KEGG   Sus scrofa (pig): 100622999
Entry
100622999         CDS       T01009                                 
Symbol
ADCY8
Name
(RefSeq) adenylate cyclase type 8 isoform X1
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00230  Purine metabolism
ssc01100  Metabolic pathways
ssc01522  Endocrine resistance
ssc04015  Rap1 signaling pathway
ssc04020  Calcium signaling pathway
ssc04022  cGMP-PKG signaling pathway
ssc04024  cAMP signaling pathway
ssc04062  Chemokine signaling pathway
ssc04072  Phospholipase D signaling pathway
ssc04081  Hormone signaling
ssc04082  Neuroactive ligand signaling
ssc04114  Oocyte meiosis
ssc04211  Longevity regulating pathway
ssc04213  Longevity regulating pathway - multiple species
ssc04261  Adrenergic signaling in cardiomyocytes
ssc04270  Vascular smooth muscle contraction
ssc04371  Apelin signaling pathway
ssc04540  Gap junction
ssc04611  Platelet activation
ssc04713  Circadian entrainment
ssc04714  Thermogenesis
ssc04720  Long-term potentiation
ssc04723  Retrograde endocannabinoid signaling
ssc04724  Glutamatergic synapse
ssc04725  Cholinergic synapse
ssc04727  GABAergic synapse
ssc04742  Taste transduction
ssc04750  Inflammatory mediator regulation of TRP channels
ssc04911  Insulin secretion
ssc04912  GnRH signaling pathway
ssc04913  Ovarian steroidogenesis
ssc04914  Progesterone-mediated oocyte maturation
ssc04915  Estrogen signaling pathway
ssc04916  Melanogenesis
ssc04918  Thyroid hormone synthesis
ssc04921  Oxytocin signaling pathway
ssc04923  Regulation of lipolysis in adipocytes
ssc04925  Aldosterone synthesis and secretion
ssc04926  Relaxin signaling pathway
ssc04927  Cortisol synthesis and secretion
ssc04928  Parathyroid hormone synthesis, secretion and action
ssc04934  Cushing syndrome
ssc04935  Growth hormone synthesis, secretion and action
ssc04970  Salivary secretion
ssc04971  Gastric acid secretion
ssc04972  Pancreatic secretion
ssc04976  Bile secretion
ssc05032  Morphine addiction
ssc05163  Human cytomegalovirus infection
ssc05166  Human T-cell leukemia virus 1 infection
ssc05200  Pathways in cancer
ssc05207  Chemical carcinogenesis - receptor activation
ssc05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100622999 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100622999 (ADCY8)
   04371 Apelin signaling pathway
    100622999 (ADCY8)
   04020 Calcium signaling pathway
    100622999 (ADCY8)
   04072 Phospholipase D signaling pathway
    100622999 (ADCY8)
   04024 cAMP signaling pathway
    100622999 (ADCY8)
   04022 cGMP-PKG signaling pathway
    100622999 (ADCY8)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100622999 (ADCY8)
   04081 Hormone signaling
    100622999 (ADCY8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100622999 (ADCY8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100622999 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100622999 (ADCY8)
   04062 Chemokine signaling pathway
    100622999 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    100622999 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    100622999 (ADCY8)
   04912 GnRH signaling pathway
    100622999 (ADCY8)
   04913 Ovarian steroidogenesis
    100622999 (ADCY8)
   04915 Estrogen signaling pathway
    100622999 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    100622999 (ADCY8)
   04921 Oxytocin signaling pathway
    100622999 (ADCY8)
   04926 Relaxin signaling pathway
    100622999 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    100622999 (ADCY8)
   04918 Thyroid hormone synthesis
    100622999 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    100622999 (ADCY8)
   04916 Melanogenesis
    100622999 (ADCY8)
   04925 Aldosterone synthesis and secretion
    100622999 (ADCY8)
   04927 Cortisol synthesis and secretion
    100622999 (ADCY8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100622999 (ADCY8)
   04270 Vascular smooth muscle contraction
    100622999 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    100622999 (ADCY8)
   04971 Gastric acid secretion
    100622999 (ADCY8)
   04972 Pancreatic secretion
    100622999 (ADCY8)
   04976 Bile secretion
    100622999 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    100622999 (ADCY8)
   04727 GABAergic synapse
    100622999 (ADCY8)
   04725 Cholinergic synapse
    100622999 (ADCY8)
   04720 Long-term potentiation
    100622999 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    100622999 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    100622999 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    100622999 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    100622999 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    100622999 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100622999 (ADCY8)
   04714 Thermogenesis
    100622999 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100622999 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    100622999 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100622999 (ADCY8)
   05163 Human cytomegalovirus infection
    100622999 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    100622999 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    100622999 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100622999 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100622999 (ADCY8)
Enzymes [BR:ssc01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     100622999 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD
Other DBs
NCBI-GeneID: 100622999
NCBI-ProteinID: XP_020944562
UniProt: A0A4X1SSS5 A0A287AWF4
LinkDB
Position
4:9645398..9867065
AA seq 1250 aa
MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGS
GSGGSGKASDPAGGGPNHHASQLSGGDSALPLYSLGPRERAHSTGGTKVFPERSGSGSGS
GGGGDLGFLHLDCAPSNSDFFLSGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKS
EVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTY
LQYSGLVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSL
LQVVLQVLIPRLAVISINQVAAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARL
RLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVK
GFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHC
CVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLE
SGGIPGRIHISKATLDCLNGDYSVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDI
VKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQ
SGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFI
VLLFITAIQSLLPSSRVMPMVIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWINET
YLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGV
LAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKEAS
LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMQELREHNENMLRNILPSHVAR
HFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDEL
LGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWEHLCALADFSLALTESIQEINKHS
FNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILK
DQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQ
SLNRQRQKQLLNENSNPGIIKGHYNRRTLLTPSGPEPGAQAEGPDKSELP
NT seq 3753 nt   +upstreamnt  +downstreamnt
atggagctctcggatgtgcgctgccttagcggcagcgaggaactctacaccatccacccg
acgcccccggccggcgacggcgggagcggctctcggccgcagcggctgctgtggcagacg
gcggtgcggcacatcaccgagcagcgcttcatccacgggcaccggggcagcggcggcagc
ggcagcggaggctcgggcaaagcctcggaccctgccggcggcggccccaaccaccacgcg
tcgcagctgtccggcggcgactcggcgttgcccctctactcgctgggccccagggagaga
gcgcacagcaccggcggcaccaaagtcttcccggaacgcagcggcagcggcagcggcagc
ggcggcgggggcgacctgggcttcctgcacctggactgcgccccgagcaactcggatttc
ttcctcagtgggggctacagctaccgaggggtcattttccccaccctgcgcaactctttc
aagtcccgggatctggagcgcctctaccagcgctatttcctgggtcagaggcgcaaatcc
gaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggttctccacttg
agcctggcctcggcccccatggacccgctgaagggcatcctgctgggcttcttcactggc
atagaggtggtgatctgcgccctggtggtggtcaggaaggacaccacctcgcacacgtac
ctgcagtacagcggcctggtcacctgggtggccatgaccacccagatcttagcggccggt
cttggctatgggctcctgggagacggcatcggctacgtgctcttcaccctcttcgccacc
tacagcatgctgccgctgccgctcacctgggccatcctggctggcctgggcacctcgctg
ctgcaggtggtcctccaagtgctcatccccaggctggcggtcatttccatcaaccaggtt
gcagcccaggcagtgttattcatgtgtatgaacacagctggaatcttcatcagttacctg
tccgaccgggcccagcgccaagccttcctggagacgcggaggtgtgtggaggccaggctg
cgcctggagacggaaaaccaaagacaggagcggctggtgctgtccgtgctcccccggttt
gtggtcctggagatgatcaacgacatgaccaacgtggaagacgagcacctgcagcatcag
ttccatcggatctacatccatcgctacgagaacgtcagtattctttttgcagatgttaaa
ggatttaccaacctctccaccaccttgtctgctcaggagctggtcaggatgctcaacgag
ctctttgccagatttgatcgactggcccatgagcaccactgcctgcgcattaaaatcctg
ggcgactgctactactgcgtttcaggacttcctgagccccgccaggaccacgcccactgc
tgtgttgagatgggcctcagcatgatcaaaaccatcaggtatgtgcggtcaaggacaaag
catgacgttgacatgcgaattggaatccactcaggctcagtgctgtgtggcgtcttgggg
ctgcggaagtggcagtttgatgtctggtcttgggatgtggacattgcaaacaagcttgaa
tctggaggaatcccagggaggattcacatctccaaggcgacactggactgcctcaacggc
gactatagtgtggaagagggtcatggtaaagagaggaacgaatttttgaggaagcataac
atagagacctatttaattaagcagccggaggagagtctgctgtctttgcccgaagacatc
gtcaaggagtctgtgagctcctcagacaggagaaacagtggggcgacattcacagaagga
tcctggagccccgagctgcctttcgataacatagtggggaaacaaaacactctggctgcc
ctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcatgtccag
tctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagtggcgat
aaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagcctggag
cacaagtattctcaaatgagggatgaagtattcaaatcaaacttggtctgtgcatttatc
gtcctcctgtttatcacggcaatacaaagtttgcttccttcctcaagggtgatgcccatg
gtcatccagttttccatcctgatcatgctgcactcggcgctggtcctcatcaccacggca
gaggattataagtgtttgcccctggtcctccggaaaacctgctgttggattaacgagacc
tatttggccaggaacgtcatcatctttgcttccatcctgattaatttcctgggcgccatc
ctaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaat
tcctcagctgtgtttacagatatctgctcctacccagagtacttcgtcttcacgggggtg
ttggccatggtgacctgtgcagttttcctccgactgaactccgtcctgaagctggctgtg
ctgctgatcatgattgctatctatgccttgctgaccgagaccatctatgcagggctcttt
ctgcgctatgacaacctgaaccacagtggagaagatttcctggggaccaaggaggcatcg
ctgctgctgatggccatgttcctgctcgctgtgttctaccatggacagcagctggagtac
acggcccgcctggacttcctgtggagggtgcaggccaaggaggagatcaacgagatgcag
gagctgagggagcacaacgagaacatgctccgaaacatcctccccagccacgtggcccgc
cacttcctggagaaggaccgggacaacgaggagctgtattctcaatcctatgatgccgtt
ggggtgatgtttgcctccatcccagggtttgcagacttttactcccagacggaaatgaat
aaccaaggagtggaatgcctgcgcctgctcaatgagatcatcgccgacttcgatgagctg
ctcggggaagaccggtttcaagacattgagaagatcaagaccattggcagcacctacatg
gccgtgtcgggcctgtcaccggagaagcagcaatgcgaggataagtgggagcacctgtgc
gccctggccgacttctccctcgccctgaccgagagcatacaggagatcaacaagcattcc
ttcaacaatttcgagctccggatcggcatcagccacggctcggtggtagctggcgtcatt
ggcgctaagaaaccacagtacgacatctggggcaaaaccgtgaacctggcaagtcgaatg
gacagcacgggggtcagcggcaggatccaggtcccggaggagacctatctcatcctgaag
gaccagggcttcgcctttgactaccgaggggagatctacgtgaagggtatcagtgagcag
gaaggcaaaatcaaaacgtactttctcctgggcagagtccaacccaaccctttcatcctg
cccccgaggagactgcccgggcagtactccttggccgccgtggtcctgggcctcgtccag
tccctcaacaggcaaaggcagaagcagctactgaacgagaacagcaacccgggcatcatc
aagggccattacaaccggcggactttgctgacacccagcgggccggagccgggagcccag
gccgaaggccccgacaagtccgagctgccataa

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