Solea senegalensis (Senegalese sole): 122779385 Help Entry 122779385         CDS       T07721                                  Symbol ryr1a Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism ssen  Solea senegalensis (Senegalese sole) Pathway ssen04020   Calcium signaling pathway ssen04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ssen00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122779385 (ryr1a)    04020 Calcium signaling pathway     122779385 (ryr1a)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ssen01009]     122779385 (ryr1a)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ssen04147]     122779385 (ryr1a)    04040 Ion channels [BR:ssen04040]     122779385 (ryr1a) Protein phosphatases and associated proteins [BR:ssen01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      122779385 (ryr1a) Exosome [BR:ssen04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    122779385 (ryr1a) Ion channels [BR:ssen04040]  Voltage-gated cation channels   Ryanodine receptor    122779385 (ryr1a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  122779385 NCBI-ProteinID:  XP_043897603 LinkDB All DBs Position LG13:complement(22643648..22692112) Genome browser AA seq 5081 aa AA seqDB search MAEGADGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSNSSVDEAVDLDKWSSQGGGHRTLLYGHAILLKHTHSS MYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYASGDLMVDASFMQTLWTMTPVMSGCELAEGFLTGGYVLRLFHGHMDECLAI PGADQGDDQRRVVHYEGGAVCSHARSLWRLEPLRIGWSGGHIKWGQSFRIRHITTGRYLC LDEEKGLLLVDPEKAVSKMSAFCFRISKEKIEVTQKRDVEGMGIPEIKYGESMCFVQHVS SALWLTYAAVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEESQAARMIFSTTGLFN QFIKGLDALSGKNKSANPPSLPMDAVVLSLQDLIFYFRPPEEELEHEDKQFKLRSLKNRQ NLFQEEGMITLVLDCVDRLNVYNTAAHFSEYAGEEAAESWKEIVNLLYELLASLIRGNRA NCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR NHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDFLLQTSIINYVTSMRPNIFLGTCEG STQYKKWYFELMVDYVEPFVTAQPYHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYG FDGLHLWSGRVPRHVATPNQHVLAAEDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDG LFFPAVSFSAGVKFRFLLGGRHGDFKFLPPPGYAPCYEAVLPRDRLRIEPIKEYKHDFDG IRNLLGPHQSLSHTAFTPCPVDTIQIVLPPHLERIREKLAENSHELWAVTRIEQGWTFGP FRDDNKKLHPCLVDFQSLPEPEKTYNLAMSGETLKTLLALGCHVGMGDEKAEENLKRTKL PKTYMQSNGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIVQDIMN KRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGPGSSRGDKIRV FRAEKSYAVTQGKWYFEFEAVTVGEMRVGWARPSVRADTELGGDELAYVFNGFKAQRWHV GSESFGRQWQSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSL GLSQVGRINLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPTDHPH FEVSRVDGTVETAPCIKVTHKTFGSQNANTDLLFFRLSMPVEFHEFFKVPAGTTLLTRAL TIPEDEVLEVDPDSDFEILKKSASRKEQEEEKKEPSVPKEMPAIKNGENEKDASTEKSKK KGFLFKAKKAALITPPPVVPTMPRLMEDVVPDDRDDVDIILNTTTYYYSVRVFAGQEPSG VWVGWITPDYHQYDLHYDLSKVRNVTVTVGDDKGNIHDSIKRSNCYMVCGGEFSSSQQTR VSQEDLLIGCLIDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSNQNMIQFELGK LKNIMPISAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLAPETGRISERLGWGV QCQEPLTMMALHIPEENKCIDILELSERMDLLKFHYHTLKLYGSVCALGNNRVAHALCSH VDESQLFYAIENTYLPGPMRSGFYDLLISMHLESAKRNRLGTNKEFIVPMTDETRSIILY TDKAHALPGVGLTTCLRPKLHFSSIGFVGVDQDIYTLSPVIPLQVLKTKALNMLTEAVQD GGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFDDEDVTHILKMIEPTVFSGKNADEPAE ENAKLKEEKEQKASPTLRGEEQEAVKEEDEEFEDDGLGDDEEDEEEVEEELEETESLRQH DETMTMQVNGEKGAEETEKELKPAETCVDTKVEHLEQGLFQMKLPESVKLQMCTLLQYFC DCELRHRVEAIIAFSDKFVNQIQSNQRQRYNELMQAFTMSAAETARKTREFRSPPQEQVN MLMNFKNCVEDEDSPVPDDVRESLLIFHNALLVHCGVHIEEEEQEEEVDNSVRGRLLRLL EKVNQFREKKVELEPEPQEDKKPSTLQELISHTMIHWAQESFIQNPELVRMMFSLLHRQY DGLGELIRALPKAYTINAVSIQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMSN KVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRVVTNCCRFLCYFCRISRQNQR SMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYLAGCGLQ SCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPAL RGEGGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENRVHLGNAIMSFYS ALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPSFGKDSSIIE PKMPASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTTEMA LALNRYLCSAVLPLITKCAPLFAGSDHRAIMIDSMLHTIYRLSRGRAFTKAQRDIIEECL MALCKHLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVA SEEELHLTRKLFWGIFESLAHKKFDAEIFKISMPCICSIAGAIPPDYVDASYSSKTEKKA SVDAEGNFDPKPVDTTNTIIPERLDPFINKYAEYTHDRWAFEKIQNNWSYGEVLDENAKN HPMLRPYKTFSEKDKEIYRWPIKESVKAMIAWEWNVEKAREEEESEKKKTASRKISQTAQ ATYDPSHGYSPQPIDVTHMALSRDLQSMAEQLAENYHNTWGRKKKMELQAKGGGTHPLLV PYDTLTAKEKARDREKAYELLKFLQLNGYAVTRGLKDMESDISSIEKRFAYGFLQKLLKW MEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMPLINQYFKNHCLYFLSTPAKVLG SGGHSSNKEKEMIASIFCKMSALVRHRVSLFGTDATAIVNCLHILARSLDARTVMKSGPE IVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSLFDH IAQHQFGDDVILDDLQMSCYRIMCSIYSLGTVKNPHVERQRPALGECLAHLAAAMPVAYL EPHLNEFNAFSVYTTKTPRERAILGLPSEVQELCPDIPELDALLKEIGDLAESGARYTEM PHVIEITLPMLCNYLPRWWERGLENFPEMESQLCTDVTSEHLNQLLGSIMKIVVNNLGID EASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKVVAEEDHLRMEGKSEGDEE DGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTFRDPDAEELFRMVGEVFIFWSKSHN FKREEQNFVVMNEINNMSFLTADSKSKMSKGGESEGGGSDTERTKKKKRGDRYSVQTSLI VAALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLQLQGKVDNPSMRW QMALYKEMAGKAEDADAPVKVVKRVQEVSAVLYHLEVTEHPFKSKKMVWHKLLSKQRRRA VVACFRMTPLYNIPRHRASNMFLEGYKRNWVHTEGYSFEDRMIDDLSKAMEQEEGDEEEE RETKPDPLHQLILHFSRTALTEKSKLDTDHLYMAYADIMAKSCHIGEEEEGGEEMVENTE DEMSFEVRQSELEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGPMVSTTLKLGI SILNGGNSEVQRKMLEYLKDKKDVGFFLSVQALMQTCCVLDLNAFERQNKAEGLGMVSEE GTKLNLDRDEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDY LLRLQESISDFYWYYSGKDVIDDPGKKNFSKAMTVAKQIFNSLTEYIQGPCTGNQQSLAH SRLWDAIVGFLHVFAHMMMKLAQGKDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTI ARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKSMDSQ KQYSPSEIQFLLSCSEADENDMINYEEFASRFQEPAKDIGFNIAVLLTNLSEHVPHDTRL KNFLGQAESVLNYFRPFLGRIEIMGASRKIERIYFEISEVNRRQWEMPQVRESKRQFIFD VVNEGGESEKMEMFVNFCEDTIFEMNIASQISEQEEEEKGEEDDEGDEGGGEAVPAGGAN GGGDEDINGEEGQPESSSAFADFINSLLSFFSIFTFRNLRRQYRRVRKMTFKEIIVALST FFWTILMSILHFIYNICKGFFMIIWQTLFGGGLVEGAKNITVTEILASMPDPTQDDVHGD GPGEPRTGEEQDTGGITDTGETGSGEEEEEDTQEKEGGRIFGIDAPGGLGDMGVEAPVEP PTPEGTPITKRKTPPEETASSQKPPEPVPVEEPPPEPEKADVESAEKESQSKEKMEPKKS ATKKEKKLKKEGGFQIWTELETQRNKFMNYLSRNFYNLRFLALFLAFALNFILLFYKVSE TPPDSEELEGSGLSEGSGLFEGSGLFEGSGEEFEGSGMDEGGDEDDEDVPIYFYLEESTG YMQPTLAFIAILHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLYISEQPEDDDI KGQWDRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGVDLASLDVSQQHEKK QEEPDNSVFAWVTSIDIKYQIWKFGVVFTDGTFLYLCWYLIMSLLGHYNNFFFACHLLDI AMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKC DDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLI IDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTFDEHNLANYMFFLMYLI NKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15246 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggtgcagatggagaggaagagattcagttcctgcgaacggacgatcaggtg gtgctgcaatgcaccgcatctatacttaaagaacagatcaagttgtgtttgtcctgcgaa ggctttgggaatcgtctttgtttccttgagaccacctcaaatgctcagaatgtccctcca gacctggctatctgttgcttcattttggagcagtccctgtctgtgcgagcattacaggag atgctgtccaactcttctgtagatgaggccgtcgatctggacaaatggtcatcacaaggc gggggtcatcgaaccctcctgtacggccatgcgattctcctgaaacacactcactccagc atgtacttgagctgtttgaccacgtcacgttcactcacagacaaactggcgtttgatgtg ggcttgcaggaggattccacaggagaggcgtgctggtggaccatacatccagcctctaag caaaggtctgaaggggagaaggtcagggtgggagatgacctcattcttgtcagtgtttcc tcagagcgatacctgcatctttcatacgccagtggtgacttgatggtagatgcgtccttc atgcaaacactgtggactatgaccccagtgatgtcaggttgtgagctagctgaaggattt ctgactggaggatatgtgctcaggctgttccatggtcacatggatgaatgtttggcaatt ccaggagctgaccaaggggacgaccagcgcagagttgttcattatgaaggtggtgcagtc tgcagtcatgcccgatccttatggagacttgagcctctacgtattggttggagtggaggt cacattaaatggggccagtctttccggatccgtcacataacaactggcaggtacctttgt ctggatgaggagaagggactgctgctggtggacccagagaaggctgtttccaagatgtct gccttctgctttagaatttcaaaggaaaaaattgaagtgacccagaagagagatgtggaa ggcatgggcattcctgaaattaaatacggagagtccatgtgcttcgtgcagcatgtttca tcagctctctggctgacatatgctgccgttgatgctaaatctgctcgtcttggcccttta aaaagaaaggccatactccacaaagaaggtcacatggatgatgcactcacagtggctcga tctcagactgaagagtcccaagctgccagaatgattttcagcacaactggcctcttcaac cagttcatcaaaggtctagatgctctgagtgggaaaaacaaatctgccaatcccccatct ctgccgatggacgcagtggtgctctccctgcaagacctcattttctacttccgtcccccg gaggaagagctggagcatgaggacaaacagttcaagcttcgctccctcaagaacagacag aacctcttccaggaggagggaatgattacacttgttctggactgtgtcgatcgactcaat gtctataacacagcagcccacttctcagagtacgctggggaggaagctgcagagtcctgg aaggagatagtaaatttactgtatgaactgttagcatctttgatcagaggtaaccgtgct aactgtgcactgttctgcgataacctcgactggcttgtcagtaaattggatcgtctggag gcatcgtcaggaatcctggaggtgttgtactgcgttctgattgagagtccagaggtgctg aatattattcaggagaatcacatcaaatcaatcatctctctgctggataagcatggacgc aatcataaggtcttggatgtgctctgttctctgtgcgtttgtaatggagtggctgttcgt tcaaatcagaatctcatcacagagaatctacttccaggacgggacttcctacttcaaacc agcattatcaattatgtaaccagcatgagacccaacattttccttggaacatgtgaagga tccactcagtataagaagtggtattttgagctgatggtggactatgtggagccgtttgta actgctcagccgtatcacctgcgtgtgggctgggctctgacggagggctacagcccttac cctggtggaggggagggctggggggggaatggagtcggagatgacctctactcctatggt tttgacgggcttcacctttggtcaggacgtgttccacgacacgttgccacacccaatcag cacgtcctggcagcagaggacgttgttagctgctgtttggatctgagtgttcccagtatt tctttccgcatcaatgggcacccagttcagggaatgtttgagaatttcaacctggacggc ctgtttttccccgcggtcagcttctctgcaggcgttaagtttcgattccttcttggaggg cgtcatggggatttcaagttcctcccacctccaggttatgctccgtgctatgaggccgtg ctgcccagggaccgtttacggattgagcccatcaaagaatataagcatgatttcgatggg atccgcaacctattgggtccacatcagtccctctcacatacagctttcacgccttgccct gtagacactatacagattgtgcttcctcctcatctggagcgcattcgagagaagcttgca gaaaatagccatgagttatgggctgttactcgcattgaacaaggatggaccttcggacca tttcgtgatgacaacaagaagctgcacccgtgcctggtggatttccagagtctgcctgaa ccagagaagacctacaatttagccatgtcaggagagactctcaagactctgctggcgcta ggctgtcacgtaggaatgggagatgagaaagcagaggagaatctcaaaaggaccaagctt cctaaaacttacatgcagagtaatggatataaaccagcacctctggacctcaaccatgtc aagctgactcccaatcaaaacactcttgtggagagactggcagaaaatggacacaatgtg tgggcaagagatcgagttcgccagggctggacttatagtatagtgcaggatataatgaac aagcgaaatcctcgtctggttccttacaatctactggatgaaaagactaaaaagaccaac agagacacggtttgtgcagctgttcgtacactcatcggatatggttacaatattgaacca cctgaccaggagagcagcgggcatggaccaggaagctcccgtggagataagatcagagtg ttcagagcggagaaatcttacgctgtcacacaagggaagtggtactttgagtttgaagct gtaacagttggggagatgagagtgggctgggccaggcccagtgttcgggcagacactgaa cttggtggagatgagctggcttatgtcttcaatggtttcaaggcccagcgttggcatgtg ggaagtgagtcatttggtcgtcagtggcagtctggtgatgtggtgggttgtatgatagac ctgacagagatgaacatcatgttcacactcaatggagagatgttgatcagtgactcaggc tctgaaatggccttcaaagatattgagataggagaaggcttcattcctgtgtgcagcctg ggcctgtcccaggtgggaaggatcaacttgggtcagaatgttagcagcctccgttacttc accatctgtggtctgcaggagggatttgagccttttgctatcaacatgaaacgagacatc acaatgtggttcagcaagagccttcctcagtttatcccggtgccgactgatcatcctcac tttgaggtgtcccgtgttgatgggacagtggaaactgccccttgtatcaaagtgacccac aagacgtttggatctcagaatgccaacacagatctgctattcttcagactaagcatgcca gttgagttccatgagttcttcaaagtcccagcagggaccaccctgcttacccgtgcactg accatccctgaggacgaggtgctggaggtcgacccagactctgactttgaaatactcaag aagtctgccagtcgcaaggagcaggaggaggagaagaaagaaccttctgtgccgaaagag atgcctgccatcaagaatggagagaatgagaaggatgcctcaactgagaaaagcaagaag aaaggattcctttttaaggctaagaaggctgcattaatcacgccaccacctgttgttcct accatgcctcgcctaatggaggacgtggtgccagacgacagagatgatgttgacatcatc ctcaacaccactacatattactactccgtgcgagtatttgcaggacaggagcccagtggt gtttgggtgggctggatcacacctgactatcaccagtatgaccttcattatgatctgagt aaagtgagaaatgtaacagtcactgtaggtgatgataaaggaaacatccacgatagtata aaacgcagcaactgctacatggtgtgtgggggggagttcagcagctcccagcagacccga gtcagtcaggaggatttactgattggctgcctaattgatttggacacaggactcatgact ttcactgcaaatggaaaagagattaacacattttaccaggtggagcccaacacaaaattg ttccccgccgtctttgtcctcccttccaatcagaatatgatacagtttgaactaggcaag ctcaagaacattatgccgatctctgctgccatgttccggagtgaacgcaagaaccctgtc ccccagtgccctcctagactggatgtccagatgttaacccccgtcatctggagccgcatg cccaaccacttcctggctccagagacagggcgtattagtgagagactgggctggggggtg cagtgtcaagagccccttaccatgatggcccttcacatcccagaggagaacaagtgtatt gacatcctggagctgtctgaacgtatggacctactgaagttccactatcatactctgaag ctgtacggctcggtgtgtgctttgggaaacaaccgcgtggctcacgccctgtgtagccat gtggatgagtcccagctcttctacgctatagagaacacctacctacctggaccaatgagg agcggcttttatgacctgctaatcagtatgcacctggaatctgccaagaggaaccggttg ggaaccaacaaggaattcatagttccaatgacagatgaaacgcgcagtattattctgtac actgataaagctcatgctttgcctggagtcggactcactacctgcctacgtccaaagctc catttctcatccattggatttgtgggagtagatcaagatatctacaccctgagtccagtc attcccttacaggtgctaaagaccaaggctctgaacatgcttactgaggcagtacaagat ggaggtcaagccatgagagatcctgtgggaggcagtgttgagtttcactttgtcccaatc ctgaagctgatcagtaccctcctcatcatgggtgtctttgatgatgaagatgtcacgcac attctaaagatgattgagcccacagtcttcagtggcaagaatgcagatgagcctgctgag gaaaatgccaagctgaaggaagagaaggaacaaaaagcttctccaacattgaggggagaa gagcaggaagctgtcaaggaagaagatgaggaatttgaggatgatggcttgggtgatgat gaggaggatgaggaagaagtggaggaagagttagaggagactgaatcgctcaggcaacat gatgaaacaatgaccatgcaagtaaatggcgaaaagggtgcagaggaaacggaaaaagag ctcaaacctgcagagacatgtgtggatactaaagtagaacatctggagcaaggacttttc cagatgaagcttcctgagtctgtcaaattacagatgtgtacactactgcagtatttctgt gactgtgagctacgtcaccgagtggaggccatcattgccttttcagacaagtttgtcaac caaatacagtccaatcagaggcagcgctacaatgaactcatgcaggccttcaccatgagt gctgctgagactgcccgcaagacccgagaatttcgatcgccaccacaagagcaggtcaac atgctcatgaactttaagaactgtgttgaagatgaagactctcctgtacctgacgatgtc cgagagtctctactcatttttcacaatgctctgttggtgcactgtggtgttcatattgaa gaagaggaacaagaggaggaggtggataattctgtccgtggacgactgctccgtttgttg gaaaaggtaaaccaattccgtgagaagaaggtcgagctggagcctgagccacaggaagat aaaaaaccaagcacattgcaggagctgatttcccacactatgatccactgggcccaggaa tcatttattcagaaccctgagctggtgcgcatgatgtttagccttctccacaggcagtat gacgggctgggggagcttattcgagcccttcccaaagcctacaccatcaatgcagtgtca attcaggacactatggacctgctggagtgcttgggccagattcgatcactgctaattgtc cagatgggtccagaagaggagaggctaatgattcaaagcattgggaacatcatgagtaac aaagttttctatcagcatcccaacttgatgcgagctctgggcatgcatgaaactgtcatg gaggttatggttaatgtattgggcggtggggattccaaggagatcagattccctcgagtg gtgacaaactgttgccgttttctttgttatttctgtcgtatcagtcgccaaaaccagcgc tctatgtttgaccacctcagctaccttctccaaaacagtggcatcggccttgggatgcgg ggctccactcccttggacgtggccgcagcctcttgtatcgacaacaatgagcttgcattg gctctccaagagcaggaccttgaaatggtggtgaagtacttagctggatgtggactgcag agctgtccgatgcttctgtctaaaggctaccctgacataggctggaatccttgtggtgga gaaaaataccttgacttccttcgttttgctgtatttgtcaatggagagagtgtggaagaa aatgccaatgtggtggtacgtctactcattcggagacctgagtgctttggtccagccctc agaggggagggcggcaacggtctgctggctgcaatagaggaggccatcaaaatatcagag gaccctgcacgggatggaccaagtgttaagaaagacagacgcttccctatgtttggagga gaggagcagcatgaggagaacagggtgcatctgggaaatgccatcatgtctttctattct gctctgatcgacttgctggggcgctgtgctccagagatgcatttgatccaggctggtaag ggcgaagctctgaggatcagggccattctgaggtctctggtccctattgaggacctggtg ggagtcatcagccttcctgttcagattccttcttttggaaaagacagtagtatcatcgaa ccaaagatgccagctagttttgtgccagatcacaaggctcccatggtgctgttcctggac agagtgtatggtattgacaaccaggatttcttgctccatgtgctggaggtgggctttctg cctgacatgagggctgcggcatctcttgacacggttgctttcagtaccacagagatggcc ctcgctttgaaccgttacctgtgttctgctgtgttgccactcatcaccaagtgtgcccca ctctttgctggcagtgaccaccgagccataatgatcgactccatgttgcacacaatctac cgtctgtctcgtggaagagctttcacaaaggcccagagagacatcattgaagagtgcctc atggctttgtgcaaacatctccgtccgtccatgcttcagcacttgctaagaaggctggtc tttgatgtacccatcctcaatgagtacgccaaaatgccactgaagcttttgacaaatcac tatgagcgttgttggaaatattattgcctccctaatggttgggccaactttggggtggca tcagaggaggagctgcatctgacccgcaaattgttttgggggatctttgagtcacttgca cacaagaaatttgatgctgagatttttaaaatctctatgccatgcatctgttccattgct ggagccattcctccggactatgtagatgccagctactcctccaagacagagaagaaagcg tcagtggatgcagagggaaactttgatcctaaaccagtggataccacaaacaccatcata ccagagagactggatccctttatcaacaaatatgctgaatatacacacgatagatgggct tttgagaagattcagaataactggtcctacggtgaggtgctggatgaaaatgcaaaaaac caccccatgctcagaccgtacaaaaccttctcagagaaagacaaagagatctatcgttgg cctatcaaagagtcagtcaaagccatgattgcatgggagtggaacgttgagaaagccaga gaggaagaagagtcagaaaagaagaagacggcctcacgaaaaatctcacagactgctcag gctacttatgacccaagtcatggttacagtccacagcctattgatgttacacacatggct ctttcaagagacctgcagtctatggccgagcaactggcagaaaattaccataacacctgg ggacggaagaagaagatggagctgcaagccaaaggaggtggaacacatcctcttctggtg ccctatgatactctcacagccaaagaaaaggcccgggatcgagagaaggcttatgaactg ctcaagttcctgcagcttaatggatatgctgtcactaggggccttaaagatatggagtcg gacatttcatcaatcgagaagagatttgcgtatggtttcctgcagaagctgttgaaatgg atggagattgcacaggaattcatcgctcatcttgaggctgtagtaagcagtgggcgagtg gaaaagtctcctcatgagcaggaaatcaaattctttgccaagatcttgatgcctctcatc aaccagtatttcaaaaaccactgcctctactttttgtcaacacctgcaaaggttctgggc agtggcggccattcttccaataaggagaaggaaatgattgcaagtatcttctgtaaaatg tccgccctggtgagacacagagtttctctctttggaacggatgctacagcgattgtaaac tgtcttcacattctggcaaggtcactggatgcaaggactgtaatgaagtcagggccagag atcgtcaaagcaggtctgcgctcattctttgagagtgctgctgatgatatagagaagatg gttgaaaacctcaaactgggcaaagtatccaaagggaatcagcaagttaaaggtgtttcc cagaacattaactacactaccattgccctgctgccagtgcttacgtcactgttcgaccac atcgcgcagcaccagtttggagatgatgtcatcttggacgatctacaaatgtcatgctat cggattatgtgtagtatctactccttagggactgtcaagaatccacatgttgagaggcag aggccagctcttggagagtgtttggctcaccttgcagcagctatgcccgtagcctacttg gaaccacatctaaatgaattcaacgctttctctgtctataccacaaagacaccgagagag agagccatcttgggacttcccagtgaggtccaggaactatgtccagacattccagagctg gatgccctattaaaggagattggggacctggcagagtcaggggctcgttacactgagatg cctcatgtgattgaaattactttgcctatgctgtgtaactacctgcctcgctggtgggag agaggactggaaaacttcccagaaatggagagccagctctgcactgatgtcacatcagag caccttaatcagctgctgggcagcatcatgaagattgttgtcaataacttgggtattgat gaggcctcgtggatgaagaggcttgctgtgttttcacagcccattgtcagcagggcaaag ccagaaatgctcaagtcccacttcatccctacgatggagaagctgaaaaaacgcacctcc aaagtggtggctgaagaagaccacctgaggatggaggggaaatcagagggagacgaagaa gacggcactatacgtgacgagtttgctgtcctctgcagagacttgtatgctctctaccct ctgctcattcgctatgtggacaacaacagggccagatggctcacgttccgtgacccagat gcagaagagctctttcgaatggttggagaagtctttatcttttggtccaaatctcataac ttcaagcgagaggaacagaactttgtggtgatgaatgagataaataacatgtcattcctc actgctgacagcaagagcaaaatgagcaagggcggggaatcagagggcgggggctcagat accgagcgcactaagaagaagaaacgtggtgatcgttactcagtgcagacctcacttatt gtggctgcgttgaaaaagatgctccccataggcctgaacatgtgctctcccgcagatcag gagcttatcaacttggctaagatccgatactctttgagagacacagatgaagaagtaaga gagtttctgcagaacaaccttcagctgcagggaaaggtggacaatccatccatgcgctgg cagatggccctgtacaaggagatggcaggcaaagctgaagatgctgatgctcctgtgaaa gttgtcaagagagtgcaggaggtgtctgctgtcctctaccacctggaagtgacggagcac ccgtttaaatccaagaagatggtgtggcacaaactgttgtccaagcagcgacgcagagct gtggtggcttgcttcagaatgaccccgctctacaacattcctaggcacagagcttcaaat atgttccttgagggatacaaacgcaactgggttcacactgagggttactcatttgaagac aggatgatagatgacttatctaaagcaatggagcaagaggaaggagatgaagaggaggag agagaaacaaagccagatccactccaccagcttattctgcatttcagtcgcactgctctt acagagaagagtaaactggacacagatcatctttatatggcttatgccgatattatggca aagagttgtcatattggtgaggaagaagaaggaggagaggaaatggtggaaaatactgag gatgagatgtcctttgaggtgcgacagtcagaactggaaaaagaaatggagaaacaaagg ctcctgtaccaacagtcaagacttcataatcgtggcgctgcagagatggttctgcaaatg atcagtgcgtgcaaaggcgagactggacccatggtgtctacaacacttaaactgggtatt tctatcctcaatggcggcaacagtgaggttcagcgaaaaatgctggagtacctgaaagat aagaaagatgtgggtttctttttaagtgtccaagcactgatgcagacatgctgtgtcctg gatctaaatgcctttgagaggcagaacaaggcagaagggcttggtatggtttcagaggag ggcacaaagttgaacctagatcgggatgagaaagtgatggcggatgacgagttcacctgt gacctcttccgtttcttacagctgctttgtgaaggtcacaataacgattttcagaactat ttgcggacacagaccggcagcacaacgaccatcaacgtcatcatctgtactgtagattat ctcctccgactccaggagtccatcagtgatttctactggtattactctggaaaggatgtc atcgatgatccgggcaaaaagaatttctccaaagctatgacagttgcaaaacagattttc aacagtctaactgaatacattcagggcccgtgtactggtaaccagcagtctctggcacac agcaggctgtgggatgctatcgtcggattccttcatgtctttgcccacatgatgatgaag ctggcacagggtaaagactccagccagattggtttgctgaaggagcttcttgatctgcag aaagacatggttgttatgttgctctcgttgttggagggaaacgtggtcaatggtactatt gctcggcagatggtagacatgttggtagagtcgtccagcaacgtagagatgatcctcaag ttctttgacatgttcctcaaactgaaagacatcgtggcttcggacgcattccgtgattat gtcactgaccctcgaggactgatctccaagaaggacttccagaagtctatggacagtcag aaacagtactccccatctgagatccagtttcttctgtcctgctcagaggcagacgagaac gacatgatcaactatgaggagtttgccagtcggttccaggaacctgcaaaagacatcggc ttcaatattgcagtgttgttgaccaacctgtctgagcatgtcccccatgacaccaggctc aagaatttcctgggacaagcagagagtgtgctcaactacttccgtccgttcctgggccgt attgagatcatgggtgccagcagaaagattgagcgcatttactttgaaatcagtgaagtg aaccgcagacagtgggagatgcctcaggtcagagagtccaaacgccagtttatctttgat gttgttaatgaaggcggtgaatcagagaagatggagatgtttgtcaacttctgtgaggac accatctttgagatgaatatagcttctcagatttcggagcaggaagaagaggagaaggga gaggaagatgatgaaggagatgaaggtggaggtgaggcagtgccagcagggggagccaat ggaggaggcgatgaggatattaatggggaggaaggacagcctgaatcaagctctgctttt gcagacttcataaacagtctgctgagcttcttcagcattttcaccttccgtaaccttcgc agacaatatcgcagagtgagaaagatgaccttcaaggagataatagtggctctgtccact ttcttctggaccatcctcatgagcatactacacttcatttacaacatatgcaagggcttc tttatgatcatctggcaaactttgtttggaggtggtttagtggagggagcaaaaaatatc actgtgactgagattttagcaagcatgccagaccccacgcaggatgatgtgcatggagat ggaccaggggagccaaggacaggagaagagcaggacactggaggaataactgacactgga gagactgggagtggagaggaggaggaggaggacacccaggaaaaagaaggtgggaggata tttggcatcgatgctccaggtggacttggagacatgggtgtagaggcacctgttgaacct ccaactcctgaaggaacccccataactaagagaaaaacgccaccagaagaaaccgcttct agccagaaacctcctgaacctgttcctgtagaggagcctcctccagaaccagaaaaggca gatgttgaaagtgcagagaaagaatcacagagcaaagagaaaatggagccaaagaaatct gcaacaaaaaaagagaagaagctgaaaaaagaaggaggttttcagatctggaccgagctg gaaacacaaagaaataaatttatgaactacctgtccagaaatttctacaacctgaggttt ttggctctcttccttgcgtttgccctgaacttcattctgctgttctacaaggtgtctgag actccacctgattctgaggaactggaaggatccggattgtcggagggaagtgggctgttt gaaggctctgggttgtttgaaggttcaggagaagaatttgagggatctggaatggatgaa ggtggagatgaggatgatgaagacgtgccaatttatttctatttagaggagagcacaggc tacatgcaacccacgttggcctttattgccatcctgcacactgtcatctccttcatctgc atcatcggctacaactgtctcaagattccacttgtgatctttaaacgggagaaagagctt gcgagaaagttggagtttgacggcctgtacatcagtgagcagcctgaggacgacgacatt aaaggccagtgggatcgactggttcttaacacaccctctttcccgaacaactattgggat aaatttgtcaaacgaaaggttctggataagtatggagatatttatggcagagaaagaatc gctgaactgctcggtgttgatttagcttccctggatgtgagtcaacaacatgagaagaaa caggaagaaccagacaactctgtgtttgcatgggtgacctccattgacatcaagtaccag atctggaaatttggtgtagtgttcacagatggtacgttcctttacctctgctggtatctg atcatgtctctgctcggacattacaacaacttcttcttcgcctgtcacctgctggacatc gccatgggtgtgaagactctgcgcaccatcctgtcctcagtcacacacaacggcaaacag ctcatgatgacggtgggattgttggccgtggtcgtttacctctacactgtcgtcgccttc aatttcttccgcaagttttacaacaagagtgaagacgaggatgaacccgatatgaaatgt gacgacatgatgacatgttacctgttccacatgtacgtgggagtccgtgctggtggagga attggagatgagatcgaggatcctgccggagacgaatatgagctttatagagtagtcttt gatatcaccttcttcttctttgtcatcgtcattctgctggctattattcaaggtctgatc attgatgcctttggagaactaagagaccaacaagagcaggtcaaagaggacatggagaca aaatgcttcatctgcggcatcggaagtgactactttgatacaacaccacacggctttgag acgcacacttttgatgagcacaatctggccaattacatgtttttcttgatgtacctaatc aacaaagatgagacggagcacactggccaggagtcgtatgtgtggaaaatgtaccaggaa cgttgctgggacttttttcctgctggcgactgcttcagaaaacaatatgaagatcaactt tcttag

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