KEGG   Symphalangus syndactylus (siamang): 129474522
Entry
129474522         CDS       T10134                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn00562  Inositol phosphate metabolism
ssyn01100  Metabolic pathways
ssyn01521  EGFR tyrosine kinase inhibitor resistance
ssyn04012  ErbB signaling pathway
ssyn04014  Ras signaling pathway
ssyn04015  Rap1 signaling pathway
ssyn04020  Calcium signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04064  NF-kappa B signaling pathway
ssyn04066  HIF-1 signaling pathway
ssyn04070  Phosphatidylinositol signaling system
ssyn04072  Phospholipase D signaling pathway
ssyn04360  Axon guidance
ssyn04370  VEGF signaling pathway
ssyn04613  Neutrophil extracellular trap formation
ssyn04650  Natural killer cell mediated cytotoxicity
ssyn04658  Th1 and Th2 cell differentiation
ssyn04659  Th17 cell differentiation
ssyn04660  T cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04666  Fc gamma R-mediated phagocytosis
ssyn04670  Leukocyte transendothelial migration
ssyn04722  Neurotrophin signaling pathway
ssyn04750  Inflammatory mediator regulation of TRP channels
ssyn04919  Thyroid hormone signaling pathway
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04935  Growth hormone synthesis, secretion and action
ssyn05012  Parkinson disease
ssyn05022  Pathways of neurodegeneration - multiple diseases
ssyn05135  Yersinia infection
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05171  Coronavirus disease - COVID-19
ssyn05200  Pathways in cancer
ssyn05205  Proteoglycans in cancer
ssyn05206  MicroRNAs in cancer
ssyn05214  Glioma
ssyn05223  Non-small cell lung cancer
ssyn05225  Hepatocellular carcinoma
ssyn05231  Choline metabolism in cancer
ssyn05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ssyn05417  Lipid and atherosclerosis
Module
ssyn_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssyn00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129474522 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129474522 (PLCG1)
   04014 Ras signaling pathway
    129474522 (PLCG1)
   04015 Rap1 signaling pathway
    129474522 (PLCG1)
   04370 VEGF signaling pathway
    129474522 (PLCG1)
   04064 NF-kappa B signaling pathway
    129474522 (PLCG1)
   04066 HIF-1 signaling pathway
    129474522 (PLCG1)
   04020 Calcium signaling pathway
    129474522 (PLCG1)
   04070 Phosphatidylinositol signaling system
    129474522 (PLCG1)
   04072 Phospholipase D signaling pathway
    129474522 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    129474522 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    129474522 (PLCG1)
   04660 T cell receptor signaling pathway
    129474522 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    129474522 (PLCG1)
   04659 Th17 cell differentiation
    129474522 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    129474522 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    129474522 (PLCG1)
   04670 Leukocyte transendothelial migration
    129474522 (PLCG1)
   04062 Chemokine signaling pathway
    129474522 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    129474522 (PLCG1)
   04919 Thyroid hormone signaling pathway
    129474522 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    129474522 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129474522 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    129474522 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129474522 (PLCG1)
   05206 MicroRNAs in cancer
    129474522 (PLCG1)
   05205 Proteoglycans in cancer
    129474522 (PLCG1)
   05231 Choline metabolism in cancer
    129474522 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129474522 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    129474522 (PLCG1)
   05214 Glioma
    129474522 (PLCG1)
   05223 Non-small cell lung cancer
    129474522 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129474522 (PLCG1)
   05171 Coronavirus disease - COVID-19
    129474522 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129474522 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    129474522 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    129474522 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    129474522 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129474522 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129474522 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129474522 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ssyn04131]
    129474522 (PLCG1)
Enzymes [BR:ssyn01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129474522 (PLCG1)
Membrane trafficking [BR:ssyn04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129474522 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129474522 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 129474522
NCBI-ProteinID: XP_055121830
LinkDB
Position
24:complement(31374933..31414168)
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLLTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSNMRDEAFDPFDKS
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRTREGSFESRYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccttgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatcgagggggccattgatattcgcgaaattaaggag
atccgcccggggaagacctcacgggactttgatcgctatcaagaggacccagctttccgg
ccggaccagtcacattgctttgtcattctctatggaatggaatttcgcctgaaaacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagatagagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagtggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaagagttcatgctcagcttc
ctccgagaccccttacgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcacagctggatgcagtatgcccggac
accatgaacaaccctctttcccactactggatctcctcctcacacaacacgtacctgacc
ggggaccagttctccagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccggatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgctcaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaagaaggtgctaggggacacactcctcaccaag
cccgtggagatctctgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggttcctacctccatgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactactttgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgat
gggcgtcacatcgctgagcgcctgctcactgagtactgcatcgagaccggagcccctgac
ggctccttccttgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcccggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacgcactaccag
caggtgcccctgcgctgtaatgagtttgagatgagactttcagagcctgtcccacagacc
aacgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctaatgcgcgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgagggcaagatcaagcattgccgtgtccagcaagag
ggccagacagtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaaacacccgctgtaccgcaagatgaagctgcgctatcccatcaacgaggaggca
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagggaggacgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccggagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcctggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagattgccctggagctctctgaacttgtcgtctattgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctcgtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggccctcttcatgacaggcaggcactgt
ggctacgtgctgcagccaagcaacatgcgggatgaggcctttgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctattgaggtgctgggggcccgacatctg
ccaaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccagccaagcccttccacttccaaatcagtaaccctgaatttgcctttctgcgcttcgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagcgaggacctg
gagttggcctccctgctgatcaagattgatattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
tttcacggccgaacccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcatctcccaggagcatctcgcagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag

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