Triplophysa dalaica: 130435579 Help Entry 130435579         CDS       T09616                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b isoform X1   KO K04961   ryanodine receptor 1 Organism tdw  Triplophysa dalaica Pathway tdw04020   Calcium signaling pathway tdw04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tdw00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     130435579 (ryr1b)    04020 Calcium signaling pathway     130435579 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:tdw01009]     130435579 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:tdw04147]     130435579 (ryr1b)    04040 Ion channels [BR:tdw04040]     130435579 (ryr1b) Protein phosphatases and associated proteins [BR:tdw01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      130435579 (ryr1b) Exosome [BR:tdw04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    130435579 (ryr1b) Ion channels [BR:tdw04040]  Voltage-gated cation channels   Ryanodine receptor    130435579 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 YebO Motif Other DBs NCBI-GeneID:  130435579 NCBI-ProteinID:  XP_056622271 LinkDB All DBs Position 14:11461357..11535199 Genome browser AA seq 5086 aa AA seqDB search MAEGEGGDEEIQFLRTEDQVVLQCSATVLKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICAFILEQSLSVRALQEMLANTVDMSEAIDLEKWSSQGGGHRTLLYGHAILLRHHHS GMYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGDLMVDASFMQTLWNMNPVLSGCELAEGHLTGGYVIRLFHGHMDECLA ISQPDQGEDQRKIAQYEGGAVCSQARSLWRLEPLRIGWSGSHMKWGQAFRVRHITTGRYL CLDEEKGLMVLDPEKANTKQSAFCFRASKEKVEGAQKKRDVEGMGVPEIKYGESMCFVQH LSTGLWLTYAALDAKAARLGTVKRRAILHQEGHMDDALTVSRSQTEESQAARMIYNTTGL YTQFIKGLDSLSGKNKSSGPVSLPLDGVILSLQDLIHYFRPPEEELEHEEKQTKLRSLRN RQNLFQEEGMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGN RSNCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKH GRNHKVLDVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIVNYVSSVRPNIFLGTC EGSTQYKKWYFEVMVDYVEAYVTAQATHLRVGWGMTEGYSPYPGGGEGWGGNGVGDDFYS YGFDGLHLWSGHVSRQVASPNQHALAADDVVSCCLDLSVPSISFRVNGHPVQGMFENFNL DGLFFPVISFSAGVKARFLLGGRHGDFKFLPPPGYAPCYEALLPKDRMRIESIKEYKHDF DGVRNLLGPTQSLTHTSFTPCPVDTAQIVLPPHLERIREKLAENIHELWAVTRIEQGWIY GLFRDDNKKLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKI KLPKTYMMSNGYKPAALDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDI MNKRNPRLVPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESSSLGEDNTRGDKV RIFRAEKHYGVTSGKWYFEFEAVTTGEMRVGWARPNVRADIELGSDELAYVFNGNRAQRW HIGNDPFGRQWLSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGDGFIPVC TLGLSQVGRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTEH NHIEVSRVDGTVDTAPCLKMTHKTFGSQNANTDMLFFRLSMPVEFDLTFKVLAGSTPLTR TLNIPEEEVLEVDPDSDFEVLKKSAGRKEQEEKEKESSVPKDIPSNHENDKDAASEKGKK KGFLFKAKKAAMIAPPPPPLMPRLFEDVVPDDRDDPEIILNTTTYYYSVRIFAGQEPSGV WVGWVTPDFHMYDLNFDLSKIRTVTLTVGDDKGNIHDSIRRSNCYMVWGGEFGSSQQRFS QEDLVIGCLIDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFSLPSSQNMLQLELGKLK NIMPISAAMFRSERKNPVPQCPPRLDVEMLTPVIWSRMPNHFLKPEVGRVSEKHGWMVEC VEPLTMMALHIPEENRCIDVLELSERHDLLKFHYHTLMLYCAVCALGNNRVAHALCSHVD ESQLFYAIENTYLPGPLRSGYYDLLISIHLESAKRNRLGTNREFIIPMTQETLSIKLYPD TEGAHDLPGVGLTTCLRPKLHFSPINFVGTDPHLYTISPVIPLQELKIKALSMLTEAVFD GSHAMRDPVGGSVEFHFVPILKLISTLLIMGIFNNDDVKHILKMIDPNVFGKKEEETVEE ESGEEAAPKEEGEEVKEKEEVAEGEEEAVDEGVGEEEDEEELKALEKVEEGEEGEEAEKE EGEKVDGEKAEEEKEAEEVAEEPKEEEEEAPEEGLLQMKLPESVKLQMCTLLQYFCDCEL RHRVEAILAFSNDFVEQVQSNQRERYKELMRAFTMSAAETARKTREFRSPPHEQVILLTN FKHCPDDEECPVPEEVRETLQNFHNDILSHCGVHVEEETEEKEVDTSLRGRLLSLVVKVK SLRKKKEEEEPEPEEEVKPSTLQELISHTMIHWAQEAFIQNPELVRLMFSLLHRQYDALG ELIRALPKAYAISSVSVQDTMDLLECLGQIRSLLIVQMGPEEETLMIQSIGNIMNNKVFY QHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTSCCRFLCYFCRISRQNQRSMF DHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLQMCP MLLSKGYPDIGWNPSGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGE GGAGLLAAIEEAIKISEDPARDGPTTKKDRRFMFGAEEQQEENRVHLGNAVMSFYSALID LLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPTLGKDSQIVEPKMS ASFVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTLVFSTTEMALALN RYLCSAVLPLLTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEDCLMSLV KYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVTSEEE LHLSRKLFWGIFESLAHKKFDAELFKIAMPCICAIGGAIPPDYVDASFSSMTEKKASVDA EGNFDPKPVETTNTIIPERLDAFINKYAEHTHDKWAFEKIQNNWTYGEVLDENGKTHPML RPYKTFSEKDKEIYRWPFKESIKAMLAWEWTLEKARDGETEKVEVKTTRKISQTAHATYD PSQGYSPQPVDLTSMALSRELQSMAEQIAENYHNTWGRKKKMELQAKGGGTHPLLVPYDT LTAKEKARDREKAQDLLKFLQFNGFAVTRGLKDMEQEISSIEKRFAYGFLQKLLKWMEIA QEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHCMYFLSTPAKVLGSGGH ASNKEKEMIASIFCKLAGLVRHRVSLFGTDASAVVNCLHILSHSLDARTVMKSGPEIVKA GLRSFFESAADDIEKMVENLKLGKVSTKNQVKGVSQNINYTTTALLPVLTSLFDHIAQYQ FGDDVMMDDLQISCYRIMCSIYSLGTVKTPHAENQRPALGECLAHLAAAMPVAFLEPNLN EFNSYSVYTTKTPRERTILGLPSQVQELCLDIPELDVLMKEIGDLAESGARYTEMPHVIE ITLPMLCNYLPRWWERGLENFPEMEGRLCTDVTSEQLNQLLGSIMKIVVNNLGIDEASWM KRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEDQLRMEGKGEVDSEQGTIR DEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEDLFRMVGEVFIFWSKSHNFKREE QNFVVMNEINNMSFLTADSKSKMSKGGDAEGGGSDVERTKKKRRGDRYSVQTSLIVAALK KLLPIGLNMCSPADQELINMAKIRYSLKDTDEEVREFLQNNLHLHGKEEDPSMRWQMALY KETSGKADDADAPDKVVKRVQEVSAVLFHIELTEHPFKSKKMVWHKLLSKQRRRAVVACF RMTPLYNIPRHRGSNMFLDGYRRNWIENEGYSFEDKMIDDLSKTLEQEEEEEEETEAKPD PLHQLILHFSRTALTEKTKLDVDHLYMSYADIMAKSCHMGEEDEEGEEGGEEPSFEVRQT EMDKEMEKQRLLYQQSRLHERGAAEMVLQMISACTGETGAMVSSTLKLGISILNGGNCDV QQRMLDYLKDKKDVGFFLSLQSLMQTCSVLDLNAFERQNKAEGLGMVSEEGKKEKVMSDD EFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWYYS GKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAH MMMKLAQMHPDLGLRNSDPFWNRTHAEDSSQIGLLKELLDLQKDMVVMLLSLLEGNIVNG TIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMD SQKQYTPSEIQFLLSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDT RLKNFLGQAESVLNYFRPFLGRIEIMGASKRIERIYFEISEANRNQWEMPQVRESKRQFI FDVVNEGQESEKMEMFVNFCEDTIFEMNIASQISEVEEEVQEDEDEEEEEESGGGGKREG DGEEGNGEAPPESSSAFADFIKSIVSLLSLFTFRNLRRRYRKIRKMTIKDMVVGLVMFLY TVLFGILHFIYSVCKGFFILIWNTLFGGGLVEGAKKMTLTEILTNMPDPTQDEVHDDLPP EPGARNVQESGGTGDGEEGTGGGEVEEEDGEEDGGERTGFGPHGGLGDMGETEPEEPPTP EGSPLLKRKLVGEVEGEVVVEEKVKEEEPAPEPEKADAENGEKTEKEAEAEPEEKMKELE EIKAKAKTKKGKKEEGHGFEIWNELEVQRNKFMNSLARNFYNLRFLALFIAFALNFILLF YKVAEGPRGEDELEGSAMYEGSGVFEGSGVFEGSGGEAEGSGIEENGEEDDEEGYVYFCL EESTGYMEPAMAFFSILHSVIAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYVTEQP EDDDIKGQWDRLVLNTQSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSA MIHGKKPQPDTSMLTWLTSIDIKYQIWKFGVVFTDNTFLYLVWYTVMSLLGHYNNFFYAC HLLDIAMGVKTLRTILSSVTHNGKQLLMTVGLLAVVVYLYTVVAFNFFRKFYNMSEDEDE PDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDDYELYRVVFDITFFFFVIVILLAI IQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYFDSTPHGFETHTMEEHNLANYMFF LMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15261 nt NT seq  +upstreamnt  +downstreamnt atggcagagggagaggggggagatgaggagatacagttcctacggacggaagaccaagtt gtgctccagtgctctgcgaccgttctgaaggagcagatcaagctatgcctttcctgtgaa ggcttcggaaaccgtctgtgttttcttgagacaacgtcaaatgcccagaatgtcccgcct gatctggcgatctgtgcctttatactggagcagtcgctctcggtacgagccctacaggag atgctggcaaacaccgtggatatgagtgaggcaatcgatttggagaaatggtcttctcag ggaggaggacaccgaacgctgctctacggtcacgccatccttcttagacaccatcactct ggcatgtatctaagctgcttgacaacatcacgctcacttacagacaagctggcttttgat gtcggcctgcaggaggattcaacgggggaagcatgctggtggaccatccaccccgcatcc aagcagaggtcagagggtgagaaagtcagagtaggagatgacctgatcctggttagcgta tcatcagagagatacctgcatctgtcgtacgccagtggggatctgatggtcgatgcttcc ttcatgcagactttatggaacatgaatcccgtcttatcagggtgtgagctggcagaaggg cacttaaccggaggttatgtcataagattgttccatggtcacatggatgagtgtctggcc atctcacaacctgatcaaggagaggatcagcgcaagattgcacaatatgaaggaggggcc gtatgtagtcaggcccgatcgttgtggagacttgagccactgagaataggttggagcggt agccacatgaagtggggtcaggccttccgtgtacgtcacatcacaacgggtcgctacctg tgtctagatgaggagaagggtcttatggttctggatccagagaaagccaacaccaaacag tctgcattttgtttccgcgcatcgaaggagaaggttgaaggggctcagaagaagcgagat gtggaaggaatgggtgttcctgagatcaaatatggcgagtccatgtgctttgtgcagcat ctctccacaggcctgtggctcacatacgctgctctagatgctaaagcggctcgtctggga actgtgaagagaagggccattttacatcaagagggccatatggatgatgcgctcaccgtg tctcggtcccagacagaagaatctcaggctgcccgtatgatttataacaccactggcctt tatacacaatttatcaaaggtctagactctctgagtgggaagaacaaatcgtctgggccg gtgtccttgccactggacggagtgattctatctctgcaggatttaatccattacttccgt ccgccggaggaggagctggaacacgaggagaaacagaccaagctgcgctctctacgcaac cgacagaacctcttccaagaagaggggatgatcaccatcgttctggaatgtatagatcgt ctgaatgtctacaacactgctgcgcacttctcagagtttgccggggaggaggcagctgaa tcttggaaggagattgtcaatcttctctacgaactgctcgcatctctgatcagaggaaac cgttctaactgtgctttgttctgtgataatctggattggctggtcagtaaactggatcgt ctggaggcttcttcaggcattcttgaggtgctgtattgtgttttgatcgaaagtcctgaa gtcttgaacatcatccaggagaaccacataaagtccatcatttcccttttagacaaacac ggtcgaaaccataaggttttggacgtactacgttctttgtgtgtgtgtaacggtgttgct gtgaggtccaatcaaaacctcatcacagaaaatttgcttccgggtcgtgacctcctgctg cagactaacattgttaactatgtatcaagcgtgagacccaatatcttcttgggtacctgt gaaggttccacccagtacaaaaagtggtactttgaggtaatggtggactacgtggaagcg tatgtgacggctcaggcgacccacctgcgtgtgggctggggcatgactgagggctacagt ccgtaccctggaggaggagaaggatggggcggcaacggtgtgggtgatgacttttactcc tatggatttgatggtcttcacctgtggtcaggtcacgtgtcacgtcaggtggcttcaccc aaccagcacgccctggcagccgatgacgtcgtgagctgctgtctggatctgagcgtgccc agcatctccttccgtgtcaacggtcatccggtccaggggatgtttgagaacttcaaccta gacggcttgttcttccccgtcattagcttctctgctggagtgaaagcgcgcttcctctta ggtggtcgccatggtgatttcaagttcctaccgcctcccggttacgcaccgtgttacgaa gcccttctgcccaaagacagaatgcgcatcgagtctattaaagagtacaagcacgacttc gatggcgtccgaaaccttctgggtcccacacagtctctcacgcacacctcattcactccc tgtcccgttgacaccgcccagatcgtgttacctcctcatttggagcgcatcagagagaag cttgctgaaaacattcacgagctttgggccgtgacccgtattgagcagggctggatctat ggattgttcagggacgataataagaagctacacccgtgcctggtggatttccatagtctt cctgaacctgagaggaactataaccttcagatgtctggagagaccctcaaaaccctctta gctcttgggtgtcatgtgggcatgggagatgagaaagcagaggagaacctgaagaagatc aaactgcctaaaacgtatatgatgagcaatggatacaagcctgctgctctggacctcaat catgtcaaactgacacccaatcagaaccagctggtggagaagctggcagaaaatgggcac aatgtttgggcacgggacagagtgagacagggctggacctacagcatcgtgcaggacatc atgaataagcgcaaccctcgtctggtgccttacaacttgctggacgagagaaccaaaaaa accaacagggacagcgtgaacaacgcagtacgcactctgatcggttatggatacaacatt gaacctccagatcaggagagcagtagtcttggtgaagacaacacgcgaggagataaagtg cgtatcttcagagctgagaagcattatggtgtcacatcaggaaaatggtactttgagttt gaggccgtaaccacaggagagatgagggtgggctgggctcgaccgaatgtccgtgctgac atcgagctcggttctgacgagttggcatatgtcttcaatggaaacagggctcaacgatgg cacattgggaacgatccgtttggccgtcagtggctgtctggtgatgtggtgggctgtatg atagacttgactgaaatgaacatcatgttcacactgaatggagagatgctgatcagcgat tctggctctgaaatggccttcaaagacattgagattggagatggttttattccagtctgc acattgggtctgtctcaggtgggccgtattaacctgggtcagaatgttagcagtctgcgt tatttcgcaatctgtgggctccaagaaggcttcgagccattcgctatcaacatgaaaaga gatattacaatgtggttcagtaagagtctaccacagtttgttcctgtacctactgaacac aatcacattgaggtttctcgtgtggatggaaccgtggacaccgccccctgcttgaaaatg acccataagacattcggatcccagaacgccaacacagatatgctgttcttcagactgagc atgcctgtggagtttgaccttaccttcaaggttctcgcaggcagcactcctctcacacgt accctcaacatcccagaagaagaggtgctggaggtagaccctgactctgactttgaggtc ctgaaaaagtcggccggtcgcaaagagcaggaggaaaaggaaaaggagtcgtcggtgccc aaagatattcccagcaaccatgagaatgacaaagatgcagcgtctgagaaaggaaagaag aaaggttttctgtttaaagctaaaaaagcagcaatgattgcccctccaccacctccactc atgccccgcttgttcgaagatgtggtgcccgatgaccgtgatgacccagagatcatcctc aatacaaccacatactattactctgtgcgtatcttcgctgggcaagagcctagcggcgtg tgggtaggctgggtcaccccagatttccacatgtatgacctgaactttgacctgtctaag atccgtaccgtcacgctgacagtcggagatgacaagggtaacatacacgacagtatacgg agaagtaactgctacatggtttggggaggagagttcggcagcagccaacagaggttcagc caggaggatctagtgattggttgcttgattgacctggcaacaggtctcatgactttcaca gccaatgggaaggagatcaacactttctatcaggtggagccaaacacaaagctgttcccg gctgtgttttcactgccaagcagtcagaacatgctgcaactggaacttggaaaactcaag aacatcatgcctatttcagcagccatgttccgtagtgagcgcaagaacccggttccccag tgtcctcctcggctggatgttgagatgttgaccccggtgatctggagcagaatgccaaat cacttcctgaaaccagaagtgggacgggtcagtgaaaagcacggctggatggtggaatgt gttgaacctctcaccatgatggctctgcacatacctgaagagaataggtgtatcgatgtc ctggaactgtctgagcgtcacgacctgctgaaattccactaccacaccctgatgctttat tgtgccgtttgcgcattgggcaacaaccgcgtggcccatgccctctgcagccacgtagac gaatctcagctcttctacgctattgagaacacctacctgcccggcccactccgcagcggc tactacgatctcctcatcagtatccacctagagtcagccaaacgcaaccgcttgggaacc aaccgggagttcatcattcccatgacgcaagagaccctcagtatcaaactttacccggat actgagggggcccatgacctgcccggagtgggtcttactacctgtctcagacccaagcta cacttctcacccatcaactttgtgggcaccgacccacacctgtacaccataagtcctgtc atccctctgcaggagctgaagatcaaggctctgagcatgttaaccgaagctgtgtttgat ggcagtcatgccatgcgtgatcctgtagggggcagcgttgagttccacttcgttcccatc ctcaaactcatcagcaccctcctcatcatgggcattttcaacaacgacgacgtcaagcac atcctcaagatgatcgaccccaacgtttttggaaagaaggaggaggagacagtggaggag gaatcgggagaggaagctgcacccaaggaggagggtgaggaggtgaaagaaaaagaagaa gtggctgaaggagaggaggaggcggtggatgaaggagtgggcgaggaggaagacgaggag gagcttaaagctctagaaaaggtggaggagggggaggaaggagaggaggcggagaaggag gaaggagagaaggttgatggagaaaaagcagaagaagagaaggaggcggaggaagtagca gaggagccaaaagaggaggaagaggaggcaccagaggaagggctgcttcagatgaagcta ccggagtctgtaaaactgcagatgtgcaccctgctacagtatttctgtgactgtgagctc agacacagagtcgaggccattttggcgttctccaatgacttcgttgagcaggtccagtca aaccagcgtgaacgctacaaagagctgatgagagcgtttaccatgtctgctgcagagact gcccgcaagaccagagagttccgctctcctcctcatgaacaggttattctgttgactaac ttcaagcactgccctgatgatgaggagtgtcccgtgcccgaggaagtgcgagaaaccctc cagaacttccacaatgacattctgtctcactgcggggtccatgttgaagaagaaacagag gagaaagaggtggacacatctctgagagggagattgcttagtctggtagtcaaggtcaag agcctcagaaagaaaaaagaggaagaggagcctgaacctgaggaagaagtcaaacctagt actttacaggagctgatatcccacactatgatccactgggcccaggaggctttcattcag aatcctgagctggttcgcctcatgttcagtcttctccaccggcagtatgatgctctggga gagttgatccgcgccctgcctaaagcctacgccatcagcagtgtgtccgtacaggacacc atggaccttctggagtgcctggggcagatacgctccctgctcatcgtccagatggggcca gaagaggagacgcttatgattcagagcattgggaacatcatgaacaacaaagttttctac cagcatcctaacctgatgcgtgcactgggaatgcacgagacggtcatggaggtgatggtc aacgtgctgggaggtggtggagactctaaggaaattcgattcccacaaatggtgaccagc tgctgtcgcttcctgtgctacttctgcaggatcagccgtcagaaccaacgttccatgttt gaccacctctcgtacctgctacagaacagtggcattggactgggaatgcgtggatctacc cctctggatgttgccgccgcatcttgcattgacaacaatgagcttgctttggctctgcag gagcaagacctcgaaatggtggtgacgtacctggctggctgcggcctgcagatgtgcccc atgcttttatcaaaaggctaccctgacataggatggaacccgagcggaggagagagatac ctggacttcctgcgctttgctgtgtttgtcaatggcgagagcgtagaggagaacgctaat gtggttgttcgtctgttgattcgtcggcctgagtgctttggccccgccctcagaggagag ggtggtgcgggtctgttagccgccattgaggaggccattaagatctctgaggaccctgcc agagatggaccgaccactaaaaaggacagacgtttcatgtttggagcggaggagcaacag gaggagaacagggtgcatcttggaaatgctgttatgtcattttactctgcgcttattgac ttgctgggacgctgcgcccctgagatgcatttgatccaagcagggaaaggtgaggctttg agaatcagggccatcttgaggtctttggtgcccattgaagatctggtaggagtcatcagt ctgtccgttcagatacccaccttaggcaaagatagtcagattgttgagccaaaaatgtca gccagttttgtaccagaccacaaagcctccatggtgctgttcctggacagagtgtacggc attgataaccaggacttcctgttacatgtgctggaggtgggcttcctgcctgatatgaga gccgcagcttctctggatacgttggtgttcagcaccacagagatggcactcgctctcaac cgttacctgtgctcagctgtgctgcctctgctcactaagtgtgccccactgttcgctggc acagaccatcgggctattatgatcgactctatgctgcacaccatttacagactttctcgt ggccgagccctaaccaaggcccagagggatgttatagaggactgtctcatgtctcttgtg aaatatttgaggccatctatgttgcagcatctgttgaggagacttgtgtttgatgtgcca atcctaaatgagtatgccaagatgcccctcaagttgctgaccaatcactacgagcgctgt tggaagtattattgtctgcctaacggatgggcgaactttggagtcacatcagaagaggag ttacatctttctcgaaaactattctggggcatctttgaatccctcgcacacaagaaattc gatgctgagctgtttaagatcgccatgccctgcatttgtgccattggtggtgccattcct ccggattacgtagatgctagcttttcatccatgactgagaagaaagcatctgttgacgct gagggcaacttcgatcctaaaccagtggaaacaactaataccatcattcctgagaggctg gatgcttttattaacaaatatgctgagcacacgcatgataagtgggcttttgagaagatc caaaacaactggacttatggagaggttctagatgagaacggcaaaacccatcccatgctc cggccgtacaagactttctcagagaaggataaagagatctatcgctggccatttaaagag tccatcaaggccatgttggcttgggaatggactttggagaaagccagagatggagaaact gaaaaagtggaagtgaagaccacaaggaagatctctcagactgctcatgcaacctatgac ccgagccagggatactctccccaaccggtggaccttacaagcatggccttgtccagagaa ctacagtctatggcagagcagattgctgagaattaccacaacacatggggccgtaaaaag aaaatggaactccaagccaagggtggtggaacccatcctttgctggtaccgtatgacaca ctgacagccaaagagaaggcaagagatcgagagaaagctcaagatctgctcaaattcctc cagtttaacggattcgctgtcaccagaggtttaaaggacatggagcaagagatttcctcc attgagaagcgttttgcttacgggttcctacagaagctgttgaagtggatggagatcgca caggagtttattgctcatcttgaggctgttgtgagcagcggaagagttgagaaatctcct catgagcaggaaattaaattctttgctaagattctgcttcccttgataaaccagtacttt aaaaatcactgcatgtatttcctgtccacacctgctaaagtcttgggtagtggtggccac gcctccaacaaagagaaggagatgatcgctagtatcttctgtaagttggccggtctggtg agacacagagtttccctctttggcactgatgcttcagcagtggtcaactgtcttcatatc ctgtcccactcattggatgccaggactgtgatgaaatctgggcctgagattgtgaaggct ggtctgcgctccttctttgaaagtgcagccgatgatattgagaagatggttgagaacctt aagttagggaaggtgtcgactaaaaaccaggtgaaaggtgtatctcagaacataaactac accaccacagctcttctgccagtgctcacctctctgttcgaccacattgcccagtaccag tttggagatgatgtcatgatggatgacttgcagatatcctgttatcgtatcatgtgcagc atctactcactgggcactgtaaagacccctcatgcagagaaccaaaggccagctctagga gagtgtttggctcatctggccgctgccatgcctgtcgccttcctggagcctaacctcaat gaattcaactcatactctgtgtacactaccaaaaccccacgagagaggacaattctgggt ctgcccagtcaagtacaggagctgtgcctggacatccctgaacttgatgtgttgatgaag gagatcggagatctggcagagagtggggcccgttacacagagatgcctcatgtgattgag atcaccctgcctatgttgtgtaactacctgcctcgctggtgggagagaggactggagaac ttccctgagatggagggacgtctctgcacggatgtcacctctgaacagctcaatcaactt ctgggcagcatcatgaagatagtggtcaataatcttggcattgatgaagcttcctggatg aaaagactggcagtgtttgctcagccaattgtaagcagagcgaagccagagatgctcaag tcccacttcattcccaccatggagaagctgaaaaagcgtagtggaaaggtggtggcagag gaggatcagctgcggatggagggcaagggggaggtagacagtgaacagggaaccatccgg gatgagtttgctgtgctctgcagggatctgtatgctctttacccgctgctcatccgatac gtggacaacaacagagcaaggtggttgacctgtcccgaccctgatgctgaggacctcttc agaatggttggagaagttttcatcttctggtccaaatctcacaacttcaagcgtgaggag cagaacttcgtggtgatgaatgagatcaataacatgtccttcctcaccgctgacagcaaa agcaaaatgagcaagggcggggatgcagagggtggtggttcagatgttgagcgaaccaag aagaagcgccgtggagaccgttactctgttcagacctcactgattgtagccgccctgaag aaactgctgcccatcggtctcaacatgtgttcccctgcagaccaagagctcattaacatg gccaagatccgctactctctgaaagacactgatgaggaagtaagagagtttctgcagaat aacctccatcttcacggcaaggaagaggacccttccatgcgctggcagatggctctttat aaggagacctcaggtaaagctgatgatgccgatgcacctgataaggttgtgaagagagtt caggaggtttctgccgttctcttccacattgagctgactgagcatcctttcaaatccaag aagatggtttggcacaagcttctgtccaaacagcgtcgcagggcggtggtggcctgcttc aggatgacgccgctctataacattcctaggcataggggatctaacatgttccttgacgga tacaggcgcaactggatcgaaaatgaaggttactcatttgaagacaagatgatcgacgat ttgtctaaaacgctggagcaggaagaggaagaagaggaagaaactgaggcaaaaccagac cctcttcatcagcttatccttcattttagccgtaccgctctcaccgagaaaactaaactt gacgttgatcatctctacatgtcatacgctgatattatggcaaaaagctgccacatgggt gaggaggatgaagagggagaggagggtggagaggagccttcctttgaggtgcgacagaca gagatggacaaggagatggaaaagcaaaggcttctgtaccagcagtcccgtctgcatgaa cgcggagcagccgagatggtgctgcagatgatcagcgcctgcacaggtgagacgggagcc atggtatcctctactctcaaacttggcatctccatcctcaacggtggcaactgtgatgtt cagcagagaatgctggactacctgaaggacaagaaagatgtgggcttcttcctgagctta cagtccctcatgcagacatgcagtgttttggacctgaatgcttttgagaggcagaataaa gcagagggtcttgggatggtgtcagaggagggcaaaaaggagaaagtgatgtcggatgat gaattcacttgcgacctcttccgcttcctgcaactgctctgtgaaggccacaacaacgat tttcagaactatctgcgcacacagacaggcagcacaaccacaattaacatcatcatctgc actgtcgactatctgctcagactgcaggaatctatcagtgatttctactggtattactcg gggaaagacatcattgatgaaccaggcaaaaggaacttctctaaagcgatgacagttgct aaacaggtcttcaacagcctgactgagtacatacagggcccctgtacggggaatcagcag tctctggcccacagcaggttgtgggacgccgtggtgggtttcctgcacgtgttcgcacac atgatgatgaagcttgcacagatgcaccctgaccttggacttcgaaatagcgaccctttt tggaatagaacacatgctgaggattccagtcaaattggtcttttgaaggagctgcttgat ctgcaaaaggacatggtggtcatgcttctctctctactggagggcaacatcgtgaatggc accatcgctcgccagatggttgacatgctcgttgagtcatccagcaacgtggagatgatt ctaaagttcttcgacatgttccttaaactgaaggatattgtggcatcagacgccttccgt gactacgtgaccgacccccgtggcctcatctccaagaaggacttttccaaagctatggac agtcagaagcagtacacaccatctgagatccagttcctcttgtcttgctcggaggccgat gagaacgaaatgatcaatttcgaggagtttgcagatcgcttccaggagccagccaaagac atcggcttcaacatcgctgtgctgcttaccaacctctccgagcatgttcctcacgacact cgccttaagaacttcttggggcaagccgagagcgtgctgaactacttccgccccttcctg ggccgtatcgagatcatgggtgctagcaagcggatcgaacgcatctactttgaaatcagt gaagccaatcgcaaccagtgggagatgccacaggtcagagagtcgaaaaggcagttcatc ttcgatgtggtcaacgagggtcaagaatcagagaagatggagatgttcgtgaacttctgc gaggacaccatctttgagatgaacatcgcctcgcagatctctgaggtggaggaagaagtg caagaagatgaagacgaggaagaggaagaggagagcggcggtggaggaaaacgagaagga gatggagaggaaggaaacggagaagcaccgcctgaatccagctcagcgtttgcagacttc atcaagagcattgtgagcctcttgagcctgttcactttccgtaatctcagacggcggtac cgcaaaatcaggaagatgacaatcaaggatatggttgttgggttggtgatgttcctctac accgtcctctttggcatcctccatttcatctacagcgtttgcaaaggattcttcatcctc atctggaacaccctcttcggaggtggcctggtggagggagcaaagaagatgacgttgacc gagattttgactaacatgcccgacccaactcaggacgaggtgcacgacgacctcccccct gagccaggagcgagaaatgttcaagagtcaggtggaaccggagacggcgaggaaggaaca ggaggaggagaagtggaggaggaagatggagaagaagatggtggggaaaggactgggttt ggtccgcatggtggacttggagacatgggtgaaactgagccagaggaacctccgactcca gaaggaagcccgcttctgaagagaaagctggtgggtgaagtagagggagaggtggtagtg gaagagaaagtaaaagaagaagaaccagccccggaacccgagaaagcagatgctgaaaat ggagagaaaactgagaaggaagctgaagctgaaccggaggagaaaatgaaagagctagaa gaaataaaggcaaaggctaaaacaaagaaagggaagaaagaagaaggacatggctttgaa atttggaatgaacttgaagtccaaagaaacaagttcatgaactccctggctcgtaatttc tacaatctgcgtttcctggctcttttcattgcctttgccctgaacttcattctgctcttc tacaaggtcgctgaaggcccccgtggcgaggacgagttggaaggttcggctatgtatgag ggttcgggtgtatttgaaggctctggtgtgtttgaaggctctggtggagaggctgaaggt tcaggtattgaggagaacggagaggaagatgacgaagaaggatacgtctatttctgcctg gaggagagcaccggatatatggaacccgcaatggccttcttttctatattacactccgtc attgccttcctttgtatcattggctacaactgtctgaaggttcctctcgtcatctttaag agagaaaaggaactggctcgcaaattggagttcgatggtctgtatgtgaccgagcagcca gaggatgatgatatcaagggccagtgggacagactcgtcctcaatacacagtctttccca aacaactactgggacaaatttgtgaagagaaaggtgctagataagtacggtgacatctac ggtagagaaagaatcgctgagctactgggaatggatctggcgtctctcgatgtcagcgct atgatacacgggaagaaacctcagcctgatacttcgatgttgacatggttgacatctatc gacatcaagtaccagatctggaaattcggcgtcgtgttcactgataacacgttcctgtac ttggtctggtatacggttatgtccttgctcggccactacaacaatttcttctatgcctgc catctgctggatatcgccatgggtgttaaaaccctgcgcaccattctgtcctctgtaacc cacaatggcaaacagctgttgatgacagtgggtctgctggctgtggtggtctacctctac accgtggtggcctttaacttcttccgcaagttctacaacatgagcgaggatgaagatgaa ccggatatgaagtgtgatgacatgatgacttgttatttgtttcacatgtatgtgggtgtg cgagccggtgggggtataggagacgagatcgaggatccggccggggacgactacgagctt tatcgtgtggtctttgacatcaccttcttctttttcgtgattgtcattctgctggctatc attcagggtctgattattgatgctttcggtgagctgagagatcagcaggagcaggtcaga gaagacatggagactaagtgcttcatttgtggaattggaagcgactactttgactcgact ccgcacggctttgagacgcatacgatggaagagcacaatttagccaattacatgttcttc ctgatgtatttaatcaataaagatgaaacggagcacacaggacaggagtcgtatgtgtgg aagatgtatcaggagagatgttgggatttcttccccgctggtgactgtttcagaaagcaa tatgaggatcagctaagctaa

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