Talpa occidentalis (Iberian mole): 119240421 Help Entry 119240421         CDS       T07495                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism tod  Talpa occidentalis (Iberian mole) Pathway tod04010   MAPK signaling pathway tod04014   Ras signaling pathway tod04015   Rap1 signaling pathway tod04022   cGMP-PKG signaling pathway tod04066   HIF-1 signaling pathway tod04068   FoxO signaling pathway tod04072   Phospholipase D signaling pathway tod04081   Hormone signaling tod04150   mTOR signaling pathway tod04151   PI3K-Akt signaling pathway tod04152   AMPK signaling pathway tod04211   Longevity regulating pathway tod04213   Longevity regulating pathway - multiple species tod04520   Adherens junction tod04910   Insulin signaling pathway tod04913   Ovarian steroidogenesis tod04923   Regulation of lipolysis in adipocytes tod04930   Type II diabetes mellitus tod04931   Insulin resistance tod04932   Non-alcoholic fatty liver disease tod04960   Aldosterone-regulated sodium reabsorption tod05010   Alzheimer disease tod05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:tod00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     119240421 (INSR)    04014 Ras signaling pathway     119240421 (INSR)    04015 Rap1 signaling pathway     119240421 (INSR)    04066 HIF-1 signaling pathway     119240421 (INSR)    04068 FoxO signaling pathway     119240421 (INSR)    04072 Phospholipase D signaling pathway     119240421 (INSR)    04022 cGMP-PKG signaling pathway     119240421 (INSR)    04151 PI3K-Akt signaling pathway     119240421 (INSR)    04152 AMPK signaling pathway     119240421 (INSR)    04150 mTOR signaling pathway     119240421 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     119240421 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     119240421 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     119240421 (INSR)    04923 Regulation of lipolysis in adipocytes     119240421 (INSR)    04913 Ovarian steroidogenesis     119240421 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     119240421 (INSR)   09149 Aging    04211 Longevity regulating pathway     119240421 (INSR)    04213 Longevity regulating pathway - multiple species     119240421 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     119240421 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     119240421 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     119240421 (INSR)    04932 Non-alcoholic fatty liver disease     119240421 (INSR)    04931 Insulin resistance     119240421 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tod01001]     119240421 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:tod04090]     119240421 (INSR) Enzymes [BR:tod01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      119240421 (INSR) Protein kinases [BR:tod01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    119240421 (INSR) CD molecules [BR:tod04090]  Proteins   119240421 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  119240421 NCBI-ProteinID:  XP_037360691 LinkDB All DBs Position Unknown AA seq 1369 aa AA seqDB search MGARGGRGAAAPLVLAVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHLQ ILLMFKTKPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALV VFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEE CGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSQGCTAEGLCCHSECLG NCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRPGC HQYVVHDNKCVPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGCT VINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLE IGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEKISGTKGRQER NDIALKTNGDQASCENELLKFSYIRTSFDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQN VTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNQPGWLMRGLKPWTQYAIFVKTLVTFSD ERRTYGAKSDIIYVQTEATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWER QAEDSELFELDYCLKGLKLPSRTWSPPFESEGAQKHNQSEYEEAAGECCSCPKTDSQILK ELEESSFRKTFEDYLHNVVFVPRPSRKRRALSEVANATAAVPTAPGFPNTSSTSAPTSSE EHRPFEKVVNKESLVISGLRHFTGYRIELQACNKDAPEERCSVAAYVSARTMPEAKADDI VGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRL RGLPPGNYSVRVRATSLAGNGSWTEATHFYVADYLDVPSNIAKIIIGPLIFVFLFSLVIG SIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKIALLRELGQGS FGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVV SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVF TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGFLDQPDNCPERVTDLMRMCW QFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRSS HSQREEAGGRDGGSALGLKRNYEEHIPYTHMNGGKKNGRILTLPRSSPS NT seq 4110 nt NT seq  +upstreamnt  +downstreamnt atgggcgcccggggcgggcggggggcggcggcgccgctggtgctggcggtggccgcgctg ctggtgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatattcgg aacaacctcacgagacttcacgagctggcaaactgctctgtcattgaaggacatttgcag atactgttgatgttcaaaacaaagcccgaggatttccgagacctcagtttccccaaactc atcatgatcactgattacctgctgctcttccgggtctatgggctggagagcctgaaggac ctgttcccgaacctcactgtcatccggggctcgcgcctcttcttcaactacgcgctggtc gtcttcgagatggtccacctcaaggagcttggcctgtacaacctcatgaacatcacccgg ggctccgtccgaatagagaagaacaatgagctctgctacctggccaccatcgactggtcc cgcatcctggactccgtggaggataattacattgtgctcaacaaagacgacaacgaggag tgtggcgacatctgcccaggcactgcgaagggcaagaccaactgccctgccaccgtcatc aacgggcagttcgtggagcggtgctggacacacagccattgccagaaagtgtgcccgacc atctgcaagtctcagggctgcacggccgaggggctctgctgtcacagcgagtgcctgggc aactgctccgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctggac ggcaggtgcgtggagacctgcccgcctccctactaccacttccaggactggcgctgcgtg aacttcagcttctgccaggacctgcacaacaagtgcaagaactcacggcggccgggctgc caccagtatgtggtgcatgacaacaagtgcgtccccgagtgtccctccggatacaccatg aattccagcaacctgatgtgcaccccatgcctgggcccctgccccaaagtctgccacatc ctggagggtgagaagaccatcgactcggtgacctctgcccaggagctgcgtggctgcact gtcatcaacgggagcctcatcatcaatatccgggggggcaacaacctggcggctgagctg gaggccaaccttggcctcattgaagaaatttcagggtatctaaaaatccgccggtcctac gccctggtgtcgctttccttcttccggaagttacgcctgattcgaggagagaccttggag atcgggaactactctttctatgctctggacaaccagaatctaaggcagctgtgggactgg agcaagcacaacctcactatcactcaggggaaactcttcttccactataatcccaagctc tgcttgtcggaaatacataagatggaaaaaatttcgggaaccaaggggcgccaggagagg aacgacatcgccctgaagaccaacggggaccaggcatcctgtgaaaatgagttactgaaa ttttcttacatccggacgtctttcgacaagatcttgctgaagtgggagccatactggccc cctgactttcgagacctcctggggttcatgctcttctataaagaggccccctaccagaat gtgacggagttcgacgggcaggacgcctgcggctccaacagctggacggtggtggacatc gacccgcctctgaggtccaatgaccccaagtcgcagaaccagcctgggtggctgatgcgg ggcctcaagccctggactcagtacgccatcttcgtcaagaccttggtcaccttttctgac gaacgccgaacatacggtgccaagagcgacatcatctatgtgcagacagaagccaccaac ccttccgtgccgttggaccccatctctgtctccaattcctcatcccagatcattctgaag tggaagcctccctctgaccccaacggcaacatcacgcactacctggtgttctgggagagg caggcagaggacagcgagctgttcgagctggactactgcctcaaagggctgaagctgccc tccaggacctggtctcccccattcgagtccgagggtgcccagaagcacaaccagagcgag tacgaggaggcggccggtgagtgctgctcctgccccaagaccgactcccagatcctgaag gagctggaggaatcctcgttcaggaagaccttcgaggactacctgcacaacgtggtcttc gtccccagaccgtccaggaagcgccgggccctcagtgaggtcgccaacgccacggcagcc gtgcccacggcccccggcttccccaacacctcttccaccagcgcgcccaccagctccgag gagcacaggccatttgagaaggtggtgaacaaggagtccctggtcatctccggcctgcgc cacttcacagggtaccgcatcgagctgcaggcctgcaacaaggacgcccccgaagagcgg tgcagcgtggcggcctatgtcagtgccaggaccatgcccgaagccaaggcagatgatatc gtcggcccagtgacccacgagatcttcgagaataatgtagttcacttgatgtggcaggag ccaaaggagcccaacgggctgatcgtgctgtacgaagtgagttatcggcgctatggcgat gaggaactgcacctctgtgtctcccgcaggcactttgctctggagcgggggtgcaggctg cgcgggctgccccccggcaactacagcgtgcgggtccgggccacctctctggcgggcaac ggctcctggacagaagccacccacttttatgtggcggactatttagatgtcccgtccaat attgcaaaaattatcatcggccccctcatctttgtgtttctcttcagtcttgtgattgga agcatttatctgttcctgaggaagaggcagccggatgggccgctgggacccctgtatgcg tcttcaaaccccgagtacctcagtgccagcgatgtgttcccgtgttctgtgtatgtgccg gacgagtgggaggtgccgcgggagaagatcgcgctgctgcgggagctgggccagggctcc ttcggcatggtgtacgagggcaacgccagggacatcattaagggcgaggcggagacgcgc gtggcggtgaagacggtcaacgagtccgccagtcttcgggagcggatcgagttcctcaac gaggcctcggtcatgaagggcttcacctgccaccacgtggtgcgcctcctgggggtggtg tccaaaggccagccgaccttggtggtgatggagctgatggcgcacggggacctgaagagc tacctgcgttccctgcggccggaggctgagaataaccccggccgccccccgcccaccctg caagagatgatccagatggcagcggagatcgcagatggaatggcctacctgaacgccaag aagttcgtgcaccgcgacctcgcagcgcggaactgcatggtcgcccatgacttcaccgtc aaaatcggagactttggaatgaccagagacatctacgaaacggattactaccggaaaggg ggcaagggcctgctccccgtgcgctggatggcaccggaatccctgaaagatggggttttt accacttcttccgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttggca gaacaaccttaccaaggcctgtctaatgagcaggtgttgaagtttgtcatggatggaggg tttctggatcaacccgacaattgtccagagagagtcaccgacctgatgcgcatgtgctgg cagttcaacccaaagatgcggccgaccttcctggagatcgtggacctgctcaaggacgac ctgcaccccagcttcccggaagtttctttcttccacagcgaggagaacaaggcgcccgag agcgaggaactggagatggagtttgaggacatggagagtgtccccctggaccgctcctcg cactcccagagagaggaggccgggggccgggacggcgggtccgcgctgggcctcaagcgg aactacgaggagcacatcccctacacccacatgaacgggggcaagaagaacggccggatt ctgactctgcctcggtccagtccttcctaa

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