgaatcgcagagctgctgggtatggatctggcatcgctggatgtcagcaaacaa cagacagacaagaaacccgaagagccagacaactctatgcttgcatggctcacttccatt gacatcaagtatcagatctggaaatttggagttgtgtttacagacaatactttcctctac ctggtgtggtacacagttatgtcacttcttggacattacaacaatttcttctttgcttgt cacctgctggacatcgcaatgggtgtcaagaccctgcgtacaattctttcctcggtcaca cacaatggaaaacagctgatgatgactgtgggtttgctggctgtggttgtgtacctctac actgtggtggccttcaacttcttcaggaagttctacaataagagcgaggatgaggatgag ccggacatgaagtgtgatgacatgatgacgtgttatctgttccacatgtacgtgggtgtg cgggcaggtggaggcataggagacgagattgaggacccagcaggggatgagtatgaactc tatcgggtggttttcgacatcaccttcttcttctttgtcatcgtcatcttgctggccatc attcaaggtctgatcattgatgcttttggtgagctgagagaccagcaagagcaggtcaaa gaagacatggagaccaaatgctttatatgtggtattgggagtgattacttcgatacaacg ccacatggctttgagacacatacgcttgaagaacacaacctggccaattacatgttcttc ctgatgtacttgatcaacaaggatgaaactgagcacactgggcaggaatcatacgtgtgg aagatgtaccaggagagatgctgggatttcttccctgctggagactgcttcagaaaacaa tatgaagaccagcttggataa

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