KEGG   Thunnus thynnus (Atlantic bluefin tuna): 137184613
Entry
137184613         CDS       T11154                                 
Symbol
plcg1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
tty  Thunnus thynnus (Atlantic bluefin tuna)
Pathway
tty00562  Inositol phosphate metabolism
tty01100  Metabolic pathways
tty04012  ErbB signaling pathway
tty04020  Calcium signaling pathway
tty04070  Phosphatidylinositol signaling system
tty04370  VEGF signaling pathway
Module
tty_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:tty00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    137184613 (plcg1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    137184613 (plcg1)
   04370 VEGF signaling pathway
    137184613 (plcg1)
   04020 Calcium signaling pathway
    137184613 (plcg1)
   04070 Phosphatidylinositol signaling system
    137184613 (plcg1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tty04131]
    137184613 (plcg1)
Enzymes [BR:tty01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     137184613 (plcg1)
Membrane trafficking [BR:tty04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    137184613 (plcg1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    137184613 (plcg1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 PH_12 SH3_2 GDPD EF-hand_7 Mcp5_PH EF-hand_6
Other DBs
NCBI-GeneID: 137184613
NCBI-ProteinID: XP_067448545
LinkDB
Position
6:19720528..19749871
AA seq 1315 aa
MAGTSGFFSNGPGPWMDNDTEMNNLYRDLELGTVLTLFYAKKSQRPERRTFQVKLETRTI
IWTRGTDKIEGEIDIREIKEIRTGQKSRDFERYVEDSSVRLDQTYCFVILYGTEFRLKSL
SLSATSDEEMTMWVKGLNWLVADTLKSPTPLQIERWLRKQFYAVDRNREDRISCKDLKSM
LSQVNYRVPNMRFLREKLPDSEMRNGDVSFSQFAQLYRSLMFDAQKNMEIPFLQRFIDRP
EQRISLEDFKSFLLESQKEMWATDKNKVQEFMFGYLKDPLREVEQPYFHQDELLTYLFSK
ENTIWDCTLDQVCPENMKNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE
LDCWDGPDGMPVIYHGHTLTTKIKFCDVLNTIKEHAFVTSEYPIILSIEDHCSIVQQRNM
ATHFKKVFGDMLLTKAVDIAADGLPSPTQLKRKILIKHKKLAEGSAYEEVSTSTPYSEND
ISNSLKNGILYLEDPINHEWYPHFFVLTSSKIYYSEETSSNQLNDDEEEHREVSNGMDQH
VTEKWFHGKLGAGRDGRQIAERLLSEYCLETGAPDGSFLVRESETFVGDYTLSFWRSGRV
QHCRIHSRQEAGSPKFYLTDNLVFDTLFALINHYQQVALRCNEFEMKLTEPVPQTNAHES
KEWYHANLSRSHAENMLMRVPRDGAFLVRKRAEPNSFAISFRAEGKIKHCRVQQEGQNVV
LGTSEFESLVDLISYYEKHPLYRKMKLRYPINEDTLEKIGTAEPDYGSLYEGRNPGFYVE
ANQMPTFKCTVKAMYEYKAQRDDELSFTKNAIISNVDKQEGGWWKGDCGGKKQFWFPANY
VEEISPSTAEPDRTQEMTENSPLGDLLRGSVDVSSCQIVQRPDGKGTRPHVFSLVPTTSL
RTGMVLDVAASSAEELKEWVLKIREVTVTSEAKLEEGKMMERRKKIALELSELVIYCRPV
PFDEDKIGTERACFRDMSSFPETKAEKYVNKIKGKKFLQYNRLQLSRIYPRGQRLDSSNY
DPLPMWLCGSQLVALNFQTADKPMQMNQALFMLNGKSGYVLQPPIMRDDNFDPFDRHTLR
GLEQVTLEIEVLGARHLPKHGRGIVCPLIEIEVCGADYDSAKQKTDSEADNGLNPTWPRK
PFQFTVCNSAFAFLRFVVYEIDMFNDQNFLAQATFPIHSLKTGYRSVPLKNSYNEDLELA
SLLVHMDISRGRDENGEVLSPFLAVGATSVAASAQAGRERLGDMSSVSSTSSNMSPLPQS
PAQAMAYRGREGSFESRYQSPLEDFRVSQEALLDHMDPQNRRMLRRTRVGGENRV
NT seq 3948 nt   +upstreamnt  +downstreamnt
atggctgggacttcgggcttcttttccaacggacctggcccgtggatggacaacgacacg
gagatgaacaacctgtaccgagacctggagctggggacagtactgacactgttttatgct
aagaagtcccaacggccagagagaaggacatttcaagtcaagctcgagaccaggacaatt
atctggactcgtggcacggataaaatagagggagagatcgacattcgagaaatcaaggag
atccgtactggacagaagtcacgggactttgagcgctatgtggaggactcgtcggtgcgg
ctggaccagacttactgctttgtcattctgtatggcaccgagtttcgccttaaatccctc
agcctgtcagcaacgtccgatgaggagatgaccatgtgggtgaaggggttaaactggctg
gtggctgacacactgaagtccccgacaccgctccagatagagaggtggttacgcaagcag
ttctacgccgttgatcgcaacagagaagacaggatatcctgtaaggatctgaagagcatg
ctgagccaggtcaactacagggtgcccaacatgaggttcctccgagagaaacttccggac
tcagagatgaggaacggagacgtgtccttcagccagtttgcccagctctatcgcagtctc
atgtttgatgctcagaaaaacatggagatcccgtttctacagaggttcattgacagacca
gaacagagaatctccctagaggacttcaagagcttccttctggagtctcaaaaggaaatg
tgggctacagacaagaacaaggttcaggagtttatgttcggctacctgaaagaccccctg
agagaagtggagcagccttatttccaccaggacgagctcctgacatacttgttctccaaa
gagaacaccatctgggattgcaccctggaccaagtgtgtcctgaaaacatgaaaaacccc
ctgtcccactactggatctcctcttcgcacaacacttacctgacgggagaccagttttcc
agcgagtcgtccctggaggcatacgctcgatgtctgaggatgggctgccgctgtattgaa
ttggactgttgggacggtccagatggaatgccagtcatctaccacggacacaccctcaca
acaaagatcaagttctgcgatgtcttgaacaccatcaaagaacacgctttcgtcacatcc
gagtatcccatcatcctgtccattgaggatcactgtagtattgtccagcagaggaatatg
gccactcactttaagaaggtgtttggagatatgctgctgaccaaggcggtggatattgca
gcagatggcctgccctcacccacccagctcaagaggaagatcctcatcaagcataagaag
ctcgcagaaggcagtgcctatgaggaggtgtccacctccactccctactcagagaacgat
atcagcaactccctcaaaaacggcatcctgtacctggaggaccccatcaaccatgagtgg
taccctcatttctttgtcctgaccagcagtaagatctattactcagaagagacctccagt
aaccagttgaacgatgatgaggaggagcacagagaggtgtccaatggcatggaccagcac
gtgacagagaaatggttccatgggaagctgggcgcagggcgggacgggcggcagatagcc
gaaaggctcctgtctgagtactgcctggagactggagctcctgatggctccttcctagtc
cgagagagcgagacctttgtgggagactacacactgtctttctggcgttcagggcgcgtg
cagcactgtcgtattcactcccgtcaagaggcaggcagcccaaagttctacctgactgac
aacctggtgttcgacaccctctttgccctaatcaaccactaccagcaggtggcgctgcgc
tgcaacgagtttgagatgaagctcactgagcccgtgcctcagaccaatgcccacgagagc
aaagagtggtaccatgccaacctctctcggagccatgcggagaacatgctgatgagggtt
cctcgtgacggggctttccttgtcaggaagagggcagaacccaactcgttcgccatttcc
ttcagggctgagggtaaaattaagcactgtcgcgtgcagcaggagggtcagaacgtggtg
ctgggcacctcagagtttgaaagtcttgtagatctcatcagctactatgagaagcaccct
ctgtaccgcaaaatgaagctgcgctatcccatcaatgaggacacactggagaaaataggc
actgctgagccagactacgggtcactgtatgagggcaggaatccaggcttttacgtggag
gccaatcaaatgcctacatttaagtgcacggtgaaagccatgtatgagtataaagcccaa
agggacgatgagctctccttcacaaagaacgccatcatctctaatgtggacaaacaggaa
ggaggatggtggaagggtgactgtggcgggaagaagcaattttggtttcctgctaactac
gtggaagagatcagtccatcaacagcggagcccgacagaactcaggagatgacagagaac
agccctctgggagatctgctgagaggaagtgtggatgtctcttcctgtcagattgtccag
cgccccgacgggaaaggcaccaggcctcacgtcttctctctggtgccgactacctctcta
cggacgggcatggtgctggacgtcgctgccagcagtgcagaagaacttaaggagtgggtg
ctcaagatccgtgaggtcactgtgacctcagaggccaagctggaggaggggaagatgatg
gagaggaggaagaagattgcactggagttatccgaactggtcatctactgtaggcctgtg
ccgtttgatgaagacaaaattggcacagagcgagcctgtttccgggacatgtcatccttt
cccgagaccaaggcagagaagtacgtcaataagatcaagggaaaaaagttcctgcagtac
aatcgactacagctgtccaggatctaccccagaggccagagactagactcctctaattac
gaccctctacccatgtggctctgtgggtcccagctggtagcactcaacttccagacagca
gacaagcccatgcagatgaaccaggccctgttcatgctgaacggaaagagcggctacgtc
cttcagccgcccatcatgagggacgataactttgatccctttgaccgtcacacgctccga
ggcctcgaacaagtcactctagagatagaggttttgggcgcccggcacctgcccaagcac
ggacgaggcatcgtttgtcctctgatcgagattgaggtgtgtggggcggactatgacagt
gccaagcaaaaaactgactcagaagctgataacggtttgaaccccacatggccccgaaag
ccgttccagttcacagtgtgcaactctgcctttgccttcctgcgttttgtggtttatgag
atagacatgttcaacgaccaaaacttcctggctcaggccacattccccatccacagcctg
aagacaggttaccggtcagtacctctgaagaacagctacaatgaggatctggagttggct
tcgttgttagtccacatggacataagcagaggaagggatgaaaatggagaggttctgagc
ccgttcctcgcagtcggggccacatcagtggcggcatcggcccaagctgggcgggaacgt
ttgggggatatgagctcagtgtcgtcgacttcctccaacatgtctcctctgccccagtct
ccagcccaggccatggcctacagagggagagagggctcctttgaatcccgctaccagtcg
cctctagaggacttcagggtgtcccaggaagccctgttggaccacatggacccacagaac
agaaggatgttgcggaggaccagagtgggcggagagaaccgtgtctaa

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