KEGG   Trichechus manatus latirostris (Florida manatee): 101359597
Entry
101359597         CDS       T05135                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu00562  Inositol phosphate metabolism
tmu01100  Metabolic pathways
tmu01521  EGFR tyrosine kinase inhibitor resistance
tmu04012  ErbB signaling pathway
tmu04014  Ras signaling pathway
tmu04015  Rap1 signaling pathway
tmu04020  Calcium signaling pathway
tmu04062  Chemokine signaling pathway
tmu04064  NF-kappa B signaling pathway
tmu04066  HIF-1 signaling pathway
tmu04070  Phosphatidylinositol signaling system
tmu04072  Phospholipase D signaling pathway
tmu04360  Axon guidance
tmu04370  VEGF signaling pathway
tmu04613  Neutrophil extracellular trap formation
tmu04650  Natural killer cell mediated cytotoxicity
tmu04658  Th1 and Th2 cell differentiation
tmu04659  Th17 cell differentiation
tmu04660  T cell receptor signaling pathway
tmu04664  Fc epsilon RI signaling pathway
tmu04666  Fc gamma R-mediated phagocytosis
tmu04670  Leukocyte transendothelial migration
tmu04722  Neurotrophin signaling pathway
tmu04750  Inflammatory mediator regulation of TRP channels
tmu04919  Thyroid hormone signaling pathway
tmu04933  AGE-RAGE signaling pathway in diabetic complications
tmu04935  Growth hormone synthesis, secretion and action
tmu05012  Parkinson disease
tmu05022  Pathways of neurodegeneration - multiple diseases
tmu05135  Yersinia infection
tmu05167  Kaposi sarcoma-associated herpesvirus infection
tmu05170  Human immunodeficiency virus 1 infection
tmu05171  Coronavirus disease - COVID-19
tmu05200  Pathways in cancer
tmu05205  Proteoglycans in cancer
tmu05206  MicroRNAs in cancer
tmu05214  Glioma
tmu05223  Non-small cell lung cancer
tmu05225  Hepatocellular carcinoma
tmu05231  Choline metabolism in cancer
tmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tmu05417  Lipid and atherosclerosis
Module
tmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101359597
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101359597
   04014 Ras signaling pathway
    101359597
   04015 Rap1 signaling pathway
    101359597
   04370 VEGF signaling pathway
    101359597
   04064 NF-kappa B signaling pathway
    101359597
   04066 HIF-1 signaling pathway
    101359597
   04020 Calcium signaling pathway
    101359597
   04070 Phosphatidylinositol signaling system
    101359597
   04072 Phospholipase D signaling pathway
    101359597
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101359597
   04650 Natural killer cell mediated cytotoxicity
    101359597
   04660 T cell receptor signaling pathway
    101359597
   04658 Th1 and Th2 cell differentiation
    101359597
   04659 Th17 cell differentiation
    101359597
   04664 Fc epsilon RI signaling pathway
    101359597
   04666 Fc gamma R-mediated phagocytosis
    101359597
   04670 Leukocyte transendothelial migration
    101359597
   04062 Chemokine signaling pathway
    101359597
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101359597
   04919 Thyroid hormone signaling pathway
    101359597
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101359597
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101359597
  09158 Development and regeneration
   04360 Axon guidance
    101359597
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101359597
   05206 MicroRNAs in cancer
    101359597
   05205 Proteoglycans in cancer
    101359597
   05231 Choline metabolism in cancer
    101359597
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101359597
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101359597
   05214 Glioma
    101359597
   05223 Non-small cell lung cancer
    101359597
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101359597
   05171 Coronavirus disease - COVID-19
    101359597
   05167 Kaposi sarcoma-associated herpesvirus infection
    101359597
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101359597
  09164 Neurodegenerative disease
   05012 Parkinson disease
    101359597
   05022 Pathways of neurodegeneration - multiple diseases
    101359597
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101359597
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101359597
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101359597
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tmu04131]
    101359597
Enzymes [BR:tmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101359597
Membrane trafficking [BR:tmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101359597
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101359597
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 101359597
NCBI-ProteinID: XP_004370400
UniProt: A0A2Y9D9H4
LinkDB
Position
Unknown
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLRVQEFVLSFLRDPLREIEEPYFFLEEFVT
FLFSKENSVWNPQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLSEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSTMRDEAFDPFDKS
TLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDNIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDMSLFSGTSLRERGSDASGLLFHGRAREGSFEARYQQPFEDF
RISQEHLADHFDGRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggccggcgccgcgtccccctgcgccaatggctgcgggcccggggcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcaacggccggagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgcggcgccgacaagatcgagggagccattgatatccgtgagatcaaggag
atccgcccagggaagacctcccgggactttgaccgctaccaagaggaccctgctttccgg
ccagaccagtcacactgctttgttatcctatatggcatggagttccgcctgaagaccctg
agcctgcaagctacttctgaggatgaagtaaacatgtggatcaagggtttaacttggctg
atggaggatacattgcaggcggccacacccctgcagattgagaggtggcttcggaagcag
ttctactcagtggaccggaatcgtgaggatcgcatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacagac
ctggagcagcggagcggggacatcacctatgggcagtttgcgcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcctggaagccagtaccctgagggct
ggggagcggccagagctctgccgagtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggccgtggaccggcttcgggtgcaggagttcgtgctcagcttc
ctccgagaccctttgcgagagattgaggaaccgtacttcttcctggaggagtttgtcacc
tttctgttctccaaagagaacagcgtgtggaacccccagctggatgctgtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcacacaatacgtacctgact
ggggaccagttctccagcgagtcctccctggaagcctacgcacgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggtccagatgggatgccggtcatttaccac
ggacacactctcactaccaagatcaagttctcagatgtcttgcacaccatcaaggaacat
gcctttgtggcctcagagtacccggtcatcctctccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagtactttaaaaaggtgcttggggacacgctcctcaccaag
cccgtggacatcgccgccgatgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctatgaggaggtgccgacgtccgtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggacccc
gtgaaccatgaatggtacccccactactttgttctgaccagcagcaagatctactactct
gaagagaccagtagtgaccagggcaacgaggacgaggaagagcccaaggaggccagtggc
agcacagaactgcactccaacgagaagtggttccacgggaagcttggggccggccgggat
gggcggcacattgccgagcgcttgctcactgagtactgcattgagaccggggcgcctgat
ggctccttcctagtgcgcgagagcgagaccttcgtgggcgactacacgctctctttctgg
cggaatgggaaggtccagcactgccggatccactcccggcaggatgctgggacccccaag
ttcttcttgacagacaacctcgtgtttgactcactgtatgacctcatcacacactaccag
caggtgcccctgcgctgcaacgagtttgagatgcgcctttcagaacctgtcccgcagacc
aatgctcacgagagcaaagagtggtaccacgcaagcctgaccagagcccaggctgagcac
atgttaatgcgggttccccgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcttatgccatctccttccgggctgaggggaagatcaagcattgccgcgtccagcaggag
ggccagacagtgatgctggggaactcggagtttgacagcctcgtcgacctcatcagctat
tatgagaaacatcctctgtaccgcaagatgaagctgcgctatcccatcaacgaggaggcc
ctggagaagattggcacagctgagccagactacggggccctgtatgagggacgcaaccct
ggcttctacgtggaggcaaacccaatgccgactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagagaggacgagctgactttcaccaagagtgccatcatccagaat
gtagagaagcaagagggaggctggtggcggggggactacggtgggaagaagcagttgtgg
ttcccgtcaaactacgttgaagagatggtcagcccagcggccctggagcctgagagggag
cacttggacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccggct
tgtcagatcgccatccgaccagagggcaagaacaaccggctcttcgtcttctccatcagt
atggcgtcagtggcacactggtccctggatgttgcagccgactcacaggaggagctgcag
gactgggtgaaaaagattcgtgaagttgcccagaccgcagacgcccggctctctgagggg
aagatgatggaacggaggaagaagattgccctggagctctctgagcttgtcgtctactgc
cggcctgttccctttgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcatccttccccgaaaccaaggctgagaaatatgtgaacaaggccaaaggcaagaagttc
ctccagtacaatcgactgcagctctcccgcatctaccccaagggccagcggctggactcc
tccaattatgatcccttgcccatgtggatctgtggcagccagctcgtggccctcaacttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcctggccggcgggcactgc
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
accctccggggactggagccatgtgccatctgcatcgaggtactgggggcccggcatctg
ccgaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagctgag
tatgacaacatcaagcagaagacagagtttgtggtggacaatggactgaaccccgtgtgg
ccggccaagcccttccacttccagatcagcaaccccgaatttgctttcttgcgcttcgtg
gtatatgaggaagacatgtttagtgaccagaatttcttggctcaggctactttccccgtg
aaaggcctgaagacaggatacagagctgtgcctttgaagaacaactacagtgaggacctg
gagttggcctccctgctcatcaagatcgatattttccctgccaaggagaacggtgacatg
agtctcttcagtggtacgtccctgcgggagcggggctcggatgcctcaggcctgctgttc
catggccgggcccgggaaggctccttcgaagcccgctaccagcagccgtttgaggacttc
cgcatctcccaggagcatctcgcagaccactttgatggtcgggaacgaagggccccgcga
aggactcgggtcaatggggacaaccgcctctag

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