Tachysurus fulvidraco (yellow catfish): 113650233 Help Entry 113650233         CDS       T08119                                  Symbol ryr1a Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism tfd  Tachysurus fulvidraco (yellow catfish) Pathway tfd04020   Calcium signaling pathway tfd04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tfd00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113650233 (ryr1a)    04020 Calcium signaling pathway     113650233 (ryr1a)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:tfd01009]     113650233 (ryr1a)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:tfd04147]     113650233 (ryr1a)    04040 Ion channels [BR:tfd04040]     113650233 (ryr1a) Protein phosphatases and associated proteins [BR:tfd01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      113650233 (ryr1a) Exosome [BR:tfd04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    113650233 (ryr1a) Ion channels [BR:tfd04040]  Voltage-gated cation channels   Ryanodine receptor    113650233 (ryr1a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  113650233 NCBI-ProteinID:  XP_047660701 LinkDB All DBs Position 20:complement(326138..409396) Genome browser AA seq 5079 aa AA seqDB search MAEGGEGDEEIQFVRTEDQVVLQCTATILKEQIKLCLSCEGFGNRLCFLEATSNAQNVPP DLAICVFILEQSLSVRALQEMLSHTSEDVDLDKWSSQGGGHRTLLYGHAILLRHTHSGMY LSCLTTSRSLTDKLAFDVGLQEDSAGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSE RYLHLSYASGDLMVDASFMQTLWNVNPVSSGCELVEGYLTGGYVLRLFHGHMDECLAIPA ADQGDERKNAHYEGGAVCSHARSLWRLEPLRIGWSGGHIKWGQPFRVRHITTGRYLCLDD EKGLLVVDPEKANTQSSAFCFRASKEKTEVAQKRDVEGMGAPEIKYGESMCFVQHVATGL WLTYASVDAKSARLGPVKRKAILHQEGHMDDALTVARSQTEESQAARMIYSTAGLFTQFI KSLDSLSGKNKSSAPPPPPPPPPPLPLDSVVLSLQDLIFYFRSPEEELEHEEKQSKLRSL KNRQNLFQEEGMITLVLDCIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIR GNRANCALFCDNLDWLVSKLDRLEASSGILEVLYCILIESPEVLNIIQENHIKSIIALLD KHGRNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPRRDLLLQTQIINYVTSMRPNIFLG TCEGSTQYKKWYYELIVDHVEPFLTAQAGHLRVGWALTEGYSPYPGGGEGWGGNGVGDDL YSYGFDGLCLWSGRVPRHVASPSQHILAAEDVVSCCLDLSVPSISFRINGHPVQGMFENF NLDGLFFPVVSFSAGIKVRFLLGGRHGDFKFVPPPGYAPCYEAVLPKDRLRIEPIKEYKN DLNNDVRNLLGPTQSLSHTAFTPNPVDTVQIVLPPHLERIREKLAENSHELWAVTRIEQG WTYGPFRDDNKKLHPCLLDFQSLPEPERNYNLAMSGETLKTLLALGCHVGMGDEKAEENL KRIKLPKTYTQSNSYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIV QDIVNKRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHVGNGTRN KIRVFRAEKSYAVTQGKWYFEFEAVTVGEMRVGWARPNVHADTELGADDLAYVFNGCKAQ RWHVGSEPFGRQWQPGDVVGCMIDLAEQNIMFTLNGEMLISDSGSEMAFKDIEIGEGFVP VCSLGLSQVGRLNLGQNVGSLRYFTICGLQEGFEPFAINMKRDITTWFSKSLPQFIPVPT DHPHIEVSRVDGTVDSAPCLKLTHRTYGSQNANTDLLFFRLSMPIEFHEVFKVEAGATPL TRALTIPEDEALEVDPNSEYELLKKSATRKEQEEKEKEVSVAKDLPGTKEVENEKDTTTE KSKKRGFFSKAKKAAFIAPPPVVPTVPRLVVDVVPDDRDDVDIISSTTTYYYSVRIFAGQ EPSGVWVGWVTPDYHQYDPHFDISKVRNVTVTVGDDKGNIHHSMKRSNCYMVWGGEFSGS QQTRITQEDFVIGCLVDLDTGLMTFTANGKEVNTFYQVEPNTKLFPAVFCLPSSQNMLQV ELGKLKNIMPISAAMFRSDHKNPVPQCPPRLDVQMLTPVIWSRMPNHFLSPETGRASERL GWMVQCTEPLTMMALHIPEENKCIDILELSESTDLLKFHYHTLKLYGSVCALGNNRVSHA LCSHVDESQLFYAIENQYLPGPIRSGYYDLLISMHLESAKRNRLMTNREFIVPMTDKTRS ITLRAHTLPAVGCSTCLRPTLNFSHTGFVGTNADLYTLSPFIPLQILKDHALSMLTEAVQ DGGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFEDEDVKHILKLIEPTVFREDKGSHVA EDKSREGEEQQIASKEERMEVKEKEEAVDEWTEDEGMVEEEEEEEEQEEEEEDQTEREDE DEHPAPEKSDKEKAKHRGAEPKAELEAGPTVGKEEPKEEEEVGEGLLHMKLPESVKLQMC TLLQYFCDCELRHRVEAIVAFSDRFVTQVQSNQRLRYNELMQAFTMTAAETARKTREFRS PPQEQVNMLMNFKNCPDEEDTPVPEEIRAELQMFHSDLLGHCGIHVEEEEEEEHVDTSLR GRFFRLLEKVKRLRRRKQETELEPEEEKKPSTLQELISHTMIHWAQESFIQDPELVRLMF SLLHRQYDALGELIRALPKAYTINAVSMQDTMELLECLSQIRSLLIVQMGPEEERLMIQS IGNIMNNRVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRMVTNCCRFLCYFCR ISRQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVKY LAGCGLQSCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRP ECFGPALRGEGGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENRVHLGN AIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPLQIPAFG KDNSIIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAA FSTTEMALALNRYLCSAVLPLITKCAPLIAGTDHRAIMIDSMLHTIYRLSRGRSLTKAQR DVIEECLMSLCRYLRPSMLQHLLRRLVFDVPILNAYAKMPLKLLTNHYERCWKYYCLPNG WANFGVSSEEELHLTRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYS SKTEKKASVDAEGNFDPKPVDTTNTIIPEKLDGFINRYAEYTHDKWAFEKIQNNWTFGEV LDENAKTHPMLRPYKTFSEKDKEIYRWPIKESIKAVIAWEWTLDKARDGDEDRGEKKAAR KISQTAQATYDPSHGYNPQPINISGMTLSRELQSMAEQLAENYHNTWGRKKKMELQAKGG GTHPLLVPYDTLTAKEKARDREKAHDLLRFLQLNGYAVTRGLKDMESDISSIEKRFAYGF LQKLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHCLYFLS TPAKILGSGGHASNKEKEMIASIFCKMSALVRHRVFLFGTDAPAIVNCLHILARSLDART VMKSGPEIVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQPVKGVSQNINYTTVALLPV LTSLFDHIAQHQFGDDVILDDLQMSCYRIMCSIYSLGTVKTPHAERHRPALGECLAHLAA AMPVAYLEPHLNEYNAFSVYTTKTPRERAILGLPNEVQELCLDIPELDLLIREISHLAES GARYTEMPHVIEVTLPMLCNYLPRWWERGVENHPELEGKLCTHVTSEHLNQLLGSIMKIV VNNLGIDEAPWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTAKVVAEEEHLRMEG KMEGDEEEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFI FWSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKAGNTEAGGSDVERTKKKRRGDRY SVQTSLIVAALKKMLPIGLNMCSPADHELINLAKFRYSLKDTDEEVREVLQNNLHLQGKV EDPSMRWQMALYKMMAGKADDADAPEKVVKRVQEVAAVLYHIEVTEHPFKSKKMVWHKLL SKQRRRAVVACFRMTPLYNLPSHRASNMFLDGYKRNWLRTEGLSFEDRMIDDLSKAMEEE EEEEEEKETKPDPLHQLILHFSRTALTEKSKLDVDHLYMAYADIMAKSCHIGEEDEGGDE DQEGDQEEMSFEVRQSETEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGCMVSS TLKLGISILNGGNSDVQQKMLDYLKDKKDVGFFLSMQTLMQTCCVLDLNAFERQNKAEGL GMVSEEGTNMKLERGEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINII ICTVDYLLRLQESISDFYWYYSGKEIIDEPGKRNFSKAMTVAKQVFNTLTEYIQGPCTGN QQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIALLKELLDLQKDMVVMLLSLLEGNIV NGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASGSFRDCVTDPRGLISKKDFQKA MDSQKQYTPSEIQFLLSCSEADENEMINYAEFASRYQEPAKDIGFNIAVLLTNLSEHVPH DTRLKNFLEQAENVLNYFRPFLGRIEIMGASRKIERIYFEISEVNRKQWEMPQVRESKRQ FIFDVVNEGGESEKMELFVNFCEDTIFEMNIASQISEKDEEEKEEDDEEVDEGNETGGGG ADDEDGDKSQSESSSAFADFLNSVVHFMGMFTFRNLRKQYRRLRKMTIKEIIFGIATFLW TILLGVFFFIFSLCKGFFLIVWHTLFGGSLVEGAKNLTVTELLASMPDPTQDEVHGDLPG EPGSGEEQETGGVTDSTEAAQGEEEDEDSTEQDVGKIPGIDTPGGLGDMGDTTPLEPPTP EGSPLTKRKMQPEEGGTEQVEAPVEPPPEPEKSDTENGKKLEKEAEQKTEEPQEQVRVQK RSKAKKEKPRVRDGGFELWNELDVQRNKFMNYLSRNFYNLRFLALFIAFALNFILLFYRV SDTPPGDELEGVFEGSGLFDGSGEQLDGSGSDDMGGDEDDDGDDEGPVYFFLEESTGYMQ PTLSFLAIIHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLYITDQPEDDDIKGQ WDRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLATLDVSKQQSEKKPQ EPDNSMFAWIAAVDMKYQVWKFGVVFTDNTFLYLVWYTVMSLLGHYNNFFFACHLLDIAM GVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDD MMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIID AFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYLFFLMYLINK EETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15240 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggggaaggagatgaagagattcagtttgtacggacggaggatcaggtg gtgctgcagtgtacagccactatactgaaggaacagattaaactctgcttgtcctgtgag ggttttggaaatcgactctgcttcctcgaggcaacatctaatgctcagaatgtcccacct gatctggccatttgtgtcttcatcctggagcagtcgttatctgtacgagctctacaggag atgctctctcacaccagcgaggatgtggatttggataaatggtcttcacaaggtggaggc catcggacgctgctgtatggacacgccatcctgctcagacacacacactcgggcatgtat ctgagctgtttgacaacatcacggtctctcacagacaaactggcctttgacgtgggctta caggaagattcggcaggtgaggcatgttggtggacgatccatcctgcttccaaacagagg tcagagggtgagaaggtcagagtgggtgatgacctcatcctggtcagtgtgtcatcggaa agatacctgcatctgtcctatgcgagtggagatctgatggtggacgcctccttcatgcag actctgtggaacgtcaacccggtgtccagtggatgtgagctggttgaagggtatttaact ggaggatacgtgcttcggctctttcacggacacatggatgagtgtttagccattcctgct gctgaccagggggatgagcgcaaaaatgcccattatgagggaggagctgtgtgcagtcat gcaagatctctgtggagactcgagcctctccgcattggatggagtggtggtcatattaaa tgggggcagccttttagagtgcgtcacatcactacggggcgatatctgtgtttagatgat gaaaaagggctgttggtggtggatccagagaaagcgaatacacagagctctgcattctgc ttccgagcctcaaaggagaagacagaagtggctcagaagcgtgatgtagaagggatgggt gctccagagataaagtatggggagtccatgtgctttgtgcaacacgtagctacaggcctg tggctcacctacgcctctgtagatgcaaaatctgctcgtctggggcctgtgaagcggaag gcaattcttcatcaggaaggtcacatggatgatgcgctgactgttgctcgctcacagact gaagagtctcaggctgctagaatgatctacagcactgctggactcttcactcagttcata aaaagtttagactctctgagtggaaagaataaaagcagcgctccaccaccaccaccacca ccaccaccacctctcccactggattctgttgtcctctcgctccaggatctgatcttctac ttcagatcaccagaggaggagctggagcacgaggagaaacagagcaaactgagatctctc aaaaatcgacagaatctgtttcaggaagaggggatgataactctggtgttggactgcatt gatcgtctgaatgtctacaacactgcagctcatttttccgagtttgctggagaggaggca gctgagtcctggaaggagattgtaaacctgctctacgagctgctggcgtctctgattaga gggaacagggcaaattgcgcactcttctgtgacaatctggactggctggtcagcaaatta gaccgactggaggcgtcatcaggcatcctggaagtgctgtactgtattctcatcgaaagc cccgaggtgttaaacatcatccaggagaaccacatcaagtccatcattgctctgctggac aaacatggacgtaatcacaaggtgttggacgtactttgctctctgtgtgtgtgtaacggt gtggctgtgaggtctaatcagaatctcatcacagagaatcttctgccacgtcgtgacctt ttgctccaaacacaaatcattaattatgtcacaagcatgagaccaaacatcttcctcggg acctgtgaaggatccacacagtataaaaagtggtattatgaactgatcgtggatcacgtg gagccgttcctgacggcccaggcaggtcacctgcgggtgggctgggcactgaccgagggt tacagcccataccccgggggaggagagggttggggcggtaatggtgtaggagacgacctc tactcctacggctttgatggcctctgtctgtggtcgggacgtgttcctcgacacgtggca tcgcccagtcagcacattctggctgcagaagatgttgtgagctgctgtctggacctcagt gtgcccagtatctcatttcgcattaacgggcatcctgttcagggcatgtttgagaacttc aacctagacggcctcttcttccctgttgttagcttctctgctggaatcaaggtccggttt cttctgggagggcgacatggagactttaagtttgttccgccgccgggatacgcgccgtgc tacgaggccgtactgcctaaagacagacttcgtatcgagcccattaaggaatataaaaac gacttgaataacgacgtgaggaacctgttgggtccaacacagtctctgtcccacacggcc ttcacccccaaccctgtggacactgtacagattgttcttcctccacatttggagcggatc agagaaaagctggctgagaacagtcatgagctctgggctgtaactcgtatagaacagggc tggacttatggacctttccgtgatgataataaaaagctgcatccgtgtctgctggacttc cagagccttccagagccagagaggaactacaacctggccatgtctggagaaacactcaaa actcttcttgcgctgggttgccatgttggaatgggagatgagaaagcagaggaaaattta aaaaggatcaaactgcccaaaacctacacacagagcaacagctacaaacctgcccctctg gacctgaaccatgttaaactgacccccaaccagaacacactggtggagcgactcgctgaa aacgggcacaacgtatgggcacgtgaccgagtgcgacagggctggacatacagcatcgta caggacatagtgaacaagaggaacccacgcctcgtaccatacaatctcctggatgagaaa accaagaagacaaacagagacactgtgtgtgctgcggttcgaaccttgatcggttacggc tacaacatcgagcctccagaccaggagagcagcggccatgtcggtaacgggactaggaat aagatccgcgtgttcagggctgagaagtcgtacgctgtgactcagggaaaatggtacttt gagtttgaggcagtgactgtgggtgagatgagggtcggctgggcgagacccaatgtccac gctgatacggagctcggggcagatgatctcgcctatgtctttaacggctgtaaggctcag cgttggcatgtgggcagcgagccctttggtcgtcagtggcagcccggagacgtcgtgggc tgcatgatcgatcttgccgagcagaatatcatgttcacactgaacggagagatgctgatc agtgactccggttctgagatggccttcaaagacattgagattggagaaggtttcgttcct gtgtgtagtctgggcctctctcaggtgggccgtctcaacctgggccagaacgtcggcagc ctgcgatattttactatctgtggcctgcaagaaggcttcgagcccttcgccattaacatg aagagagacatcaccacgtggttcagcaaaagcctgccacagttcattcctgttcccact gaccaccctcacatcgaggtatcccgtgtggatggcacagtggacagcgccccctgtctg aaactgacccacaggacatatggatcccagaatgccaatacggaccttctcttcttcaga ctgagcatgcccatcgagttccacgaggtgtttaaggtagaggcaggggcgacaccactg acacgtgccctcaccatccctgaggacgaggccctggaggttgaccccaactctgagtat gagctgttaaagaagagcgccactcgtaaagagcaggaggagaaagaaaaggaagtgtct gtagccaaagatctgccaggcaccaaggaggtggagaacgagaaggacaccactacagag aagagcaaaaagaggggatttttctccaaagcgaagaaagctgcttttattgctcctcca cctgttgttcccactgtccctcgtctggtggtggatgttgtccccgatgatcgggacgat gtggatattatttccagcacaactacatactactactcagtgcgtatatttgcaggacag gagcccagtggcgtgtgggtcggttgggttactcctgattaccatcagtacgaccctcac tttgatatcagtaaagtgagaaatgtcacagtcactgtgggtgatgataaaggcaacata catcacagtatgaaacgcagtaactgttacatggtgtgggggggggagttcagcggctcg cagcaaacacgcatcactcaggaggactttgtaatcggctgccttgtggatctggacacg ggtctcatgaccttcacagccaatgggaaagaggtgaacaccttctaccaggtggagccc aacaccaaactcttccctgcggttttctgtttgccgtccagccagaacatgctgcaggtg gagctcggcaagctcaagaatatcatgcctatctcggcagccatgtttcggagcgatcat aagaatccggtcccgcagtgccccccccgcctcgatgtccaaatgctgaccccggtgatc tggagccgcatgccaaaccacttcctgtctcctgagacgggccgtgctagtgagagactt ggctggatggtgcagtgcactgagccgctcaccatgatggcactacacattcctgaggaa aacaagtgtattgatatcctggagctttcggagagtaccgacctgctgaagtttcactac cacacactgaaactgtacggctcggtgtgtgctttgggaaacaaccgtgtgtctcacgcc ctctgcagccatgtggacgagtctcagctcttctatgctatagagaaccagtacctgccc ggcccgatccgcagcggctactacgacctgctcatctccatgcacctggaatcagccaag aggaaccgccttatgactaaccgggagttcatcgtgcccatgacagataagacgcgctcc atcacgctgagggctcacacacttcctgctgttggatgctcaacctgcctcagacccaca ctgaacttctcacacactggctttgtgggcaccaacgctgacctctacacactcagcccc ttcattccactgcagattctgaaggaccacgccctgagcatgttaacagaggccgtacaa gacggaggccaggcaatgcgtgaccctgtagggggcagtgtggagttccattttgttcct atcctgaagctgatcagtacgctgctcatcatgggtgtgtttgaggacgaggacgtgaaa cacatcctcaaactcatcgagcccaccgtgttccgggaggacaaaggctctcacgtggca gaggacaagagcagagaaggagaagagcagcagattgcttcgaaagaggagagaatggaa gtgaaggaaaaagaggaagcggtggatgagtggactgaggacgaagggatggtagaggag gaagaggaggaagaggagcaggaagaagaggaggaagaccagacagaacgtgaagatgag gacgagcacccggcacctgaaaaatctgacaaagagaaagccaagcacagaggggcggag cctaaagctgagctggaggctgggcctacagtggggaaggaggagccaaaagaggaagag gaagttggggaaggtcttctgcatatgaaactcccagaatctgtaaagttgcagatgtgt actttgctgcagtatttctgtgactgtgagctgcgtcaccgtgtcgaggccatcgtggct ttctctgataggttcgtcactcaggtgcagtccaatcagaggctgcggtataatgagctc atgcaggcctttaccatgaccgctgccgagacggctcgcaagaccagagagttccgttca ccaccacaagaacaggtgaacatgctgatgaattttaagaattgcccagatgaagaggac actcctgttcctgaggaaatccgtgctgaacttcagatgtttcacagtgacctactgggt cattgtggtattcatgttgaggaagaagaggaggaagagcacgtggacacgtctctgcgt ggacggttctttaggttacttgaaaaagtgaagcgactacgaaggagaaagcaggagaca gagctggagccagaagaggagaagaaacccagtactttacaggagctgatctcacacacc atgatccactgggctcaggagtccttcatccaggaccccgagctggtgcggctcatgttc agcctgctgcaccggcagtatgacgctctaggagaactgatcagagctttgcccaaagcc tacaccatcaacgccgtgtccatgcaggacactatggagctactggagtgtctcagccag atccgctcactgctcatcgtccagatgggtcctgaggaggagaggctcatgatccagagc atcggtaacattatgaacaacagagtgttttaccaacaccccaatctgatgagagcactg ggcatgcacgagaccgtcatggaggtcatggttaatgtcctgggaggtggagactcgaag gagatccgtttccctcgcatggtgaccaactgctgtcgtttcctgtgttatttctgtcga atcagccgtcagaatcaacgctccatgttcgatcacctgagttacctgctgcagaacagc ggcattggcctgggtatgcgaggttctacacctcttgatgtggctgcagcttcctgtatt gataacaacgagctggcgctggctcttcaggagcaggacctggagaaggtggtgaagtat ctggctggctgtgggctgcagagttgccccatgctcctgtcaaaaggttaccctgatatc ggctggaacccgtgcggaggagaaaaatacctggacttcctcagatttgctgtctttgtt aatggagagagtgtggaggagaacgctaacgtggtggtgcgtctcctgatcagacggccc gagtgtttcggccccgcgctcagaggagagggaggtaatggacttctggctgctatcgaa gaagccattaagatctcagaggatccggctagagacggacccagtgtgaagaaggacaga cgcttccctatgtttggaggagaagagcaacacgaggagaacagagttcatctgggaaac gccatcatgtccttctacgccgctctcatcgacctgctgggacgctgcgctcccgaaatg cacttgatccaggctgggaaaggagaagctctgaggatcagggccattctcaggtctctg gttcccattgaggacctggtaggtgttatcagtcttcccctgcagatacctgcgtttggg aaagataacagtattattgagccaaagatgtctgccagttttgtcccggaccacaaggcc cccatggtgctgttcctggacagagtctatggcatcgataaccaggatttcctcctacat gtgctggaagtaggattcctgcctgatatgcgagctgctgcgtctctggacacggctgcc ttcagtaccacagagatggctctggctctgaaccgttacctttgttcggccgtgctgcct ctcatcactaaatgtgctcctctgattgctggcaccgatcaccgcgctatcatgatcgac tccatgctgcacaccatctacaggctgtcccgaggacgctcgctcactaaagctcagagg gacgtcattgaggagtgtctcatgtctctgtgcagatatctgcgaccatctatgcttcag caccttctgagaagattggtgttcgacgtgccgattctaaacgcatacgccaaaatgccc ctgaagttgttgacaaatcattacgaacgctgctggaaatattactgcctgcccaacggc tgggccaactttggtgtgtcatcagaggaagagcttcacctgactcgcaaactcttctgg ggaatctttgaatctctggcacacaagaaatttgatgcagaattgtttaagatcgcgatg ccctgcatctgtgccatcgccggtgccatacctcctgattatgtggatgccagttactct tctaaaacagagaagaaagcgtctgtggatgcagagggaaactttgaccccaaaccggtg gacacgaccaacaccataattcctgagaaactggacggatttatcaacagatacgcagag tacactcatgataaatgggcgttcgagaagatccagaacaactggacatttggtgaagtg ctggatgaaaacgccaagactcatccgatgctcagaccatacaaaaccttctctgagaag gataaagaaatttaccgctggcccattaaagagtccataaaggcggtgatagcctgggag tggacgctcgacaaagccagagatggagacgaagaccgaggagagaagaaagcggcacgg aaaatctctcagactgcacaggcgacgtacgacccgagccacggctacaaccctcagccc attaacatctctggcatgactctgtcccgtgagctacagtccatggcagagcagctggct gagaattaccacaacacctgggggcgcaagaagaagatggagctgcaggccaagggtggt gggactcaccctctgctcgttccctacgacacgctaacggccaaagagaaagctcgtgac cgggagaaggcacacgatctgctgaggttcctgcagctgaatggatacgcagtgacgaga gggctgaaagacatggaaagcgacatttcctccattgagaagcgttttgcttatggattc ttacagaaactcctcaagtggatggacattgctcaggagttcatcgctcatctcgaggcg gtggtcagcagcggtcgtgtagagaaatcgcctcatgaacaggagataaaattctttgcg aagatcctcttgcctttgataaatcagtactttaagaaccactgcctgtattttttgtcc actcctgctaagatcctgggcagtggtggtcatgcctctaataaggagaaagaaatgatc gccagtatattctgtaagatgtccgctctggtgagacacagagtttttctcttcggcact gacgctcctgctattgtaaactgtctccacatcctcgctcgctcactcgacgccagaaca gtgatgaagtcaggacctgagattgtgaaggccgggctgagatctttctttgagagtgca gctgatgacatcgaaaagatggtggagaacctcaaactgggcaaagtgtccaaaggcaac cagccggtgaaaggcgtgtctcagaatataaactacactactgtggccctgctgccggtc ctcacttcactgtttgatcacatcgcacagcaccagtttggagatgatgtcatactggat gacctacagatgtcctgctacaggatcatgtgcagcatttactctctcggcaccgtcaaa actcctcatgctgaaagacacaggccggctctgggagagtgtttagctcatttagctgca gcgatgcctgtggcttaccttgaacctcatctgaatgagtacaacgccttctctgtgtac accaccaaaacccccagagagagagccatcctgggtctgcctaatgaagtgcaggagttg tgtttggacatccccgagttggatttgttgataagggagatcagtcacctggctgaatca ggtgcacgctacactgagatgccccacgtgatagaggtaaccctacccatgctatgtaac tatctgccccgctggtgggagaggggtgtagaaaaccatcctgagctggagggcaaactc tgcacccacgtcacgtcggagcatctcaaccagcttctgggcagcatcatgaagattgtc gtcaacaacctgggcattgacgaggctccatggatgaagagactggcagtgttctctcag ccgatcgtgagcagagcgaagcctgaaatgctcaagtctcacttcatccccaccatggag aagctgaagaagcgaactgcaaaggttgtggctgaggaggagcacctgcgcatggagggc aaaatggagggtgacgaggaggagggaaccatacgggacgagtttgctgtcctctgcaga gatctatatgccctttaccctctgcttattcgctacgtcgacaacaacagagcgaggtgg ttaacctgtcctgaccctgatgctgaggaactgttccgtatggtgggagaggtctttatc ttctggtccaaatctcataactttaagcgtgaggagcagaactttgtggttatgaacgag ataaacaacatgtccttcctcaccgctgacagtaagagtaagatgagtaaggccggaaac actgaggctggtggctctgatgtagaacgcactaagaagaagaggcgtggagatcgttac tctgtgcagacctctctgatcgtggctgcgctgaagaagatgcttcccatcggactcaac atgtgctctcctgctgatcacgagctcattaacctcgccaagttccgctattctctgaaa gacacagatgaagaggtgagagaggttcttcagaacaacctgcatcttcagggcaaggtg gaggatccttccatgcgatggcagatggctctgtacaagatgatggcaggaaaggcagat gatgctgacgctcctgagaaagtggtgaagagagtgcaggaggttgcagcagtgctttac cacatcgaggtgacggagcatcccttcaaatccaaaaagatggtttggcacaagctgctg tccaaacagagacggcgtgccgtggtggcctgcttcaggatgactccactgtacaacctg cccagccatcgagcctccaacatgttccttgatggatataaaagaaactggctcagaact gaaggcctctcgtttgaagacaggatgatcgatgacctatcaaaagccatggaggaagag gaggaggaagaggaggagaaggagacgaagcccgatcctctacatcagctcatccttcac ttcagccgcacggctctcacagagaaaagcaaactggatgtggatcatctgtacatggcg tacgctgacatcatggcaaagagctgccacattggtgaggaggatgaaggtggggatgaa gatcaggagggagatcaagaggaaatgtcgtttgaggtgcgacagtcagagacggagaaa gagatggagaaacagaggctcctgtatcaacagtctcgtctacataaccgtggagctgca gagatggtgctgcaaatgatcagtgcatgtaaaggtgaaactggctgcatggtgtcatct actctaaagctggggatctccatcctgaacggggggaacagtgatgtgcagcagaaaatg ttggattatctgaaggacaaaaaggacgttggctttttcctcagcatgcagactctgatg cagacctgctgtgtgttggacctgaacgcttttgagagacagaataaggctgaaggtttg gggatggtgtcagaggagggaacaaacatgaagctagaacggggtgagaaagtgatggct gatgatgagttcacctgtgacctgttccgcttcctacagctgctctgtgaaggacacaat aacgatttccagaattatctcagaacacagacagggagcactacaaccatcaacatcatc atctgcactgtcgattacctgctgcgcctacaggagtccatcagtgacttttactggtat tactctggtaaagagatcatagacgagccgggaaagagaaacttctctaaagccatgact gtggccaagcaggtgttcaacacactcactgagtacatacagggtccctgtacaggtaat cagcagtctttagctcacagcaggctttgggatgctgttgttggctttcttcatgttttt gcccacatgatgatgaagctggctcaggactcgagtcagatcgctctgctgaaggagctg ctggacctgcagaaggacatggtggtcatgctgctttctctgctcgagggcaatatagta aacggcacaattgctcgtcagatggtggacatgctggtcgaatcttccagtaatgttgag atgatcctcaagttctttgatatgttcctcaaactgaaagacattgttgcttctggctct ttccgtgactgtgtaaccgatccccgaggactgatctccaaaaaggacttccagaaagcc atggacagtcaaaaacagtacacgccctcagagatccagttccttctgtcctgctctgaa gccgacgagaacgagatgatcaactacgcggaattcgcgagccgatatcaggagccggca aaagacatcgggttcaacatcgcagtgctcctgacaaacctttccgagcatgtcccgcac gacaccaggcttaagaacttcctggaacaagccgagaacgtcctgaactacttcagaccg tttttgggaaggatcgagatcatgggtgcgagcaggaagatcgagaggatctatttcgag atcagtgaggtcaacagaaagcagtgggagatgcctcaggtccgagagtccaaacggcag tttattttcgacgtcgtcaacgaaggcggagaatctgagaagatggagctttttgtaaat ttctgtgaggacaccatctttgagatgaacattgcctcacagatctcagagaaggatgaa gaagagaaagaagaagatgatgaggaagtagatgaaggaaatgagacaggaggaggtgga gctgatgatgaagatggtgataaaagccaatcagagtcgagctccgcttttgcagacttc ctgaacagcgtggttcacttcatgggcatgttcaccttccgtaatctgcgcaaacagtac agacggcttagaaagatgaccatcaaagagatcatcttcggtattgctaccttcctctgg accatcttattgggtgtgttcttcttcattttcagcctgtgtaaaggtttcttcctgatt gtttggcacacgcttttcggaggcagtttggttgaaggagccaaaaacctcacggtgact gaactcctggccagcatgcctgaccccactcaggacgaagtgcatggagaccttcctgga gaaccaggaagtggtgaagaacaggaaactggaggagtaacggattctactgaggcagca caaggagaagaagaagatgaagacagcacagagcaagatgtaggaaaaatcccaggtatt gatacccctgggggtctgggagatatgggagatacgactcctcttgaaccaccaactcca gagggttctcctttaaccaagaggaagatgcagccagaggaaggaggaaccgagcaggta gaagctcctgtagagcctccaccagagccagagaaatctgacactgaaaatggaaagaaa ctggagaaagaagctgagcagaagacagaggagccacaggaacaagtccgggtccagaag cgcagcaaggctaagaaagagaaaccgagagtccgagacggaggatttgagctgtggaac gagctggacgtccagaggaataaatttatgaattatctgtctcgcaacttctacaacctc cgtttcctggctctgtttatcgcctttgccctgaacttcatcctgctcttctacagggtg tcagacacacctccaggtgatgagcttgaaggtgtgtttgagggttctgggctttttgat ggttcgggtgaacagctggatggctctggatcggatgatatggggggtgatgaggatgat gatggtgatgatgaaggccctgtgtatttctttctggaggagagcacaggatacatgcag cccactctgtccttccttgccatcatacacaccgtcatctccttcatctgcatcatcgga tacaactgtctcaagataccactggtgatctttaagcgagagaaggagctggcgaggaag ctggagtttgatggtctttacatcactgatcagcctgaagacgatgatattaaaggacag tgggacagactcgtgctcaacacaccctcgtttcctaataactactgggacaaatttgtc aaacgcaaggtcctggataaatatggtgatatatacggacgagagcgaatcgcagagctg ttggggatggacctcgccacgctggacgtcagcaaacaacagtctgagaaaaaaccacaa gaaccagataactccatgttcgcctggatcgctgcagttgatatgaagtatcaggtgtgg aagtttggggtcgtgtttacagacaacacgtttctctacctggtgtggtacacggtgatg tcgctgctcggacactacaacaacttcttctttgcgtgtcacctgctggacatcgccatg ggcgtgaagactctgcgcaccatcctgtcctccgtcactcacaacggcaagcagctgatg atgacagtgggtctgttagccgtggttgtgtatctctacactgtggttgcatttaatttc ttccgcaaattctacaacaagagtgaggatgaggacgaacctgacatgaagtgtgacgac atgatgacatgttatctgttccacatgtatgttggagtgagagcaggtggaggtatcggt gatgagattgaagatccagcaggtgatgagtatgaactttaccgtgtagttttcgacatc accttcttcttctttgtcatcgtcattctgctggccatcattcagggtttaattatcgat gccttcggtgagctgagagaccagcaggagcaggtcaaagaagacatggagactaaatgt tttatctgtggaattgggagtgattactttgacacgactccacacggctttgagacacac accttagaggaacacaacctggccaactacctgttcttcctgatgtacctgatcaacaaa gaggagacagagcacacagggcaggagtcatacgtgtggaagatgtatcaggaacgctgc tgggatttctttcctgctggtgactgttttagaaagcagtatgaggatcagctgggataa

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