Syngnathus scovelli (Gulf pipefish): 125972852 Help Entry 125972852         CDS       T08785                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b   KO K04961   ryanodine receptor 1 Organism sscv  Syngnathus scovelli (Gulf pipefish) Pathway sscv04020   Calcium signaling pathway sscv04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sscv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125972852 (ryr1b)    04020 Calcium signaling pathway     125972852 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:sscv01009]     125972852 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:sscv04147]     125972852 (ryr1b)    04040 Ion channels [BR:sscv04040]     125972852 (ryr1b) Protein phosphatases and associated proteins [BR:sscv01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      125972852 (ryr1b) Exosome [BR:sscv04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    125972852 (ryr1b) Ion channels [BR:sscv04040]  Voltage-gated cation channels   Ryanodine receptor    125972852 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  125972852 NCBI-ProteinID:  XP_049582818 LinkDB All DBs Position 7:3727593..3763387 Genome browser AA seq 5058 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTASILKEQQIKLCLSCEGFGNRLCFLETTSNAQKVP PDLAICSFILEQSLSVRALQEMLANTVEMTESSQGGGHRTLLYGHAILLRHNHSGMYLSC LTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYASGDLMVDASFMQTLWNMNPISSGCELAEGFLTGGHVLRLFHGHMDECLSISTPEE GEEKRRMAHYEGGAVCSQARSLWRLEPLRISWSGSHLKWGQSFRIRHITTGRYLCLDEEK GLMVADADQANTKVSAFCFRASKEKVDVAHKRDVEGMGIPEIKYGESMCFVQHVSTGLWM TYAALDAKAARLGMMKRKVILHQEGHMDDALTVSRSQTEESQAARMIYSTMGLFRQFIKG LDSLTAKNKSPGPLSLPLEGVILSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQE EGMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALF CDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLRSLCVCNGVAVRSNQNRITENLLPARDLLLQTNIVNYVTSVRPNIFLGTCEGSTQYK KWYYEMMVDYVEPFVTAQASHLRVGWAMTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWSGTVARQVASPAAHTLAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDALFFPV ISFSAGVKARFLLGGRHGDFKFMPPPGYAPCYEALLPRERMRIEPIKEYKHDFSGVRNLL GPTLSLTHTSFTPCPVDTVQIVLPPHLERIREKLAENIHELWAITRIEQGWTYGILRDDN KKLHPCLVDFQNLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKLPKTYI MSNGYKPAPLDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDILNKRNPR LVPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESTGHGLENIRGDKVRLFRAER SYAITQGKWYFEFEAVTTGEMRVGWARPNVHSDTELGADELAYVFNGNKAQRWHIGNEPF GRQWQSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCALGLSQV GRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFQPVPTDHNHLEVSR VDGTVDSAPCLKLTHKTFGSQNANTDMMFLRLSMPVQFHEIFKIPAGTTLLTRTLTIPED EVVVVEPDSEYEVLKKSASRKEQEEDKKEPSVPKEISVENEKDAMSEKGKKRGFFFKAKK AAMTPLAPPPAPPTVPRLVEDVVPDDRDDPEIILNTTTYYYSIRIFAGQEPTGVWIGWVT PDYHQFDPTFDLSKVRNVTVTVGDDKGNIHDSMKHSNCYMVWGGDLVSTQQTRFSQEDMV VGCLVDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFIQPSSQNMVQLELGKLKNIMPI SAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNRFLNPEVGKVNEKLGWMVECSEPLV MMALHIPEENRCIDILELSERQDLMKFHYHTLMLYCAVCALGNNRVAHALCSHVDESQLF YAIENTYLPGPLRSGYYDLLISIHLESAKRARLGTNKEFIVPMTEETLSISLYPDTKKAH SLPGVGLNTCLRPKLHFSSINFVGMDPDLYTLSPIFPLQELKTLAISMLTEAVLDGSQAM RDPVGGSVEFHFVPILKLISTLLIMGIFNDEDTKHILKMIDPNVFSGKEEEEEAPTEEAK GQADGEKEEGDEAELEDEGVGEEEEELKALEKGEHQMDKEPKEEAEETKEEDEAKGDKAE EEAKKEAELLEAELKEEEEGLEEGLLQMKLPESVKLQMCTLLQYFCDCELRHRVEAIVAY SDNFVHEIQSNQRVRYNDLMRAFTMSAAETARKTREFRSPPQDQVLLLTNFKHSPEDEDC PVPEDVRDTLGEFHNDLLLHCGVHIEEETEEEEVDTSLSGRLLSLVDKVTNLRKKEKEEK PEVEEEPKPSTLQELISHTMIHWAQESFIQNPELVRLMFSLLHRQYDGLGELIRALPKAY AINAVSYQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGGDSKEIRFPQMVTNCCRFLCYFCRISRQNQRSMFDHLGYLLQNS GIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLQMCPMLLSKGYPDI GWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAME EAIKISEDPARDGPTVKKDRRFMFGGEEQQEESRVHLGNAIMSFYSALIDLLGRCAPEMH LIEAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPSHGKDGQVVEPKMSGSFVPDHKAS MVLFLDRVYGIENQDFLLHVLEVGFLPDMRAAASLDTPAFSTTEMALALNRYLCSAVLPL LTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMWLCKYLRPSMLQH LLRRLVFDVPILNEYAKMSLKLLTNHYERCWKYYCLPNGWANFGVTSEEELHLSRKLFWG IFESLAHKKFDAELFKIAMPCLCGIAGAIPPDYVDASYSSHMEKKASVDAEGNFDPKPVE TTNTIIPERLDVFINKYAEHTHDKWAFEKIQNNWTYGEVLDENGKTHPMLRPYKTFSEKD KEIYRWPIKESIKAMLAWEWTLEKARDGEGDIEKAATRKLSQTAQATYDPSHGYSPQPID ITGMALSRELQSMAEQLAENYHNTWGRKKKLELQSKGGGTHPLLVPYDTLTAKEKARDRE KAQDVLKFLQLNGYAVTRGMKDMEQDISSIEKRFAYGFLQKLLKWMDIAQEFIAHLEAVV SSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKVLGSGGHSSNKEKEMIAS IFCKLAALVRHRVSLFGTDASAIVNCLHILSRSLDARTVMKSGPEIVKAGLRQFFESAAD DIEKMVENLKLGKVSSRNQVKGVAQNINYTTNALLPVLTSLFDHIAQHQFGDDVMMDDLQ ISCYRIMCSIYSLGTVKTPHVEKQRPALGECLAHLAAAMPVAFLEPELNEFNAFSVYTTK TPRERTILGLPSQVQELCPDIPELDILMKEIHDLAESGARYTEMPHVIEITLPMLCNYLP RWWERGLENFPDLEGQICTDVTSEHLNQLLGSIMKIVVNNLGIDEASWMKRLAVFAQPIV SRAKPEMLKSHFIPTMEKLKKRSGKVVAEEDHLRMEGKTEVDSENGTIRDEFAVLCRDLY ALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFKREEQNFVVMNEINN MSFLTADSKSKMSKAGDGESGGSEQERTKKKRRGDRYSVQTSLIVAALKKMLPIGLNMCS PADQELINLAKIRYSLKDTDEEVREFLHNNFHLQGKVEDPAMRWQMSLYKEMSGKAEDAE DQEKVVKRVQEVSAVLYHIEVTEHPFKSKKMVWHKLLSKQRRRAVVACFRMTPLYNIPTH RATNMFLDAYKRNWLETEGYSFEDKMIDDLSKALEEEEEEEEETETKPDPLHQLILHFSR TALTEKTKLDVDHLYMSYADIMAKSCHMGEDDEEGEQEGEEPSFEVRQTEMEKEMEKQRL LYQQSRLHGRGAAEMVLQMISACKGEPGVMVSSTLKLGISILNGGNCDVQQRMLDYLKDK KDVGFFLSVQALMQSCSVLDLNAFERQNKAEGLGMVSEEGTNKKLERDEKVMADDEFTCD LFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDYLLRLQESISDFYWYYSGKDIM DEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKL AQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIAKQMVDMLVESSSNVEMILKFFD MFLKLKDIVASDAFRDYVSDPRGLISKKDFSKAMDSQKQYSPTEIQFLLSCSEADENEMI NFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLNYFRPFLGRIEI MGASRKIERIYFEISEANRNQWEMPQVRESKRQFIFDVVNEGGESEKMELFVNFCEDTIF EMNIAASISEPEGDGAEEEDDEEEEEEAAKEGDGGEGEDGNGETPPPESASAFADFLTSV VNFFNMFTFRNLRRRYRKLRKMTVKEMVIGLATFVYTILMGVLMFVYSVCKGFFMLIWKV LFGGGLVEGAKKMTVTEILASMPDPTQDEVHGDLPPEPGAREIQDAEGAADLDAGGGEEE EEDGEEREGGRLPGFNAPGGLGDFGETTPEEPPTPEGTPLLKRKPLPEEGEGQEEAKGEI VEPEEEAPPETEKAETEADEKKPEKVEPEPEVKEEEPEKPTVKTKVKEKKAVEEGFELWN ELEVQRNKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVSDSPPGEEEFEGSGLFEGGS GLFEGSGADEEGSGFEDGGEDDEDEGPLYYFLEESTGYMEPALAFLSIVHTIISFLCIIG YNCLKVPLVIFKREKELARKLEFDGVYVTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFV KRKVLDKYGDIYGRERIAELLGMDLASLDVSAMTHDKKPEPDNSIFSWITSIDIKYQIWK FGVVFTDNTFLYLVWYMLMSMLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLMM TVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGD EIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCF ICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCW DFFPAGDCFRKQYEDQLG NT seq 15177 nt NT seq  +upstreamnt  +downstreamnt atggcggaagggggcgagggagaggaggagatccagttcctgcgaacggacgaccaggtg gttctgcagtgcaccgcttccatcttgaaggagcagcagatcaaactttgtctgtcctgc gagggcttcgggaaccgcctctgcttcctggagaccacgtccaacgcccagaaagtgcct cctgatttggcaatatgcagcttcattctggagcagtcgctgtcggtgcgtgccctgcag gagatgctggccaacacggtggagatgaccgagtcctcgcaaggtggcggccatcgcacc ttgttgtacggtcacgccatccttctcaggcacaaccactcgggcatgtacctgagctgt ttgaccacatctcgctcgctcacagacaagctggcctttgacgtgggcctgcaagaagat tccaccggcgaagcgtgttggtggacgattcatcccgcctccaagcagaggtctgaaggt gaaaaggtccgcgtgggggatgacctcatccttgtcagcgtttcctccgagagatacctg cacctgtcctacgctagtggagatctgatggtggacgcctccttcatgcagactctgtgg aatatgaaccccattagttctggatgtgaactcgctgaagggttcctgacgggcggtcac gttctcaggctcttccacggtcacatggacgagtgtctgagtatctccacaccggaggaa ggagaggagaagcgaagaatggctcactacgaaggcggtgccgtttgcagccaggctcgt tcattgtggcggttggagcctttgcgaatcagttggagcgggagccacttaaaatggggg caatctttccgcatccgccacatcaccacgggccggtacctgtgtctggatgaggagaag ggcctgatggtggcggacgcggaccaagccaacaccaaagtgtctgccttctgcttccgc gcctccaaggagaaagtggacgtggctcacaagcgagacgtggaggggatgggcatcccg gagatcaagtacggcgagtccatgtgcttcgtgcagcacgtgtccaccggcctgtggatg acgtacgccgcgctagatgccaaagcggcgcgtctggggatgatgaagaggaaggtcatc ctgcaccaagaaggacacatggacgatgccctgaccgtgtctcgctcccaaaccgaggag tcccaagcagctcggatgatttatagcaccatgggtctctttaggcagttcatcaagggt ttggactctctgaccgccaagaacaaatctccagggcctttgtctctccctctggagggc gtcatcctctccctgcaggatctcatcttctacttccgtcctcctgaggaggagctggag cacgaggagaagcaaaccaagcttcgctcccttcgtaaccggcagaatctcttccaggag gaggggatgatcaccatcgtgctggagtgcattgaccggctcaacgtgtacaacacggcg gcccacttctcggaatttgcaggcgaggaagcggcagagtcctggaaggagattgtcaat cttctctacgagctgctggcttcgctcatcaggggcaaccgctccaactgcgccttgttc tgcgacaacctggactggctggtcagcaaactggaccgcctggaggcctcatcaggtatt ctggaggtgctctactgtgtgctcattgaaagccccgaggttctaaacatcatccaagag aaccacatcaagtccatcatctctctcctggacaagcatggacggaaccacaaggttctg gatgtcctgcgctctctctgcgtgtgtaacggtgtggctgtgaggtccaatcagaaccgc atcactgagaacctgcttccggcccgagatctcctgctgcagaccaacattgtaaattat gtaaccagcgtccggccgaatatcttcttgggcacgtgcgagggctccacgcagtacaag aagtggtactacgagatgatggtggactacgtagaacccttcgtgacggcgcaggcgtcg catctccgcgtgggctgggccatgaccgaaggctacagcccctaccccggaggcggcgag ggctgggggggcaacggcgtgggcgacgacctctactcatacggcttcgacggcctccac ttgtggtcgggcacagtggcgcggcaggtcgcgtcacccgccgcgcacactttggcggcg gacgacgtggtcagttgttgtctggatctgagcgtgcccagtatctccttccggatcaac gggcaccccgttcagggcatgtttgaaaacttcaacgtggacgcccttttcttcccagtc atcagcttctcagcgggagtcaaagctcgcttcctgctgggcggtcgccacggcgacttc aagttcatgccgccgccgggttacgcgccgtgctacgaggcgctcctgcccagagagcgg atgcgcatcgagcccatcaaggagtacaaacacgacttcagcggcgttcgcaaccttctg gggccaaccctgtcgctcacccacacctctttcacgccgtgtcccgtggacaccgttcag attgtgctaccgccacacctcgagagaatccgagagaagctggcggagaatattcacgag ctgtgggcgatcactcgcatcgagcagggatggacctacgggattttgagagatgacaac aagaagcttcatccctgcttggtggacttccagaatctcccggagcccgagaggaactac aacctgcagatgtccggagagacgcttaagactctcctggctctgggctgccatgtgggc atgggtgacgaaaaagctgaggagaacctcaagaaaatcaagctgccaaagacctacata atgagcaatggatacaagccggcgccacttgacctcaatcacgtcaagctgacacccaac cagaaccagctggtggaaaaactggccgaaaacggacataatgtttgggcaagagatcgc gtccgacagggctggacttacagcatagtgcaggacatcctcaacaagcgaaaccctcgt ctggtgccttacaacttgctggacgagagaaccaagaagaccaacagggacagcgtcaac aacgccgtccgcacgctcatcggctacggctacaacattgagcctccggaccaggagagc actggccacggcctggagaacatccgcggcgataaggtccgactcttcagggccgagagg tcgtacgccatcacgcaagggaagtggtactttgagtttgaggcggtgaccacgggcgag atgcgagtgggctgggctcgtcccaacgtccactccgacactgagttgggagccgatgag ctcgcgtacgtcttcaacggcaacaaggcgcaacggtggcacatcggcaacgagcccttc ggccgccagtggcagtccggcgacgtggtgggctgcatgatcgacctgacggagatgaac atcatgttcacgctcaacggcgaaatgctgatcagcgactctggctcggagatggcgttc aaagatattgaaattggcgaaggtttcatcccagtttgcgctttgggcttgtcccaggtc ggacgaattaatctgggccagaatgtgagcagcctacgctacttcgccatctgcggcctt caggaaggcttcgagcccttcgccatcaacatgaagcgggacatcaccatgtggttcagc aaaagcctgccccagtttcagcccgtccccaccgaccacaaccacctggaggtctcccga gtggacgggaccgtggacagtgccccctgcctgaagctgacccacaagaccttcggctcg cagaacgccaacacggacatgatgttcctcaggctcagcatgcccgtccagttccacgag atcttcaagatcccggcgggcaccacgctgctcacccgaacgctcaccattcctgaggac gaagtggtggtggtggagcccgactcggagtatgaggtcctcaagaaatcagccagtcgc aaggagcaggaggaagacaagaaggagccgtctgtacccaaagagatctcggtggaaaac gagaaggacgccatgtcagagaaaggaaagaaaagaggatttttcttcaaggccaagaag gcggccatgacacctcttgcgcctccccccgcccctccaaccgtgccccgtttggtggaa gacgtggtccctgacgaccgagacgaccccgagatcattctaaacaccaccacttattac tattcgataaggatctttgccgggcaggagccgacaggcgtgtggatcggttgggttact cccgactaccaccagtttgatccaactttcgatctctccaaagtacggaacgtcacggtc actgtgggtgacgacaaaggcaacatccacgacagcatgaagcacagcaactgttacatg gtttggggaggggacctggtcagcactcagcagacccgcttcagtcaggaggacatggtg gtcggctgcctggtggacttggccacggggctcatgaccttcacggccaatggaaaggaa attaacaccttctaccaggtggagcccaacaccaagctgttccctgctgtcttcatccaa ccttccagccagaacatggtccaactggagctgggaaaactcaagaacatcatgcccatc tcggccgccatgttccgcagcgagcgcaagaacccggtgccccagtgccccccgaggctg gacgtccaaatgctgaccccggtcatctggagccggatgcccaatcgcttcctcaaccct gaggtgggcaaagtgaatgagaagctgggctggatggtggagtgcagcgaacctcttgtc atgatggctctgcacatccctgaggagaacaggtgtattgacatcttggagctgtcggag cgccaggacctgatgaagttccactaccacaccctgatgctctactgcgccgtatgcgcc ttgggcaacaaccgcgtggcccacgctctttgcagccacgtagacgaatcgcagctcttc tacgccatcgagaacacctacttgcccggtccgctccgcagcggctactacgacctcctc atcagtatccacctggagtcggccaagcgggcgcgcctgggcaccaacaaggagttcatc gtgcccatgacggaggaaacgctcagcatcagcctctatccggacaccaagaaggcccat tcccttcccggcgtgggtctcaacacctgcttgcgaccaaaacttcatttctcctccatc aattttgtgggcatggatccggatttgtatacgctgagtccaattttcccactgcaggag ctaaagacgctagccattagcatgctaacggaagccgtgctagacggtagccaggccatg cgcgacccggtgggaggtagcgtggagttccactttgttcccatcctcaagctgatcagc acactgctcatcatgggcatcttcaacgacgaggacaccaagcacatcctgaagatgatc gatcccaacgtgttcagcgggaaggaagaggaggaagaggcgccaacggaggaagctaaa ggccaagcggacggggagaaggaggaaggggatgaagccgagctggaggacgagggtgtg ggggaggaggaagaggagctgaaagctttggagaaaggagagcaccagatggacaaagag cccaaggaggaggcagaagagaccaaagaggaagacgaggccaaaggggataaagcagaa gaggaggcgaagaaggaggctgagttgctggaggcagaattgaaggaagaagaagaaggt ctggaggagggattgcttcagatgaagttgccggaatctgtcaaactgcagatgtgcacg ctcctgcagtacttctgcgactgcgagctacgccatcgcgtggaggccatcgtggcctac tcggacaactttgtgcacgaaattcagagcaaccagcgcgtccgttacaacgacctcatg agagccttcaccatgtcggctgccgagacggcacgcaagactcgcgagttccgctcgccg ccgcaggaccaggttcttctgctgaccaatttcaaacacagtcctgaggatgaagattgt cctgtgcccgaggatgttcgggacactctgggagagtttcacaatgacctcctccttcac tgcggcgtacatatcgaagaggagacggaggaagaggaggtggacacctcgctgagtgga agacttctcagtctggtggacaaagtgacaaacttgcgaaagaaggaaaaggaggagaag cccgaggtggaggaggagcctaaacccagcacccttcaggagctgatctcccacaccatg atccactgggcccaggaatcgttcatccagaacccggagctggttcgcctgatgttcagc ctgctccaccggcagtacgacggcctgggcgagctgatccgggcgctgcccaaagcgtac gccatcaacgccgtgtcctaccaggacaccatggaccttctggagtgcctgggccagatc cgatcgttgctcatcgtccagatgggaccggaggaggagcgcctcatgatccagagcatc gggaatatcatgaacaacaaggtgttctaccagcaccccaatttgatgagagctcttggt atgcacgagacggtcatggaggtgatggtcaacgtgttgggtggcggaggagactcaaag gagatccgcttcccccaaatggtgaccaactgctgccgcttcttgtgctacttctgccga atcagccgacagaaccagcgctccatgtttgaccatctgggctacctgctccagaacagt ggcatcggattgggcatgcggggctccactcctctggacgttgcggcggcctcttgcatc gacaacaacgagctggctttggcgctgcaggagcaggacctggagatggtggtgacgtac ttggcaggttgcggcctgcagatgtgccccatgctgctgtccaagggctaccccgacatt ggctggaacccctgcggaggggaacgatatttggacttcctgcgctttgccgtctttgtg aatggagagagcgtggaggagaacgccaacgtggtggtgcgtcttctcatccgccggccc gagtgcttcggcccggcgttgcgaggtgagggcggcaacggtctgctggccgccatggag gaggccatcaagatctcggaggacccggcgagggacggacctactgtcaaaaaagacaga cgcttcatgttcggtggtgaggagcaacaggaagaaagccgcgtgcatctggggaacgcc atcatgtccttctactcggccctcattgacttgctgggtcgctgcgccccagagatgcac ctgatcgaagcaggcaagggcgaagctctgaggatccgagccatcctgaggtctctggtg ccaatcgaagatcttgttggagtcatcagtttgcccgtacagattccttcgcacggaaaa gatggtcaggttgtagagcccaagatgtccggaagcttcgtgcccgaccacaaagcctcc atggtgctcttcctggacagagtctacggtattgagaaccaggacttcctgctgcacgtg ctggaggtcggcttcctgcccgacatgcgagccgcggcttctctcgacaccccggctttc agcaccacggaaatggcgctggcactgaaccgctacctctgctcggccgtcctgcctctt ctcactaaatgcgccccgctattcgccggcaccgaccaccgcgccatcatgatcgactcc atgctgcacaccatctaccggctttcccgcggccgagccctcaccaaggcccagcgggac gtcatcgaggagtgcctcatgtggctctgcaagtacctccggccgtccatgcttcagcat ctgctcaggcggctggtgtttgacgtgcccatcctcaacgaatatgcaaagatgtcgctc aagcttctgaccaatcactacgagcgctgctggaagtattactgcttgccgaacggctgg gccaacttcggcgtgacctcggaggaggagctccatctttcccgcaaactcttctgggga atctttgagtcgttggcccacaaaaaattcgacgcggagctcttcaaaatcgccatgccg tgcctgtgcggcatcgcgggggccatcccgcccgactacgtggatgccagctactcctct cacatggaaaagaaagcgtctgtggatgccgagggcaactttgatcccaaaccggtggag accaccaacaccatcatccccgagaggttggacgtctttatcaacaagtacgcggagcat actcatgataaatgggcatttgaaaagattcagaacaactggacctacggagaggtgctg gacgagaacggcaagactcacccaatgctcaggccgtacaaaacattctcagaaaaggac aaagagatctaccgctggccaatcaaagagtccatcaaagccatgctggcatgggagtgg accttggagaaagcccgagatggcgagggagacattgaaaaggccgccacacgcaaactc tcccaaactgctcaggctacgtatgatcccagccacggttacagccctcaaccaatagac atcaccggaatggctttgtccagagagctgcagtccatggccgagcagctggctgaaaac taccacaacacgtggggccggaagaagaagctggagcttcagtctaaaggtggcggcacg catcctctgctggtgccttacgacaccttgacggctaaggagaaggccagagaccgagaa aaagcacaggatgtcctcaagttcctccaactcaacggatacgccgtcaccaggggcatg aaggacatggagcaggacatctcatccatcgagaagcgctttgcctacggcttcctccag aagcttctcaaatggatggacattgcccaggagttcatcgctcatctggaggccgtggtt agcagtgggcgagtggagaagtcaccacatgagcaagaaatcaaattttttgccaagatt ctcttaccacttgtgaatcagtacttcaagaaccactgcctctacttcctctccacccct gctaaagttctgggaagtggaggacattcctccaacaaggagaaggaaatgatcgcaagt atcttctgtaaattggctgctttggtgaggcacagagtttctctttttggaacggatgca agtgccattgtcaactgccttcacattctgtcccgctcgctggatgccaggaccgtaatg aagtcagggcccgagatcgtcaaggccggcttgcgtcagttctttgagagtgctgccgac gacattgagaagatggtggagaatctcaagctgggcaaggtttccagccgcaaccaggtg aaaggcgtggcccaaaacatcaactacaccaccaacgctctcctgcccgtcctcacgtcg ctcttcgaccacatcgctcagcaccagtttggagacgatgtcatgatggacgacttgcaa atctcctgttaccggatcatgtgcagcatctactcgctgggcacggtcaagacaccgcat gtggagaaacagcgtcccgctcttggcgaatgtttggcgcacttggcagccgccatgccc gtcgccttccttgagcccgagctgaatgagttcaatgctttttcagtttacaccactaag acgccccgagaaagaaccattcttggcctccccagccaagtacaggagttgtgccccgac atccccgagctagacatcctcatgaaggagatccacgacctggctgagtcgggggcgcgc tacacggaaatgccccatgtgatcgagatcacgctgcccatgctgtgcaattacctacca cgctggtgggagaggggcctggagaacttccccgatctggagggccagatttgcaccgac gtcacctcggagcacctcaaccagctcctgggtagcatcatgaagatcgtggtcaacaac ctgggcatcgacgaggcctcctggatgaagaggttggcagtgttcgcccagcccatcgtg agccgggccaagccggagatgctcaagtcccatttcatccccaccatggagaaactgaag aagcgctcaggcaaggtggtggccgaggaggaccatctgcgtatggaaggcaagacggag gtggacagcgagaacgggaccatccgggatgagtttgccgtgctgtgccgcgacctttac gccctctaccctttgctcatccgctacgtggacaacaacagggcgaggtggctgacgtgt cccgatcccgacgctgaggagctctttaggatggtgggcgaggtcttcattttctggtcc aaatcccacaatttcaaacgcgaggagcagaactttgtggtgatgaacgagatcaacaac atgtccttcctcaccgccgatagtaagagcaagatgagcaaggccggagacggagagtcc ggaggctccgagcaggagcgtaccaagaagaagcggcggggggaccgctactcggtgcag acctcgcttatcgtggcggcgctaaagaagatgctccccatcggcctcaacatgtgctca cccgccgatcaggagctcatcaacctagccaaaatcagatactcactgaaagataccgat gaagaagtgagggagtttttacacaacaattttcatctccaaggcaaagtggaggacccg gccatgcgctggcagatgtccctctacaaggagatgtctggaaaggcggaagatgctgag gaccaagagaaggtggtcaaaagggtccaagaggtgtctgctgtcctctaccacattgaa gtgacagagcatcccttcaagtccaagaagatggtgtggcacaagttgttgtccaaacag cggcgaagagccgtggtggcctgcttcaggatgacgcccctctacaacatccccacgcac cgagccaccaacatgtttctggacgcctacaagcgcaactggctggagacggagggctac tccttcgaggacaagatgattgacgacttatcgaaagccctggaggaagaggaggaggag gaagaagagacggagaccaagcccgacccgcttcatcagctcatcctgcatttcagccga accgctctcactgagaaaacaaaactggatgtcgaccatctctatatgtcgtacgctgac atcatggcaaagagttgccatatgggtgaggatgacgaggagggagaacaggagggggag gagccatcctttgaggtgcggcagacagagatggaaaaggagatggagaagcagaggctc ctctaccagcagtcccgcttgcatggccgcggggccgccgagatggttctgcagatgatc agcgcctgcaaaggtgagccgggagtcatggtttcttccactctcaaactgggaatctcc atcctcaatggaggcaactgcgatgtgcagcagagaatgctggactacctgaaggacaaa aaggacgtgggcttcttcctgagcgttcaagctctgatgcaaagctgcagcgttttggac ctgaatgctttcgagagacagaacaaggctgaaggacttggaatggtgtcagaagagggc accaacaagaagctcgaacgtgatgagaaagtgatggcggacgatgagttcacgtgcgac ctcttccgcttcctgcagctgctctgtgagggccacaataatgacttccagaactacctg aggacccagaccggcagcaccaccaccattaatgtcatcatttgcacggtggactacctg ctacgacttcaggaatccatcagtgacttctactggtactactcgggcaaggacatcatg gacgagcccggcaagaggaacttctccaaagccatgactgtggccaagcaagtcttcaac agcttaaccgagtacatccagggtccatgcacgggcaaccagcaatcgttggcgcacagc aggctgtgggacgccgtggtgggcttcctccacgtcttcgctcacatgatgatgaagctg gctcaggattcgagtcaaatcgggctgttgaaggaactgttggatctacagaaggacatg gtggtgatgcttctgtctcttctggaaggcaacgttgtgaacgggaccatcgccaagcag atggtggacatgctggtggagtcctccagcaacgtggagatgatcctcaagttcttcgac atgttcctcaagctgaaggacatcgtcgcatccgacgccttccgcgactacgttagcgac ccgcgagggctcatctccaagaaggacttctccaaggccatggacagccagaagcagtac tcacccacggaaatccagttcctcctgtcctgctcggaagccgacgagaatgaaatgatc aactttgaggaattcgccgaccggttccaggagccggccaaggacatcggtttcaacatc gccgtcctcctcaccaacctgtcggagcatgtgccgcacgacacgcggttgcagaacttc ttggagcaggcggagagcgtgctcaactacttccgccccttcctgggccgcatcgagatc atgggcgccagccgcaagatcgagcgaatctacttcgagatcagtgaggccaaccgcaac cagtgggagatgccacaggtgcgcgagtccaaacgccaattcatcttcgacgtggtcaac gagggcggcgagagcgagaagatggagctctttgtcaacttctgcgaggacaccatcttt gaaatgaacatcgccgcctccatctccgagcccgaaggagacggcgccgaagaggaagat gatgaggaagaggaagaagaggcggccaaagagggcgacggcggcgaaggcgaggacggc aacggcgaaactccgcctccggaatccgcctcggcctttgccgacttcctgaccagcgtg gtcaatttcttcaacatgttcaccttccgtaacctgcggcggcgttaccgcaagctacgc aagatgacggtgaaggagatggttatcggcctggccaccttcgtctacaccatcctcatg ggcgtcctgatgttcgtctacagcgtctgcaagggcttcttcatgctcatttggaaagtg ctcttcggcggcggcctggtggaaggcgccaagaagatgacggtgaccgagatcctggcc agcatgccggacccaacgcaggacgaagttcacggcgacctgccgcccgaaccgggagca agagagattcaagatgcggaaggagcggctgacttagatgcgggagggggcgaggaggaa gaggaggacggcgaggaacgggaagggggacgcctgcctggtttcaacgctcccggcgga ctcggagactttggggagaccacgccggaagaaccgcccactcctgagggcacgccgcta ctcaagaggaaaccgttgcctgaagagggtgaaggtcaagaagaggcaaaaggagaaatt gtcgaacctgaagaagaggcccctccggagacagagaaagcagagaccgaggccgacgaa aagaagcccgagaaggttgaacccgagcccgaggtcaaggaggaagaacccgagaagccg acggtgaagacaaaggtgaaggagaagaaagcggtagaggaaggttttgagttgtggaac gaactggaggtccagaggaataaattcatgaactacctctctagaaacttctacaacctg cgcttcctggccctcttcatcgcttttgccctcaacttcatcctgctcttctacaaggtg tcggacagccccccgggcgaggaggaatttgaaggatcgggtcttttcgagggcggctcg ggactgttcgaaggctccggcgctgatgaggaaggatccggtttcgaagacggcggcgag gacgacgaagacgagggccccctgtactacttcctggaggagagcaccgggtacatggag ccggcgttggccttcctcagcatcgtccacaccatcatctccttcctctgtatcatcggc tacaactgcctcaaggttcctctggttatcttcaagcgagaaaaggagctggcccggaaa ctggagtttgacggcgtttatgtaacggagcagcccgaagacgacgatatcaagggacag tgggaccgactggtgctcaacactccatctttccccaacaactactgggacaagtttgtg aaaaggaaggtgttggataaatacggcgacatctacggaagggagaggatcgccgagttg ctgggcatggacttggcttccctggacgtcagtgccatgacgcacgacaagaagccggag cccgacaactcaatcttcagctggataacatccatagacatcaagtaccagatctggaaa tttggtgttgtgttcacggacaataccttcctgtacctggtctggtacatgctcatgtcc atgctgggccattacaacaacttcttcttcgccgctcacctgctggacatcgccatggga gtcaaaaccctgcgcaccatcttgtcctcggtcacccacaacggaaagcagctgatgatg acggtgggtctcctggccgtggtggtgtacctctacaccgtggtggccttcaacttcttc cgcaagttctacaacaagagcgaggacgaggacgagcccgacatgaagtgcgacgacatg atgacatgctacttgttccacatgtacgtcggcgttcgggccggcggcggcatcggagac gagatcgaggacccggccggagacgaatacgagctctaccgagtggttttcgatatcacc ttcttcttctttgtcatcgtcatcctgctggccatcattcagggtttgatcattgatgcc ttcggcgagctgagagaccagcaggagcaggtcagggaggacatggagacaaaatgcttc atctgcgggatcggcagcgactattttgacacgacgccgcacggcttcgagacgcacact ttagaggaacacaacttggccaactatatgtttttcctgatgtatctcatcaacaaagat gaaacggagcacaccggccaggagtcgtacgtgtggaagatgtaccaggagcgctgctgg gactttttccccgccggggactgcttccgaaagcagtatgaggatcagctggggtaa

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