KEGG   Symphalangus syndactylus (siamang): 129460949
Entry
129460949         CDS       T10134                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn01521  EGFR tyrosine kinase inhibitor resistance
ssyn01522  Endocrine resistance
ssyn01524  Platinum drug resistance
ssyn04012  ErbB signaling pathway
ssyn04014  Ras signaling pathway
ssyn04015  Rap1 signaling pathway
ssyn04024  cAMP signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04066  HIF-1 signaling pathway
ssyn04068  FoxO signaling pathway
ssyn04070  Phosphatidylinositol signaling system
ssyn04071  Sphingolipid signaling pathway
ssyn04072  Phospholipase D signaling pathway
ssyn04081  Hormone signaling
ssyn04140  Autophagy - animal
ssyn04150  mTOR signaling pathway
ssyn04151  PI3K-Akt signaling pathway
ssyn04152  AMPK signaling pathway
ssyn04210  Apoptosis
ssyn04211  Longevity regulating pathway
ssyn04213  Longevity regulating pathway - multiple species
ssyn04218  Cellular senescence
ssyn04360  Axon guidance
ssyn04370  VEGF signaling pathway
ssyn04380  Osteoclast differentiation
ssyn04510  Focal adhesion
ssyn04550  Signaling pathways regulating pluripotency of stem cells
ssyn04611  Platelet activation
ssyn04613  Neutrophil extracellular trap formation
ssyn04620  Toll-like receptor signaling pathway
ssyn04625  C-type lectin receptor signaling pathway
ssyn04630  JAK-STAT signaling pathway
ssyn04650  Natural killer cell mediated cytotoxicity
ssyn04660  T cell receptor signaling pathway
ssyn04662  B cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04666  Fc gamma R-mediated phagocytosis
ssyn04668  TNF signaling pathway
ssyn04670  Leukocyte transendothelial migration
ssyn04722  Neurotrophin signaling pathway
ssyn04725  Cholinergic synapse
ssyn04750  Inflammatory mediator regulation of TRP channels
ssyn04810  Regulation of actin cytoskeleton
ssyn04910  Insulin signaling pathway
ssyn04914  Progesterone-mediated oocyte maturation
ssyn04915  Estrogen signaling pathway
ssyn04917  Prolactin signaling pathway
ssyn04919  Thyroid hormone signaling pathway
ssyn04923  Regulation of lipolysis in adipocytes
ssyn04926  Relaxin signaling pathway
ssyn04929  GnRH secretion
ssyn04930  Type II diabetes mellitus
ssyn04931  Insulin resistance
ssyn04932  Non-alcoholic fatty liver disease
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04935  Growth hormone synthesis, secretion and action
ssyn04960  Aldosterone-regulated sodium reabsorption
ssyn04973  Carbohydrate digestion and absorption
ssyn05010  Alzheimer disease
ssyn05017  Spinocerebellar ataxia
ssyn05020  Prion disease
ssyn05100  Bacterial invasion of epithelial cells
ssyn05135  Yersinia infection
ssyn05142  Chagas disease
ssyn05146  Amoebiasis
ssyn05160  Hepatitis C
ssyn05161  Hepatitis B
ssyn05162  Measles
ssyn05163  Human cytomegalovirus infection
ssyn05164  Influenza A
ssyn05165  Human papillomavirus infection
ssyn05166  Human T-cell leukemia virus 1 infection
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05168  Herpes simplex virus 1 infection
ssyn05169  Epstein-Barr virus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05171  Coronavirus disease - COVID-19
ssyn05200  Pathways in cancer
ssyn05203  Viral carcinogenesis
ssyn05205  Proteoglycans in cancer
ssyn05206  MicroRNAs in cancer
ssyn05207  Chemical carcinogenesis - receptor activation
ssyn05208  Chemical carcinogenesis - reactive oxygen species
ssyn05210  Colorectal cancer
ssyn05211  Renal cell carcinoma
ssyn05212  Pancreatic cancer
ssyn05213  Endometrial cancer
ssyn05214  Glioma
ssyn05215  Prostate cancer
ssyn05218  Melanoma
ssyn05220  Chronic myeloid leukemia
ssyn05221  Acute myeloid leukemia
ssyn05222  Small cell lung cancer
ssyn05223  Non-small cell lung cancer
ssyn05224  Breast cancer
ssyn05225  Hepatocellular carcinoma
ssyn05226  Gastric cancer
ssyn05230  Central carbon metabolism in cancer
ssyn05231  Choline metabolism in cancer
ssyn05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ssyn05415  Diabetic cardiomyopathy
ssyn05417  Lipid and atherosclerosis
ssyn05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129460949 (PIK3R2)
   04014 Ras signaling pathway
    129460949 (PIK3R2)
   04015 Rap1 signaling pathway
    129460949 (PIK3R2)
   04370 VEGF signaling pathway
    129460949 (PIK3R2)
   04630 JAK-STAT signaling pathway
    129460949 (PIK3R2)
   04668 TNF signaling pathway
    129460949 (PIK3R2)
   04066 HIF-1 signaling pathway
    129460949 (PIK3R2)
   04068 FoxO signaling pathway
    129460949 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    129460949 (PIK3R2)
   04072 Phospholipase D signaling pathway
    129460949 (PIK3R2)
   04071 Sphingolipid signaling pathway
    129460949 (PIK3R2)
   04024 cAMP signaling pathway
    129460949 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    129460949 (PIK3R2)
   04152 AMPK signaling pathway
    129460949 (PIK3R2)
   04150 mTOR signaling pathway
    129460949 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    129460949 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129460949 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    129460949 (PIK3R2)
   04218 Cellular senescence
    129460949 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129460949 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    129460949 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129460949 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129460949 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    129460949 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    129460949 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    129460949 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    129460949 (PIK3R2)
   04660 T cell receptor signaling pathway
    129460949 (PIK3R2)
   04662 B cell receptor signaling pathway
    129460949 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    129460949 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    129460949 (PIK3R2)
   04670 Leukocyte transendothelial migration
    129460949 (PIK3R2)
   04062 Chemokine signaling pathway
    129460949 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129460949 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    129460949 (PIK3R2)
   04929 GnRH secretion
    129460949 (PIK3R2)
   04915 Estrogen signaling pathway
    129460949 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    129460949 (PIK3R2)
   04917 Prolactin signaling pathway
    129460949 (PIK3R2)
   04926 Relaxin signaling pathway
    129460949 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    129460949 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    129460949 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129460949 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    129460949 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    129460949 (PIK3R2)
   04722 Neurotrophin signaling pathway
    129460949 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129460949 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    129460949 (PIK3R2)
   04380 Osteoclast differentiation
    129460949 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    129460949 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    129460949 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129460949 (PIK3R2)
   05206 MicroRNAs in cancer
    129460949 (PIK3R2)
   05205 Proteoglycans in cancer
    129460949 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    129460949 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    129460949 (PIK3R2)
   05203 Viral carcinogenesis
    129460949 (PIK3R2)
   05230 Central carbon metabolism in cancer
    129460949 (PIK3R2)
   05231 Choline metabolism in cancer
    129460949 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129460949 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129460949 (PIK3R2)
   05212 Pancreatic cancer
    129460949 (PIK3R2)
   05225 Hepatocellular carcinoma
    129460949 (PIK3R2)
   05226 Gastric cancer
    129460949 (PIK3R2)
   05214 Glioma
    129460949 (PIK3R2)
   05221 Acute myeloid leukemia
    129460949 (PIK3R2)
   05220 Chronic myeloid leukemia
    129460949 (PIK3R2)
   05218 Melanoma
    129460949 (PIK3R2)
   05211 Renal cell carcinoma
    129460949 (PIK3R2)
   05215 Prostate cancer
    129460949 (PIK3R2)
   05213 Endometrial cancer
    129460949 (PIK3R2)
   05224 Breast cancer
    129460949 (PIK3R2)
   05222 Small cell lung cancer
    129460949 (PIK3R2)
   05223 Non-small cell lung cancer
    129460949 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129460949 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    129460949 (PIK3R2)
   05161 Hepatitis B
    129460949 (PIK3R2)
   05160 Hepatitis C
    129460949 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    129460949 (PIK3R2)
   05164 Influenza A
    129460949 (PIK3R2)
   05162 Measles
    129460949 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    129460949 (PIK3R2)
   05163 Human cytomegalovirus infection
    129460949 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129460949 (PIK3R2)
   05169 Epstein-Barr virus infection
    129460949 (PIK3R2)
   05165 Human papillomavirus infection
    129460949 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    129460949 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    129460949 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129460949 (PIK3R2)
   05142 Chagas disease
    129460949 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129460949 (PIK3R2)
   05017 Spinocerebellar ataxia
    129460949 (PIK3R2)
   05020 Prion disease
    129460949 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129460949 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    129460949 (PIK3R2)
   05415 Diabetic cardiomyopathy
    129460949 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    129460949 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    129460949 (PIK3R2)
   04931 Insulin resistance
    129460949 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129460949 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129460949 (PIK3R2)
   01524 Platinum drug resistance
    129460949 (PIK3R2)
   01522 Endocrine resistance
    129460949 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ssyn04131]
    129460949 (PIK3R2)
Membrane trafficking [BR:ssyn04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    129460949 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 129460949
NCBI-ProteinID: XP_055095541
LinkDB
Position
13:44310191..44328134
AA seq 727 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDAAALADGIKSFLLA
LPAPLVTPEALAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPSSPPPGGAPDGSEPSPDFSALLLEKLLQEHLEEQEVAPPA
LPPKPPKAKPAPTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKI
QGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRL
LYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAI
EAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTK
LEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNET
EDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVV
DGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGP
GPPPAAR
NT seq 2184 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggcattgcaggca
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctacgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggcgccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccggccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacgcggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcaccgctcgtgacccccgaggccttggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagccaccgacgctgccgctgcaccgtgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
tcctcgccgccaccagggggcgctcccgacgggagtgagcccagccctgacttctcggcg
ctgctgttggagaagctgcttcaggaacacttggaagagcaggaggttgcgcccccagcg
ctgccgcctaaaccccccaaggcaaagccggcccccacaggcctggccaatggagggagc
ccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtgaac
gagaaactccgggacactcccgatggcaccttcctagtccgagatgcttctagcaagatc
cagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtcttc
caccgagatgggcactatggcttctcagagccactcaccttctgctccgtcgtggacctc
atcaatcactaccgccacgagtcgctggcccagtacaacgccaagctggacacacggctc
ctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggatagcgtggaggcg
gtgggtgcccagctcaaggtctatcaccagcaataccaggacaagagccgcgagtatgac
cagctctatgaagagtacacaaggacctcccaggagctgcagatgaagcgtaccgcaatt
gaggccttcaatgagactatcaagatctttgaagagcagggccagactcaagagaagtgc
agcaaggaatacctggagcgcttccggcgtgagggcaacgagaaagagatgcagaggatc
ctgctgaactccgagcggctcaagtcccgcattgccgagatccatgagagccgcacgaag
ctggagcagcagctgcgggcccaggcctcggacaaccgggagatcgacaagcgaatgaac
agcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctc
acccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgagact
gaggaccagtacgcgctgatggaggacgaggacgatctcccccaccacgaggaacgcact
tggtacgtgggcaagatcaatcgcacgcaggcagaggagatgctgagcggcaagcgggat
ggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtagtagtg
gacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggag
ccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctc
gtgcagcacaacgacgcgctcaccgtcaccctggcgcacccagtgcgcgcccctggcccc
gggccgccgcctgccgcccgctga

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