Tupaia chinensis (Chinese tree shrew): 102472317 Help Entry 102472317         CDS       T02978                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup00230   Purine metabolism tup01100   Metabolic pathways tup01522   Endocrine resistance tup04015   Rap1 signaling pathway tup04020   Calcium signaling pathway tup04022   cGMP-PKG signaling pathway tup04024   cAMP signaling pathway tup04062   Chemokine signaling pathway tup04072   Phospholipase D signaling pathway tup04081   Hormone signaling tup04082   Neuroactive ligand signaling tup04114   Oocyte meiosis tup04211   Longevity regulating pathway tup04213   Longevity regulating pathway - multiple species tup04261   Adrenergic signaling in cardiomyocytes tup04270   Vascular smooth muscle contraction tup04371   Apelin signaling pathway tup04540   Gap junction tup04611   Platelet activation tup04713   Circadian entrainment tup04714   Thermogenesis tup04720   Long-term potentiation tup04723   Retrograde endocannabinoid signaling tup04724   Glutamatergic synapse tup04725   Cholinergic synapse tup04727   GABAergic synapse tup04742   Taste transduction tup04750   Inflammatory mediator regulation of TRP channels tup04911   Insulin secretion tup04912   GnRH signaling pathway tup04913   Ovarian steroidogenesis tup04914   Progesterone-mediated oocyte maturation tup04915   Estrogen signaling pathway tup04916   Melanogenesis tup04918   Thyroid hormone synthesis tup04921   Oxytocin signaling pathway tup04923   Regulation of lipolysis in adipocytes tup04925   Aldosterone synthesis and secretion tup04926   Relaxin signaling pathway tup04927   Cortisol synthesis and secretion tup04928   Parathyroid hormone synthesis, secretion and action tup04934   Cushing syndrome tup04935   Growth hormone synthesis, secretion and action tup04970   Salivary secretion tup04971   Gastric acid secretion tup04972   Pancreatic secretion tup04976   Bile secretion tup05032   Morphine addiction tup05163   Human cytomegalovirus infection tup05166   Human T-cell leukemia virus 1 infection tup05200   Pathways in cancer tup05207   Chemical carcinogenesis - receptor activation tup05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:tup00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     102472317 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     102472317 (ADCY8)    04371 Apelin signaling pathway     102472317 (ADCY8)    04020 Calcium signaling pathway     102472317 (ADCY8)    04072 Phospholipase D signaling pathway     102472317 (ADCY8)    04024 cAMP signaling pathway     102472317 (ADCY8)    04022 cGMP-PKG signaling pathway     102472317 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     102472317 (ADCY8)    04081 Hormone signaling     102472317 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     102472317 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     102472317 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102472317 (ADCY8)    04062 Chemokine signaling pathway     102472317 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     102472317 (ADCY8)    04923 Regulation of lipolysis in adipocytes     102472317 (ADCY8)    04912 GnRH signaling pathway     102472317 (ADCY8)    04913 Ovarian steroidogenesis     102472317 (ADCY8)    04915 Estrogen signaling pathway     102472317 (ADCY8)    04914 Progesterone-mediated oocyte maturation     102472317 (ADCY8)    04921 Oxytocin signaling pathway     102472317 (ADCY8)    04926 Relaxin signaling pathway     102472317 (ADCY8)    04935 Growth hormone synthesis, secretion and action     102472317 (ADCY8)    04918 Thyroid hormone synthesis     102472317 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     102472317 (ADCY8)    04916 Melanogenesis     102472317 (ADCY8)    04925 Aldosterone synthesis and secretion     102472317 (ADCY8)    04927 Cortisol synthesis and secretion     102472317 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102472317 (ADCY8)    04270 Vascular smooth muscle contraction     102472317 (ADCY8)   09154 Digestive system    04970 Salivary secretion     102472317 (ADCY8)    04971 Gastric acid secretion     102472317 (ADCY8)    04972 Pancreatic secretion     102472317 (ADCY8)    04976 Bile secretion     102472317 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     102472317 (ADCY8)    04727 GABAergic synapse     102472317 (ADCY8)    04725 Cholinergic synapse     102472317 (ADCY8)    04720 Long-term potentiation     102472317 (ADCY8)    04723 Retrograde endocannabinoid signaling     102472317 (ADCY8)   09157 Sensory system    04742 Taste transduction     102472317 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     102472317 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     102472317 (ADCY8)    04213 Longevity regulating pathway - multiple species     102472317 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     102472317 (ADCY8)    04714 Thermogenesis     102472317 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102472317 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     102472317 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102472317 (ADCY8)    05163 Human cytomegalovirus infection     102472317 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     102472317 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     102472317 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102472317 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     102472317 (ADCY8) Enzymes [BR:tup01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      102472317 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  102472317 NCBI-ProteinID:  XP_006156759 LinkDB All DBs Position Un AA seq 1256 aa AA seqDB search MELSDVRCLSGSEELYTIHPTPPAGDSGGGPPPGGGGPQRLLWQTAVRHITEQRFIHGHR GAGGGGSGGSGKASNLAGGGLNHHAPQLASDSALPLYSLGPGERAHSTGSTKVFPERSGS GSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFL GQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKD TTSHTYLQYSAVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILA GLGTSLLQLILQVVIPRLVVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRR CVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSI LFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR QDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVD IANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLL SLPEDIVKESVSASDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLA QALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSN LVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLVLRKTC CWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEY FVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETLYAGLFLRYDNLNHSGEDFL GTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNIL PSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEII ADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQ EINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGLSGRIQVPEE TYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAV VLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLTPSGPEPGVQAEGTDKSDLP NT seq 3771 nt NT seq  +upstreamnt  +downstreamnt atggagctctcggatgtgcgctgccttagcggcagcgaggaactctacaccatccacccg acgcccccggccggcgacagcgggggggggcccccccccgggggtggcgggccgcagcgg ctgctgtggcagacggcggtgcggcacatcacggagcagcgcttcattcatgggcaccgg ggcgccggaggtggtgggagcggaggttcaggcaaagcctccaacctggccggaggcggt ctcaaccatcacgcaccgcagctggccagtgactccgcactgccgctctactcgctgggc cctggggagcgagcgcacagcaccggcagcaccaaagtcttcccggaacgcagcgggagc ggcagtgccagcggcagcggaggcggaggcgacctgggcttcttgcaccttgactgtgcc ccaagcaactcggatttcttcctcaatgggggctatagctaccgaggggtcattttcccc accctgcgcaactccttcaagtctcgggatctggaacgcctctaccagcgctatttcctg ggccaaaggcgcaaatccgaagtggtgatgaatgtactggacgtgctgaccaaactcacc ctcttggtcctccacttgagcctggcctctgctcccatggacccgctcaagggcatcctg ttgggcttcttcaccggcatcgaagtggtgatctgtgccctcgtggtggtcaggaaggac accacctcgcacacatacctgcagtacagtgccgtggtcacctgggtggccatgaccacc cagatcctggcagcaggccttggttacgggcttctgggagacggcataggctacgtgctc ttcacactcttcgccacctacagcatgctgccgctgccactcacgtgggccatcctagcc ggcctgggcacctcgctgctgcagctgatccttcaggtggtcatcccgcgactggtggtc atttccatcaaccaggtggtggcccaggctgtgttgttcatgtgtatgaacacagctgga atcttcatcagctacctgtcagaccgggctcagcgacaagccttcctggagacacggaga tgtgtggaggccaggttgcgcctggagacagagaaccaaagacaggagcggcttgtgctg tctgtgcttccccggtttgtcgtcctggaaatgatcaatgacatgaccaatgtggaagat gagcacctgcaacaccaattccatcggatctacatccatcgctatgagaacgtcagtatt ctttttgcagatgttaaaggatttaccaacctctctacgaccttgtctgctcaggagctg gtcaggatgctcaacgagctctttgccagatttgatcgactggcccatgagcatcactgc ctccgcattaaaatcctgggagactgctactactgtgtctctgggcttcctgagccccgc caggaccatgcccactgctgtgtggaaatgggcctcagcatgatcaaaaccatcagatat gtgcggtcaaggacaaagcatgacgttgacatgcggattgggatccactcaggctcagtg ctgtgtggagtgctgggccttaggaagtggcagtttgatgtctggtcttgggatgtggac atcgcaaacaaactggaatctggaggaatccctgggaggatccacatttccaaagccaca ctggattgcctcaacggtgactataatgtggaagagggtcatggtaaagagaggaatgag ttcttgaggaaacataatatagagacctatttgattaagcagcctgaggaaagtctgcta tccttgcccgaagacattgtcaaggagtcggtgagcgcttcagacaggagaaatagtggg gctacattcacagaaggatcctggagtcctgaactgccctttgataacattgtggggaaa caaaacactctggctgccctaacaagaaattcaataaatctgcttccaaaccatcttgca caagctttgcatgtccagtctgggcctgaggaaattaacaagagaatagaacataccatc gacttgcggagtggcgataaattgagaagagagcatatcaagccattctcactgatgttt aaagactccagcctggagcacaagtattctcaaatgagggatgaagtgttcaagtcaaac ttggtctgcgcatttatcgttctcctatttatcacagcaatacaaagtttgcttccttct tcaagagtgatgccaatgaccatccagttctccatcctgataatgctgcactcagctctg gtcctcatcaccacggcagaggattataagtgtttgcccctcgtcctccggaaaacttgc tgttggattaatgagacctatttggcccggaacgtcatcatctttgcatccatattgatt aattttctgggtgccatcctaaatattctgtggtgtgattttgacaagtcgatacccttg aagaacctgactttcaattcctcagctgtgtttacagatatctgctcctacccagagtac ttcgtcttcacgggggtgttggccatggtgacctgtgctgttttcctccgacttaactcc gtcctgaagctggcagtgctgttgattatgattgccatctatgccctgttgaccgagacc ctctatgcaggtctctttctgcgttatgacaacctgaaccacagtggagaagatttcctg ggaaccaaggaagcatccctgctgctgatggccatgtttctcctcgctgtattctaccat ggacagcagctggagtacacagcccgactggacttcctttggcgagtacaggccaaagag gagatcaatgagatgaaggaactgagggaacacaacgagaacatgctccggaatatctta cccagtcatgtggcccgccattttctggagaaagaccgggacaatgaggagctgtattct caatcctatgatgctgttggggtgatgtttgcctccatcccagggtttgcagacttttac tctcagactgaaatgaataaccagggagtggaatgcctacgcttgctgaatgagatcatt gctgactttgatgagcttcttggtgaagaccggtttcaagatatagaaaagattaagacg attggcagcacctacatggctgtttcaggcctgtcccctgaaaaacagcaatgtgaggac aagtggggacacttgtgtgctctggctgatttctctcttgccctgaccgaaagcatccag gagatcaataagcattcgttcaacaactttgaactccggattggcatcagccatggctca gtggtagctggagttattggcgcaaagaaaccacagtatgacatttggggcaaaaccgtg aacctggcaagccgaatggacagtactgggcttagtggccggatccaagtcccagaggag acctatctcatcctgaaggaccagggctttgcttttgactaccgaggggagatctacgta aaaggcatcagtgaacaggaaggaaaaattaaaacgtactttctcctgggaagagttcaa cccaacccattcatcttgcccccaagaagactgcctgggcaatactctttggctgctgtc gtcctgggccttgtccagtccctcaacaggcaaaggcagaagcagctactgaatgagaac aacaacacgggcatcatcaagggtcattataaccggcggactttgttgacacccagtggg ccagagcctggagtccaagctgaaggcaccgacaaatctgatttgccataa

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