KEGG   Talpa occidentalis (Iberian mole): 119237093
Entry
119237093         CDS       T07495                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01521  EGFR tyrosine kinase inhibitor resistance
tod01522  Endocrine resistance
tod01524  Platinum drug resistance
tod04012  ErbB signaling pathway
tod04014  Ras signaling pathway
tod04015  Rap1 signaling pathway
tod04024  cAMP signaling pathway
tod04062  Chemokine signaling pathway
tod04066  HIF-1 signaling pathway
tod04068  FoxO signaling pathway
tod04070  Phosphatidylinositol signaling system
tod04071  Sphingolipid signaling pathway
tod04072  Phospholipase D signaling pathway
tod04081  Hormone signaling
tod04140  Autophagy - animal
tod04150  mTOR signaling pathway
tod04151  PI3K-Akt signaling pathway
tod04152  AMPK signaling pathway
tod04210  Apoptosis
tod04211  Longevity regulating pathway
tod04213  Longevity regulating pathway - multiple species
tod04218  Cellular senescence
tod04360  Axon guidance
tod04370  VEGF signaling pathway
tod04380  Osteoclast differentiation
tod04510  Focal adhesion
tod04550  Signaling pathways regulating pluripotency of stem cells
tod04611  Platelet activation
tod04613  Neutrophil extracellular trap formation
tod04620  Toll-like receptor signaling pathway
tod04625  C-type lectin receptor signaling pathway
tod04630  JAK-STAT signaling pathway
tod04650  Natural killer cell mediated cytotoxicity
tod04660  T cell receptor signaling pathway
tod04662  B cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04666  Fc gamma R-mediated phagocytosis
tod04668  TNF signaling pathway
tod04670  Leukocyte transendothelial migration
tod04722  Neurotrophin signaling pathway
tod04725  Cholinergic synapse
tod04750  Inflammatory mediator regulation of TRP channels
tod04810  Regulation of actin cytoskeleton
tod04910  Insulin signaling pathway
tod04914  Progesterone-mediated oocyte maturation
tod04915  Estrogen signaling pathway
tod04917  Prolactin signaling pathway
tod04919  Thyroid hormone signaling pathway
tod04923  Regulation of lipolysis in adipocytes
tod04926  Relaxin signaling pathway
tod04929  GnRH secretion
tod04930  Type II diabetes mellitus
tod04931  Insulin resistance
tod04932  Non-alcoholic fatty liver disease
tod04933  AGE-RAGE signaling pathway in diabetic complications
tod04935  Growth hormone synthesis, secretion and action
tod04960  Aldosterone-regulated sodium reabsorption
tod04973  Carbohydrate digestion and absorption
tod05010  Alzheimer disease
tod05017  Spinocerebellar ataxia
tod05020  Prion disease
tod05100  Bacterial invasion of epithelial cells
tod05135  Yersinia infection
tod05142  Chagas disease
tod05146  Amoebiasis
tod05160  Hepatitis C
tod05161  Hepatitis B
tod05162  Measles
tod05163  Human cytomegalovirus infection
tod05164  Influenza A
tod05165  Human papillomavirus infection
tod05166  Human T-cell leukemia virus 1 infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05168  Herpes simplex virus 1 infection
tod05169  Epstein-Barr virus infection
tod05170  Human immunodeficiency virus 1 infection
tod05171  Coronavirus disease - COVID-19
tod05200  Pathways in cancer
tod05203  Viral carcinogenesis
tod05205  Proteoglycans in cancer
tod05206  MicroRNAs in cancer
tod05207  Chemical carcinogenesis - receptor activation
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05210  Colorectal cancer
tod05211  Renal cell carcinoma
tod05212  Pancreatic cancer
tod05213  Endometrial cancer
tod05214  Glioma
tod05215  Prostate cancer
tod05218  Melanoma
tod05220  Chronic myeloid leukemia
tod05221  Acute myeloid leukemia
tod05222  Small cell lung cancer
tod05223  Non-small cell lung cancer
tod05224  Breast cancer
tod05225  Hepatocellular carcinoma
tod05226  Gastric cancer
tod05230  Central carbon metabolism in cancer
tod05231  Choline metabolism in cancer
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tod05415  Diabetic cardiomyopathy
tod05417  Lipid and atherosclerosis
tod05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    119237093 (PIK3R3)
   04014 Ras signaling pathway
    119237093 (PIK3R3)
   04015 Rap1 signaling pathway
    119237093 (PIK3R3)
   04370 VEGF signaling pathway
    119237093 (PIK3R3)
   04630 JAK-STAT signaling pathway
    119237093 (PIK3R3)
   04668 TNF signaling pathway
    119237093 (PIK3R3)
   04066 HIF-1 signaling pathway
    119237093 (PIK3R3)
   04068 FoxO signaling pathway
    119237093 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    119237093 (PIK3R3)
   04072 Phospholipase D signaling pathway
    119237093 (PIK3R3)
   04071 Sphingolipid signaling pathway
    119237093 (PIK3R3)
   04024 cAMP signaling pathway
    119237093 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    119237093 (PIK3R3)
   04152 AMPK signaling pathway
    119237093 (PIK3R3)
   04150 mTOR signaling pathway
    119237093 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    119237093 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119237093 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    119237093 (PIK3R3)
   04218 Cellular senescence
    119237093 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119237093 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    119237093 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119237093 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119237093 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    119237093 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    119237093 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    119237093 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    119237093 (PIK3R3)
   04660 T cell receptor signaling pathway
    119237093 (PIK3R3)
   04662 B cell receptor signaling pathway
    119237093 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    119237093 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    119237093 (PIK3R3)
   04670 Leukocyte transendothelial migration
    119237093 (PIK3R3)
   04062 Chemokine signaling pathway
    119237093 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119237093 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    119237093 (PIK3R3)
   04929 GnRH secretion
    119237093 (PIK3R3)
   04915 Estrogen signaling pathway
    119237093 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    119237093 (PIK3R3)
   04917 Prolactin signaling pathway
    119237093 (PIK3R3)
   04926 Relaxin signaling pathway
    119237093 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    119237093 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    119237093 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119237093 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    119237093 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    119237093 (PIK3R3)
   04722 Neurotrophin signaling pathway
    119237093 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    119237093 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    119237093 (PIK3R3)
   04380 Osteoclast differentiation
    119237093 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    119237093 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    119237093 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119237093 (PIK3R3)
   05206 MicroRNAs in cancer
    119237093 (PIK3R3)
   05205 Proteoglycans in cancer
    119237093 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    119237093 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    119237093 (PIK3R3)
   05203 Viral carcinogenesis
    119237093 (PIK3R3)
   05230 Central carbon metabolism in cancer
    119237093 (PIK3R3)
   05231 Choline metabolism in cancer
    119237093 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119237093 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119237093 (PIK3R3)
   05212 Pancreatic cancer
    119237093 (PIK3R3)
   05225 Hepatocellular carcinoma
    119237093 (PIK3R3)
   05226 Gastric cancer
    119237093 (PIK3R3)
   05214 Glioma
    119237093 (PIK3R3)
   05221 Acute myeloid leukemia
    119237093 (PIK3R3)
   05220 Chronic myeloid leukemia
    119237093 (PIK3R3)
   05218 Melanoma
    119237093 (PIK3R3)
   05211 Renal cell carcinoma
    119237093 (PIK3R3)
   05215 Prostate cancer
    119237093 (PIK3R3)
   05213 Endometrial cancer
    119237093 (PIK3R3)
   05224 Breast cancer
    119237093 (PIK3R3)
   05222 Small cell lung cancer
    119237093 (PIK3R3)
   05223 Non-small cell lung cancer
    119237093 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119237093 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    119237093 (PIK3R3)
   05161 Hepatitis B
    119237093 (PIK3R3)
   05160 Hepatitis C
    119237093 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    119237093 (PIK3R3)
   05164 Influenza A
    119237093 (PIK3R3)
   05162 Measles
    119237093 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    119237093 (PIK3R3)
   05163 Human cytomegalovirus infection
    119237093 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119237093 (PIK3R3)
   05169 Epstein-Barr virus infection
    119237093 (PIK3R3)
   05165 Human papillomavirus infection
    119237093 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    119237093 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    119237093 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    119237093 (PIK3R3)
   05142 Chagas disease
    119237093 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119237093 (PIK3R3)
   05017 Spinocerebellar ataxia
    119237093 (PIK3R3)
   05020 Prion disease
    119237093 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119237093 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    119237093 (PIK3R3)
   05415 Diabetic cardiomyopathy
    119237093 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    119237093 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    119237093 (PIK3R3)
   04931 Insulin resistance
    119237093 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119237093 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119237093 (PIK3R3)
   01524 Platinum drug resistance
    119237093 (PIK3R3)
   01522 Endocrine resistance
    119237093 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tod04131]
    119237093 (PIK3R3)
Membrane trafficking [BR:tod04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    119237093 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act
Other DBs
NCBI-GeneID: 119237093
NCBI-ProteinID: XP_037356975
LinkDB
Position
Unknown
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTPAITNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHCQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgactccagccattacaaatgggatgaaggacagttctgtttctctt
caggatgcagaatggtattggggggatatttcaagggaggaggtaaatgacaaattacgg
gacatgccagatggtacctttttggtcagagatgcctcaacaaaaatgcaaggagattat
actttgacactacggaaaggaggcaataataagttaataaagatctatcatcgagatggt
aaatatggcttttctgatcctctgacatttaattctgtggtggagctcattaaccactat
catcatgaatcacttgctcagtacaatcccaaacttgatgtgaagttgatgtaccctgta
tccagataccaacaggatcagttggtaaaagaagataacattgatgcagtaggcaaaaaa
ttgcaagagtaccactgtcagtatcaggaaaagagcaaagagtatgataggctatatgaa
gaatataccagaacatcccaggaaatacagatgaagagaactgcaattgaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaggaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaagaaattgaacgaattatgatgaattat
gacaaattgaagtcacgtctgggtgagattcatgatagcaaaatgcgcctagagcaggat
ttgaagaaacaagctttggataaccgggaaatagataaaaaaatgaatagtatcaaacct
gacctgatccagctgcgcaaaatccgagatcagcatcttgtatggctcaatcacaaagga
gtaagacagaagcgcctgaatgcctggcttggaatcaagaatgaggatgctgatgagacc
tatttcatcaatgaggaagatgaaaacttgccccattatgatgagaaaacttggtttgtt
gaggatatcaatcgagtacaagcagaggacttgctttatgggaaacctgacggtgcattt
ttaattcgggaaagtagcaagaaaggatgctatgcttgctctgttgtggctgatggggaa
gtgaagcactgtgtgatctacagcactgctcggggatacggctttgcagagccctacaac
ctgtacagctcactgaaggagctggtgctccactaccagcagacctctctcgttcagcac
aatgactccctcaacgtcaggcttgcctaccctgtccatgcacagatgccctcgctctgc
agataa

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