KEGG   Tachyglossus aculeatus (Australian echidna): 119949207
Entry
119949207         CDS       T10703                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
tacu  Tachyglossus aculeatus (Australian echidna)
Pathway
tacu01521  EGFR tyrosine kinase inhibitor resistance
tacu01522  Endocrine resistance
tacu04010  MAPK signaling pathway
tacu04012  ErbB signaling pathway
tacu04014  Ras signaling pathway
tacu04015  Rap1 signaling pathway
tacu04022  cGMP-PKG signaling pathway
tacu04024  cAMP signaling pathway
tacu04066  HIF-1 signaling pathway
tacu04068  FoxO signaling pathway
tacu04071  Sphingolipid signaling pathway
tacu04072  Phospholipase D signaling pathway
tacu04140  Autophagy - animal
tacu04148  Efferocytosis
tacu04150  mTOR signaling pathway
tacu04151  PI3K-Akt signaling pathway
tacu04210  Apoptosis
tacu04218  Cellular senescence
tacu04270  Vascular smooth muscle contraction
tacu04370  VEGF signaling pathway
tacu04371  Apelin signaling pathway
tacu04517  IgSF CAM signaling
tacu04540  Gap junction
tacu04550  Signaling pathways regulating pluripotency of stem cells
tacu04613  Neutrophil extracellular trap formation
tacu04620  Toll-like receptor signaling pathway
tacu04650  Natural killer cell mediated cytotoxicity
tacu04660  T cell receptor signaling pathway
tacu04662  B cell receptor signaling pathway
tacu04664  Fc epsilon RI signaling pathway
tacu04720  Long-term potentiation
tacu04722  Neurotrophin signaling pathway
tacu04730  Long-term depression
tacu04810  Regulation of actin cytoskeleton
tacu04910  Insulin signaling pathway
tacu04912  GnRH signaling pathway
tacu04915  Estrogen signaling pathway
tacu04916  Melanogenesis
tacu04917  Prolactin signaling pathway
tacu04919  Thyroid hormone signaling pathway
tacu04921  Oxytocin signaling pathway
tacu04926  Relaxin signaling pathway
tacu04929  GnRH secretion
tacu04934  Cushing syndrome
tacu04935  Growth hormone synthesis, secretion and action
tacu05010  Alzheimer disease
tacu05022  Pathways of neurodegeneration - multiple diseases
tacu05132  Salmonella infection
tacu05135  Yersinia infection
tacu05160  Hepatitis C
tacu05161  Hepatitis B
tacu05163  Human cytomegalovirus infection
tacu05164  Influenza A
tacu05165  Human papillomavirus infection
tacu05166  Human T-cell leukemia virus 1 infection
tacu05167  Kaposi sarcoma-associated herpesvirus infection
tacu05170  Human immunodeficiency virus 1 infection
tacu05200  Pathways in cancer
tacu05205  Proteoglycans in cancer
tacu05206  MicroRNAs in cancer
tacu05207  Chemical carcinogenesis - receptor activation
tacu05208  Chemical carcinogenesis - reactive oxygen species
tacu05210  Colorectal cancer
tacu05211  Renal cell carcinoma
tacu05213  Endometrial cancer
tacu05214  Glioma
tacu05215  Prostate cancer
tacu05216  Thyroid cancer
tacu05218  Melanoma
tacu05219  Bladder cancer
tacu05220  Chronic myeloid leukemia
tacu05221  Acute myeloid leukemia
tacu05223  Non-small cell lung cancer
tacu05224  Breast cancer
tacu05225  Hepatocellular carcinoma
tacu05226  Gastric cancer
tacu05230  Central carbon metabolism in cancer
tacu05231  Choline metabolism in cancer
tacu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tacu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119949207 (MAP2K2)
   04012 ErbB signaling pathway
    119949207 (MAP2K2)
   04014 Ras signaling pathway
    119949207 (MAP2K2)
   04015 Rap1 signaling pathway
    119949207 (MAP2K2)
   04370 VEGF signaling pathway
    119949207 (MAP2K2)
   04371 Apelin signaling pathway
    119949207 (MAP2K2)
   04066 HIF-1 signaling pathway
    119949207 (MAP2K2)
   04068 FoxO signaling pathway
    119949207 (MAP2K2)
   04072 Phospholipase D signaling pathway
    119949207 (MAP2K2)
   04071 Sphingolipid signaling pathway
    119949207 (MAP2K2)
   04024 cAMP signaling pathway
    119949207 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    119949207 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    119949207 (MAP2K2)
   04150 mTOR signaling pathway
    119949207 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    119949207 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119949207 (MAP2K2)
   04148 Efferocytosis
    119949207 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    119949207 (MAP2K2)
   04218 Cellular senescence
    119949207 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    119949207 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    119949207 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119949207 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    119949207 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    119949207 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    119949207 (MAP2K2)
   04660 T cell receptor signaling pathway
    119949207 (MAP2K2)
   04662 B cell receptor signaling pathway
    119949207 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    119949207 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119949207 (MAP2K2)
   04929 GnRH secretion
    119949207 (MAP2K2)
   04912 GnRH signaling pathway
    119949207 (MAP2K2)
   04915 Estrogen signaling pathway
    119949207 (MAP2K2)
   04917 Prolactin signaling pathway
    119949207 (MAP2K2)
   04921 Oxytocin signaling pathway
    119949207 (MAP2K2)
   04926 Relaxin signaling pathway
    119949207 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    119949207 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    119949207 (MAP2K2)
   04916 Melanogenesis
    119949207 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    119949207 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    119949207 (MAP2K2)
   04730 Long-term depression
    119949207 (MAP2K2)
   04722 Neurotrophin signaling pathway
    119949207 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119949207 (MAP2K2)
   05206 MicroRNAs in cancer
    119949207 (MAP2K2)
   05205 Proteoglycans in cancer
    119949207 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    119949207 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    119949207 (MAP2K2)
   05230 Central carbon metabolism in cancer
    119949207 (MAP2K2)
   05231 Choline metabolism in cancer
    119949207 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119949207 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119949207 (MAP2K2)
   05225 Hepatocellular carcinoma
    119949207 (MAP2K2)
   05226 Gastric cancer
    119949207 (MAP2K2)
   05214 Glioma
    119949207 (MAP2K2)
   05216 Thyroid cancer
    119949207 (MAP2K2)
   05221 Acute myeloid leukemia
    119949207 (MAP2K2)
   05220 Chronic myeloid leukemia
    119949207 (MAP2K2)
   05218 Melanoma
    119949207 (MAP2K2)
   05211 Renal cell carcinoma
    119949207 (MAP2K2)
   05219 Bladder cancer
    119949207 (MAP2K2)
   05215 Prostate cancer
    119949207 (MAP2K2)
   05213 Endometrial cancer
    119949207 (MAP2K2)
   05224 Breast cancer
    119949207 (MAP2K2)
   05223 Non-small cell lung cancer
    119949207 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119949207 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    119949207 (MAP2K2)
   05161 Hepatitis B
    119949207 (MAP2K2)
   05160 Hepatitis C
    119949207 (MAP2K2)
   05164 Influenza A
    119949207 (MAP2K2)
   05163 Human cytomegalovirus infection
    119949207 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119949207 (MAP2K2)
   05165 Human papillomavirus infection
    119949207 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119949207 (MAP2K2)
   05135 Yersinia infection
    119949207 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119949207 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    119949207 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    119949207 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119949207 (MAP2K2)
   01522 Endocrine resistance
    119949207 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tacu01001]
    119949207 (MAP2K2)
Enzymes [BR:tacu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     119949207 (MAP2K2)
Protein kinases [BR:tacu01001]
 Serine/threonine kinases: STE group
  STE7 family
   119949207 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Seadorna_VP7 Kdo APH
Other DBs
NCBI-GeneID: 119949207
NCBI-ProteinID: XP_038626693
LinkDB
Position
X2:11703482..11725579
AA seq 400 aa
MPPKRKPVLPALNITPTIAEGPSPTSEGSSEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDTKELEAIFGRPMVDGAEGEPSSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAM
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgccacccaagaggaagccggtgctgccggcgctcaacatcactcctaccatcgccgaa
ggcccgtcccccaccagcgagggctcctccgaggcgaacctggtcgacctccagaagaaa
ttggaggagcttgagctagatgaacagcagaagaagcggctggaggctttcctcacccag
aaagccaaggtgggagagctgaaggacgatgactttgaaaggatctcggagctgggagct
ggcaacggtggggtggtcaccaaagtccaacacaaaccctcagggctcatcatggcacgg
aagttgattcacctggagatcaaacctgctattcgcaaccagatcattcgggaactccag
gtcctgcacgagtgcaattcgccttacattgtgggcttctatggagccttctatagcgat
ggggaaatcagcatctgcatggagcacatggatggagggtctctggatcaggtattaaaa
gaagccaagagaattcctgaagagatcttggggaaagtcagcattgcagttctgcgcggt
ttggcatatctaagagagaaacaccagattatgcacagagacgtgaaaccctccaacatc
cttgtcaactcccggggagagatcaagttgtgtgattttggggtgagcgggcagctcatc
gactccatggctaactccttcgtgggaacccgctcctacatgtctccggagcggttgcaa
ggcactcactactcagttcagtccgatatctggagtatgggcctgtccctagtagagctg
gccatcggaagatacccaatcccccctccagacaccaaggaattagaagcgatctttggt
cggcccatggtcgatggggcagagggagagccctccagcatctctccgcggccacgaccc
ccaggacgcccaatcagtggccacgggatggatagtcgaccagccatggccatctttgag
ctgttggactatattgttaacgagcctccacctaaacttccgaacggggttttcacgcaa
gacttccaggagtttgtaaataaatgcttaattaaaaatccagcagagcgggcagatctg
aagatgctgatgaatcatgcctttatcaaacggtcagaagtggaagaagtggattttgca
ggctggttatgtaaaacactgaggttaaaccaacccagcacccccacgcgcactgccatg
tga

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