Talpa occidentalis (Iberian mole): 119241109 Help Entry 119241109         CDS       T07495                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism tod  Talpa occidentalis (Iberian mole) Pathway tod04062   Chemokine signaling pathway tod04151   PI3K-Akt signaling pathway tod04217   Necroptosis tod04550   Signaling pathways regulating pluripotency of stem cells tod04630   JAK-STAT signaling pathway tod04658   Th1 and Th2 cell differentiation tod04659   Th17 cell differentiation tod05161   Hepatitis B tod05162   Measles tod05166   Human T-cell leukemia virus 1 infection tod05169   Epstein-Barr virus infection tod05200   Pathways in cancer tod05203   Viral carcinogenesis tod05223   Non-small cell lung cancer tod05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:tod00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     119241109 (JAK3)    04151 PI3K-Akt signaling pathway     119241109 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     119241109 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     119241109 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     119241109 (JAK3)    04659 Th17 cell differentiation     119241109 (JAK3)    04062 Chemokine signaling pathway     119241109 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     119241109 (JAK3)    05203 Viral carcinogenesis     119241109 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     119241109 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     119241109 (JAK3)    05161 Hepatitis B     119241109 (JAK3)    05162 Measles     119241109 (JAK3)    05169 Epstein-Barr virus infection     119241109 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     119241109 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tod01001]     119241109 (JAK3) Enzymes [BR:tod01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      119241109 (JAK3) Protein kinases [BR:tod01001]  Non-receptor tyrosine kinases   JAK family [OT]    119241109 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl ABC1 FERM_C_FAK1 Kdo LRR_RI_capping SH2 Haspin_kinase Motif Other DBs NCBI-GeneID:  119241109 NCBI-ProteinID:  XP_037362039 LinkDB All DBs Position Unknown AA seq 1104 aa AA seqDB search MAPPSEETPLISQRSCSLSSSEAGTLHVLLPPRGPGPPKCLSFSFGDHSAEELCVQAAKA SGILPVYHSLFALATEDLSCWFPPSHIFSVEDSGTQVLVYRLRFYFPNWYGLEKCHRFGL RKDLASAILDLPVLEHLFAQHRTDLVSGRLPVGLGLKEQGECLSLAVLDLARMACEQAQR PRDLLKTISYKVCLPPGLRDLIQGLSFVTRKRIRRTVLRALNRVAACQADRHSLMAKYII DLERLDPARAAETFCVGLPGAAGVQDAQGLLCVAGVSGIAWSPAGQEVLQPFCDFPEIVD ISIKQAQHAGLAGEHRLVTITRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSRHYFC KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSLPGSYLLRRSPQDFDSFLLTVCVQTS LGPDYKGCLIRCHPTGTFSLAGIGHSHSSLRALLSACRDGGLHVDGVALNLTFCCTPKPK EKSNLIVVRRDCSLPTSSPIQSQSQCQLSQMTFHKIPTDSLEWHENLGHGSFTKIYRGCR HETVDGESRDTEVLLKVMEAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAEDSIMVQ EFVHLGALDTYLRKCGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGG DGSPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS GVTMPISTLDPAKKLQFYEGRQQLPAPKWTELALLIQQCMAYEPGLRPSFRAVIRDLNSL ITSDYELLSDPTPGTLAPRDGLWNGAQLYASQDPTIFEERHLKYISQLGKGNFGSVELCR YDPLGDNTGALVAVKQLQHSGPEQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL VMEYVPSGCLRDFLQRHRARLDAGRLLLYASQICKGMEYLGSRRCVHRDLAARNILVESE THVKIADFGLAKLLPVDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL FTYSDKSCSPSAEFLRMMGCERDVPALCRLLELLSEGQRLPAPPACPAEVHELMKWCWAP SPQDRPSFSTLGPRLDALWTGNQG NT seq 3315 nt NT seq  +upstreamnt  +downstreamnt atggcacctccgagtgaggagacacccctgatctctcagcgctcctgcagcctctcatct tcagaggctggcacactacacgtgctgttgccccctcggggtcctggacctccgaagtgt ctatccttctcctttggggaccactcagctgaagagctatgtgttcaggctgctaaggcc agtggtattctgcccgtgtatcactctctctttgctctggccacggaggacctgtcctgc tggtttccaccaagccacatcttctctgtggaggactcgggcacccaggtccttgtctac aggctccgcttttacttccccaactggtatggactggagaagtgccaccgctttgggcta cggaaggacttggccagcgccatccttgacctgccagtcctagaacacctctttgcccag catcgcactgacctggtgagcggccgtctccccgtgggcctcggcctcaaggagcagggc gagtgtctcagtctcgcggtgctagaccttgcccggatggcctgtgagcaggcccagcgg cccagagacctgctgaagaccatcagctacaaggtctgcctgccccctggcctgcgggac ctgatccaaggcctgagcttcgtgacgcggaagcgtatccggaggacggttctacgcgcc ctgaaccgcgtggccgcctgccaggcagacaggcactcgctcatggccaagtacatcatc gacctggagcggctggatccggccagggccgctgagaccttctgcgtgggcctccctggg gccgctggggttcaggatgcgcaggggctgctctgcgtggcgggggtcagcggcatcgcc tggagcccggcaggacaggaggtcctccagcccttctgcgactttccagaaatcgtggat atcagcatcaagcaggcccagcacgccggcctggccggggagcatcgtctggtcaccatt accaggacagacaaccagatcctggaggctgagttcccagggctgccggaggccttatcc ttcgtggcacttgtggacggctacttccgactgaccaccgactcccggcactacttctgc aaggaggtggcacccccgaggctgctggaggaggtagctgagcagtgccatggccccatc actctggattttgccatcaacaagctcaagactgggggctcacttccaggttcctacctt ctccgccgaagcccccaggattttgacagtttcctcctcactgtctgtgtccagacctcc ctgggacctgattacaagggatgcctcatccggtgtcacccaacgggaaccttctccctc gctggtattgggcattcccacagcagtcttcgagcgctcctgtcagcctgccgggatggt ggactgcatgtggatggggttgcactgaacctcaccttctgctgcaccccaaaacccaaa gaaaaatccaacctgattgtggtccggagagattgcagcttgcccacatcatcccccatt cagtcccaatcgcaatgccagctgagtcagatgacgtttcacaagatccccaccgacagc ctggagtggcatgagaacctgggtcacgggtcctttaccaagatttaccggggctgtcgc catgagaccgtggatggggagtcccgggacacggaggtgctgctcaaagtgatggaggcc aagcacaagaactgcatggaatcattcctggaagcagcaagcctgatgagccaagtgtca taccagcaccttgtattgctccatggcgtgtgcatggctgaagacagtatcatggtgcag gaatttgtacacctgggagccctggacacgtatctgcgtaagtgtggccacctggttcca gccagctggaagctgcaggtgaccaaacagctggcttatgccctcaactatctggaagat aaaggccttccccatggcaatgtctcagcccggaaggtgctcctggctcgcgaggggggt gatgggagcccacctttcatcaagctgagtgaccctggtgtgagccccactgtgttaagc ttggagatgctcactgacaggatcccctgggtggcccctgagtgtctccaggaggcccgg acacttggcttggaagctgacaagtggggcttcggtgccacagtttgggaggtgttcagt ggtgtcacaatgcccatcagtacactggatcctgccaagaaactccagttttatgaggga cgacaacaactgccagcccccaagtggacagagctggccctgctcatccaacagtgcatg gcctatgagccaggcctaaggccctccttccgagctgtcatccgtgacctcaacagcctc atcacttcagattatgagctcctctcagaccccacacctgggaccttggcaccccgtgat gggctgtggaatggcgcccagctctatgcctcccaggaccccaccatcttcgaggagaga cacctcaagtacatctcgcagctgggcaagggcaactttggcagtgtggaactatgccgc tatgaccctctgggagacaacacaggtgctctggtggccgtgaagcagctgcagcatagc gggccagagcagcagagggacttccagcgggagatccagatcctcaaagccctccacagt gacttcattgtcaagtaccggggtgtcagctatggcccaggccgccagagtctgcggctg gtcatggagtatgtgcccagcggctgcctgcgcgacttcctgcagaggcaccgcgcgcgg ctagacgctggccgcctgcttctctacgcctcgcagatctgcaagggcatggagtacctg ggctcccgccgctgcgtgcaccgcgacctggccgcacgcaacatcttggtggagagcgag actcacgtcaagatcgcagacttcggtctcgccaagctgctgcccgtagacaaggactac tacgtggtccgcgagccgggccagagtcccatcttctggtacgcccccgagtccctctcc gacaacatcttctcgcgccagtcggacgtctggagcttcggagtcgtcctgtacgagctc tttacctacagtgacaagagctgcagcccctcagccgagttcctgaggatgatgggatgt gagcgagacgtccccgccctctgccgcctcctggagctgctctctgagggccagaggctg ccggcacctcctgcctgcccagctgaggttcatgagctcatgaagtggtgctgggccccc agcccgcaggaccggccatcattcagcactctgggtccccggctggatgcactgtggact ggaaaccaggggtag

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