Tachyglossus aculeatus (Australian echidna): 119937622
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Entry
119937622 CDS
T10703
Symbol
ITCH
Name
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
tacu Tachyglossus aculeatus (Australian echidna)
Pathway
tacu04120
Ubiquitin mediated proteolysis
tacu04144
Endocytosis
tacu04330
Notch signaling pathway
tacu04668
TNF signaling pathway
tacu04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
tacu00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
119937622 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
119937622 (ITCH)
04668 TNF signaling pathway
119937622 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
119937622 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
119937622 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
tacu04131
]
119937622 (ITCH)
04121 Ubiquitin system [BR:
tacu04121
]
119937622 (ITCH)
Enzymes [BR:
tacu01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
119937622 (ITCH)
Membrane trafficking [BR:
tacu04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
119937622 (ITCH)
Ubiquitin system [BR:
tacu04121
]
Ubiquitin ligases (E3)
HECT type E3
119937622 (ITCH)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
119937622
NCBI-ProteinID:
XP_038613107
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All DBs
Position
15:27208335..27243700
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AA seq
879 aa
AA seq
DB search
MTSGAARSGPAPGLTMKSQLQITVISAKLKENKKNWFGPSPYVEVSVDGQSKKTEKCSNT
SSPRWKQALTVIVTPVSKLSFRVWSHQTLKSDISLGSAVLDIQETLKSNNMKLDEVVVTL
QLAGDKEPAEIVGDLSVCLDGMHVDPEILINGSGIRPDSPTENDETRAKTEGRQSNDVPE
SREEAGSGESRRVNGNDSPSLPNGACKPSRPPRPSRPPPPTPRRPASVTSSPTAVPEAEM
SSAGSSPVGSASISSERGPEGAAAPAAGTPLPGPGAVTTPPAARPGQPGNPGSQQLSAAN
QGPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTT
TWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFTSTQNKEFDPLGPLPTGW
EKRTDSNGRLYFVNHNTRVTQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTT
TYIDPRTGKSALDNGPHIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQ
IMSFNPPDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQI
NPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEF
YNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHELKPNGSNILVTEANKEEYIRMVAEW
RLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAVYRHYTR
TSKQIGWFWQLVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENW
LPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
NT seq
2640 nt
NT seq
+upstream
nt +downstream
nt
atgactagcggtgcggcacgatcggggcccgcgcctggactgaccatgaaatcccaactg
cagatcacagtcatctcggcgaaactcaaagagaacaagaagaactggtttggaccgagc
ccctacgtggaagtgtcagtggacgggcagtccaagaagacggaaaagtgcagcaataca
agtagccccaggtggaagcaggcgctcaccgtgatcgtcactcctgtcagcaaactaagt
ttccgcgtctggagtcaccagacgttgaaatctgacatttcgctgggaagtgcggttctg
gacatccaggagacgttgaagtccaacaacatgaagctggacgaggtggtggtgaccctg
cagcttgccggtgacaaggagccagccgaaattgtgggagacttgtcggtgtgtctagat
gggatgcacgtcgatccggagatcctcatcaacggcagcgggatccgacctgacagtccc
accgagaacgatgaaaccagagccaagacggaaggcagacagagcaacgacgttcccgag
agccgtgaggaagcggggtccggtgaaagcaggagggtcaatggcaacgattctccctcc
ctcccgaatggcgcttgcaaaccctccaggcctccgaggccctcccgcccacccccgccc
accccgcggagaccggcctccgtcaccagctcgccgaccgccgtcccggaagccgagatg
tccagcgcgggctcgtcgccggtcgggagcgcgagcatatcgtcggagaggggtccggag
ggagccgccgcccctgccgccggcacccccttgcccggccccggggccgtgaccacacct
ccagccgcccggccggggcagcccggaaaccctggctcccagcagctcagcgccgccaac
caggggcctctgcccccagggtgggagcagagagtggaccagcacgggcgagtgtactac
gtggaccacgtggagaagaggaccacgtgggacaggccggagccccttcctccgggttgg
gagcggcgagtggacaatatggggcgcatctactacgtggaccacttcaccaggaccacc
acttggcagcggcccacactggagtccgtccgcaactacgagcagtggcagctgcagcgc
agtcagctccaaggggccatgcagcagttcaaccagagattcatctacgggaatcaggat
ttgtttacttcgacccagaataaagaatttgatcccttggggcccctgccaacaggatgg
gagaagaggacggacagcaacggcagactctacttcgtcaaccacaacacccgcgtcacg
cagtgggaggacccgcggagccaggggcagctgaatgagaagccgttgccggaaggctgg
gagatgcggttcacggtggatggcatcccctacttcgtggaccacaaccgcaggaccacg
acgtacatcgacccccggactgggaaatctgctctagacaacggtccccacattgcctac
gttcgagacttcaaggcgaaggtccagtatttccgattctggtgccagcaactggccatg
ccgcagcacatcaagatcaccgtgacgaggaaaacgctgtttgaggactcgtttcagcag
ataatgagcttcaacccgccggacctgcggagacgcttgtgggtcattttccctggagaa
gaaggcttggattacggaggtgtggccagagagtggttcttccttttgtcccacgaggtg
ctgaaccccatgtactgcctgtttgaatacgcaggcaaggacaactactgcctccagatc
aaccctgcctcctacatcaacccagatcacctcaaatacttccgattcatcggcaggttc
atcgccatggccctgttccacgggaagttcatcgacacgggcttctccttgccgttctac
aaacggatcctcaataagcccgtggggctcaaagacctggagtccatcgaccccgagttc
tacaactctctcatctgggtgaaggaaaacaacattgaagagtgcggcttggaaatgtac
ttctccgttgacaaggaaattctcggggagatcaaaagccacgagctgaagcccaatgga
agcaacatcctggtcacggaggcgaacaaggaggagtacatccgaatggttgccgaatgg
aggctgtctcggggcgtggaggaacagacccaggctttcttcgagggcttcaacgagatc
cttcctcagcagtacctgcagtactttgatgctaaggagctggaggtcctcctttgcggg
atgcaggagatcgacttgaacgattggcagagacacgccgtctaccgccactacaccagg
acgagcaagcagattggctggttctggcagctggtgaaagagatcgacaacgagaagagg
atgcggctgttgcagttcgtcacgggcacgtgcaggcttcctgtgggaggatttgccgac
ctgatggggagcaatggaccgcagaagttttgcattgaaaaagtgggaaaggaaaactgg
ctaccccgaagccacacctgtttcaacaggcttgacctgccgccctacaagagctacgag
cagctgaaggagaagctcctgttcgccatagaagagacagaagggttcgggcaggagtga
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