Tupaia chinensis (Chinese tree shrew): 102469651 Help Entry 102469651         CDS       T02978                                  Symbol PLCG1 Name (RefSeq) phospholipase C gamma 1   KO K01116   phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00562   Inositol phosphate metabolism tup01100   Metabolic pathways tup01521   EGFR tyrosine kinase inhibitor resistance tup04012   ErbB signaling pathway tup04014   Ras signaling pathway tup04015   Rap1 signaling pathway tup04020   Calcium signaling pathway tup04062   Chemokine signaling pathway tup04064   NF-kappa B signaling pathway tup04066   HIF-1 signaling pathway tup04070   Phosphatidylinositol signaling system tup04072   Phospholipase D signaling pathway tup04360   Axon guidance tup04370   VEGF signaling pathway tup04517   IgSF CAM signaling tup04613   Neutrophil extracellular trap formation tup04650   Natural killer cell mediated cytotoxicity tup04658   Th1 and Th2 cell differentiation tup04659   Th17 cell differentiation tup04660   T cell receptor signaling pathway tup04664   Fc epsilon RI signaling pathway tup04666   Fc gamma R-mediated phagocytosis tup04670   Leukocyte transendothelial migration tup04722   Neurotrophin signaling pathway tup04750   Inflammatory mediator regulation of TRP channels tup04919   Thyroid hormone signaling pathway tup04933   AGE-RAGE signaling pathway in diabetic complications tup04935   Growth hormone synthesis, secretion and action tup05012   Parkinson disease tup05022   Pathways of neurodegeneration - multiple diseases tup05135   Yersinia infection tup05167   Kaposi sarcoma-associated herpesvirus infection tup05170   Human immunodeficiency virus 1 infection tup05171   Coronavirus disease - COVID-19 tup05200   Pathways in cancer tup05205   Proteoglycans in cancer tup05206   MicroRNAs in cancer tup05214   Glioma tup05223   Non-small cell lung cancer tup05225   Hepatocellular carcinoma tup05231   Choline metabolism in cancer tup05235   PD-L1 expression and PD-1 checkpoint pathway in cancer tup05417   Lipid and atherosclerosis Module tup_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102469651 (PLCG1)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102469651 (PLCG1)    04014 Ras signaling pathway     102469651 (PLCG1)    04015 Rap1 signaling pathway     102469651 (PLCG1)    04370 VEGF signaling pathway     102469651 (PLCG1)    04064 NF-kappa B signaling pathway     102469651 (PLCG1)    04066 HIF-1 signaling pathway     102469651 (PLCG1)    04020 Calcium signaling pathway     102469651 (PLCG1)    04070 Phosphatidylinositol signaling system     102469651 (PLCG1)    04072 Phospholipase D signaling pathway     102469651 (PLCG1)   09133 Signaling molecules and interaction    04517 IgSF CAM signaling     102469651 (PLCG1)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102469651 (PLCG1)    04650 Natural killer cell mediated cytotoxicity     102469651 (PLCG1)    04660 T cell receptor signaling pathway     102469651 (PLCG1)    04658 Th1 and Th2 cell differentiation     102469651 (PLCG1)    04659 Th17 cell differentiation     102469651 (PLCG1)    04664 Fc epsilon RI signaling pathway     102469651 (PLCG1)    04666 Fc gamma R-mediated phagocytosis     102469651 (PLCG1)    04670 Leukocyte transendothelial migration     102469651 (PLCG1)    04062 Chemokine signaling pathway     102469651 (PLCG1)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     102469651 (PLCG1)    04919 Thyroid hormone signaling pathway     102469651 (PLCG1)   09156 Nervous system    04722 Neurotrophin signaling pathway     102469651 (PLCG1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102469651 (PLCG1)   09158 Development and regeneration    04360 Axon guidance     102469651 (PLCG1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102469651 (PLCG1)    05206 MicroRNAs in cancer     102469651 (PLCG1)    05205 Proteoglycans in cancer     102469651 (PLCG1)    05231 Choline metabolism in cancer     102469651 (PLCG1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102469651 (PLCG1)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102469651 (PLCG1)    05214 Glioma     102469651 (PLCG1)    05223 Non-small cell lung cancer     102469651 (PLCG1)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102469651 (PLCG1)    05171 Coronavirus disease - COVID-19     102469651 (PLCG1)    05167 Kaposi sarcoma-associated herpesvirus infection     102469651 (PLCG1)   09171 Infectious disease: bacterial    05135 Yersinia infection     102469651 (PLCG1)   09164 Neurodegenerative disease    05012 Parkinson disease     102469651 (PLCG1)    05022 Pathways of neurodegeneration - multiple diseases     102469651 (PLCG1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102469651 (PLCG1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102469651 (PLCG1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102469651 (PLCG1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:tup04131]     102469651 (PLCG1) Enzymes [BR:tup01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102469651 (PLCG1) Membrane trafficking [BR:tup04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102469651 (PLCG1)  Endocytosis   Macropinocytosis    Phospholipase C     102469651 (PLCG1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7 Motif Other DBs NCBI-GeneID:  102469651 NCBI-ProteinID:  XP_006144201 LinkDB All DBs Position Un AA seq 1291 aa AA seqDB search MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA GERPELCRMSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT FLFSKENSVWNTQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVVSEYPVILSIEDHCSIA QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE GQTVLLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGRHCGYVLQPSTMRDEVFDPFDKS SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDNTKQKTEFVVDNGLNPVW PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASAQLFHGRAREGSFEARYQQPFED FRISQEHLADHFDSRERRAPRRTRVNGDNRL NT seq 3876 nt NT seq  +upstreamnt  +downstreamnt atggcgggcgccgcgtccccctgcgccaatggctgcgggcctggcgcgccctcggacgcc gaggtgttgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacacgccagatc acgtggagccgcggcgctgacaagatcgagggggctattgatattcgtgaaatcaaggag atccggccagggaagacttcaagggactttgatcgctaccaagaggaccctgctttccgg ccagaccagtcacactgctttgtcatcctctatggaatggaattccgcctgaagaccctg agcctgcaagccacatccgaggatgaagtaaacatgtggatcaagggcttgacttggctg atggaggacacgttgcaggcagccacacccctgcagattgagaggtggctccgcaagcag ttctattcagtggatcggaatcgtgaggatcgtatatcggccaaggacttgaagaacatg ctgtcccaggtcaactacagggtccccaacatgcgcttcctccgagagcggctgacggac ctagagcagcgcagcagtgacatcacctatgggcagtttgctcagctgtaccgcagcctc atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgctctgagggct ggggagcggccggagctctgccgcatgtcccttcctgagttccagcagttcctcctcgag taccagggggagctgtgggctgtcgaccggctccaggtacaggagttcatgctcagcttc ctccgagaccccttgcgagagattgaagagccatatttcttcctggatgagttcgtcacc ttcttattctccaaagaaaacagcgtgtggaacacccagctggatgcggtgtgtccggac accatgaacaaccctctctcccactattggatctcctcttcgcacaacacgtacctgact ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgcgcatgggc tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat ggacacacccttaccaccaagatcaagttttcagatgtcctgcacaccatcaaggagcat gcctttgtggtctcagagtaccctgtcatcctgtccatcgaggaccactgcagcattgcc cagcagaggaacatggcccagtacttcaagaaggtgctcggggacacactcctcaccaag cccgtggacattgccgccgatgggcttccctcacccaaccagctaaagaggaagattctc atcaagcacaagaagctggctgagggcagtgcctacgaggaagtgcctacgtctgtgatg tactctgagaacgacatcagcaactccatcaagaatggcatcctctacttggaggacccc gtgaaccatgaatggtatccccattactttgttctgaccagcagcaagatctactactct gaggagaccagcagtgaccaaggcaatgaggatgaggaggagccaaaagaggccagtggc agcacagaactgcactccaacgagaagtggttccacgggaagctcggggcagggcgggat gggcggcacatcgcggagcgcctgctcaccgagtactgcattgagaccggggccccggac ggctccttcctagtgcgagagagtgagaccttcgtgggcgactacacgctgtccttctgg cggaacggaaaagttcagcactgccggatccactctcgacaggatgccgggacccccaag ttcttcttgacagacaacctcgtcttcgactccctctatgacctcatcacgcactaccag caggtgcccctgcgctgcaatgagtttgagatgcgcctctcagagcctgtcccacagact aatgcccacgagagcaaagagtggtaccacgcaagcttgacccgagcgcaagccgagcat atgctgatgcgcgtcccccgcgatggggccttcctggtgcggaaacggaatgagcccaac tcgtatgccatctccttccgggctgagggcaagatcaagcactgccgcgtccagcaggaa ggccagactgtgctgctggggaactcagagtttgacagcctcgtcgacctcatcagctac tacgagaagcacccactgtaccgcaagatgaagctgcgctaccccatcaacgaggaggca ctggagaagatcggcacagctgagccggactatggggccctgtatgagggacgcaaccct ggcttctacgtggaggcaaaccccatgccgactttcaagtgtgcagtcaaagccctcttc gactacaaggcccagagagaggatgaactgactttcaccaagagcgccatcatccagaat gtggaaaagcaagagggcggctggtggcgaggggactatggtgggaagaagcagctgtgg ttcccatcaaactacgtggaggagatggtcagccctgcagccctggagcctgagagggag cacttggatgagaatagccccctgggggacctgctgcgaggagtcttggacgtgccggcc tgtcagatagccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagt atggcatcggtggcccactggtctctggatgtcgcagctgactcgcaggaggagctgcag gactgggtgaaaaagatccgtgaagtggcccagactgcagatgccaggctcaccgagggg aaaatgatggagaggaggaagaagatcgccctggagctctctgaacttgttgtctactgc cgtcctgttcccttcgatgaagaaaagattggcacagagcgggcctgctaccgggatatg tcgtccttcccggaaaccaaggcagagaagtatgtgaacaaggccaaaggcaagaaattc ctgcagtacaaccggctgcagctgtcccgcatctaccccaagggccagcgactggactcc tccaattatgaccctctgcccatgtggatctgtggcagtcagcttgtggccctcaacttc cagactccagataagcccatgcagatgaaccaggccctcttcatggcgggcaggcactgc ggctatgtgctgcagccaagcaccatgcgggacgaagtctttgacccctttgacaagagc agtctccgtgggctggagccgtgtgccatctgcatcgaggtgctgggggcccggcatctg ccaaagaatggccgaggcatcgtctgtccctttgtggagattgaagtggctggagctgag tatgacaacaccaagcagaagacggagtttgtggtggacaatggactgaatcctgtgtgg ccagccaagcctttccatttccagatcagtaaccccgaatttgctttcctacgttttgtg gtgtatgaggaagatatgtttagtgatcaaaacttcttggctcaggctactttcccagta aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagcgaggacctg gagttggcctctctgctcatcaagattgacatcttccctgccaagcaggagaacggtgac ctgagtccgttcagtggcacgtccctgcgggagcggggctcagatgcatcagcccagctg tttcatggccgggcccgagagggctcctttgaagcccgctaccagcaaccatttgaggat ttccgcatctcccaggaacatctggcagaccatttcgatagtcgggagcgaagggcccca aggaggactcgggtcaatggagacaaccgcctctag

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