Theropithecus gelada (gelada): 112636552 Help Entry 112636552         CDS       T08041                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism tge  Theropithecus gelada (gelada) Pathway tge04022   cGMP-PKG signaling pathway tge04068   FoxO signaling pathway tge04081   Hormone signaling tge04140   Autophagy - animal tge04150   mTOR signaling pathway tge04151   PI3K-Akt signaling pathway tge04152   AMPK signaling pathway tge04211   Longevity regulating pathway tge04213   Longevity regulating pathway - multiple species tge04722   Neurotrophin signaling pathway tge04910   Insulin signaling pathway tge04920   Adipocytokine signaling pathway tge04923   Regulation of lipolysis in adipocytes tge04930   Type II diabetes mellitus tge04931   Insulin resistance tge04932   Non-alcoholic fatty liver disease tge04935   Growth hormone synthesis, secretion and action tge04960   Aldosterone-regulated sodium reabsorption tge05010   Alzheimer disease tge05206   MicroRNAs in cancer tge05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:tge00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     112636552 (IRS1)    04022 cGMP-PKG signaling pathway     112636552 (IRS1)    04151 PI3K-Akt signaling pathway     112636552 (IRS1)    04152 AMPK signaling pathway     112636552 (IRS1)    04150 mTOR signaling pathway     112636552 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     112636552 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     112636552 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     112636552 (IRS1)    04923 Regulation of lipolysis in adipocytes     112636552 (IRS1)    04920 Adipocytokine signaling pathway     112636552 (IRS1)    04935 Growth hormone synthesis, secretion and action     112636552 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     112636552 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     112636552 (IRS1)   09149 Aging    04211 Longevity regulating pathway     112636552 (IRS1)    04213 Longevity regulating pathway - multiple species     112636552 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     112636552 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     112636552 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     112636552 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     112636552 (IRS1)    04932 Non-alcoholic fatty liver disease     112636552 (IRS1)    04931 Insulin resistance     112636552 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  112636552 NCBI-ProteinID:  XP_025261080 Ensembl:  ENSTGEG00000015114 LinkDB All DBs Position 12:complement(103434982..103497163) Genome browser AA seq 1246 aa AA seqDB search MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN GHYILSRGGNGHRYTPGTGLGTSPALAGDEASSAGDLDNRFRKRTHSAGTSPTITHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDSSTLHSDDGYMPMSPGVAPVPSTRKGSGDYMPMSPKSVSAPQQIINPSRRHPQRVDPN GYMMMSPSGGCSPDIGGGPSSSSSSAVPSGSSYGKLWTNGVGGHHSHVLPHPKPPVESSG GKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEE GARHQHLRLSASSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLP RKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQQQQQQPLLHPPEPKSPGEYV NIEFGSDQPGYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQES TGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPIAPVSYADMRT GIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELTAHSSLLGGPQGPGGMSAFTRVNL SPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAIGGGGGSSSSSED VKRHSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQRPQECTP QPQPPPPPPPHQPLGSSESSSTRRRSSEDLSAYASISFQKQPEDLQ NT seq 3741 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag gcggagcaagacagctggtaccaggctctcctacagctgcacaaccgtgccaagggccac cacgacggagctgcggccctcggggctggaggtggcgggggcagctgcagtggcagctcc ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcgttc aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcagccgccgtggtgctgcagctgatgaacatcaggcgctgcggccactcggagaacttc ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggctatg agcgatgagttccgccctcgcagcaaaagccagtcctcgtccaactgctccaaccccatc agcgtccccctgcgccggcaccatctcaacaaccccccgcccagccaggtggggctgacc cgacgatctcgcactgagagcatcactgccacctccccggccagcatggtgggcgggaaa ccaggctccttccgcgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc tcggtggatggcagccctgtgagtccgagcaccaacagaacccacgcccaccggcatcgg ggcagtgcccggctgcaccccccgctcaaccacagccgctccatccccatgccagcttcc cgctgctcgccttcggccaccagccccgtcagtctgtcgtccagcagcaccagcggccat ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttctccc agcgatggcggtttcatctcctcagatgagtatggctccagtccctgcgatttccggagt tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag gagctaagcaactatatctgcatgggcggcaaggggccctccaccctgaccgcccccaac ggtcactacattttgtctcggggtggcaatggtcaccgctacaccccaggaacaggcttg ggcacgagtccagccttggctggggatgaagcatccagtgctggggatctggataatcgc ttccgaaagagaactcactctgcaggcacatcccctaccattacccaccagaagaccccg tcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgccgggacacaggcactctgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcgtcgggggggccaccaccgc ccagacagctctaccctccacagtgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagcacccgaaagggcagtggagactatatgcccatgagccccaagagcgtg tctgccccacagcagatcatcaatcccagcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc agcagcagcagcagtgccgtcccttccgggagcagctatggaaagctgtggacaaacggg gtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagcagcggt ggcaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggactccaac accagcagcccctccgactgctactatggccctgaggacccgcagcacaagccagtcctc tcgtactactcattgccaagatcctttaagcacacccagcgccctggggagccggaggag ggtgcccggcatcagcacctccgcctttccgctagctctggtcgccttctctatgctgca acagcggatgattcttcctcctccaccagcagcgacagcctgggtgggggatactgtggg gctaggctggagcccagccttccacatccccaccatcaggttctgcagccccatctgcct cgaaaggtggacacagctgctcagaccaatagccgcctggcccggcctacgaggctgtcc ctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcagcagcaa cagcagcaacagcagcccctgctgcaccctccggagcccaagagcccaggggaatatgtg aatattgaatttgggagtgatcagcctggctacttgtctggcccggtggcttcccgtagc tcaccttctgtcaggtgtccatcccagctccagccagctcccagagaggaagagactggc actgaggagtacatgaagatggacttggggccaggccggagggcagcctggcaggagagc actggggtcgagatgggcagactgggccccgcacctcccggggctgctagcatttgcagg cctacccgggcagtgcccagcagccggggtgactatatgaccatgcagatgagttgtccc cgccagagctatgtggacacctcgccaattgcccctgtaagctatgctgacatgcggaca ggcattgctgcagaggaggtgagcctgcccagggccaccatggctgctgcctcctcatcc tcagcagcctctgcttcccccactgggcctcaaggggcagcagagctgactgcccactca tccctgctggggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctc agtcctaaccgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggagg aggcatagctccgagaccttctcctcaacacccagtgccacccgggtgggcaacacagtg ccctttggagccggggcagcaatagggggtggtggcggtagcagcagcagcagtgaggat gtgaaacgtcacagctctgcttcctttgagaatgtgtggctgaggcctggggaacttggg ggagcccccaaggagccagcccaactgtgtggggctgctgggggtttggagaatggtctt aactacatagatctggatttggtcaaagacttcaaacagcgccctcaggagtgcacccct caaccgcagcctcccccacccccaccccctcatcaacccctgggtagcagtgagagcagc tccacccgccgccgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaag cagccagaggaccttcagtag

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