Sceloporus undulatus (fence lizard): 121915128 Help Entry 121915128         CDS       T07740                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism sund  Sceloporus undulatus (fence lizard) Pathway sund04020   Calcium signaling pathway sund04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sund00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121915128 (RYR1)    04020 Calcium signaling pathway     121915128 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:sund01009]     121915128 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:sund04147]     121915128 (RYR1)    04040 Ion channels [BR:sund04040]     121915128 (RYR1) Protein phosphatases and associated proteins [BR:sund01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      121915128 (RYR1) Exosome [BR:sund04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    121915128 (RYR1) Ion channels [BR:sund04040]  Voltage-gated cation channels   Ryanodine receptor    121915128 (RYR1) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  121915128 NCBI-ProteinID:  XP_042294944 LinkDB All DBs Position 9:21273151..21377741 Genome browser AA seq 5064 aa AA seqDB search MAEGGGEGEDDVQFLRTDDEVVLQCSATILKEQLKLCLASEGFGNRLCFLEPTSNAQKVP PDLAICCFSLEQSLSVRALQEMLANTVEVGSESSQGGGHRTLLYGHAILLRHSHSGMYLS CLTTSRSLTDKLAFDVGLQEDATGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERY LHLSTASGELQADASFMQTLWNMNPICSGCEEGCVTGGHVMRLFHGHMDECLTISTTDPN EDQRRVVNYEGGAVCSQARSLWRLEPLRISWSGSHMKWGQPFRVRHVTTGRYLALTEEKG LIVVDAEKANTKATAFCFRVSKEKLDVAPKRDVEGMGAPEIKYGESMCFVQHVDSGLWVT YAAADAKALRLGLLKRRAILHQEGHMDDALSLTRCQHEESQAARMIYSTSGLYNQFIKGL DTLSGKVKSSTPVSLPIDGMILSLQDLITYFQHPEEELQHEEKQTKLRSLKNRQNLFQEE GMITLVLNCIDRLNVYSTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS NNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTKLINYVTSMRPNIFLGTHEGSTQYKK WYYEMIVDYVEPFVTSQATHLRVGWAMAEGYSPYPGGGEGWGGNGVGDDLYSFGFDGLHL WSGRVARPVTSPGQHTLGADDVVSCCLDLSVPSISFRINGFPVQGMFENFNLDGLFFPVV SFSAGIKVRFLLGGRHGDFKFLPPPGYAPCYEALLPRDKMRVEPIKEYKHDFNGVRNLLG PTQSLSHTAFTPYPVDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGTIRDDNK RLHPCLLDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEENLKKTKLPKTYMM SNGYKPAPLDLNHIKLTPAQNTLVDKLAENGHNVWARDRVQQGWTYSVLQDIKNKRNPRL VPYSLLDERTKKTNRDSLREAVRTLIGYGYNIEPPDQETTGQDQTKARSEKVRIFRAEQF YAIKSGKWYFEFEAVTTGEMRVGWARPNVRPDVELGADELSYVFNGHRGQRWHIGSEPFG RPWQPGDVVGCMIDLIDQNIMFTLNGEMLISDSGSELAFKDIEIGDGFIPVCSLGLSQVG RLNLGQDVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFSPVPTEHPHYEVSRM DGTVDNPPCLKLTHRTFGSQNAILELLFLRLSMPVEFHEKFKITAGTTPLTHAFTIPEDE VKDIDLDSEFEQLKKTASRKEAEEAEKEKQGPPPPGTPKEPPKEPPKAENEKDSSTEKSK TKRGFLFKAKKATTFITPPPVVPTVPRLEEEVVPDDRDDPEIIMNTTTYYYSVRIFAGQE PTCVWVGWVTPDYHQYDMNFDLTKVRNVTVTMGDDKGNIHDSIKRSNCYMVWGGDFVSST QQTRVSTVDLVIGCLVDLATGLMTFTANGKEVNTFFQVEPNTKLFPAVFALPTSQNVIQF ELGKLKNIMPLSAAMFRSERKNPEPQCPPRLVIQMLTPMTWSRMPNEFLRVDVARFSDRH GWMVECTDPNIMMALHIPEESRCIDILELSERLELLKFHSHSLKLYCAVCALGNNRVAHA LCSHVDESQLLYTIESNHLPGLLRSGYYDLLISMHLESAKRSRLMMNSEFIVPMTDQTKG ITLFPDDTKKPGLPGVGMSACLRPPLHFSETCFVSTNSELYQLSPSIPLDILKVKAINML TEAVQDGGQHTRDPVGGSVEFQFVPVLKLICTLLIMAIFEDEDVRHILKMIEPYVFGESK EEEEEVPAGEEGAEEGEELVAEEEEELVAMEEEEGDGAEKEAGGGQKEEAEEGDKRELKA IEAGEAEAKEEEEGLEEGLLQMKLPESVKLQMCNLLQFFCDRELQHRVEAIIAFSERYVD NLQINQRQRYNTLMQDFAMSAAETARRTREFRSPPQEQINMLLNFKNGADEEECPVPDEI RDELLEFHTDLLAHCGIQAEGEEEEEEEDTSFRRRLMSLVDKVVSFRKKKEEQEEEQPAE EEPKPSTLQELISHTMVHWAQESFIQSPELVRVMFSLLHRQYDGLGELIRAMPKAYTINA NSVEDTMSLLECLGQIRSLLIVQMGPEEENLMIQSIGNIMNNKVFYQHPNLMRALGMHET VMEVMVNVLGGGDSKEIRFPKMVTNCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLG MRGSTPLDVAAASVIDNNELALALQEQDLEKVVTYLAGAGLQSCPMLLSKGYPDIGWNPC GGERYLDFLRFTVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAIEEAIQI SQDPARDGPTVKKDRRRELFGGEDTHEENRVHLGNAVMSFYAALIDLLGRCAPEMHLIQA GKGEALRIRAILRSLVPIEDLVGVISLPLQIPSFGKDGSVVEPKMSASFVPDHKAPMVLF LDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFSTTEMALALNRYLCSAVLPLITKC APLFAGTEHRAIMVDSMLHTIYRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRR LVFDVPILNEFAKMSLKLLTNHYERCWKYYCLPTGWANYGVSSEEELHLTRKLFWGIFES LSHKKFDSDLYKLAMPCLCAIAGAIPPDYVDASYSSKTEKKASVDAEGNFDPKPVETLNV IIPEKLDSFINKYAEYTHEKWAFDKIQNNWSFGEAYDEEAKTSPMLRPYKTFSEKDKEIY RWPIKESLKAMIAWEWTVEKAREGEEEKSEKKKTRKISQTQTYDPSHGYNPQPIDLSGVT LSRELQAMAEQLAENYHNTWGRKKKVELEAKGGGTHPLLVPYDTLTAKEKARDREKAQEL LRFLQLNGYAVTRGLKDMELDTSSIEKRFAYGFLQQLLKWMDISQEFIAHLEAVVSSGRV EKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKL AALVRHRVSLFGTDAAAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFEGASDDIEKM VENLKLGKVSQSRTQVKGVGQNITYTTVALLPVLTSIFEHIAQHQFGDDVILDDVQVSCY RTLCSIYSLGTTKNPYVERQRPQLGECLARLAAAMPVAFLEPHINEYNPFSVYTTKSPRE RAILGLPNSVEEMCPDIPVLERLMKEISGLAESGARYTEMPHVIEITLPMLCNYLPRWWE RGPENNPQGPWCTDVTSDQLNTLLGNILKIIVNNLGIDEASWMKRLAVFAQPIVSKAKPE LLRSHFIPTMEKLKKRSGKVVAEEDQLRLEAKTESEDAELLIRDEFSVLCRDLYALYPLL IRYVDNNRANWLTEPNSDAEELFRMVGEVFIYWSKSHNFKREEQNFVVQNEINNMSFLTA DSKSKMSKSGEGQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCSPTDQEL INLAKLRYALKDTDEEVREFLNNNLHLQGKCENSSSMRWQMALYKEMSGKAEDCNNPEKI VKRVQEVSAVLYHLELTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPRHRACNM FLESYKLSWILSEEHPFEDRMIDDLSKPGEEEEEEEEEAEKKPDPLHQLILHFSRTALTE KTKLEEDYLYMAYADIMAKSCHLNEEEGDEGEEGEEAEVPFEEKEMEKQKLLYQQSRLHN RGAAEMVLQMISACKGEPGAMVSSTLKLGISILNGGNEEVQQKMLDYLKEKREVGFFQSI QALMQTCSVLDLNAFERQNKAEGLGMVTEDGTIISRENGEKVMADDLFTQDLFRFLQLLC EGHNNDFQNYLRTQTGNTNTINIIICTVDYLLRLQESISDFYWYYSGKDVIDEQGKRNFS KAMAVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVIGFLHVFAHMMMKLAQMTQPPGL RNGDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFF DMFLKLKDIVASDAFRDYITDPRGLISKKDFQKAMDSQKQYTPSEIQFLLSCSEADENEM IDYEEFANRFQEPAKDIGFNIAVLLTNLSEHMPHDHRLKTFLELAECILNYFSPYLGRIE IMGASKRIERIYFEISETNKAQWEMPQVKESKRQFIFDVVNEGGESEKMELFINFCEDTI FEMQIAAQISEEEGQEEEEEEEEGEGAEAGEAEKASAPSEASSAFGEFLESVLNFFRMFT YRNIRRQFRKIKKMTVKEMAMAIATFVYTILMGILFFFYNIFKGIFLLIWNTLFGGGLVE EAKKITMTELLASMPDPTQDEVHGDVAPSEEAEQVMEEGEEVEIDESGKEEAPAEGGELG ADKKEHFRSMAADAPGGLGDMGDTTPVEPPTPEGSPILKRKLGMDGEEEIVEPEKIEEPP VEPEKADAENGEKAAKEEEEEKKKEEEATPEEEEPHKPVKEKKKVTQREKKESEAAGSEF WNELEVQRIKFLNYLSRNFYNLRFLALFLAFAINFILLFYKVSDSPPGEEEFEGSGFEGE LDAASGAGSGFGGDDDGGDGNGNGNGDEDEEDSVVYYFLEESTGYMQPALQFLSIVHTLV AFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDIKGQWDRLVLNAPSFPS NYWDKFIKRKVLDKYGDIYGRERIAELLGMDLASLEITAQNEKKSEPDKSFLTWITSIDL KYKIWKFGVIFTDNSFLYLFWYMVMSVLGHYNNFFFASHLLDIAMGVKTLRTILSSVTHN GKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRA GGGIGDEIEDPAGDEYELYRVIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKED METKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKM YQERCWDFFPAGDCFRKQYEDQLG NT seq 15195 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggaggcggcgagggagaggacgacgtccagttcctccggacagatgatgaa gtcgtccttcagtgttcagccacaatcttaaaggaacagttgaagttatgtctggcttcc gaaggctttgggaaccggctctgttttctggaacctacctccaatgctcagaaagtccct ccagatctggcgatatgttgcttcagcctggaacagtccttgtccgtaagagccctgcag gagatgctggccaacactgtggaggtaggatccgagtcttctcaaggtggtggacaccgg actctgctgtatggacacgctattcttctccgtcattcccacagcggcatgtatttaagc tgcctaaccacatctcgctccctgacggataaactcgcctttgacgtgggcctgcaagag gatgcgacaggagaagcctgttggtggaccatccatcctgcctccaaacagcggtcagaa ggagagaaggtccgcgtcggtgatgatctcatccttgtaagcgtctcttctgagcgctac ctgcatctgtcgacggccagtggagaacttcaggcagacgcctccttcatgcaaacgctt tggaacatgaaccccatctgctcaggctgtgaagaagggtgtgtgactgggggccatgtt atgcgtctcttccacggccacatggatgagtgcctcaccatctctaccacagacccgaat gaagaccagcgcagggtggtgaactatgaaggtggagctgtctgttcccaggctcgttct ctctggcgtctggagcccttgcgcatcagctggagcggtagccacatgaagtggggccag ccattccgcgtccgccatgtcaccacaggccgctacctggccttgacggaggaaaaggga ctgattgtagtggatgctgagaaagccaacaccaaagccacagctttttgcttccgggtc tctaaggaaaagctggatgtcgcccccaaacgagacgtggaagggatgggagctccagag atcaagtatggggagtccatgtgctttgtgcagcatgtcgacagtggcctctgggtgacg tatgcagcggctgatgccaaggcactgcgcctggggctgctcaagagaagggccatcttg catcaagaagggcacatggacgatgcactttcactgactcgctgccagcatgaggagtca caggctgcccggatgatctacagcacatctggactctataaccagtttatcaaaggcctg gacacactgagcggaaaggtgaagtcaagcaccccagtgagtcttcccatcgatgggatg attctcagcttgcaggacctgatcacctacttccagcacccagaggaagagctccagcat gaggagaaacagaccaagctccgttctctcaaaaacaggcaaaacctcttccaggaggag gggatgatcaccctcgttctgaattgcattgaccgtctcaatgtgtacagcactgccgcg cactttgcagagtatgctggcgaggaggcagcagagtcctggaaggagattgtcaacctg ttgtatgagttgcttgcctccctgatccgtgggaaccgctccaattgtgcccttttctcc aacaacctggattggctggtcagcaaactggatcgactggaggcttcatctggcatcttg gaggttttgtactgtgtgctgattgaaagccctgaagtgctgaatatcatccaggagaac cacatcaagtccatcatttcactactggacaaacatgggcgaaatcataaggttctggat gtcctctgttctttgtgtgtctgcaatggggtggccgtccgttccaaccaaaaccttatc actgaaaacttgcttccggggagggacctgcttttgcagaccaaactcatcaactatgtc accagcatgcgtcccaacatctttctgggaacccatgaaggctccactcaatacaagaaa tggtactatgaaatgattgtggattatgtggagccatttgtgacttcgcaggccacgcat ttgcgagtcggctgggccatggcagagggctacagcccctatcctggaggtggggaaggc tggggaggcaacggtgttggagatgacctctactcctttggttttgatgggctgcaccta tggtcaggccgtgtggcacggccagtgacatcgcctggacagcacacgctgggggcagat gatgtagtgagctgttgtctagacctgagcgtacccagcatttcattccgcatcaacggc ttccctgtccagggaatgtttgagaacttcaacttggatgggctcttctttcctgtggtc agcttttctgcaggcatcaaggtgcggttcctcctaggaggacgtcatggggacttcaag ttccttcctcctccaggttatgctccatgctatgaggccctcctaccccgcgacaagatg cgtgtggagcccatcaaggagtataagcatgacttcaatggggtccggaatcttttaggt cctacacagtctttgtcccacactgccttcactccttaccctgtggacaccatccagatt gtgttacctccccatcttgagcggatccgggaaaaattggcggagaatatccatgaactt tgggccctaacccgcattgaacaaggatggacttatggaactattcgggacgacaacaag cgcttacatccatgtttgctggatttccacagcctgcctgagccagaacgcaattacaat ctgcagatgtcaggagaaacactcaagaccttacttgctctgggttgccatgtggggatg gcagatgagaaagctgaagagaacctcaagaaaacgaagcttcccaaaacgtacatgatg tcaaatggctataaaccagcaccactggatctcaaccacatcaagctaactccagcccag aataccctagtggacaaactggccgagaatgggcacaacgtctgggcaagggatcgtgtc caacagggctggacctatagtgtgttgcaggacatcaaaaacaaacgcaacccccgtctg gtaccctacagcctgttagatgagcgaaccaagaaaacaaaccgggacagcttgcgtgaa gcagtgcgcactctcatcggctatggatacaacattgagccaccagaccaagaaaccaca ggtcaagatcagaccaaagctcggtcagagaaggtccgcatcttcagggctgaacaattc tatgcaatcaaatcaggcaaatggtactttgagtttgaggcggtcaccactggtgagatg cgcgtgggctgggcacgaccaaatgtgcgcccagatgtggaactgggagcggatgagctt tcctacgtctttaatggacatcggggtcagcgctggcacataggtagtgaaccttttggc cgtccatggcaaccaggtgatgtggttggctgcatgatagacctcattgaccaaaacatc atgttcacccttaatggggagatgctgatcagtgactctggatcggagctggcctttaaa gacattgagattggagatggcttcatcccagtatgcagcttgggcttgtcccaggttggg cgtcttaacttgggtcaggacgtcagcagtcttcgctacttcaccatctgtggcttacag gagggctttgagccctttgctatcaacatgaagcgggacatcaccatgtggttcagcaag agcctgccccagttttccccagtgccaacagaacacccacattatgaggtgtcacggatg gatggtactgtggacaacccaccatgcctcaaactgacacaccggacatttggctcacag aacgcaattttagaactccttttcttgcgcctcagcatgcctgtggagttccacgagaag ttcaaaatcacagctggcaccactccgctcacccatgctttcaccatcccagaagatgaa gtcaaggatattgacctcgattcggagtttgagcagctgaagaaaactgccagccgcaag gaagctgaggaggctgagaaggagaaacaaggccctccgccacccggcacccctaaagag cctcctaaagagccccccaaggctgagaatgaaaaggactcctccacagaaaaaagcaag acgaaacgaggcttcctgttcaaagccaagaaggccactacgttcatcaccccaccacct gtggtccccacagtacctcggctggaagaagaggtggtcccagatgaccgagatgatccc gagatcatcatgaacaccacaacgtattactactcagtccggatctttgcaggccaggag cccacatgtgtctgggtaggctgggtcacacctgactaccatcaatatgacatgaacttt gacctcaccaaagtgcgaaatgtcacggtgaccatgggtgatgacaagggaaacatccat gacagcatcaagcgaagcaactgctacatggtctggggaggagactttgtcagcagtact cagcagacccgggtcagcactgtggacttggtcattgggtgccttgttgaccttgccacc ggcctgatgaccttcacagccaacggaaaagaggtcaacactttcttccaagtggagcca aacacaaagctgtttcctgctgtctttgctctgccaacaagccagaatgtcatccagttt gaactgggcaaattgaagaacatcatgcccctctcagctgccatgttccgtagtgaacgg aagaacccagaaccccagtgcccaccaaggcttgttatccagatgctgacaccaatgacc tggagccgcatgcccaatgagttcctgcgggttgatgttgctcgcttcagcgatcggcat ggctggatggtcgagtgcacggatcccaacatcatgatggctctccacatcccagaagaa agtcggtgcatcgacatcttggagctgtcagaacgtctggaactgctgaagttccactcc cacagcctgaagctctactgtgctgtgtgtgctttgggcaacaatcgggtggcgcatgcc ttgtgcagccatgtggatgagtcgcagctgctgtacaccattgagagcaaccatcttcct ggccttctgcgcagtggctactacgacctgctcatcagcatgcacttagagtctgccaaa cgctcccgcctcatgatgaacagcgagttcattgtccccatgacggatcaaaccaagggc atcacacttttcccagatgacaccaagaagcctggtttacctggcgtgggcatgagcgcc tgtttgcgtcctcctctgcacttctcagaaacctgctttgttagcaccaactccgagctg taccagctgagtccttccatccccttggatatcctcaaggtgaaggccatcaacatgctg accgaggctgtccaagatggtgggcagcacacccgtgatcctgttggcggcagcgtggag ttccagtttgtgccagtcctcaagttaatctgcaccctcctcatcatggctatctttgaa gatgaggatgtacggcacatcctcaagatgatcgaaccctatgtctttggggagtccaag gaagaggaggaggaagtgccggcgggtgaagaaggagctgaagaaggggaagagctggtg gctgaggaagaagaggagttggtggcaatggaggaggaagaaggcgatggggcagagaaa gaggctggaggagggcagaaggaggaagcagaggagggtgacaagagggagttgaaagcc attgaggctggggaagcagaagccaaggaagaagaggaaggattggaggagggcctgcta cagatgaagcttcctgaatctgtcaaactgcagatgtgcaacctgttgcaattcttctgt gaccgggagctgcaacaccgtgtagaagccatcattgcattctcagagcgctatgtggac aacctgcagatcaaccagcgccagcgctacaacacactgatgcaggactttgcaatgtcg gccgctgagacggctcggcgcaccagggagttccgctccccaccacaggagcagattaat atgctgctgaacttcaagaatggggctgatgaggaagagtgcccagtgccagacgaaatc cgtgatgagttgctggagtttcacactgacttgttggctcactgtggtatccaggcggag ggtgaggaagaagaggaggaagaagacacatccttccgacggcggttgatgagcttagtg gataaggtggtgagcttccgcaagaagaaagaggaacaggaagaggaacagcctgcagaa gaggagcctaaacctagcactctgcaggagttgatctcacacactatggtccattgggcc caagagtccttcattcagagcccagagctggtgcgggtcatgttcagccttcttcatcgg cagtacgacggccttggggagttaattcgtgccatgcccaaggcctacaccattaatgcc aactctgtagaggatactatgagcctgctggagtgcctgggccagatccgttcactgctc attgtccagatgggcccggaggaggagaacctgatgattcagagcattggcaacattatg aacaataaggtcttctaccagcatcccaacctgatgagggccctaggcatgcatgaaact gtcatggaggtgatggtgaatgtattgggaggaggagattcaaaggagatccggttcccc aagatggtgaccaactgttgccgcttcctgtgctacttttgccgtatcagccgccagaac cagcgctccatgtttgaccacctgagctatttgctggagaacagcggcattgggttgggc atgcgtggatccactcccttggatgtggctgccgcttctgtcattgataacaatgagctg gccctggccctgcaggaacaagacctggagaaggtggtgacatatctggccggagctggc ctccagagctgccctatgctgctctccaagggttatcctgacatcgggtggaacccgtgc ggaggagaacgttatttggacttcctgcgcttcactgtctttgtcaacggggagagcgtg gaagagaatgccaatgtagttgtgcgcctgttaatccgacgccccgagtgctttggccca gccctaagaggtgaaggtggcaatggtttgttggcagccatagaggaagccatccagatc tcccaggatccagcccgcgatgggcccactgtcaaaaaggatcgccgtcgggagctgttt gggggagaagacactcatgaggagaaccgggttcatttgggcaatgcagtcatgtccttc tatgctgcactcatcgatttgctggggcgttgtgcccccgaaatgcatctcatccaggcc gggaaaggtgaagcgctcaggatcagagccatcttgcgctctttggtgcccatcgaagac ctcgtcggagtcattagccttccactgcagatcccttcatttggcaaagatggcagtgtt gttgagcccaagatgtcggccagcttcgtgcctgaccacaaggctcccatggtgttgttc ctggaccgggtctatggcattgacaaccaggacttccttctccatgtgctggaagtgggc ttcttgcctgacatgagagccgctgcctcattggacacagctgccttcagtaccactgag atggcactggccttgaaccgctatctctgttcagccgtgttgccgctcatcaccaagtgt gctccgctttttgctggcactgagcaccgggccatcatggtggactccatgcttcatacc atctaccgtctctcacgtggacgctccctcaccaaggctcagcgtgatgtcattgaagag tgcctcatggcgctgtgcaggtacatccggccctccatgcttcaacacctcttgcgccgg ttggtctttgacgtgcccatcctgaatgagtttgccaagatgtccctgaagctactgacc aaccattatgaacgctgctggaagtattactgccttcctaccggctgggccaactatggg gtcagctcagaagaggagcttcacctgaccaggaaactcttctggggcatctttgagtcc ttgtcccacaagaaatttgactctgacctatacaagctcgccatgccctgcctatgtgcc attgcaggggccatcccacctgactacgtggatgctagctactcttccaagactgagaag aaggcttctgtggatgctgagggcaactttgaccccaaacctgtggagacactcaatgtc atcattccagagaaactggactctttcatcaacaagtatgctgaatacactcatgagaaa tgggcctttgataagattcagaataactggtctttcggagaggcttacgatgaggaggcc aagacaagccccatgttgcgtccatataaaacattctcagaaaaggataaggaaatttac cggtggcccatcaaggagtctttgaaggccatgatagcttgggagtggaccgttgagaaa gcccgggagggtgaagaggagaagagtgagaagaaaaagacccgcaagatctcgcagact cagacatatgatcctagccatggatacaatcctcagcctatagatctgtctggagttact ctttccagggaattgcaggccatggcagagcagctggctgagaattaccacaacacctgg ggacgcaagaagaaagtagagctagaagccaaaggtggaggcacccatcctcttctggtg ccttatgatacattaacagcaaaggagaaagcccgggaccgagaaaaggcccaagagttg ctcagattcttgcagcttaatggttatgcagtgacaaggggtttgaaggacatggagctg gacacatcatccattgagaaacgctttgcctatggtttcctgcaacagctgttgaaatgg atggacatctctcaggagttcattgcccatctggaggccgtggtgagcagcggacgggta gagaaatcccctcatgagcaagagatcaagttctttgccaagatccttttgccactgatc aaccaatacttcaccaaccactgcctctacttcttgtccacaccggccaaagtgctaggc agtgggggccatgcttccaacaaggagaaggagatgataaccagccttttctgcaaactg gcagccctggtcaggcaccgggtctctctctttggcacagatgctgctgctgtggttaac tgcctccatatccttgctcgctctttggatgccaggacagtgatgaaatcaggccctgag attgtgaaggctgggctgcgttctttctttgaaggtgcctcagatgacattgagaagatg gtggagaatctcaagctgggcaaagtgtcacaatcccgcacccaggtcaagggtgtgggc cagaatatcacttacaccactgtggcactgctgcctgtccttacatccatctttgagcac attgcccagcaccagttcggggatgatgtgatattggatgatgtccaggtctcctgctac cgaactctgtgcagtatctattcccttggtacaaccaaaaatccttatgtggagaggcaa cgcccacaacttggggaatgtttggcacgactagcagcagcgatgcccgtggccttcttg gagcctcatatcaacgaatacaaccccttctccgtttacaccaccaaatcacccagagag cgagccatcttgggcctaccaaacagtgtggaggagatgtgtccagatatccccgtcctg gagaggctcatgaaggaaatcagtgggctggctgagtctggagcccgctacactgagatg ccccacgtgattgagatcaccttgccaatgctctgcaactacttacctcgctggtgggag cggggccctgaaaacaacccccagggtccctggtgcactgatgtgacgtctgaccaactc aacaccttgctgggcaacatcctgaagatcattgtcaacaacctgggtatagatgaagct tcctggatgaagcggttggcagtctttgcacagcccattgtcagcaaggcaaaaccagaa ctgcttcgctcccacttcattcccaccatggagaaactgaagaagcgctcagggaaggtg gtagctgaggaggaccagttgcgcttggaagctaagacagagtccgaggatgctgagcta ctcattcgggacgagttctcggtgctttgtcgggacctctatgccctatacccactgctc atccgatatgtggacaacaacagggccaattggttgacggaaccaaactcggatgctgag gagctgtttcggatggttggggaggtgttcatttactggtccaagtcacacaacttcaaa cgagaagaacaaaactttgtggtgcagaatgaaatcaacaacatgtccttcctaacagct gatagcaagagcaaaatgtccaagtctggagaaggccagtcaggtggctcagaccaggag cggacgaagaagaaacgccgtggggaccgctactctgtccagacctctctcattgtggcc actctgaagaagatgctgcccattggcctgaatatgtgctcccccactgaccaggagctg atcaacttggccaagctacgctatgccctgaaagatacagatgaagaggtgcgtgaattc ctcaacaacaacctacaccttcagggcaagtgtgagaattcctcatccatgcgctggcag atggctctctataaggagatgtctggcaaagccgaggactgtaacaatccagagaagatt gtcaaacgggttcaggaggtctcagctgtgctttatcacctggagctgacggagcaccca tacaagtcaaagaaggctgtgtggcataaactgctctccaaacaacgccggcgtgccgtg gtggcctgcttccgcatgacacccctctacaacctgcccaggcatcgggcttgcaatatg ttcttggagagctacaagctgtcctggatcctttctgaagagcatccttttgaagacagg atgattgacgatttgtctaaaccaggagaggaagaagaggaagaggaggaagaggcagaa aagaagccagacccattgcaccagctcatcctgcacttcagcaggactgccctgacagag aagaccaaactggaggaagattacctgtacatggcatacgctgacatcatggcaaaaagt tgccacttaaacgaagaagaaggtgatgagggtgaagaaggggaagaagctgaagttcct tttgaagagaaggaaatggagaaacagaaacttctgtatcaacagtcccgactgcacaac cgtggggcagccgagatggttctgcagatgattagcgcctgtaaaggggagcctggtgcc atggtatcttccacgctgaaactgggcatctccatcctgaatggtggcaatgaggaagtg cagcagaaaatgctggattatctgaaggagaaacgtgaagtgggattcttccagagcatc caagcactaatgcagacatgcagtgtgctggatctcaatgcctttgagaggcaaaacaaa gccgaaggactgggaatggtgacagaggatggaacgatcatcagtcgtgaaaatggagag aaggtgatggcggacgatttgttcacacaggacctctttcggttcctgcagcttctatgt gaaggtcataacaacgattttcagaactacctgcggacgcagacaggaaacacaaacaca atcaacattatcatctgtactgttgactatcttctgcgtcttcaggagtccatcagtgat ttctactggtattactctggcaaggatgtgattgatgagcaaggcaaacgcaacttctcc aaagccatggcggtggccaagcaggtcttcaacagccttaccgagtatatccagggaccg tgcactgggaaccaacagagcctggcacatagcagactgtgggatgctgtaattggtttt ctccatgtctttgctcacatgatgatgaagttggctcagatgacccaaccccccggactt cgaaatggcgactcaagccaaattggccttctgaaggagctgttggacctgcagaaagac atggtggtgatgctgctgtccttactggaagggaatgtggtgaatggcaccattgcccgg cagatggtggacatgttggtggaatcctccagcaatgtagagatgattctcaagttcttt gatatgttcttgaagttgaaggacattgtggcctctgatgccttccgggattacatcaca gatcctcgggggctcatatccaagaaggatttccagaaagccatggatagccagaagcaa tacacaccatctgagatccagttcttgctgtcgtgttcagaggctgacgagaatgagatg attgactatgaggagtttgccaaccgcttccaagagcccgccaaagacattggttttaat atcgctgtactgttgactaacctctctgagcacatgccacatgaccaccgcctcaagacc ttcttggaactggcagagtgcatcctcaactacttcagtccctatctgggccgcattgag atcatgggtgccagcaagcgtattgagcgcatctactttgaaatcagtgagaccaacaaa gcccagtgggaaatgcctcaagtgaaggagtccaagcggcaattcatttttgatgtggtc aatgaggggggagagtcagagaagatggagctcttcatcaatttctgtgaggacaccatc tttgagatgcagattgcagctcagatttccgaggaggaagggcaggaggaagaagaggag gaagaagaaggagaaggagcagaagcaggggaggccgagaaggcgtcagcaccatcagag gcttcttcagcttttggggagtttttggaaagcgtcctgaacttcttccgaatgttcact taccgcaacatccgtcggcagttccgtaaaatcaagaagatgactgtgaaggagatggcc atggcaattgccactttcgtttatactattctgatgggcatcctctttttcttctacaac atcttcaagggcatcttccttctcatctggaacacacttttcggtggtggcctagtggaa gaggccaagaagatcaccatgactgaactgttggccagcatgcctgaccccacacaagat gaggtgcatggggacgtagccccatctgaagaggctgagcaagtgatggaggaaggggag gaagtagagatagacgagtctggcaaagaggaagcacctgccgaaggaggagagcttgga gcagacaagaaggagcatttccggtccatggctgccgacgcacctggtgggcttggggat atgggcgatacaacccctgtggaaccacctacacctgaaggatcacccatccttaagagg aaactaggaatggatggagaggaagagatagtggagccagagaaaatagaagagcctcct gtagaaccagagaaagctgatgctgaaaatggggaaaaggcagcaaaggaggaggaagag gagaagaagaaggaggaggaggcaacacctgaggaagaagagccccacaaaccagtcaag gagaagaagaaggtgacccagcgggagaagaaggagtccgaggcagcaggctcagaattt tggaacgagctggaagtccagcggataaaatttctgaactatctgtctaggaatttctac aacctccgcttccttgccctcttcttggccttcgcgatcaacttcatcctgctcttctac aaggtgtcagactcgcccccaggtgaggaagagtttgaaggctctggctttgaaggagag ctggatgcagcctctggtgctggctcaggttttggtggggacgatgacggcggggatggc aacgggaatggcaacggggatgaggacgaagaagacagcgtggtctactacttcctggag gagagcacgggctacatgcagccagccttgcagttcctgtccattgtccatacccttgtg gccttcctttgcatcatcggctacaactgcctcaaggtgccgctggtcatcttcaagcgt gagaaggagctggcgcgcaagctggagttcgatgggctctacatcacggagcagcctgag gacgatgacatcaagggccagtgggaccgcctggtcctcaatgccccgtcattcccgagc aattattgggataaattcatcaagagaaaggtgcttgataaatacggtgacatctatgga cgggagagaattgcagaactgctggggatggatttggccagtctggaaattacagcgcag aacgagaaaaaatctgagccggacaagtctttccttacttggatcacctctattgacctg aaatacaagatctggaagtttggagtcatctttacagacaactccttcttgtatctcttc tggtacatggtgatgtccgtcctcggccactacaacaacttcttctttgcttcccacctt ctggacatcgctatgggcgtcaagacgctgcggaccatcctctcatctgtcactcacaat ggcaaacagctgatgatgacagtggggctgctggcagtggttgtgtatctctacactgtg gtcgccttcaactttttccgcaagttctacaacaagagtgaggatgaggacgagcctgac atgaaatgcgatgacatgatgacgtgttacctgtttcacatgtatgttggggtccgagct ggtgggggcattggtgacgagatcgaggacccggccggtgatgagtatgagctttatcgt gtcatctttgacatcactttcttcttctttgtcattgtcatcctactggccattatccaa ggtttgattattgatgcctttggggagctgagagaccagcaggagcaggtgaaggaggac atggagaccaaatgtttcatctgtggaatcgggagtgactattttgacacgacacctcac ggctttgaaacccacacgctggaggagcataacttggcaaattatatgttcttcctcatg tatctcatcaacaaggatgaaacggagcacactggccaggagtcctatgtctggaagatg taccaagaacgctgctgggacttcttccctgctggcgactgcttccgcaagcagtatgaa gatcagctcggctag

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